Supplemental Table 2: List of mass-spectrometry results Accession Description # # # # # # Peptides PSM Peptides PSM Peptides PSM (EV) (EV) (T1) (T1) (T10) (T10) O75717 WD repeat and HMG-box DNA-binding 43 155 59 224 36 61 protein 1 OS=Homo sapiens GN=WDHD1 PE=1 SV=1 - [WDHD1_HUMAN] O75717-2 Isoform 2 of WD repeat and HMG-box 37 117 51 192 30 47 DNA-binding protein 1 OS=Homo sapiens GN=WDHD1 - [WDHD1_HUMAN] P11142 Heat shock cognate 71 kDa protein 14 24 31 104 26 100 OS=Homo sapiens GN=HSPA8 PE=1 SV=1 - [HSP7C_HUMAN] P0DMV8 Heat shock 70 kDa protein 1A OS=Homo 14 23 26 93 23 101 sapiens GN=HSPA1A PE=1 SV=1 - [HS71A_HUMAN] A0A0G2JIW1 Heat shock 70 kDa protein 1B OS=Homo 14 23 26 93 23 101 sapiens GN=HSPA1B PE=1 SV=1 - [A0A0G2JIW1_HUMAN] E9PKE3 Heat shock cognate 71 kDa protein 13 22 29 91 24 88 OS=Homo sapiens GN=HSPA8 PE=1 SV=1 - [E9PKE3_HUMAN] P0DMV8-2 Isoform 2 of Heat shock 70 kDa protein 13 19 25 86 22 95 1A OS=Homo sapiens GN=HSPA1A - [HS71A_HUMAN] Chaf1a (bait) 24 82 27 141 P26641 Elongation factor 1-gamma OS=Homo 11 50 21 81 11 22 sapiens GN=EEF1G PE=1 SV=3 - [EF1G_HUMAN] P26641-2 Isoform 2 of Elongation factor 1-gamma 11 50 21 81 11 22 OS=Homo sapiens GN=EEF1G - [EF1G_HUMAN] P11142-2 Isoform 2 of Heat shock cognate 71 kDa 11 20 26 79 21 74 protein OS=Homo sapiens GN=HSPA8 - [HSP7C_HUMAN] P09874 Poly [ADP-ribose] polymerase 1 9 10 39 70 13 15 OS=Homo sapiens GN=PARP1 PE=1 SV=4 - [PARP1_HUMAN] Q15233 Non-POU domain-containing octamer- 5 7 23 69 13 28 binding protein OS=Homo sapiens GN=NONO PE=1 SV=4 - [NONO_HUMAN] E9PNE6 Heat shock cognate 71 kDa protein 7 13 20 65 16 64 OS=Homo sapiens GN=HSPA8 PE=1 SV=1 - [E9PNE6_HUMAN] Q13112 Chromatin assembly factor 1 subunit B 23 65 21 72 OS=Homo sapiens GN=CHAF1B PE=1 SV=1 - [CAF1B_HUMAN] Q15233-2 Isoform 2 of Non-POU domain- 5 7 22 63 12 27 containing octamer-binding protein OS=Homo sapiens GN=NONO - [NONO_HUMAN] P04264 Keratin, type II cytoskeletal 1 OS=Homo 15 22 27 60 27 64 sapiens GN=KRT1 PE=1 SV=6 - [K2C1_HUMAN] Q09028 Histone-binding protein RBBP4 15 60 16 86 OS=Homo sapiens GN=RBBP4 PE=1 SV=3 - [RBBP4_HUMAN] Q09028-3 Isoform 3 of Histone-binding protein 15 60 16 86 RBBP4 OS=Homo sapiens GN=RBBP4 - [RBBP4_HUMAN] >sp|K2C1_HUMAN| 14 21 26 59 26 62 Q09028-2 Isoform 2 of Histone-binding protein 14 59 15 85 RBBP4 OS=Homo sapiens GN=RBBP4 - [RBBP4_HUMAN] E9PLF4 Heat shock cognate 71 kDa protein 9 18 15 58 15 62 (Fragment) OS=Homo sapiens GN=HSPA8 PE=1 SV=1 - [E9PLF4_HUMAN] P29692-2 Isoform 2 of Elongation factor 1-delta 8 51 17 56 8 15 OS=Homo sapiens GN=EEF1D - [EF1D_HUMAN] E9PK54 Heat shock cognate 71 kDa protein 8 16 14 56 14 60 (Fragment) OS=Homo sapiens GN=HSPA8 PE=1 SV=7 - [E9PK54_HUMAN] E9PQQ4 Heat shock cognate 71 kDa protein 8 16 14 56 14 60 (Fragment) OS=Homo sapiens GN=HSPA8 PE=1 SV=1 - [E9PQQ4_HUMAN] E9PRY8 Elongation factor 1-delta OS=Homo 8 51 17 56 8 15 sapiens GN=EEF1D PE=1 SV=1 - [E9PRY8_HUMAN] E9PQK7 Heat shock cognate 71 kDa protein 8 16 14 56 14 60 (Fragment) OS=Homo sapiens GN=HSPA8 PE=1 SV=1 - [E9PQK7_HUMAN] A0A087X1X7 Elongation factor 1-delta OS=Homo 8 51 17 56 8 15 sapiens GN=EEF1D PE=1 SV=1 - [A0A087X1X7_HUMAN] Q09028-4 Isoform 4 of Histone-binding protein 11 56 13 80 RBBP4 OS=Homo sapiens GN=RBBP4 - [RBBP4_HUMAN] P38646 Stress-70 protein, mitochondrial 11 16 22 52 21 37 OS=Homo sapiens GN=HSPA9 PE=1 SV=2 - [GRP75_HUMAN] E9PN89 Heat shock cognate 71 kDa protein 7 11 20 52 15 43 (Fragment) OS=Homo sapiens GN=HSPA8 PE=1 SV=1 - [E9PN89_HUMAN] P11021 78 kDa glucose-regulated protein 11 18 27 51 18 35 OS=Homo sapiens GN=HSPA5 PE=1 SV=2 - [GRP78_HUMAN] P29692 Elongation factor 1-delta OS=Homo 7 50 12 50 8 15 sapiens GN=EEF1D PE=1 SV=5 - [EF1D_HUMAN] E9PK01 Elongation factor 1-delta (Fragment) 7 50 12 50 8 15 OS=Homo sapiens GN=EEF1D PE=1 SV=1 - [E9PK01_HUMAN] O75152 Zinc finger CCCH domain-containing 30 44 34 49 20 26 protein 11A OS=Homo sapiens GN=ZC3H11A PE=1 SV=3 - [ZC11A_HUMAN] P13645 Keratin, type I cytoskeletal 10 OS=Homo 14 18 25 48 22 35 sapiens GN=KRT10 PE=1 SV=6 - [K1C10_HUMAN] E9PI65 Heat shock cognate 71 kDa protein 7 14 11 48 11 49 (Fragment) OS=Homo sapiens GN=HSPA8 PE=1 SV=1 - [E9PI65_HUMAN] >sp|K1C10_HUMAN| 14 18 24 47 21 34 P68104 Elongation factor 1-alpha 1 OS=Homo 6 11 15 47 6 11 sapiens GN=EEF1A1 PE=1 SV=1 - [EF1A1_HUMAN] Q5VTE0 Putative elongation factor 1-alpha-like 3 6 11 15 47 6 11 OS=Homo sapiens GN=EEF1A1P5 PE=5 SV=1 - [EF1A3_HUMAN] P22626 Heterogeneous nuclear 9 28 17 47 9 20 ribonucleoproteins A2/B1 OS=Homo sapiens GN=HNRNPA2B1 PE=1 SV=2 - [ROA2_HUMAN] E9PI39 Elongation factor 1-delta (Fragment) 6 49 11 47 7 14 OS=Homo sapiens GN=EEF1D PE=1 SV=1 - [E9PI39_HUMAN] E9PQ49 Elongation factor 1-delta (Fragment) 6 49 11 47 7 14 OS=Homo sapiens GN=EEF1D PE=1 SV=7 - [E9PQ49_HUMAN] Q16576 Histone-binding protein RBBP7 16 47 15 