Supporting Information Table 4. List of human protein-protein interactons. Entrez ID 1 Symbol 1 Entrez ID 2 Symbol 2 Data Source (R: Rual et al; S: Stelzl et al; L: Literature curation) 1 A1BG 10321 CRISP3 L 2 A2M 259 AMBP L 2 A2M 348 APOE L 2 A2M 351 APP L 2 A2M 354 KLK3 L 2 A2M 567 B2M L 2 A2M 1508 CTSB L 2 A2M 1990 ELA1 L 2 A2M 3309 HSPA5 L 2 A2M 3553 IL1B L 2 A2M 3586 IL10 L 2 A2M 3931 LCAT L 2 A2M 3952 LEP L 2 A2M 4035 LRP1 L 2 A2M 4803 NGFB L 2 A2M 5047 PAEP L 2 A2M 7045 TGFBI L 2 A2M 8728 ADAM19 L 2 A2M 9510 ADAMTS1 L 2 A2M 10944 SMAP S 2 A2M 55729 ATF7IP L 9 NAT1 8260 ARD1A L 12 SERPINA3 351 APP L 12 SERPINA3 354 KLK3 L 12 SERPINA3 1215 CMA1 L 12 SERPINA3 1504 CTRB1 L 12 SERPINA3 1506 CTRL L 12 SERPINA3 1511 CTSG L 12 SERPINA3 1990 ELA1 L 12 SERPINA3 1991 ELA2 L 12 SERPINA3 2064 ERBB2 L 12 SERPINA3 2153 F5 L 12 SERPINA3 3817 KLK2 L 12 SERPINA3 4035 LRP1 L 12 SERPINA3 4485 MST1 L 12 SERPINA3 5422 POLA L 12 SERPINA3 64215 DNAJC1 L 14 AAMP 51497 TH1L S 15 AANAT 7534 YWHAZ L 18 ABAT 7915 ALDH5A1 L 19 ABCA1 335 APOA1 L 19 ABCA1 6645 SNTB2 L 19 ABCA1 8772 FADD L 20 ABCA2 55755 CDK5RAP2 L 22 ABCB7 2235 FECH L 23 ABCF1 3692 ITGB4BP S 24 ABCA4 1258 CNGB1 L 25 ABL1 27 ABL2 L 25 ABL1 472 ATM L 25 ABL1 613 BCR L 25 ABL1 718 C3 L 25 ABL1 867 CBL L 25 ABL1 1501 CTNND2 L 25 ABL1 2048 EPHB2 L 25 ABL1 2547 XRCC6 L 25 ABL1 2876 GPX1 L 25 ABL1 2885 GRB2 L 25 ABL1 3055 HCK L 25 ABL1 3636 INPPL1 L 25 ABL1 3716 JAK1 L 25 ABL1 4193 MDM2 L 25 ABL1 4690 NCK1 L 25 ABL1 4914 NTRK1 L 25 ABL1 5062 PAK2 L 25 ABL1 5295 PIK3R1 L 25 ABL1 5335 PLCG1 L 25 ABL1 5591 PRKDC L 25 ABL1 5829 PXN L 25 ABL1 5883 RAD9A L 25 ABL1 5901 RAN L 25 ABL1 5921 RASA1 L 25 ABL1 5925 RB1 L 25 ABL1 5989 RFX1 L 25 ABL1 6091 ROBO1 L 25 ABL1 6098 ROS1 L 25 ABL1 6549 SLC9A2 L 25 ABL1 6714 SRC L 25 ABL1 6764 ST5 L 25 ABL1 7157 TP53 L 25 ABL1 7161 TP73 L 25 ABL1 7275 TUB L 25 ABL1 7535 ZAP70 L 25 ABL1 8751 ADAM15 L 25 ABL1 8936 WASF1 L 25 