CURRICULUM VITAE (maximum 4 pages) May 7, 2018 Part A. PERSONAL INFORMATION CV date First and Family name Rafael Jiménez Medina Social Security, Age Passport, ID number Researcher ID Researcher numbers Author ID ORCID code A.1. Current position Name of University of Granada University/Institution Department Genetics Faculty of Sciences, Avda. Fuentenueva S/N, 18001 Granada, Address and Country Spain Phone number +34-958243260 E-mail [email protected] Current position Full Professor From 2016 UNESCO code 240991 Mammalian Developmental Genetics, Mammalian Sex Determination, Sex reversal, True hermafroditism, Intersexuality, Key words Gonadal Development, Ovotestis development, Gene expression, Seasonal Testis Regression A.2. Education Degree/PhD University Year Degree in Biology University of Granada 1983 Doctor in Biology (Genetics) University of Granada 1989 A.3. JCR ARTICLES, h-INDEX, THESIS SUPERVISED… Number of 6-year periods: 5, the last one approved in 2016. Number of supervised doctoral thesis during the last 10 years: 4 (7 in total). Number of grants participating as a researcher: 5. Number of grants participating as the principal investigator: 7. Number of doctoral theses supervised (last 10 years): 4. Number of articles indexed in the JCR: 90 (first author in 18, last author in 22, corresponding author in 39). Number of articles in the first quartile (Q1): 31. Number of articles with I.F.>5: 7. Number of articles with I.F.>10: 2. Number of books and chapters in books: 7. Number of meeting contributions: 74. Total number of citations: 1304. h-Index: 24 (Google Scholar). Part B. CV SUMMARY (max. 3500 characters, including spaces) Currently I have 5 consecutive six-years periods of research approved, the last of which was granted in 2016. I am University Full Professor since 2016. I have supervised 7 doctoral theses. I have participated in 10 competitive project grants (financed with more than 700.000,00 €), in 6 of them as principal investigator. I belong to the Editorial Panel of Sexual Development and Biomedicine Hub. I was Secretary of the Dept. of Genetics of the University of Granada for 8 years and Departament Director since 2016. I was a member of two external evaluation committees (in one of them I acted as president) that evaluated 9 master's degrees from the University of Valencia and the Polytechnic University of Valencia. I evaluated 7 research projects for the Spanish Science Agency and 8 more for foreign agencies from USA, Argentina, Georgia and France and acted as external reviewer of many manuscripts for several journals, including PLOS Genetics, Development, Scientific Reports, Biology of Reproduction and PLOS One. In the field of scientific research, during my initial stage as a cytogeneticist, I published 25 articles, some of them in such prestigious journals as J. Cell Sci., Heredity or Exp. Cell Res. (Q1). Subsequently, after detecting two cases of sexual reversal, one in the 1 CURRICULUM VITAE (maximum 4 pages) Cabrera’s vole, Microtus cabrerae (Cytogenet Cell Genet 49: 275-277, 1988) and another in the Iberian mole, Talpa occidentalis (Genet Res 52: 135-140, 1988). ), I entered the field of Developmental Genetics, focusing mainly on the study of the development of ovotestes in female moles. I have developed the necessary technology for its management and study (traps and procedures to collect embryos and infants), which allowed us to study the gonadal development in this species. Some of the articles derived from these works have had a good impact, and have been published in journals such as Development, Dev. Biol. or J. Exp. Zool. (Q1). I have also made various theoretical reviews published in journals such as Trend. Genet (D1) and Bioessays (Q1). We are the only group in the world capable of collecting mole embryos, which has attracted other researchers to request our collaboration to carry out studies that would have been impossible otherwise. Thus, we conducted a study on the development of the eye with Dr. John M. Collinson (Aberdeen) (publications in BMC Biol. and Proc. Roy. Soc (Q1). We are studying the development of the front legs with Drs Mike Richardson (Leiden), resulting in several publications, including one in EvoDevo (Q1) and Stefan Mundlos (Berlin), with which we have sequenced the complete genome of the Iberian mole. We have studied the development of the placenta with Dr. Uklrich Zeller (Berlin). We have addressed the study of the role of microRNAs during sexual determination, demonstrating that miR-124 is sufficient to inhibit the expression of Sox9 during ovarian development (Biol Reprod; Q1). Our paper on the role of Sox9 and Sox8 in male sex maintenance was published in eLife (D1). We have also developed a line of research on the genetic control of seasonal