US 20090104295A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2009/0104295 A1 Kohno (43) Pub. Date: Apr. 23, 2009 (54) AGENT FOR HAIR GROWTH Publication Classification (76) Inventor: Kenji Kohno, Kanagawa (JP) (51) A6IRInt. Cl. 36/48 (2006.01) Correspondence Address: (52) U.S. Cl. ........................................................ 424/757 THE WEBB LAW FIRM, P.C. (57) ABSTRACT 700 KOPPERS BUILDING, 436 SEVENTH AVENUE growth,The whichA. SN, has excellents 1S hairl offer growth a IN effects butE. notfor S1de PITTSBURGH, PA 15219 (US) effects. The agent for hair growth of the present invention is (21) Appl. No.: 12AO63611 characterized by comprising a processed semi-mature Soy ppl. No.: 9 bean and/or a processed semi-mature soybean extracts and at 1-1. least one Substance selected from the group consisting of a (22)22) PCT Fled:1. Jun.un. 30,5U, 2006 processed Polygoni Multiflori Radix, processed Polygoni (86) PCT NO.: PCT/UP2006/31314.6 Multiflori Radix eXtracts, a processed Cynanchum bungei Decne or processed Cynanchum bungei Decne extracts, pref S371 (c)(1), erably further comprising Longan seed and/or Longan seed (2), (4) Date: Feb. 12, 2008 extracts as active ingredients. This agent for hair growth has no side effects when used externally or internally, it can (30) Foreign Application Priority Data notably improve hair growth within a short period of time; ranging from 6 to 12 weeks, can return hair to its normal hair Aug. 12, 2005 (JP) ................................. 2005-261312 colour (for example from white to black) and can improve the Feb. 1, 2006 (JP) ................................. 2006-024532 gloss of hair. Patent Application Publication Apr. 23, 2009 Sheet 1 of 5 US 2009/0104295 A1 F.G. NS: not significant 5 p=0, NS p:0.6, NS pro.59,ww. NS 4. 3 - d 2 Tw a ) Aft. Bef, Aft, Bef. Aft, Bef. Aft Bef. Aft raw yellow processed semi mature yellow boiled black Huangjiu soybean mature soybean soybean soybean 5 p:0.7, NS p20.3, NS A. p:10, NS . & 3 s 3 2 g a O Bgf. Aft Bef. Aft, . Aft. Bef. Aft, Bef. Aft. Bef. Aft, raw P. processed P. raw C. bungei processed C. Longan seed processed multiflori multiflori bungei Longan seed 5 A. p:0.006 significant p=0.02 significant p=0.02, significant s 3 2 compound compound compound ingredients 1 ingredients 2 ingredients 3 Patent Application Publication Apr. 23, 2009 Sheet 2 of 5 US 2009/O104295 A1 FIG 2 g: : Patent Application Publication Apr. 23, 2009 Sheet 3 of 5 US 2009/O104295 A1 FIG Patent Application Publication Apr. 23, 2009 Sheet 4 of 5 US 2009/O104295 A1 FIG. 4 Area Before Area 2 Before Area. After Area 2. After Patent Application Publication Apr. 23, 2009 Sheet 5 of 5 US 2009/0104295 A1 FIG. 5 raw yellow processed semi mature yellow soybean mature soybean soybean soybean Huangjiu processed P. Longan seed processed multifori Longan seed 2 compound compound compound ingredients 1 ingredients 2 ingredients 3 US 2009/01 04295 A1 Apr. 23, 2009 AGENT FOR HAR GROWTH 0008. It is therefore understandable, that I am consulted by a lot of patients with hair trouble who claim, that they have FIELD OF THE INVENTION never found a useful tonic. 0009 Patent document 1: JP 2001-238637 A 0001. This invention relates to a hair growth. More spe 0010 Patent document 2: JP 2002-053434 A cifically, this invention relates to a Substance which has an O011 Patent document 3: JP H08-127517 A excellent hair growth effect and is very safety. 0012 Patent document 4: JP H03-206019A 0013 Patent document 5: JP HO6-227.946A 0014 Patent document 6: JP HO6-100421 A BACKGROUND ART 0.015 Patent document 7:JP 2002-145732A 0002 Alopecia and thin hair are some of the most com DISCLOSURE OF THE INVENTION mon problems for mankind in the world. It is considered that various factors, for example, excessive activation of male Problem to be Solved by the Invention hormones, decrease of blood flow to the hair follicle and excessive secretion of sebum etc. may cause alopecia and thin 0016. The aim of this invention is to offer a novel agent for hair. These factors may be cause by aging, stress or/and life hair growth, which has excellent hair growth effects but not styles etc. side effects. 