ABL1 9051 PSTPIP1 L 25 ABL1 9564 BCAR1 L 25 ABL1 9610 RIN1 L 25 ABL1 10006 ABI1 L 25 ABL1 10152 ABI2 L 25 ABL1 10580 SORBS1 L 25 ABL1 11183 MAP4K5 L 25 ABL1 23385 NCSTN L 25 ABL1 23616 SH3BP1 L 25 ABL1 51466 EVL L 25 ABL1 55824 PAG1 L 25 ABL1 91746 YT521 L 26 ABP1 1785 DNM2 L 27 ABL2 613 BCR L 27 ABL2 847 CAT L 27 ABL2 1398 CRK L 27 ABL2 2048 EPHB2 L 27 ABL2 2876 GPX1 L 27 ABL2 3055 HCK L 31 ACACA 672 BRCA1 L 31 ACACA 1114 CHGB S 39 ACAT2 1045 CDX2 L 40 ACCN1 41 ACCN2 L 40 ACCN1 9311 ACCN3 L 43 ACHE 351 APP L 43 ACHE 1282 COL4A1 L 43 ACHE 1939 LGTN L 43 ACHE 8292 COLQ L 43 ACHE 284217 LAMA1 L 49 ACR 5104 SERPINA5 L 49 ACR 7783 ZP2 L 51 ACOX1 6342 SCP2 L 52 ACP1 1969 EPHA2 L 52 ACP1 2047 EPHB1 L 52 ACP1 2048 EPHB2 L 52 ACP1 7535 ZAP70 L 52 ACP1 51460 SFMBT1 R 52 ACP1 54874 FNBP1L S 52 ACP1 55052 MRPL20 S 54 ACP5 1959 EGR2 S 54 ACP5 2239 GPC4 L 54 ACP5 5601 MAPK9 S 54 ACP5 6118 RPA2 S 54 ACP5 7704 ZBTB16 S 54 ACP5 8743 TNFSF10 S 54 ACP5 9141 PDCD5 S 54 ACP5 9410 WDR57 S 54 ACP5 54978 C2orf18 S 58 ACTA1 1072 CFL1 L 58 ACTA1 1756 DMD L 58 ACTA1 1773 DNASE1 L 58 ACTA1 2638 GC L 58 ACTA1 2934 GSN L 58 ACTA1 4632 MYL1 L 58 ACTA1 5216 PFN1 L 58 ACTA1 5578 PRKCA L 58 ACTA1 5879 RAC1 L 58 ACTA1 6525 SMTN L 58 ACTA1 6624 FSCN1 L 58 ACTA1 6876 TAGLN L 58 ACTA1 7094 TLN1 L 58 ACTA1 7114 TMSB4X L 58 ACTA1 7187 TRAF3 L 58 ACTA1 9468 PCYT1B L 58 ACTA1 10575 CCT4 L 58 ACTA1 22948 CCT5 L 59 ACTA2 1072 CFL1 L 59 ACTA2 1773 DNASE1 L 59 ACTA2 2638 GC L 59 ACTA2 4632 MYL1 L 59 ACTA2 7114 TMSB4X L 59 ACTA2 9468 PCYT1B L 59 ACTA2 10575 CCT4 L 59 ACTA2 22948 CCT5 L 60 ACTB 70 ACTC L 60 ACTB 71 ACTG1 R 60 ACTB 1072 CFL1 R 60 ACTB 1073 CFL2 R 60 ACTB 2010 EMD L 60 ACTB 2314 FLII L 60 ACTB 2934 GSN L 60 ACTB 4093 SMAD9 L 60 ACTB 4687 NCF1 L 60 ACTB 4892 NRAP L 60 ACTB 5027 P2RX7 L 60 ACTB 5201 PFDN1 L 60 ACTB 5216 PFN1 L 60 ACTB 5217 PFN2 L 60 ACTB 5337 PLD1 L 60 ACTB 5338 PLD2 L 60 ACTB 5764 PTN L 60 ACTB 5879 RAC1 