1199SEIU Benefit Funds The following codes are under management for members who have health benefits covered by 1199SEIU Benefit Funds, administered by eviCore healthcare. Commercial Effective 5/1/14 Claims Policies Effective 7/1/14 Procedure Code Full Description How Code is Managed Effective Date Termination Date Human Platelet Antigen 1 genotyping (HPA-1), ITGB3 (integrin, beta 3 [platelet glycoprotein IIIa], 81105 antigen CD61 [GPIIIa]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura), Claim Policies Apply 01/01/18 None gene analysis, common variant, HPA-1a/b (L33P) Human Platelet Antigen 2 genotyping (HPA-2), GP1BA (glycoprotein Ib [platelet], alpha polypeptide 81106 [GPIba]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura), gene Claim Policies Apply 01/01/18 None analysis, common variant, HPA-2a/b (T145M) Human Platelet Antigen 3 genotyping (HPA-3), ITGA2B (integrin, alpha 2b [platelet glycoprotein IIb of 81107 IIb/IIIa complex], antigen CD41 [GPIIb]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post- Claim Policies Apply 01/01/18 None transfusion purpura), gene analysis, common variant, HPA-3a/b (I843S) Human Platelet Antigen 4 genotyping (HPA-4), ITGB3 (integrin, beta 3 [platelet glycoprotein IIIa], 81108 antigen CD61 [GPIIIa]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura), Claim Policies Apply 01/01/18 None gene analysis, common variant, HPA-4a/b (R143Q) Human Platelet Antigen 5 genotyping (HPA-5), ITGA2 (integrin, alpha 2 [CD49B, alpha 2 subunit of 81109 VLA-2 receptor] [GPIa]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion Claim Policies Apply 01/01/18 None purpura), gene analysis, common variant (eg, HPA-5a/b (K505E)) Human Platelet Antigen 6 genotyping (HPA-6w), ITGB3 (integrin, beta 3 [platelet glycoprotein IIIa, 81110 antigen CD61] [GPIIIa]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion Claim Policies Apply 01/01/18 None purpura), gene analysis, common variant, HPA-6a/b (R489Q) Human Platelet Antigen 9 genotyping (HPA-9w), ITGA2B (integrin, alpha 2b [platelet glycoprotein IIb 81111 of IIb/IIIa complex, antigen CD41] [GPIIb]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post- Claim Policies Apply 01/01/18 None transfusion purpura), gene analysis, common variant, HPA-9a/b (V837M) Human Platelet Antigen 15 genotyping (HPA-15), CD109 (CD109 molecule) (eg, neonatal alloimmune 81112 thrombocytopenia [NAIT], post-transfusion purpura), gene analysis, common variant, HPA-15a/b Claim Policies Apply 01/01/18 None (S682Y) IDH1 (isocitrate dehydrogenase 1 [NADP+], soluble) (eg, glioma), common variants (eg, R132H, 81120 R132C) Claim Policies Apply 01/01/18 None IDH2 (isocitrate dehydrogenase 2 [NADP+], mitochondrial) (eg, glioma), common variants (eg, 81121 R140W, R172M) Claim Policies Apply 01/01/18 None DMD (dystrophin) (eg, Duchenne/Becker muscular dystrophy) deletion analysis, and duplication Claim Policies Apply 01/01/13 None 81161 analysis, if performed BRCA1 (BRCA1, DNA repair associated), BRCA2 (BRCA2, DNA repair associated) (eg, hereditary 81162 breast and ovarian cancer) gene analysis; full sequence analysis and full duplication/deletion analysis Requires Prior Authorization 01/01/16 None (ie, detection of large gene rearrangements BRCA1 (BRCA1, DNA repair associated), BRCA2 (BRCA2, DNA repair associated) (eg, hereditary Requires Prior Authorization 01/01/19 None 81163 breast and ovarian cancer) gene analysis; full sequence analysis BRCA1 (BRCA1, DNA repair associated), BRCA2 (BRCA2, DNA repair associated) (eg, hereditary 81164 breast and ovarian cancer) gene analysis; full duplication/deletion analysis (ie, detection of large gene Requires Prior Authorization 01/01/19 None rearrangements) BRCA1 (BRCA1, DNA repair associated) (eg, hereditary breast and ovarian cancer) gene analysis; Requires Prior Authorization 01/01/19 None 81165 full sequence analysis BRCA1 (BRCA1, DNA repair associated) (eg, hereditary breast and ovarian cancer) gene analysis; Requires Prior Authorization 01/01/19 None 81166 full duplication/deletion anlaysis (ie, detection of large gene rearrangements) Page 1 of 21 Procedure Code Full Description How Code is Managed Effective Date Termination Date BRCA2 (BRCA2, DNA repair associated) (eg, hereditary breast and ovarian cancer) gene analysis; 01/01/19 None 81167 full duplication/deletion analysis (ie, detection of large gene rearrangements) Requires Prior Authorization ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) (eg, acquired imatinib tyrosine kinase 81170 inhibitor resistance), gene analysis, variants in the kinase domain Claim Policies Apply 01/01/16 None AFF2 (AF4/FMR2 family, member 2 [FMR2]) (eg,fragile X mental retardation 2 [FRAXE]) gene 01/01/19 None 81171 analysis; evaluation