Table S2. Results of expression profiling analysis (A) Up-regulated genes in HCC827-GR-high2 compared to parental HCC827 Fold Fold Fold Unique ID Symbol Unique ID Symbol Unique ID Symbol change* change* change* ILMN_1709348 ALDH1A1 577.587 ILMN_2310814 MAPT 13.003 ILMN_1741017 PIP4K2B 7.331 ILMN_1651354 SPP1 441.316 ILMN_1748650 MRPL45 12.988 ILMN_3237623 RNY1 7.297 ILMN_1701831 GSTA1 260.591 ILMN_1755897 UGT2B7 12.629 ILMN_1734897 SLC4A4 7.285 ILMN_1658835 CAV2 12.357 ILMN_1746359 RERG 7.280 ILMN_2094875 ABCB1 183.050 ILMN_1678939 VNN2 11.935 ILMN_1671337 SLC2A5 7.257 ILMN_3251540 GSTA2 145.982 ILMN_1729905 GAL3ST1 11.910 ILMN_1691606 LYG2 7.254 ILMN_2062468 IGFBP7 127.721 ILMN_1672536 FBLN1 11.716 ILMN_1785646 PMP22 7.246 ILMN_1795190 CLDN2 111.439 ILMN_1796339 PLEKHA2 11.631 ILMN_1737387 LOC728441 7.207 ILMN_1782937 LOC647169 98.612 ILMN_1676563 HTRA1 11.592 ILMN_1684401 FMO1 7.117 ILMN_1754247 SLC3A1 81.001 ILMN_3263423 LOC100129027 11.346 ILMN_1687035 ADAMTSL4 7.098 ILMN_1662795 CA2 79.581 ILMN_1694898 LOC653857 10.906 ILMN_2153572 MAGEA3 7.086 ILMN_2168747 GSTA2 66.250 ILMN_2404625 LAT 10.560 ILMN_1784283 USH1C 7.079 ILMN_1764228 DAB2 64.709 ILMN_1666546 DUSP14 10.375 ILMN_1731374 CPE 7.046 ILMN_1675797 EPDR1 63.605 ILMN_1764571 ARHGAP23 10.299 ILMN_1765446 EMP3 6.933 ILMN_1708341 PDZK1 59.714 ILMN_3200140 LOC645638 10.284 ILMN_1754002 IL1F8 6.863 ILMN_1713529 SEMA6A 52.575 ILMN_3244343 SNORA21 10.171 ILMN_1878007 FUT9 6.835 ILMN_1708391 NR1H4 43.218 ILMN_1671489 PC 10.075 ILMN_1699208 NAP1L1 6.763 ILMN_2412336 AKR1C2 42.826 ILMN_2404688 NUPR1 10.044 ILMN_2403237 CHN2 6.749 ILMN_3272081 LOC100130221 39.774 ILMN_1772824 WNT5B 10.037 ILMN_1687757 AKR1C4 6.720 ILMN_3243598 PDZK1P1 39.514 ILMN_1741356 PRICKLE1 9.893 ILMN_1810560 P8 6.594 ILMN_1754076 CACNA2D3 39.414 ILMN_1758146 SIRPA 9.804 ILMN_1892403 SNORD13 6.570 ILMN_1808157 RUNDC3B 38.375 ILMN_1801090 KRT222 9.757 ILMN_2332553 MSRB3 6.534 ILMN_1704617 EFHB 37.932 ILMN_1731941 APOM 9.724 ILMN_1720771 STX11 6.527 ILMN_1760412 SHISA2 36.244 ILMN_1709153 PRR16 9.707 ILMN_2400219 SRI 6.526 ILMN_2336094 ODZ3 33.505 ILMN_1804357 GNG4 9.638 ILMN_1798210 E2F7 6.505 ILMN_1657373 LEPREL1 29.033 ILMN_1706664 FAM80A 9.622 ILMN_1782419 GNG11 6.499 ILMN_1715508 NNMT 27.320 ILMN_1669393 GGT1 9.572 ILMN_2188521 PVRL3 6.475 ILMN_2141482 SERPINF1 27.052 ILMN_1810797 WASF3 9.553 ILMN_2225135 GCNT1 6.458 ILMN_2315044 FGG 