CURRICULUM VITAE Dr. Ibrahim Hamza Kankia, MRSB BSc (UDUS), MSc (UK), PhD (UK) Emails: Mobile : [email protected] +447447181221 [email protected] +447466347529 [email protected] +2348066225056 [email protected] Permanent Home Address: Unguwar Kanawa Kankia, Katsina State. Correspondence Address: Department of Biochemistry, Umaru Musa Yar’adua University, 2218, Katsina State – Nigeria. Qualification: PhD Molecular and Cellular Pharmacology Area of Specialization: Molecular, Biotechnological and Pharmacological approaches to improving breast and ovarian cancer therapy Experience: Academic (Teaching/Research) & Non-academic (Academic Planning) Applications and techniques used in my research: 1. Bioinformatics 2. DNA/RNA Isolation, 3. PCR, and RTPCR 4. Molecular Cloning and Gene delivery, 5. Expression and Trafficking Analysis; 6. Gene Promoter Constructs and Reporter Assays; 7. Biochemical Techniques involving Protein Expression and Characterisation (Extraction, Quantification and Purification) 8. ELISA based assays; 9. Fluorescence and Luminescence based assays; 10. Immuno-detection techniques including Western blotting, Immunocytochemistry 11. Cell culture Techniques (2D & 3D) and Stable cell lines; 12. Cell Viability/Cytotoxicity Assays such as MTT and MTS assays and 13. Drug Internalisation and Metabolism Assays, etc Research Interest My research interest involves the use of monoclonal antibodies and small molecule inhibitors for the treatment of cancer. Drug resistance is a major challenge in cancer research, since it limits the efficacy of most current cancer therapy. The resistance to a drug may be intrinsic or acquired during administration and may account for more than 90% of treatment failure in patients with metastatic cancer. There is need to discover and develop new molecules or strategies with anticancer efficacy. In the past novel anticancer principles like single or combined drug treatments have been used. My research will follow such tract to explore, and develop anticancer principles by reprograming some genes and inhibiting some signaling pathways. Then use recombinant DNA technology, tissue culture, microscopy, immunohistochemistry and enzymes assay techniques to study cancer cells dynamics/survivorship and to inform treatment design and efficacy of these anticancer principles from reprograming of genes and inhibition of certain signaling pathways like that of EGFR and NRF2. Objective To offer first class solutions that will boost the accomplishments of my institution’s goal and develops my skills for thorough success. Personal Profile Date of Birth 10th October, 1982 Age 35 Marital Status Married Number of Children 2 Local Govt. Kankia State of Origin. Katsina Nationality Nigeria Summary of 2014-2017 University of Abertay, Dundee, Scotland, UK institutions PhD Molecular and Cellular Pharmacology attended with dates, and 2012-2013 University of Chester, United Kingdom qualifications M Sc. Biomedical Science 2002-2005 Usmanu Danfodiyo University Sokoto B sc. Biochemistry 1995-2000 Govt. Sci. Sec. Sch. Dutsin-ma Katsina State Senior Secondary School Certificate 1988-1994 Nuhu Model Pri. Sch. Kankia Katsina State First School Leaving Certificate 2007-2008 Ubong Etuk Computer Center Akwa Ibom Diploma in Computer Application Professional 2007 Nigerian Institute of Management Qualifications Certificate Assistant Lecturer, Present Position Department of Biochemistry, Umaru Musa Yar’adua University, Katsina, Nigeria List of Researches/on- 1. Ibrahim H. Kankia, Hilal S. Khalil, Simon P. Langdon, going and yet to Peter R. Moult, David J. Harrison James L. Bown, and be published Yusuf Y. Deeni 'NRF2 Regulates HER4 Signalling Pathway in Ovarian Cancer Cells (In preparation for submission). 2. Ibrahim H. Kankia, Hilal S. Khalil, Simon P. Langdon, Peter R. Moult, David J. Harrison James L. Bown, and Yusuf Y. Deeni 'Targetting HER4 Signalling Pathway to Modulate the Sensitivity of Ovarian Cancer Cells to RTK Chemotherapy (In preparation for submission). 3. Phytochemical screening and effect of Datura metel aqueous seed extract on some kidney function indices in albino rats (June, 2011- Sept., 2011) 4. Phytochemical screening and anticancer effects of some certain medicinal plants (Sept., 2010-August, 2014). 5. Beneficial effects of aloe vera and honey on trichlorfon induced some biochemical modifications in experimental rats 6. Effect of Honey (Apis Melifera) on Serum glucose level of diabetic and non-diabetic induced rats. 7. Influence of Blood Group on Fertility “A case study of Middle aged women attending Kankia General Hospital” 8. Hypoglycemic Effect of Aloe Vera Extract on streptozocin induced diabetic Experimental rats. Selected Publications 1. Ibrahim H. Kankia, Hilal S. Khalil, Simon P. Langdon, Peter R. Moult, David J. Harrison James L. Bown, and Yusuf Y. Deeni 'NRF2 Regulates HER1 Signalling Pathway to Modulate the Sensitivity of Ovarian Cancer Cells to Lapatinib and Erlotinib', Oxidative Medicine and Cellular Longevity, Oxidative Medicine and Cellular Longevity (ACCEPTED, IN PRESS). 