ITPKA polyclonal antibody inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein Catalog Number: PAB4051 phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, Regulatory Status: For research use only (RUO) calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. ITPKA and ITPKB are 68% Product Description: Rabbit polyclonal antibody raised identical in the C-terminus region. [provided by RefSeq] against synthetic peptide of ITPKA. References: Immunogen: A synthetic peptide (conjugated with KLH) 1. Structure of a human inositol 1,4,5-trisphosphate corresponding to N-terminus of human ITPKA. 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase. Gonzalez B, Schell MJ, Host: Rabbit Letcher AJ, Veprintsev DB, Irvine RF, Williams RL. Mol Cell. 2004 Sep 10;15(5):689-701. Reactivity: Human 2. Simulations of inositol phosphate metabolism and its Applications: ELISA, WB-Ce interaction with InsP(3)-mediated calcium release. (See our web site product page for detailed applications Mishra J, Bhalla US. Biophys J. 2002 information) Sep;83(3):1298-316. 3. Inositol 1,4,5-trisphosphate 3-kinase A associates with Protocols: See our web site at F-actin and dendritic spines via its N terminus. Schell http://www.abnova.com/support/protocols.asp or product MJ, Erneux C, Irvine RF. J Biol Chem. 2001 Oct page for detailed protocols 5;276(40):37537-46. Epub 2001 Jul 23. Form: Liquid Purification: Protein G purification Recommend Usage: ELISA (1:1000) Western Blot (1:100-500) The optimal working dilution should be determined by the end user. Storage Buffer: In PBS (0.09% sodium azide) Storage Instruction: Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. Entrez GeneID: 3706 Gene Symbol: ITPKA Gene Alias: IP3KA Gene Summary: Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of Page 1/1 Powered by TCPDF (www.tcpdf.org).