61 OS=Homo sapiens GN=RBBP7 PE=1 SV=1 - [RBBP7_HUMAN] >sp|K1C9_HUMAN| 12 19 19 45 16 41 P35527 Keratin, type I cytoskeletal 9 OS=Homo 12 19 19 45 16 41 sapiens GN=KRT9 PE=1 SV=3 - [K1C9_HUMAN] P22626-2 Isoform A2 of Heterogeneous nuclear 9 28 16 45 9 20 ribonucleoproteins A2/B1 OS=Homo sapiens GN=HNRNPA2B1 - [ROA2_HUMAN] E9PQ61 Zinc finger CCCH domain-containing 26 37 30 44 18 24 protein 11A OS=Homo sapiens GN=ZC3H11A PE=1 SV=1 - [E9PQ61_HUMAN] P12004 Proliferating cell nuclear antigen 17 44 11 16 OS=Homo sapiens GN=PCNA PE=1 SV=1 - [PCNA_HUMAN] E9PC52 Histone-binding protein RBBP7 15 44 15 61 OS=Homo sapiens GN=RBBP7 PE=1 SV=1 - [E9PC52_HUMAN] P34931 Heat shock 70 kDa protein 1-like 8 16 12 43 11 50 OS=Homo sapiens GN=HSPA1L PE=1 SV=2 - [HS71L_HUMAN] P29692-3 Isoform 3 of Elongation factor 1-delta 6 41 11 43 6 10 OS=Homo sapiens GN=EEF1D - [EF1D_HUMAN] Q53FA3 Heat shock 70 kDa protein 1-like 8 16 12 43 11 50 (Fragment) OS=Homo sapiens GN=HSPA1L PE=1 SV=1 - [Q53FA3_HUMAN] E9PL12 Elongation factor 1-delta (Fragment) 6 49 8 43 6 13 OS=Homo sapiens GN=EEF1D PE=1 SV=1 - [E9PL12_HUMAN] E9PPR1 Elongation factor 1-delta (Fragment) 6 49 8 43 6 13 OS=Homo sapiens GN=EEF1D PE=1 SV=1 - [E9PPR1_HUMAN] H0YCK7 Elongation factor 1-delta (Fragment) 6 44 10 42 5 12 OS=Homo sapiens GN=EEF1D PE=1 SV=1 - [H0YCK7_HUMAN] P60709 Actin, cytoplasmic 1 OS=Homo sapiens 11 16 17 41 13 24 GN=ACTB PE=1 SV=1 - [ACTB_HUMAN] P63261 Actin, cytoplasmic 2 OS=Homo sapiens 11 16 17 41 13 24 GN=ACTG1 PE=1 SV=1 - [ACTG_HUMAN] P68104-2 Isoform 2 of Elongation factor 1-alpha 1 6 11 11 41 5 10 OS=Homo sapiens GN=EEF1A1 - [EF1A1_HUMAN] E9PPY6 Heat shock cognate 71 kDa protein 6 13 11 41 11 46 (Fragment) OS=Homo sapiens GN=HSPA8 PE=1 SV=1 - [E9PPY6_HUMAN] A0A087WVQ9 Elongation factor 1-alpha 1 OS=Homo 6 11 11 41 5 10 sapiens GN=EEF1A1 PE=1 SV=1 - [A0A087WVQ9_HUMAN] A8K7Q2 Heat shock cognate 71 kDa protein 3 4 14 40 9 32 OS=Homo sapiens GN=HSPA8 PE=1 SV=1 - [A8K7Q2_HUMAN] E9PL71 Elongation factor 1-delta (Fragment) 5 40 10 40 5 9 OS=Homo sapiens GN=EEF1D PE=1 SV=1 - [E9PL71_HUMAN] Q16576-2 Isoform 2 of Histone-binding protein 16 40 15 53 RBBP7 OS=Homo sapiens GN=RBBP7 - [RBBP7_HUMAN] P19338 Nucleolin OS=Homo sapiens GN=NCL 10 11 25 39 18 21 PE=1 SV=3 - [NUCL_HUMAN] E9PMW7 Elongation factor 1-delta OS=Homo 5 43 7 38 5 12 sapiens GN=EEF1D PE=1 SV=1 - [E9PMW7_HUMAN] E9PIZ1 Elongation factor 1-delta (Fragment) 