26.902 ILMN_1808238 RBPMS2 9.526 ILMN_1691662 LOC100101266 6.425 ILMN_1811303 NR5A2 26.868 ILMN_1680682 TADA2A 9.525 ILMN_1751453 ABCC9 6.422 ILMN_1788122 GSTA5 26.123 ILMN_2363988 GSG1 9.385 ILMN_1681260 LOC643272 6.384 ILMN_2289593 FXYD2 25.330 ILMN_1729216 CRYAB 9.348 ILMN_2105919 FGF2 6.365 ILMN_1789502 GPC4 23.773 ILMN_1678353 FARP1 9.338 ILMN_1672591 SCN9A 6.326 ILMN_1785732 TNFAIP6 23.401 ILMN_1677200 CYFIP2 9.312 ILMN_2135321 CHDH 6.297 ILMN_1694840 MATN2 22.663 ILMN_1728734 PSG5 9.180 ILMN_2234956 LEPR 6.265 ILMN_3243831 CAPN6 21.834 ILMN_2366790 DDX52 9.083 ILMN_3238435 SNORA12 6.255 ILMN_1809859 PCGF2 21.378 ILMN_1774261 DOK4 8.954 ILMN_1701032 TFPI 6.168 ILMN_1806754 GLDC 21.314 ILMN_3216979 LOC646949 8.937 ILMN_2376263 SMARCA1 6.079 ILMN_2368530 IL32 19.690 ILMN_1676088 MSRB3 8.929 ILMN_2151281 GABARAPL1 6.071 ILMN_1678842 THBS2 19.454 ILMN_1771652 BAIAP2L2 8.831 ILMN_1800512 HMOX1 6.037 ILMN_3235709 HNF1B 19.325 ILMN_2170949 SNX10 8.471 ILMN_1762155 FBXO40 6.024 ILMN_1687306 LGALS2 18.691 ILMN_2149766 APPBP2 8.445 ILMN_1740443 LOC728811 6.016 ILMN_1703301 LOC653479 18.372 ILMN_1691702 ZNF775 8.443 ILMN_1737255 C22orf36 6.006 ILMN_2058251 VIM 18.289 ILMN_1727091 ACMSD 8.384 ILMN_1712545 S100A3 5.890 ILMN_1697548 LPHN2 18.020 ILMN_1812461 WISP2 8.326 ILMN_1705346 NBEA 5.886 ILMN_1678049 FGB 18.003 ILMN_1656368 ALDH4A1 8.208 ILMN_1759785 LOC644111 5.839 ILMN_1730454 FOLR3 17.458 ILMN_1690223 CNTNAP2 8.093 ILMN_1804419 LRMP 5.780 ILMN_1808301 MRPL45 16.535 ILMN_1805826 BIVM 7.972 ILMN_2337923 TPD52L1 5.770 ILMN_2367172 AMACR 16.517 ILMN_1789599 NBL1 7.911 ILMN_1711408 ANXA4 5.769 ILMN_1800787 RFTN1 15.849 ILMN_2415467 AP1GBP1 7.889 ILMN_3187623 SYCE1L 5.759 ILMN_1778337 TCF2 15.128 ILMN_1720233 CCDC49 7.822 ILMN_1698020 DLC1 5.736 ILMN_2081087 HSPA12A 15.058 ILMN_2102257 FBXO48 7.776 ILMN_1724061 PAX3 5.714 ILMN_2315789 PTPRD 14.388 ILMN_1708098 LIX1L 7.705 ILMN_1721770 PAPPA 5.709 ILMN_2307903 VCAM1 13.721 ILMN_3248094 ANO2 7.688 ILMN_1717327 KCNJ14 5.686 ILMN_2401344 PPP2R2C 13.709 ILMN_1718734 MLLT6 7.586 ILMN_2384745 PSG4 5.668 ILMN_1766675 CDH6 13.679 ILMN_1678170 MME 7.582 ILMN_1765304 psiTPTE22 5.649 ILMN_1746013 SPOCK1 13.672 ILMN_3247139 C17orf96 7.522 ILMN_1776850 ITGB1BP3 5.609 ILMN_1745976 TRAF4 13.505 ILMN_1782429 TMEM56 7.496 ILMN_2171295 PFTK1 5.607 ILMN_1750062 PPARGC1A 13.359 ILMN_1783276 NEXN 7.414 ILMN_1737406 KLF6 5.598 ILMN_1691410 