Supplementary Table 1. Regulated genes in mice skeletal muscle after DHT and E2 Probe Set Gene Title Gene Symbol Fold Change Down/Up P Genes regulated after DHT 1419487_at myosin binding protein H Mybph 11.9 down 0.000 1415927_at Actin. alpha. cardiac Actc1 3.8 down 0.000 1419606_a_at troponin T1. skeletal. slow Tnnt1 2.8 down 0.004 1448553_at myosin. heavy polypeptide 7. cardiac muscle. beta Myh7 2.6 down 0.001 1417765_a_at amylase 1. salivary Amy1 2.5 down 0.000 1416411_at glutathione S-transferase. mu 2 Gstm2 2.5 down 0.000 1418492_at gremlin 2 homolog. cysteine knot superfamily (Xenopus laevis) Grem2 2.4 down 0.000 1424392_at alcohol dehydrogenase. iron containing. 1 Adhfe1 2.2 down 0.000 1418370_at troponin C. cardiac/slow skeletal Tnnc1 2.2 down 0.002 1448394_at myosin. light polypeptide 2. regulatory. cardiac. slow Myl2 2.2 down 0.004 1450813_a_at troponin I. skeletal. slow 1 Tnni1 2.1 down 0.001 1449996_a_at tropomyosin 3. gamma Tpm3 2.1 down 0.017 1449118_at dihydrolipoamide branched chain transacylase E2 Dbt 1.8 down 0.002 1418507_s_at suppressor of cytokine signaling 2 Socs2 1.8 down 0.038 1449059_a_at 3-oxoacid CoA transferase 1 Oxct1 1.8 down 0.000 1453552_at RIKEN cDNA 2310014F07 gene 2310014F07Rik 1.8 down 0.012 1436913_at CDC14 cell division cycle 14 homolog A (S. cerevisiae) Cdc14a 1.8 down 0.014 1448554_s_at myosin. heavy polypeptide 6. cardiac muscle. alpha Myh6 1.7 down 0.008 1427168_a_at procollagen. type XIV. alpha 1 Col14a1 1.7 down 0.005 1423607_at lumican Lum 1.7 down 0.005 1451310_a_at cathepsin L Ctsl 1.7 down 0.001 1452363_a_at ATPase. Ca++ transporting. cardiac muscle. slow twitch 2 Atp2a2 1.7 down 0.002 1452203_at oligonucleotide/oligosaccharide-binding fold containing 2A Obfc2a 1.7 down 0.007 1420523_at coiled-coil domain containing 50 Ccdc50 1.6 down 0.008 1417719_at sin3 associated polypeptide Sap30 1.6 down 0.007 1418152_at nucleosome binding protein 1 Nsbp1 1.6 down 0.012 1424649_a_at tetraspanin 8 Tspan8 1.6 down 0.003 1425090_s_at potassium voltage gated channel. Shaw-related subfamily. member 4 Kcnc4 1.6 down 0.001 1421891_at ST3 beta-galactoside alpha-2.3-sialyltransferase 2 St3gal2 1.6 down 0.014 1455007_s_at glutamic pyruvate transaminase (alanine aminotransferase) 2 Gpt2 1.6 down 0.004 1427343_at RASD family. member 2 Rasd2 1.6 down 0.014 1460451_at transmembrane protein 52 Tmem52 1.6 down 0.003 1427769_x_at myosin. light polypeptide 3 Myl3 1.6 down 0.002 1423606_at periostin. osteoblast specific factor Postn 1.6 down 0.025 1443299_at PDZ and LIM domain 3 (Pdlim3). mRNA Pdlim3 1.5 down 0.011 1426236_a_at glutamate-ammonia ligase (glutamine synthetase) Glul 1.5 down 0.014 1438855_x_at tumor necrosis factor. alpha-induced protein 2 Tnfaip2 1.5 down 0.028 1448181_at Kruppel-like factor 15 Klf15 1.5 down 0.002 1451047_at integral membrane protein 2A Itm2a 1.5 down 0.000 1425458_a_at growth factor receptor bound protein 10 Grb10 1.5 down 0.001 1424151_at JTV1 gene Jtv1 1.5 down 0.000 1450637_a_at AE binding protein 1 Aebp1 1.5 down 0.000 1451031_at