L 60 ACTB 5880 RAC2 L 60 ACTB 6336 SCN10A L 60 ACTB 6597 SMARCA4 L 60 ACTB 6709 SPTAN1 L 60 ACTB 7168 TPM1 L 60 ACTB 7169 TPM2 L 60 ACTB 7170 TPM3 L 60 ACTB 7430 VIL2 L 60 ACTB 7447 VSNL1 L 60 ACTB 8655 DNCL1 L 60 ACTB 8904 CPNE1 L 60 ACTB 11034 DSTN R 60 ACTB 23214 XPO6 L 60 ACTB 25932 CLIC4 L 60 ACTB 55729 ATF7IP L 60 ACTB 83988 NCALD L 60 ACTB 131034 CPNE4 L 60 ACTB 221184 CPNE2 L 70 ACTC 81 ACTN4 L 70 ACTC 283 ANG L 70 ACTC 1072 CFL1 L 70 ACTC 1756 DMD L 70 ACTC 2039 EPB49 L 70 ACTC 2638 GC L 70 ACTC 3315 HSPB1 L 70 ACTC 3927 LASP1 L 70 ACTC 4638 MYLK L 70 ACTC 5339 PLEC1 L 70 ACTC 5581 PRKCE L 70 ACTC 5756 PTK9 L 70 ACTC 6624 FSCN1 L 70 ACTC 7094 TLN1 L 70 ACTC 7414 VCL L 70 ACTC 7430 VIL2 L 70 ACTC 7454 WAS L 70 ACTC 7456 WASPIP L 70 ACTC 8655 DNCL1 L 70 ACTC 10097 ACTR2 L 70 ACTC 23224 SYNE2 L 70 ACTC 23345 SYNE1 L 70 ACTC 51660 BRP44L S 70 ACTC 60312 AFAP L 70 ACTC 84687 PPP1R9B L 70 ACTC 85477 SCIN L 70 ACTC 137735 STARS L 71 ACTG1 308 ANXA5 L 71 ACTG1 1072 CFL1 R 71 ACTG1 1073 CFL2 R 71 ACTG1 1773 DNASE1 L 71 ACTG1 3692 ITGB4BP S 71 ACTG1 4640 MYO1A L 71 ACTG1 5217 PFN2 S 71 ACTG1 5800 PTPRO S 71 ACTG1 5829 PXN L 71 ACTG1 6456 SH3GL2 S 71 ACTG1 6487 ST3GAL3 S 71 ACTG1 7094 TLN1 L 71 ACTG1 7114 TMSB4X L 71 ACTG1 7414 VCL L 71 ACTG1 8655 DNCL1 L 71 ACTG1 8936 WASF1 L 71 ACTG1 10134 BCAP31 L 71 ACTG1 11034 DSTN R 71 ACTG1 11098 PRSS23 S 71 ACTG1 55729 ATF7IP L 81 ACTN4 135 ADORA2A L 81 ACTN4 525 ATP6V1B1 L 81 ACTN4 818 CAMK2G L 81 ACTN4 1308 COL17A1 L 81 ACTN4 2934 GSN L 81 ACTN4 3688 ITGB1 L 81 ACTN4 4703 NEB L 81 ACTN4 9124 PDLIM1 RL 81 ACTN4 9223 MAGI1 L 81 ACTN4 9351 SLC9A3R2 L 81 ACTN4 9712 USP6NL L 81 ACTN4 10612 TRIM3 L 81 ACTN4 51778 MYOZ2 R 81 ACTN4 57554 LRRC7 L 81 ACTN4 58529 MYOZ1 R 86 ACTL6A 396 ARHGDIA S 86 ACTL6A 2130 EWSR1 R 86 ACTL6A 4609 MYC L 86 ACTL6A 5430 POLR2A L 86 ACTL6A 6597 SMARCA4 L 86 ACTL6A 9031 BAZ1B L 87 ACTN1 135 ADORA2A L 87 ACTN1 815 CAMK2A L 87 