BAMBI 13.170 ILMN_1758825 ABLIM2 7.406 ILMN_1805543 ADAMTS9 5.571 ILMN_2399463 VAV3 13.164 Fold Fold Fold Unique ID Symbol Unique ID Symbol Unique ID Symbol change* change* change* ILMN_1742044 GNAI1 5.546 ILMN_1710001 RPL41 4.698 ILMN_1738849 SLC9A2 4.147 ILMN_1664170 CUGBP2 5.514 ILMN_3195372 LOC100128056 4.698 ILMN_2195482 CACNB3 4.146 ILMN_3253901 HAVCR1 5.506 ILMN_1670875 PPM1D 4.695 ILMN_3249501 ZNF697 4.145 ILMN_1690979 SLC17A3 5.493 ILMN_1668531 LOC440386 4.689 ILMN_1675062 MYL9 4.123 ILMN_1743394 HNF4G 5.448 ILMN_1700887 TDRD5 4.677 ILMN_2361862 VLDLR 4.108 ILMN_1693912 SLC47A2 5.399 ILMN_1692398 CNTNAP1 4.676 ILMN_1736863 TMEM140 4.102 ILMN_2302118 CCDC50 5.391 ILMN_1680521 AV PR1 B 4.670 ILMN_1677684 BTBD16 4.093 ILMN_1767934 PCSK5 5.390 ILMN_3238898 LOC100192378 4.658 ILMN_1693738 CTSE 4.093 ILMN_1656378 NMT2 5.358 ILMN_1721657 RSU1 4.657 ILMN_1654112 PARD6A 4.089 ILMN_1699226 UBR4 5.348 ILMN_2246956 BCL2 4.654 ILMN_2282081 QRICH1 4.088 ILMN_1749962 NCAM2 5.324 ILMN_1690644 LOC652605 4.621 ILMN_1712159 AV PR1 A 4.085 ILMN_2197365 RGS2 5.319 ILMN_2275126 RHBDF2 4.614 ILMN_2186137 RRAD 4.082 ILMN_1799600 STARD8 5.291 ILMN_1768804 LOC644014 4.610 ILMN_1722953 USP47 4.055 ILMN_1652631 GLIPR2 5.288 ILMN_1723978 LGALS1 4.599 ILMN_3245684 C12orf27 4.047 ILMN_2360710 TPM1 5.275 ILMN_1719543 MAF 4.598 ILMN_1742069 ZSWIM5 4.041 ILMN_2174481 TEX9 5.248 ILMN_1662846 GPR160 4.574 ILMN_1806603 MESP1 4.039 ILMN_1667018 ACE2 5.227 ILMN_2194009 ABCC4 4.556 ILMN_1754969 LMCD1 4.037 ILMN_2094360 NR2F2 5.224 ILMN_1810684 TINAG 4.549 ILMN_3240365 MNX1 4.034 ILMN_3251737 EEF1A1 5.212 ILMN_1655595 SERPINE2 4.545 ILMN_2374244 DYRK2 4.033 ILMN_1804629 TPK1 5.179 ILMN_3235853 S1PR1 4.544 ILMN_2284222 PCTK3 4.032 ILMN_1796349 SMPDL3A 5.178 ILMN_1696339 ZIC2 4.525 ILMN_3235185 SNRNP200 4.026 ILMN_1767657 MAT1A 5.141 ILMN_2405602 OSBPL1A 4.519 ILMN_1738657 SATB2 4.007 ILMN_1669631 GLRB 5.140 ILMN_1737025 PLCL2 4.517 ILMN_1736104 LOC645218 4.000 ILMN_1668374 ITGB5 5.139 ILMN_1692865 VPS37D 4.515 ILMN_1794959 SLC35F3 3.993 ILMN_1662839 PLEKHA1 5.113 ILMN_1794598 SCHIP1 4.506 ILMN_3276119 LOC645251 3.984 ILMN_1686116 THBS1 5.093 ILMN_1746888 PCOLCE2 4.499 ILMN_1802519 VPS36 3.983 ILMN_1687301 VCAN 5.079 ILMN_1767900 LGI2 4.489 ILMN_1712419 DCDC2 3.971 ILMN_1803676 ENOSF1 5.078 ILMN_1732127 RBKS 4.469 ILMN_3194217 LOC100129424 3.956 ILMN_1680874 TUBB2B 5.045 ILMN_1716957 C1QL1 