5 43 7 38 5 12 OS=Homo sapiens GN=EEF1D PE=1 SV=1 - [E9PIZ1_HUMAN] C9JYB3 WD repeat and HMG-box DNA-binding 8 40 10 37 8 16 protein 1 (Fragment) OS=Homo sapiens GN=WDHD1 PE=1 SV=1 - [C9JYB3_HUMAN] P09651 Heterogeneous nuclear 6 14 13 36 4 8 ribonucleoprotein A1 OS=Homo sapiens GN=HNRNPA1 PE=1 SV=5 - [ROA1_HUMAN] E9PBY7 Zinc finger CCCH domain-containing 17 27 24 36 14 19 protein 11A (Fragment) OS=Homo sapiens GN=ZC3H11A PE=1 SV=1 - [E9PBY7_HUMAN] P46821 Microtubule-associated protein 1B 30 36 OS=Homo sapiens GN=MAP1B PE=1 SV=2 - [MAP1B_HUMAN] >sp|TRYP_PIG| 3 12 4 35 4 28 P07910-2 Isoform C1 of Heterogeneous nuclear 7 13 15 35 7 15 ribonucleoproteins C1/C2 OS=Homo sapiens GN=HNRNPC - [HNRPC_HUMAN] P29692-4 Isoform 4 of Elongation factor 1-delta 5 39 9 35 6 12 OS=Homo sapiens GN=EEF1D - [EF1D_HUMAN] B4DY08 Heterogeneous nuclear 7 13 15 35 7 15 ribonucleoproteins C1/C2 OS=Homo sapiens GN=HNRNPC PE=1 SV=1 - [B4DY08_HUMAN] G3V4C1 Heterogeneous nuclear 7 13 15 35 7 15 ribonucleoproteins C1/C2 OS=Homo sapiens GN=HNRNPC PE=1 SV=1 - [G3V4C1_HUMAN] G3V4W0 Heterogeneous nuclear 7 13 15 35 7 15 ribonucleoproteins C1/C2 (Fragment) OS=Homo sapiens GN=HNRNPC PE=1 SV=1 - [G3V4W0_HUMAN] E9PN25 Heat shock cognate 71 kDa protein 6 13 9 35 9 40 (Fragment) OS=Homo sapiens GN=HSPA8 PE=1 SV=1 - [E9PN25_HUMAN] B2R5W2 Heterogeneous nuclear 7 13 15 35 7 15 ribonucleoproteins C1/C2 OS=Homo sapiens GN=HNRNPC PE=1 SV=1 - [B2R5W2_HUMAN] Q92841 Probable ATP-dependent RNA helicase 14 16 22 34 17 21 DDX17 OS=Homo sapiens GN=DDX17 PE=1 SV=2 - [DDX17_HUMAN] P07910 Heterogeneous nuclear 7 13 14 34 7 15 ribonucleoproteins C1/C2 OS=Homo sapiens GN=HNRNPC PE=1 SV=4 - [HNRPC_HUMAN] P14866 Heterogeneous nuclear 10 15 17 34 10 16 ribonucleoprotein L OS=Homo sapiens GN=HNRNPL PE=1 SV=2 - [HNRPL_HUMAN] Q00839 Heterogeneous nuclear 6 13 15 34 9 18 ribonucleoprotein U OS=Homo sapiens GN=HNRNPU PE=1 SV=6 - [HNRPU_HUMAN] Q00839-2 Isoform Short of Heterogeneous nuclear 6 13 15 34 9 18 ribonucleoprotein U OS=Homo sapiens GN=HNRNPU - [HNRPU_HUMAN] P09651-2 Isoform A1-A of Heterogeneous nuclear 5 11 12 34 4 8 ribonucleoprotein A1 OS=Homo sapiens GN=HNRNPA1 - [ROA1_HUMAN] P08670 Vimentin OS=Homo sapiens GN=VIM 15 19 19 34 23 49 PE=1 SV=4 - [VIME_HUMAN] G3V576 Heterogeneous nuclear 7 13 14 34 7 15 ribonucleoproteins C1/C2 OS=Homo sapiens GN=HNRNPC PE=1 SV=1 - [G3V576_HUMAN] V9GZ37 Heat shock 70 kDa protein 1A