ACTN1 1308 COL17A1 L 87 ACTN1 1495 CTNNA1 L 87 ACTN1 2203 FBP1 L 87 ACTN1 2903 GRIN2A L 87 ACTN1 4110 MAGEA11 R 87 ACTN1 5585 PKN1 L 87 ACTN1 5834 PYGB L 87 ACTN1 7273 TTN L 87 ACTN1 7518 XRCC4 R 87 ACTN1 7791 ZYX L 87 ACTN1 8048 CSRP3 L 87 ACTN1 8851 CDK5R1 L 87 ACTN1 8941 CDK5R2 L 87 ACTN1 9124 PDLIM1 L 87 ACTN1 9499 MYOT L 87 ACTN1 10755 GIPC1 L 87 ACTN1 26136 TES L 87 ACTN1 51778 MYOZ2 L 87 ACTN1 58529 MYOZ1 RL 87 ACTN1 117178 SSX2IP L 87 ACTN1 125950 RAVER1 L 88 ACTN2 89 ACTN3 L 88 ACTN2 135 ADORA2A L 88 ACTN2 1739 DLG1 L 88 ACTN2 1742 DLG4 L 88 ACTN2 2904 GRIN2B L 88 ACTN2 3739 KCNA4 L 88 ACTN2 3741 KCNA5 L 88 ACTN2 5585 PKN1 L 88 ACTN2 6401 SELE L 88 ACTN2 8038 ADAM12 L 88 ACTN2 9124 PDLIM1 L 88 ACTN2 22142 (null) S 88 ACTN2 23022 KIAA0992 L 88 ACTN2 27185 DISC1 L 88 ACTN2 51778 MYOZ2 L 88 ACTN2 58529 MYOZ1 L 88 ACTN2 84665 MYPN L 88 ACTN2 117178 SSX2IP L 88 ACTN2 125950 RAVER1 L 89 ACTN3 135 ADORA2A L 89 ACTN3 84665 MYPN L 90 ACVR1 91 ACVR1B L 90 ACVR1 650 BMP2 L 90 ACVR1 655 BMP7 L 90 ACVR1 2022 ENG L 90 ACVR1 2339 FNTA L 90 ACVR1 3547 IGSF1 L 90 ACVR1 3624 INHBA L 90 ACVR1 3625 INHBB L 90 ACVR1 3626 INHBC L 90 ACVR1 4086 SMAD1 L 90 ACVR1 4090 SMAD5 L 90 ACVR1 4093 SMAD9 L 90 ACVR1 8200 GDF5 L 91 ACVR1B 92 ACVR2A L 91 ACVR1B 93 ACVR2B L 91 ACVR1B 3547 IGSF1 L 91 ACVR1B 3624 INHBA L 91 ACVR1B 3625 INHBB L 91 ACVR1B 3626 INHBC L 91 ACVR1B 4089 SMAD4 L 91 ACVR1B 4092 SMAD7 L 91 ACVR1B 6642 SNX1 L 91 ACVR1B 6997 TDGF1 L 91 ACVR1B 9392 TGFBRAP1 L 92 ACVR2A 650 BMP2 L 92 ACVR2A 654 BMP6 L 92 ACVR2A 655 BMP7 L 92 ACVR2A 2022 ENG L 92 ACVR2A 2661 GDF9 L 92 ACVR2A 3547 IGSF1 L 92 ACVR2A 3624 INHBA L 92 ACVR2A 3625 INHBB L 92 ACVR2A 3626 INHBC L 92 ACVR2A 7049 TGFBR3 L 92 ACVR2A 8200 GDF5 L 93 ACVR2B 655 BMP7 L 93 ACVR2B 2660 GDF8 L 93 ACVR2B 3547 IGSF1 L 93 ACVR2B 3624 INHBA L 93 ACVR2B 3625 INHBB L 93 ACVR2B 3626 INHBC L 93 ACVR2B 6642 SNX1 L 93 ACVR2B 6643 SNX2 L 93 ACVR2B 8200 GDF5 L 93 