4.457 ILMN_1691237 CAP2 3.950 ILMN_2410929 PAPSS2 5.044 ILMN_2403896 GGTLC2 4.433 ILMN_1729453 TSPAN9 3.942 ILMN_1796229 FGFR1 5.038 ILMN_1752299 RAB6B 4.422 ILMN_2059535 PPM1F 3.919 ILMN_1811238 ALPK2 5.026 ILMN_1767523 IL17RB 4.408 ILMN_2388070 TMEM44 3.910 ILMN_3248282 LOC100134539 5.023 ILMN_2201678 FSTL1 4.392 ILMN_2381899 OPTN 3.908 ILMN_1775508 CYLD 5.006 ILMN_1763196 WDR72 4.384 ILMN_1813685 RAB7L1 3.908 ILMN_1655563 KIAA0427 5.004 ILMN_3310421 MIR1292 4.381 ILMN_1655796 37681 3.907 ILMN_1778333 MMP24 4.990 ILMN_1779228 CDH2 4.380 ILMN_2364384 PPARG 3.906 ILMN_3241021 RNY4 4.989 ILMN_1782243 LOC643248 4.375 ILMN_1782349 LOC648066 3.903 ILMN_3237439 SNORD61 4.981 ILMN_2075643 ANKRD29 4.374 ILMN_1755822 SYDE1 3.903 ILMN_1777397 MSX1 4.978 ILMN_1758523 ABCA3 4.374 ILMN_1699489 TUBB6 3.902 ILMN_1707727 ANGPTL4 4.966 ILMN_1781691 TRAK2 4.373 ILMN_3248599 LOC100134825 3.901 ILMN_1685275 MCAM 4.963 ILMN_1774387 ZHX3 4.366 ILMN_1697959 SLC35B4 3.892 ILMN_1810233 UGT2B11 4.928 ILMN_1752914 CDGAP 4.354 ILMN_1717393 PTCHD1 3.891 ILMN_1719792 PHLDB2 4.927 ILMN_1803862 LCN15 4.354 ILMN_1801776 PSG9 3.890 ILMN_1723969 PLCB1 4.923 ILMN_1662038 LARGE 4.321 ILMN_2381064 TPD52 3.887 ILMN_1712913 UNC5A 4.913 ILMN_1758392 ANKS1B 4.320 ILMN_1788931 DOCK8 3.884 ILMN_1706498 DSE 4.913 ILMN_1680037 FAM65A 4.320 ILMN_1787324 C16orf48 3.883 ILMN_1729455 EML1 4.895 ILMN_1810941 COMT 4.299 ILMN_1806930 LOC651040 3.872 ILMN_2346339 FOLR1 4.869 ILMN_2193706 HRK 4.286 ILMN_1688935 DLK2 3.870 ILMN_2143250 FAR1 4.860 ILMN_2068991 TBC1D3G 4.285 ILMN_1673941 RBM24 3.869 ILMN_1731714 CREB5 4.859 ILMN_1658498 SLC44A3 4.272 ILMN_1761281 LOC441019 3.867 ILMN_1724686 CLDN1 4.835 ILMN_1708709 KIAA1211 4.268 ILMN_1759660 LOC648153 3.854 ILMN_1722845 RAB3B 4.815 ILMN_1724480 AXIN2 4.257 ILMN_1706660 HYI 3.848 ILMN_1805448 EPB41L2 4.814 ILMN_1665909 LASP1 4.253 ILMN_1727805 SYNGR1 3.844 ILMN_3269395 GGT2 4.805 ILMN_1719570 BICC1 4.231 ILMN_1781400 SLC7A2 3.841 ILMN_1748281 MAPK10 4.792 ILMN_3251472 TOMM20 4.229 ILMN_1809490 NCKAP5 3.841 ILMN_1674193 EMX1 4.787 ILMN_1664922 FLNB 4.217 ILMN_1716264 ANKRD1 3.838 ILMN_1742866 F2R 4.781 ILMN_1755115 RPL23 4.212 ILMN_1732584 FLJ45455 3.835 ILMN_1705869 LOC440297 4.780 ILMN_1709683 RASSF2 4.187 ILMN_2131523 SACS 3.833 ILMN_1661940 CAMTA1 4.765 ILMN_1768391 ARL4C 4.184 ILMN_2298588 TAOK2 3.815 ILMN_2348788 CD44 4.760 ILMN_1727813 BRP44 4.172 ILMN_2140990