reproduction of mammalian species, which has allowed us to publish several articles in J. Exp. Zool, and Biol. Reprod. and Plos One (Q1), becoming a world reference group in this field Part C. RELEVANT MERITS C.1. PUBLICATIONS (including books) • Barrionuevo FJ, Hurtado A, Kim G-J, Real FM, Bakkali M, Kopp JL, Sander M, Scherer G, Burgos M, Jiménez R. (2016). Sox9 and Sox8 protect the adult testis from male-to- female genetic reprogramming and complete degeneration. eLife 2016;5:e15635. (IF: 7,725) (corresponding author). • Real FM, Sekido R, Lupianez DG, Lovell-Badge R, Jimenez R, Burgos M. (2013) A microRNA (mmu-miR-124) prevents Sox9 expression in developing mouse ovarian cells. Biology of Reproduction 89(4): 1-11.. (IF: 4,027) (corresponding author). • Dadhich RK, Barrionuevo FJ, Real FM, Lupiáñez DG, Ortega E,, Burgos M, Jiménez R. (2013). Identification of live germ-cell desquamation as a major mechanism of seasonal testis regression in mammals. A study in the Iberian mole Talpa occidentalis. Biology of Reproduction 88(4):1-12. (IF: 4,027) (corresponding author). • Carmona FD, Glosmann M, Ou J, Jiménez R and Collinson JM (2010). Retinal development and function in a ‘blind’ mole. Proceeding of the Royal Society B 277(1687): 1513-1522. (IF: 5,064) (researcher). • Dadhich RK, Real FM, Zurita F, Barrionuevo FJ, Burgos M, Jiménez R. (2010). Role of Apoptosis and Cell Proliferation in the Testicular Dynamics of Seasonal Breeding Mammals: A Study in the Iberian Mole, Talpa occidentalis. Biology of Reproduction 83: 83-91. (IF: 4,027) (corresponding author). • Carmona FD, Jiménez R and Collinson JM (2008). The molecular basis of defective lens development in the Iberian mole. BMC Biology 6-44: 1-9. (IF: 4,734) (researcher). • Barrionuevo FJ, ZuritaF, Burgos M, Jiménez R. (2004). Testis-like development of gonads in female moles. New insights on mammalian gonad organogenesis. Developmental Biology 268: 39-52. (IF: 5,432) (corresponding author). • Jiménez R, Burgos M. (1998) Mammalian sex determination: joining pieces of the genetic puzzle. BioEssays 20: 696-699 (IF: 7,580) (corresponding author). • Sánchez A, Bullejos M, Burgos M, Jiménez R, Díaz de la Guardia R. (1996). An alternative to blunt-end ligation for cloning DNA fragments with incompatible ends. Trends in Genetics 12: 44 (IF: 10,781) (researcher). 2 CURRICULUM VITAE (maximum 4 pages) • Jiménez, R. A. Sánchez, M. Burgos, R. Díaz de la Guardia (1996). Puzzling out the genetics of mammalian sex determination. Trends in Genetics 12: 164-166. (IF: 10,781) (corresponding author). • Jiménez R, Burgos M, Sánchez A, Sinclair , Alarcón FJ, Marín JJ, Ortega E, Díaz de la Guardia R. (1993). Fertile females of the mole Talpa occidentalis are phenotypic intersexes with ovotestes. Development 118: 1303-1311. (IF: 7,503) (corresponding author). C.2. RESEARCH PROJECTS AND GRANTS Participation in National Projects granted by Spanish Agencies Reference: CVI2057 Title: Implicación de miRNAs en el control de genes de determinación sexual Funding Agency: Proyectos de Excelencia de la Junta de Andalucía. Consejería de Innovación Ciencia y Empresa. Duration, from: 2007 to: 2009 Principal Investigator: Rafael Jimenez Medina Number of researchers: 9 Amount: 201.636,00 € + 1 pre-doctoral contract Reference: CGL2008-00828/BOS Title: Elementos Geneticos Ambientales que controlan los cambios gonadales en mamiferos con reproduccion estacional Funding Agency: Dirección General de Investigación. Duration, from: 2009 to: 2012 Principal Investigator: Rafael Jimenez Medina Number of researchers: 9 Amount: 85.500,00 € + 1 pre-doctoral contract Reference: CGL2011-23368/BOS Title: Identificación y Función de miRNAs implicados en la determinación del sexo en mamíferos. Funding Agency: Dirección General de Investigación. Duration, from: 2012 to: 2014 Principal Investigator: Rafael Jimenez Medina Number of researchers: 7 Amount: 199.000,00 € + 1 pre-doctoral contract Reference: P11-CVI-7291 Title: Partes biobrics y estudios funcionales de microRNAs implicados en la diferenciación sexual Funding Agency: Junta de Andalucía Duration, from: 2013 to: 2017 Principal Investigator: Miguel Burgos Poyatos Number of researchers: 5 Amount: 222.573,30 € + 1 pre-doctoral contract Reference: CGL2015-67108-P Title: Mecanismos de regresión y activación testicular en mamíferos con reproducción estacional: control genético y susceptibilidad a cambios ambientales Funding Agency: Ministerio de Economía y Competitividad Duration, from: 2016 to: 2019 Principal Investigator: Rafael Jiménez Medina Number of researchers: 9 Amount: 74.400,00 € + 1 pre-doctoral contract 3 CURRICULUM VITAE (maximum 4 pages) Participation in International Granted Projects Reference: 31003A_133032 Title: Heterochrony and modularity in mammalian