ACVR2B 9392 TGFBRAP1 L 93 ACVR2B 10220 GDF11 L 94 ACVRL1 7040 TGFB1 L 94 ACVRL1 7048 TGFBR2 L 94 ACVRL1 9392 TGFBRAP1 L 95 ACY1 7265 TTC1 R 100 ADA 134 ADORA1 L 100 ADA 135 ADORA2A L 100 ADA 1803 DPP4 L 100 ADA 1812 DRD1 L 100 ADA 2885 GRB2 L 100 ADA 2908 NR3C1 L 102 ADAM10 1943 EFNA2 L 103 ADAR 7514 XPO1 L 107 ADCY1 108 ADCY2 L 108 ADCY2 111 ADCY5 L 108 ADCY2 2778 GNAS L 111 ADCY5 2770 GNAI1 L 111 ADCY5 2778 GNAS L 111 ADCY5 5578 PRKCA L 111 ADCY5 5590 PRKCZ L 111 ADCY5 5997 RGS2 L 112 ADCY6 1139 CHRNA7 L 116 ADCYAP1 117 ADCYAP1R1 L 116 ADCYAP1 6344 SCTR L 116 ADCYAP1 6469 SHH L 116 ADCYAP1 7434 VIPR2 L 118 ADD1 119 ADD2 L 118 ADD1 801 CALM1 L 118 ADD1 3398 ID2 L 118 ADD1 6708 SPTA1 L 118 ADD1 6709 SPTAN1 L 118 ADD1 6710 SPTB L 118 ADD1 10808 HSPH1 L 119 ADD2 801 CALM1 L 119 ADD2 2534 FYN L 119 ADD2 6709 SPTAN1 L 128 ADH5 1107 CHD3 S 133 ADM 1906 EDN1 L 133 ADM 3075 CFH L 133 ADM 4880 NPPC L 133 ADM 11318 ADMR L 134 ADORA1 1812 DRD1 L 134 ADORA1 2037 EPB41L2 L 134 ADORA1 2771 GNAI2 L 134 ADORA1 2775 GNAO1 L 134 ADORA1 2781 GNAZ L 134 ADORA1 2911 GRM1 L 134 ADORA1 5028 P2RY1 L 135 ADORA2A 1813 DRD2 L 142 PARP1 596 BCL2 L 142 PARP1 836 CASP3 L 142 PARP1 1026 CDKN1A L 142 PARP1 1058 CENPA L 142 PARP1 1059 CENPB L 142 PARP1 4605 MYBL2 L 142 PARP1 4790 NFKB1 L 142 PARP1 5111 PCNA L 142 PARP1 5422 POLA L 142 PARP1 5451 POU2F1 L 142 PARP1 5970 RELA L 142 PARP1 6189 RPS3A L 142 PARP1 6256 RXRA L 142 PARP1 7157 TP53 L 142 PARP1 7515 XRCC1 L 142 PARP1 9184 BUB3 L 142 PARP1 10038 PARP2 L 142 PARP1 10039 PARP3 L 142 PARP1 10432 RBM14 L 142 PARP1 23090 ZNF423 L 142 PARP1 23649 POLA2 L 142 PARP1 54840 APTX L 143 PARP4 9961 MVP L 147 ADRA1B 1173 AP2M1 L 147 ADRA1B 2767 GNA11 L 147 ADRA1B 6295 SAG L 148 ADRA1A 84687 PPP1R9B L 150 ADRA2A 153 ADRB1 L 150 ADRA2A 1967 EIF2B1 L 150 ADRA2A 2770 GNAI1 L 150 ADRA2A 2775 GNAO1 L 150 ADRA2A 7534 YWHAZ L 151 ADRA2B 1967 EIF2B1 L 151 ADRA2B 2771 GNAI2 L 151 ADRA2B