to detect abnormal (eg,expanded) alleles Claim Policies Apply AFF2 (AF4/FMR2 family, member 2 [FMR2]) (eg,fragile X mental retardation 2 [FRAXE]) gene 01/01/19 None 81172 analysis; characterization of alleles (eg, expanded size and methylation status) Claim Policies Apply AR (androgen receptor) (eg, spinal and bulbar muscular atrophy, Kennedy disease, X chromosome 01/01/19 None 81173 inactivation) gene analysis; full gene sequence Requires Prior Authorization AR (androgen receptor) (eg, spinal and bulbar muscular atrophy, Kennedy disease, X chromosome 01/01/19 None 81174 inactivation) gene analysis; known familial variant Requires Prior Authorization ASXL1 (additional sex combs like 1, transcriptional regulator) (eg, myelodysplastic syndrome, 81175 myeloproliferative neoplasms, chronic myelomonocytic leukemia), gene analysis; full gene sequence Claim Policies Apply 01/01/18 None ASXL1 (additional sex combs like 1, transcriptional regulator) (eg, myelodysplastic syndrome, 81176 myeloproliferative neoplasms, chronic myelomonocytic leukemia), gene analysis; targeted sequence Claim Policies Apply 01/01/18 None analysis (eg, exon 12) 81177 ATN1 (atrophin 1) (eg, dentatorubral-pallidoluysian atrophy) gene analysis, evaluation to detect Claim Policies Apply 01/01/19 None abnormal (eg, expanded) allele 81178 ATXN1 (ataxin 1) (eg, spinocerebellar ataxia) gene analysis, evaluation to detect abnormal (eg, Claim Policies Apply 01/01/19 None expanded) allele ATXN2 (ataxin 2) (eg, spinocerebellar ataxia) gene analysis, evaluation to detect abnormal (eg, 01/01/19 None 81179 expanded) alleles Claim Policies Apply ATXN3 (ataxin 3) (eg, spinocerebellar ataxia, Machado-Joseph disease) gene analysis, evaluation to 01/01/19 None 81180 detect abnormal (eg, expanded) allele Claim Policies Apply ATXN7 (ataxin 7) (eg, spinocerebellar ataxia) gene analysis, evaluation to detect abnormal (eg, 01/01/19 None 81181 expanded) alleles Claim Policies Apply ATXN8OS (ATXN8 opposite strand [non-protein coding]) (eg, spinocerebellar ataxia) gene analysis, Claim Policies Apply 01/01/19 None 81182 evaluation to detect abnormal (eg, expanded) alleles ATXN10 (ataxin 10) (eg, spinocerebellar ataxia) gene analysis, evaluation to detect abnormal (eg, Claim Policies Apply 01/01/19 None 81183 expanded) alleles CACNA1A (calcium voltage-gated channel subunit alpha1 A) (eg, spinocerebellar ataxia) gene Claim Policies Apply 01/01/19 None 81184 analysis; evaluation to detect abnormal (eg, expanded) alleles CACNA1A (calcium voltage-gated channel subunit alpha1 A) (eg, spinocerebellar ataxia) gene 81185 analysis; full gene sequence Requires Prior Authorization 01/01/19 None CACNA1A (calcium voltage-gated channel subunit alpha1 A) (eg, spinocerebellar ataxia) gene Requires Prior Authorization 01/01/19 None 81186 analysis; known familial variant CNBP (CCHC-type zinc finger nucleic acid binding protein) (eg, myotonic dystrophy type 2) gene Claim Policies Apply 01/01/19 None 81187 analysis, evaluation to detect abnormal (eg, expanded) alleles CSTB (cystatin B) (eg, Unverricht-Lundborg disease) gene analysis; evaluation to detect abnormal Claim Policies Apply 01/01/19 None 81188 (eg, expanded) alleles 81189 CSTB (cystatin B) (eg, Unverricht-Lundborg disease) gene analysis; full gene sequence Requires Prior Authorization 01/01/19 None 81190 CSTB (cystatin B) (eg, Unverricht-Lundborg disease) gene analysis; known familial variant (s) Requires Prior Authorization 01/01/19 None 81200 ASPA (aspartoacylase) (eg, Canavan disease) gene analysis, common variants (eg, E285A, Y231X) Claim Policies Apply 01/01/12 None APC (adenomatous polyposis coli) (eg, familial adenomatosis polyposis [FAP], attenuated FAP) gene Requires Prior Authorization 01/01/13 None 81201 analysis; full gene sequence APC (adenomatous polyposis coli) (eg, familial adenomatosis polyposis [FAP], attenuated FAP) gene Requires Prior Authorization 01/01/13 None 81202 analysis; known familial variants APC (adenomatous polyposis coli) (eg, familial adenomatosis polyposis [FAP], attenuated FAP) gene Requires Prior Authorization 01/01/13 None 81203 analysis; duplication/deletion variants AR (androgen receptor) (eg,spinal and bulbar muscular atrophy, Kennedy disease, X chromosome Claim Policies Apply 01/01/19 None 81204 inactivation) gene analysis; characterization of alleles (eg,expanded size or methylation status) Page 2 of 21 Procedure Code Full Description How Code is Managed Effective Date Termination Date BCKDHB (branched-chain keto acid dehydrogenase E1, beta polypeptide) (eg, maple syrup urine 01/01/12 None 81205 disease) gene analysis, common variants (eg, R183P, G278S, E422X) Claim Policies Apply BCR/ABL1 (t(9;22)) (eg, chronic myelogenous leukemia) translocation