secreted frizzled-related sequence protein 4 Sfrp4 1.5 down 0.001 1427153_at branched chain ketoacid dehydrogenase E1. beta polypeptide Bckdhb 1.5 down 0.003 1437273_at HtrA serine peptidase 4 Htra4 1.5 down 0.004 1422982_at androgen receptor Ar 1.5 down 0.001 1435148_at ATPase. Na+/K+ transporting. beta 2 polypeptide Atp1b2 1.5 down 0.000 1433711_s_at sestrin 1 Sesn1 1.5 down 0.000 1438641_x_at RIKEN cDNA 1500016O10 gene 1500016O10Rik 1.5 down 0.041 1433924_at --- --- 1.6 down 0.002 1436092_at --- --- 1.7 down 0.000 AFFX-18SRNAMur/X00686_M_at 1.5 down 0.029 AFFX-18SRNAMur/X00686_3_at 1.6 down 0.007 AFFX-18SRNAMur/X00686_5_at 3.4 down 0.003 1451601_a_at spinster homolog 2 (Drosophila) Spns2 3.4 up 0.000 1455031_at cell division cycle 2-like 6 (CDK8-like) Cdc2l6 3.0 up 0.000 1427339_at solute carrier family 30 (zinc transporter). member 2 Slc30a2 3.0 up 0.000 1427364_a_at ornithine decarboxylase. structural 1 Odc1 2.8 up 0.000 1424268_at spermine oxidase Smox 2.6 up 0.000 1427722_at RIKEN cDNA 9830102E05 gene 9830102E05Rik 2.6 up 0.001 1419423_at stabilin 2 Stab2 2.5 up 0.000 1455898_x_at solute carrier family 2 (facilitated glucose transporter). member 3 Slc2a3 2.5 up 0.000 1455377_at tubulin tyrosine ligase-like family. member 7 Ttll7 2.5 up 0.000 1448881_at haptoglobin Hp 2.4 up 0.020 1457587_at Voltage-gated potassium channel KCNQ5 (Kcnq5) Kcnq5 2.3 up 0.001 1451465_at ubiquitin-like 7 (bone marrow stromal cell-derived) Ubl7 2.3 up 0.000 1416835_s_at S-adenosylmethionine decarboxylase 1 /// S-adenosylmethionine decarboxylase 2 Amd1 /// Amd2 2.3 up 0.000 1460241_a_at ST3 beta-galactoside alpha-2.3-sialyltransferase 5 St3gal5 2.3 up 0.000 1428111_at solute carrier family 38. member 4 Slc38a4 2.3 up 0.010 1418509_at carbonyl reductase 2 Cbr2 2.2 up 0.000 1452035_at procollagen. type IV. alpha 1 Col4a1 2.2 up 0.000 1416138_at annexin A7 Anxa7 2.2 up 0.000 1438676_at macrophage activation 2 like Mpa2l 2.2 up 0.002 1448747_at F-box only protein 32 Fbxo32 2.1 up 0.004 1455794_at smoothelin-like 2 Smtnl2 2.1 up 0.000 1417611_at transmembrane protein 37 Tmem37 2.1 up 0.013 1435605_at ARP3 actin-related protein 3 homolog B (yeast) Actr3b 2.1 up 0.001 1424514_at ring finger protein 126 Rnf126 2.0 up 0.000 1450138_a_at serine (or cysteine) peptidase inhibitor. clade B. member 6a Serpinb6a 2.0 up 0.000 1418003_at RIKEN cDNA 1190002H23 gene 1190002H23Rik 2.0 up 0.004 1434548_at serine incorporator 3 Serinc3 2.0 up 0.002 1418091_at transcription factor CP2-like 1 Tcfcp2l1 1.9 up 0.002 1455399_at connector enhancer of kinase suppressor of Ras 1 Cnksr1 1.9 up 0.001 1433702_at endoplasmic reticulum metallopeptidase 1 Ermp1 1.9 up 0.016 1418697_at indolethylamine N-methyltransferase Inmt 1.9 up 0.002 1415897_a_at microsomal glutathione S-transferase 1 Mgst1 1.9 up 0.004 1424854_at histone 1. H4i Hist1h4i 1.9 up 0.008 1436309_at neuropilin (NRP) and tolloid (TLL)-like 2 Neto2 1.9 up 0.002 1424051_at procollagen. type IV. alpha 2 Col4a2 1.9 up 0.001 1432001_at zinc finger. MYND domain containing 17 Zmynd17 