0003 Hair restorers, that are being suggested or put on the market today can, for example, consist of various herbal Means for Solving the Problem extracts, food extracts and vasodilator chemical compounds, 0017. The inventor of this invention found that the pro which can eliminate the cause of allopecia and thin hair. cessed semi-mature Soybean has significantly enhanced 0004 Up to now, it was suggested that isoflavone etc. effects on hair growth compared to the raw or fully matured contents in Soybean, had an effects on hair growth, therefore form. The processed semi-mature Soybean was obtained by Soybean was used as a component of a hair restorer. For removing the typical taste of the raw soybeans without pull example, in the patent document 1 (JP 2001-238637A), it was Verizing them by excessive heating. On completion of this disclosed that food components which contained extracts of invention, the inventor established that the processed semi millet and ginkgo leaf and isoflavones extracted from Soy mature Soybean plays an important role as a ingredient in the bean etc. have a positive effect on hair growth. In the patent agent for hair growth. document 2 (JP 2002-053434 A), it was disclosed that a hair 0018. In the agent for hair growth of the invention, the tonic contained isoflavone extracted from soybean and/or inventor combined the processed semi-mature Soybean and kudzu. And, in the patent document 3 (JPH08-127517A), it the processed Polygoni Multiflori Radix or the processed was disclosed that black soybean broth was included into an Cynanchum bungei Decne to increase synergy effect on hair external hair growth tonic and an external anti hair loss agent growth. In here, the processed Polygoni Multiflori Radix and as a compound. And, it was also suggested to apply herbal processed Cynanchum bungei Decne were made from raw medicines, such as Polygoni multiflori Radix etc. to a hair Polygoni Multiflori Radix and raw Cynanchum bungei growth tonic. Decne, obtained by soaking them in dark soybean extracts 0005. In the patent document 4 (JPH03-206019A), it was and alcohol. Further, the color and gloss of hair can be also described that dark soybean, Polygoni multiflori Radix improved by increasing the content of Longan seed. In addi etc. were used as external components for restoring lost hair. tion, in the agent for hair growth of the invention, the extracts And, in the patent document 5 (JP H06-227946 A), it was of the processed semi-mature soybean, the processed described that herbal medicine extracts, such as extracts of Polygoni Multiflori Radix, the processed Cynanchum bungei ginseng etc. which were extracted with alcohol Such as “Hua Decne and the Longan seed can be combined. ngjiu (yellow rice or millet wine; a type of Chinese alcohol) 0019. The agent for hair growth of the invention can be etc. were used for promoting hair growth. taken orally or can be added to foods or drinks. On the other 0006 Further, in regard to the Sapindaceous plant Longan hand, it also can be prepared as an external product. (Euphoria Longana (Lour.) Steud.), it is common knowledge that components extracted from the flesh of the Longan fruit EFFECT OF THE INVENTION with water and/or organic solvents had positive effects on hair 0020. In this invention the positive results of the agent for growth and restoring hair (patent documentó: JPH06-100421 hair growth is based on the use processed semi-mature Soy A). And, it was described that The Longan seed extracts have bean, processed Polygoni Multiflori Radix, processed Cyn a moisturizing effect and can be mixed into an external skin anchum bungei Decne, and Longan seed etc. as active ingre preventive (patent document 7:JP 2002-145732A). dients. Especially, this agent for hair growth has no side 0007. However, as mentioned above, the conventional hair effects when used externally or internally, it can notably tonics (in Japan are classified into the quasi-drug tonics (a improve hair growth within a short period of time; ranging term of Japanese Pharmaceutical Affairs Law)), which have from 6 to 12 weeks, can return hair to its normal hair colour components extracted from herbal medicines and foods. (for example from white to black) and can improve the gloss These tonics are easily obtainable, but the hair growth effect of hair. is insufficient. On the other hand, hair tonics, which are clas 0021 Moreover, existing hair tonics usually are offered as sified as drugs (a term of Japanese Pharmaceutical Affairs capsules or tablets types and therefore not convenient to take, Law) and are used as antihypertensive and male hormone because they resemble drugS/medication. The agent for hair inhibitor, have some hair growth effect, but their side effects growth of the invention has not only an excellent hair growth are severe. Further, in order to be able to purchase drug hair effect, but also can be regarded as a delicious food, for tonics it is necessary to see a doctor and obtain a prescription. example in form of a cookie, a rice cracker, an Okaki (a US 2009/01 04295 A1 Apr. 23, 2009 Japanese cake), an Arare (a Japanese cake), Japanese cakes color of the seed coat. Yellow soybeans are usually called and cracker etc.