2. Hilal S. Khalil, Simon P. Langdon, Ibrahim H. Kankia, James Bown, and Yusuf Y. Deeni (2016) 'NRF2 Regulates HER2 and HER3 Signalling Pathway to Modulate Sensitivity to Targeted Immunotherapies', Oxidative Medicine and Cellular Longevity, pp. 22. http://dx.doi.org/10.1155/2016/4148791 3. Isah Musa Fakai1, Lukman Ango, Abubakar Abdulhamid, Ibrahim Sani, Ibrahim Hamza Kankia (2016). Alterations in Marker Enzymes and Kidney Function Indices Following Administration of Datura metel Aqueous Seed Extract in Albino Rats. International Journal of Biomedical and Clinical Sciences. Vol. 1, No. 1, 2016, pp. 7-13. http://www.aiscience.org/journal/ijbcs 4. Kankia, I. H (2015). Immunomodulatory effects of carbohydrates and advanced glycation end products. Academic Journals, Biotechnology and Molecular Biology Reviews. Vol. 10(1), pp. 1-11, January 2015 DOI: 10.5897/BMBR2014-0237 ISSN 1538-2273 http://www.academicjournals.org/BMBR 5. Kankia, H. I., Zainab, S. A (2015). Phytochemical Analysis and Antimicrobial Activity of Methanolic and Ethanolic Leaves, Barks and Roots Crude Extracts of Khaya Senegalensis. International Journal of Scientific and Research Publications (IJSRP), Volume 5, Issue 1, January 2015 Edition [ISSN 2250-3153], http://www.ijsrp.org/research-paper- 0115.php?rp=P373591 6. Kankia, I. H. (2015) Determination of the effects of Complex Carbohydrates on Cytokine status of Monocytes. International Journal of Current Research, Vol. 7, Issue, 01, pp.11858-11865, January, 2015 7. Kankia, I. H. (2014). Phytochemical Screening and Antibacterial Activities of Leaf Extracts of Terminalia catappa (Umbrella Tree). International Journal of Science and Research (IJSR), ISSN (Online): 2319-7064. Volume 3 Issue 12, December 2014. 8. Kankia, I. H., Safiyya Y. S (2014). Pregnancy Complications and Mental Health Related Problems Associated With Type 2 Diabetic Patients Attending General Hospital Katsina, Nigeria. International Journal of Science and Research (IJSR), ISSN (Online): 2319-7064. Volume 3 Issue 12, December 2014. 9. Suleiman, M., Kankia, I. H and Sani, Z. (2014) Efficacy of Euphorbia balsamifera L. and Jotropha curcas L. leaf powders against Callosbrucus maculatus F. [Coleoptera: bruchidae. European Journal of Zoological Research, 2014, 3 (3):15-20 10. Kankia I. H., Zainab S. A. and Fakai I. M. (2014) Effects of complex carbohydrates on Human monocytes. Proceedings of International Conference on Science and Sustainable Development, Vol. 6. Number 1, University Auditorium, University of Lome, Lome, Togo (July 14-17, 2014) 11. Kankia, I. H. (2014). Phytochemical analysis and antimicrobial activity of crude extract of Datura metel leaves. Scholarly Research Library. Archives of Applied Science Research, 2014, 6 (6):138-143 Selected 1. 22nd World Congress on Advances in Oncology and 20th Conferences / International Symposium on Molecular Medicine is organized Seminars/ by Spandidos Publications and would be held during Oct 05 - Workshops 07, 2017 at Metropolitan Hotel, Athens, Attica, Greece. attended 2. Beatson International Cancer Conference, FEEDING THE BEAST - The Metabolic Landscape of the Tumour and its Host, 2-5 July 2017, Glasgow, Scotland 3. Postgraduate Research Student Conference held on 20 -21 July, 2017, Abertay University Dundee, UK 4. Cell Symposia: Cancer, Inflammation, and Immunity, June 11- 13, 2017-San Diego, CA, USA 5. Abertay University Postgraduate Research Seminar held on 16th February, 2017, Abertay University, UK 6. Abertay University Postgraduate Research Seminar held on 25th November, 2016, Abertay University, UK 7. University of Dundee School of Medicine Research Symposium held on 10th November, 2016, University of Dundee, UK 8. Postgraduate Research Student Conference Wednesday 9 and Thursday 20 October, 2016, Abertay University Dundee nd 9. 2 Congress of Polish Biochemistry, Cell biology, Biotechnology and Bioinformatics “Bio2016, September, 2016 At Wroclaw, Poland 10. 2nd International conference on CLINICAL SCIENCES AND DRUG DISCOVERY held on 27-29 July, 2016 in Dundee, United Kingdom. 11. Postgraduate Research Student Conference held on 29 -30 June, 2016, Abertay University Dundee, UK 12. 17th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants, Redox World Congress, At Paris, Volume: Journal of ISANH Volume 3: Special Issue for Paris Redox 2016 (2016) 13. Abertay University Postgraduate Research Seminar held on 17th March, 2016, Abertay University,