LABORATORY SAFETY and CHEMICAL HYGIENE PLAN INDIANA UNIVERSITY Produced by University Environmental Health and Safety December 1996 in cooperation with University Chemical Hygiene Committees Revised 2015 Page 1 Table of Contents EMERGENCY INFORMATION .................................................................................................. 4 Major Emergencies............................................................................................................ 4 Minor Emergencies............................................................................................................ 4 Accident Reports ............................................................................................................... 4 Fires and Fire Alarms ........................................................................................................ 5 Tornado Watches and Warnings (Sirens) .......................................................................... 6 LABORATORY SAFETY CONTACTS ...................................................................................... 7 1. INTRODUCTION ........................................................................................................10 1.1. Purpose ................................................................................................................ 10 1.2. Regulatory Basis ................................................................................................... 10 1.3. Applicability ........................................................................................................... 11 1.4. Organization and Content ..................................................................................... 11 1.5. Definitions ............................................................................................................. 12 1.6. Authority and Responsibility .................................................................................. 14 1.7. Chemical Laboratory Inspections and Corrective Action Procedures .................... 17 2. CONTROL MEASURES .............................................................................................20 2.1. Administrative Controls ......................................................................................... 20 2.2. Procedural Controls .............................................................................................. 22 2.3. Engineering Controls ............................................................................................ 22 2.4. Personal Protective Equipment ............................................................................. 22 3. STANDARD OPERATING PROCEDURES ...............................................................25 3.1. General Laboratory Safety Procedures ................................................................. 25 3.2. Procedures for Proper Labeling, Storage, and Management of Chemicals ........... 27 3.3. Chemical Fume Hoods – Procedures for Proper and Safe Use ............................ 31 3.4. Corrosive Chemicals – Procedures for Safe Handling and Storage ...................... 33 3.5. Flammable and Combustible Liquids – Procedures for Safe Handling and Storage ................................................................................................................. 34 3.6. Oxidizing Agents – Procedures for Safe Handling and Storage............................. 36 3.7. Reactive Chemicals – Procedures for Safe Handling and Storage ........................ 37 3.8. Particularly Hazardous Substances - Procedures for Safe Handling and Storage ................................................................................................................. 40 3.9. Compressed Gases – Procedures for Safe Handling and Storage ........................ 43 3.10. Cryogenic Liquids – Procedures for Safe Handling and Storage ........................... 46 3.11. Electrical Safety Procedures ................................................................................. 48 3.12. Glassware and Sharps – Procedures for Safe Handling and Disposal .................. 49 3.13. Chemical Spill Response Procedures ................................................................... 51 3.14. Glass Apparatus and Plasticware Assembly ......................................................... 54 3.15. Solvent Stills – Procedures for Set-up, Use, and Neutralization ............................ 57 3.16. Personal Protective Equipment – Procedures for Selection and Use .................... 60 Page 2 3.17. Peroxide-Forming Chemicals and Other Time-Sensitive Materials – Procedures for Safe Handling and Management ..................................................................... 66 3.18. Nanotechnology Safety Procedures ...................................................................... 70 3.19. Hot Oil Bath and Other Heating Sources – Procedures for Set-Up and Safe Operation.............................................................................................................. 71 3.20. Chemical Allergens – Procedures for Safe Handling and Storage ......................... 74 3.21. Reproductive Toxins, Mutagens, Teratogens, and Embryotoxins – Procedures for Safe Handling and Storage .............................................................................. 75 3.22. Chemicals with Moderate Chronic and High Chronic Toxicity- Procedures for Safe Handling and Storage ................................................................................... 79 3.23. Animal Work with Chemicals of High Toxicity – Safety Procedures ....................... 82 3.24. Chemical Transportation Procedures .................................................................... 87 3.25. Laboratory Closeout Procedures ........................................................................... 88 4. TRAINING REQUIREMENTS .....................................................................................93 4.1. Required Training Content .................................................................................... 93 4.2. Training Resources ............................................................................................... 93 4.3. Training Documentation ........................................................................................ 93 5. MEDICAL CONSULATATION AND EXAMINATIONS ...............................................94 5.1. Medical Facilities .................................................................................................. 94 5.1.1. The medical care facilities and hours of operation for your respective campus can be found at IU Human Resources. ................................................................. 94 5.2. Examination Criteria .............................................................................................. 94 5.3. Information to the Physician .................................................................................. 94 5.4. Physician’s Written Opinion .................................................................................. 94 5.5. Medical Services ................................................................................................... 95 6. LABORATORY SAFETY EQUIPMENT .....................................................................95 6.1. Chemical Fume Hoods ......................................................................................... 95 6.2. Safety Showers ..................................................................................................... 96 6.3. Eyewash Stations ................................................................................................. 96 6.4. Fire Extinguishers ................................................................................................. 96 6.5. Fire Blankets ......................................................................................................... 96 6.6. Flammable Liquid Storage Cabinets ..................................................................... 97 6.7. Safety Cans .......................................................................................................... 97 6.8. Laboratory-Safe and Explosion-Proof Refrigeration Equipment ............................ 97 6.9. First Aid Kits and CPR .......................................................................................... 98 6.10. Chemical Spill Kits ................................................................................................ 98 6.11. Portable Safety Shields ......................................................................................... 99 APPENDIX A – FORMS .........................................................................................................100 APPENDIX B – REFERENCES ..................................................................................................113 Page 3 EMERGENCY INFORMATION Major Emergencies In the event of an accident in the laboratory which involves a fire, explosion, or a large release of a hazardous chemical: • Evacuate the building by activating the nearest fire alarm. • Call 911 to give the details of the accident including the location, personal injuries, and types of hazardous material involved. If the accident also involves chemical contamination or serious personal injury (e.g. profuse bleeding, broken bone, unconsciousness, immobile victim, etc.) follow the steps above and: • Move the victim from the immediate area of the fire, explosion, or spill (but only if this can be done without further