<p> Chapter 14 Outline DNA: The Genetic Material Advanced Placement Biology Roslyn High School</p><p>What is the genetic material?</p><p>How did the Hammerling experiment show that cells store hereditary information in the nucleus?</p><p>How was surgery performed upon cells?</p><p>How did the transplantation experiment show each cell contains a full set of genetic instructions?</p><p>How were nuclei successfully transplanted? What is totipotency with respect to plants?</p><p>How did the Griffith experiment show hereditary information can pass between organisms?</p><p>How did the Avery and Hershey-Chase experiments show that DNA was the active principle?</p><p>Avery: Hershey-Chase:</p><p>What is the structure of DNA?</p><p>What is the chemical nature of nucleic acids?</p><p>How did Levene’s analysis show that DNA is a polymer? How did Chargaff’s analysis show that DNA is not a simple repeating polymer?</p><p>How did Rosalind Franklin’s X-ray diffraction detect patterns of DNA?</p><p>How did Watson and Crick develop their model of the DNA double helix? How does DNA replicate?</p><p>How did the Meselson-Stahl experiment show that DNA replication is semiconservative? How does DNA replicate?</p><p>What is a replication origin?</p><p>What are polymerases?</p><p>How do leading and lagging strands differ? How do other enzymes play a role in DNA replication?</p><p>What happens at the replication fork?</p><p>How do polymerases play a role in DNA replication?</p><p>What is a replisome? What are the stages of replication?</p><p>Initiation:</p><p>Elongation:</p><p>Termination:</p><p>How does eukaryotic DNA replicate? What is a gene?</p><p>How was the one-gene/one-polypeptide hypothesis developed?</p><p>How did Garrod show that inherited disorders can involve specific enzymes?</p><p>How did Beadle and Tatum show that genes specify enzyme production?</p><p>What is a defined system?</p><p>How were growth deficient mutants isolated?</p><p>How were the deficiencies identified? How was the one-gene/one-polypeptide hypothesis developed?</p><p>How does DNA encode protein structure?</p><p>How did Sanger show proteins consist of defined sequences of amino acids?</p><p>How did Ingram show a single amino acid change in a protein can have profound effects?</p>