Anti-CTH (aa 250-350) polyclonal antibody (DPABH-26846) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Antigen Description Catalyzes the last step in the transsulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Immunogen Synthetic peptide conjugated to KLH derived from within residues 250 - 350 of Human Cystathionase. Isotype IgG Source/Host Rabbit Species Reactivity Human Purification Immunogen affinity purified Conjugate Unconjugated Applications WB, ICC/IF Format Liquid Size 100 μg Buffer pH: 7.40; Constituent: PBS Preservative 0.02% Sodium Azide Storage Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. GENE INFORMATION Gene Name CTH cystathionase (cystathionine gamma-lyase) [ Homo sapiens ] 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Official Symbol CTH Synonyms CTH; cystathionase (cystathionine gamma-lyase); cystathionine gamma-lyase; gamma- cystathionase; homoserine deaminase; cysteine desulfhydrase; homoserine dehydratase; cysteine-protein sulfhydrase; Entrez Gene ID 1491 Protein Refseq NP_001177392.1 UniProt ID P32929 Pathway Biosynthesis of amino acids; Cysteine and methionine metabolism; Cysteine biosynthesis, homocysteine + serine => cysteine; Cysteine formation from homocysteine Function L-cysteine desulfhydrase activity; L-cystine L-cysteine-lyase (deaminating); calmodulin binding; carbon-sulfur lyase activity 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.