<p>Version FINAL rev 140813</p><p>Electronic Supplementary Material</p><p>No </p><p>All Warfarin Aspirin treatment*</p><p> n 41810 15680 14236 9959</p><p>Clopidogrel 2,0% 0,3% 2,5% 0,0%</p><p>Low molecular weight heparin 3,3% 4,1% 2,1% 3,1%</p><p>Antihypertensive or antianginal drugs 85,9% 94,7% 92,2% 60,8%</p><p>Lipid-lowering drugs 31,7% 40,3% 31,8% 14,1%</p><p>Insulin 5,9% 6,2% 6,7% 3,9%</p><p>Oral antidiabetic drugs 8,3% 10,6% 8,1% 4,1%</p><p>*clopidogrel excluded</p><p>Supplementary Table 1 – Other drug treatment among 41 810 atrial fibrillation patients in the Stockholm County Council.</p><p>1 Version FINAL rev 140813</p><p>Supplementary Figure 1 – Factors contributing to CHA2DS2VASc scores 1 and 2 in 9 032 AF patients with warfarin, aspirin or no treatment*. </p><p>*clopidogrel excluded</p><p>2 Version FINAL rev 140813</p><p>Supplementary Figure 2 –Risks of suffering ischemic (IS) and hemorrhagic stroke (HS) during 2010 in 41810 AF patients, warfarin vs. no warfarin (i.e. aspirin or no treatment according to [3]). </p><p>Patients who had claimed prescriptions of both warfarin and aspirin are included in the warfarin group.</p><p>The patients having claimed both warfarin and aspirin between between July 1st 2009 and Dec 31st </p><p>2009 (n=1574) represented 3.8% of the total atrial fibrillation cohort. They were younger than the patients in the warfarin and aspirin groups: their mean age was 72.3 years and 71.1 % were under </p><p> the age of 80. The majority were men (63.0%). The mean CHA2DS2VASc score was 4.0 and 47.9% had vascular disease, which was more common than in the other treatment groups. Also, diabetes </p><p>(24.5%) and hypertension (72.2%) were slightly more common. Other co-morbidity was similar to the warfarin treated patients, while clopidogrel (5.8%) and lipid lowering treatment (53.2%) were more common.</p><p>Their risk of suffering ischemic stroke was 5.2%, thromboembolism 7.2%, hemorrhagic stroke 0.8%, traumatic intracranial bleeding 0.3%, any severe bleed 3.4%, and death 9.0%</p><p>3 Version FINAL rev 140813</p><p>Supplementary Text – Characteristics and Outcomes of 1574 AF Patients Claiming both Warfarin and Aspirin</p><p>4 Version FINAL rev 140813</p><p>Diagnosis ICD-code beginning with</p><p>Alcohol abuse E244, F10, G312, G621, G721, I426, K292, K70, </p><p>K860, O354, P043, Q860, T51, Y90-91, Z502, Z714</p><p>Anemia D50-64</p><p>Any severe bleed I60-62, I690-I692,, S064-S066, I850, I983, K25-28 </p><p>(subcodes 0-2 and 4-6 only), K625, K922, D629</p><p>Atrial fibrillation I48</p><p>Cancer entire C-series </p><p>Cardioversion Procedure codes DF026, DF027</p><p>COPD/Emphysema J43-44 </p><p>Dementia F00-F03 </p><p>Diabetes E10-E14</p><p>Frequent falls (more than one W00-19 registration)</p><p>Gastric duadenal bleeding K25-28 (subcodes 0-2 and 4-6 only)</p><p>Heart failure I50</p><p>Hypertension I10-I15</p><p>Ischemic stroke, arterial I63, I64, I679, I693, I694, I698, I67-, I69-, Z866, embolism, and stroke, Z867, G450, G451, G452, G453, G458, G45.9, unspecified G45-, I74 </p><p>Intracranial bleeding I60-I62, I690-I692, S064-S066</p><p>Liver disease K70-77</p><p>Mechanical valve Procedure codes FCA60, FCA70, FDC10, FGE00, </p><p>FGE10, FGE20, FGE96, FJF00, FJF10, FJF12, FJF20, </p><p>FJF96, FKD00, FKD10, FKD20, FKD96, FMD00, </p><p>FMD10, FMD12, FMD13, FMD20, FMD30, FMD40,</p><p>5 Version FINAL rev 140813</p><p>FMD96</p><p>Mitral stenosis I050, I052, I342</p><p>Obesity E65-66 </p><p>Renal disease N17-19</p><p>Vascular disease I20-I25, I70, I739</p><p>Venous thromboembolism I26, I80-I82</p><p>Outcomes </p><p>(only inpatient care or specialist ambulatory care)</p><p>Any severe bleed I60-62, S064-S066, I850, I983, K25-28 (subcodes </p><p>0-2 and 4-6 only), K625, K922, D629</p><p>Intracranial bleeding I60-I62, S064-S066</p><p>Ischemic stroke I63 </p><p>Hemorrhagic stroke I60-I62 </p><p>Thromboembolism I63, I64, G450, G451, G452, G453, G458, G459, </p><p>I74 </p><p>Traumatic intracranial bleeding S064-S066 </p><p>Supplementary Appendix A - Definitions of co-morbidities and outcomes by ICD-10, primary care codes and procedure codes.</p><p>Treatment ATC-code beginning with</p><p>Acetylsalicylic acid (aspirin) B01AC06</p><p>Antihypertensive drugs C03, C07, C08, C09</p><p>Clopidogrel B01AC04</p><p>Insulin A10A</p><p>Lipid-lowering treatment C10</p><p>Low molecular weight heparin B01AB04, B01AB05</p><p>Oral antidiabetic treatment A10B</p><p>Warfarin B01AA</p><p>6 Version FINAL rev 140813</p><p>Supplementary Appendix B – ATC-codes of concomitant treatments.</p><p>7</p>