1.9 up 0.024 1415698_at golgi phosphoprotein 2 Golph2 1.9 up 0.002 1453851_a_at growth arrest and DNA-damage-inducible 45 gamma Gadd45g 1.9 up 0.002 1435902_at nudix (nucleoside diphosphate linked moiety X)-type motif 18 Nudt18 1.9 up 0.005 1426464_at nuclear receptor subfamily 1. group D. member 1 Nr1d1 1.9 up 0.015 1448300_at microsomal glutathione S-transferase 3 Mgst3 1.8 up 0.000 1449005_at solute carrier family 16 (monocarboxylic acid transporters). member 3 Slc16a3 1.8 up 0.000 1427883_a_at procollagen. type III. alpha 1 Col3a1 1.8 up 0.013 1423086_at Niemann Pick type C1 Npc1 1.8 up 0.012 1451342_at spondin 1. (f-spondin) extracellular matrix protein Spon1 1.8 up 0.000 1423296_at proteasome (prosome. macropain) 26S subunit. non-ATPase. 8 Psmd8 1.8 up 0.000 1452661_at transferrin receptor Tfrc 1.8 up 0.002 1416125_at FK506 binding protein 5 Fkbp5 1.8 up 0.002 1424126_at aminolevulinic acid synthase 1 Alas1 1.8 up 0.001 1427992_a_at RAB12. member RAS oncogene family Rab12 1.7 up 0.000 1436715_s_at CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) Cdipt 1.7 up 0.003 1434947_at kinesin family member 3C Kif3c 1.7 up 0.001 1423110_at collagen. type I. alpha 2 Col1a2 1.7 up 0.049 1431213_a_at hypothetical gene LOC433762 LOC433762 1.7 up 0.003 1424795_a_at RIKEN cDNA 1700001O22 gene 1700001O22Rik 1.7 up 0.003 1416514_a_at fascin homolog 1. actin bundling protein (Strongylocentrotus) purpuratus) Fscn1 1.7 up 0.011 1455628_at erythrocyte protein band 4.1-like 4b Epb4.1l4b 1.7 up 0.013 1417562_at eukaryotic translation initiation factor 4E binding protein 1 Eif4ebp1 1.7 up 0.000 1417279_at inositol 1.4.5-triphosphate receptor 1 Itpr1 1.7 up 0.004 1428357_at RIKEN cDNA 2610019F03 gene 2610019F03Rik 1.7 up 0.000 1422437_at procollagen. type V. alpha 2 Col5a2 1.7 up 0.015 1448566_at solute carrier family 40 (iron-regulated transporter). member 1 Slc40a1 1.7 up 0.000 1450914_at protein phosphatase 1. regulatory (inhibitor) subunit 14B Ppp1r14b 1.7 up 0.000 1453898_at integrin beta 1 binding protein 3 Itgb1bp3 1.7 up 0.043 1428536_at potassium voltage-gated channel. subfamily G. member 4 Kcng4 1.7 up 0.003 1421413_a_at PDZ and LIM domain 5 Pdlim5 1.7 up 0.000 1423596_at NIMA (never in mitosis gene a)-related expressed kinase 6 Nek6 1.7 up 0.002 1455493_at synaptic nuclear envelope 1 Syne1 1.7 up 0.001 1440085_at ectodysplasin A2 isoform receptor Eda2r 1.6 up 0.037 1416589_at secreted acidic cysteine rich glycoprotein Sparc 1.6 up 0.003 1426951_at cysteine rich transmembrane BMP regulator 1 (chordin like) Crim1 1.6 up 0.022 1435950_at hairless Hr 1.6 up 0.001 1449533_at transmembrane protein 100 Tmem100 1.6 up 0.033 1422324_a_at parathyroid hormone-like peptide Pthlh 1.6 up 0.001 1417409_at Jun oncogene Jun 1.6 up 0.011 1455494_at procollagen. type I. alpha 1 Col1a1 1.6 up 0.044 1429273_at BMP-binding endothelial regulator Bmper 1.6 up 0.001 1424842_a_at Rho GTPase activating protein 24 Arhgap24 1.6 up 0.004 1438426_at shisa homolog 4 (Xenopus laevis) Shisa4 1.6 up 0.005 1455548_at discs.