Melanoma Associated Antigen (Mutated) 1 (36%)

Table S1 Summary of amino acid sequence homology analysis by NCBI Protein Blast Program with 124 tryptic peptides identified from CA215 by MALDI-TOF MS Amino Acid Sequence of Tryptic Peptides Sequence Homology Searched (%) 1. AAAGGLAMLTSMRPTLCSR Immunoglobulin heavy chain variable region (68%)ICAM-3 (36%)2. ADQGSETPSCLEVQCWGSR CD55 antigen, decay accelerating factor for complement (Cromer blood group), isoform CRA_j (52%)Protocadherin alpha-10 isoform 3 precursor (36%)3. AEALRTLTK Nestin (100%)Microtubule-based motor (77%)4. AFGSAAAFCWLCPCRCWK Adhesion molecule with Ig-like domain 1 (27%)5. AGLLCHLDDACISNPCHK Delta and Notch-like epidermal growth factor-related receptor precursor (72%)Dynein heavy chain 14, axonemal isoform 1 (83%)Cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila), isoform CRA_a (66%)6. ALACSGMKIGR ligatin, isoform CRA_c (54%)TCR (72%)MHC class I antigen (90%)7. ANESGLAMTDISSLASQNK Melanoma associated antigen (mutated) 1 (36%) Tubulin gamma-1 chain (57%)1 Cathepsin F (63%)8. ANPQCMGQNHK Prolow-density lipoprotein receptor-related protein 1 precursor (90%)9. APQLLCYAATNLQSGGPSR Anti-tetanus toxoid immunoglobulin light chain variable region (100%)10. APTVVLHMTK Ig heavy chain variable region, VH3 family (70%)Mucin 5AC protein (70%)NF-IL6-beta protein (80%) 11. AQCVVSLAPR Interleukin-1 receptor accessory protein isoform 3 (50%)MEGF10 protein, isoform CRA_b (100%)Obscurin (80%)12. ATVASGISPGWMGLDCGPESNK Circulating B cell antibody heavy chain variable region (59%)Immunoglobulin E heavy chain variable region (50%)Multiple epidermal growth factor-like domains protein 11 precursor (40%)13. ATVMGSKCHR Mucin-16 (70%)14. AVMNGLAPGSNGQDKDMDLTK Cellular myosin heavy chain (38%)Fc receptor-like A (100%)15. AVPSAEPQAGSPMTLSCQTK Leukocyte immunoglobulin-like receptor subfamily A member 2 soluble isoform 2 (85%) 16. CDVLK WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2, isoform CRA_b (100%) 17. CNGLMTIVFEENSKVTVPHMIK Immunoglobulin lambda chain variable region (59%)2 18. DGLLYDTLVLINLESCDKK Nuclear receptor ROR-gamma isoform b (47%)19. DHPYISEIK Fat-like cadherin FATJ protein (77%)20. EAHFVRTSGK neural cell adhesion molecule 1, isoform CRA_h (70%)21. EEAGKEEPPPLTPPAR T-box 3 (ulnar mammary syndrome), isoform CRA_d (100%) 22. EGAAGAFLPACK Multiple epidermal growth factor-like domains protein 8 (66%)Immunoglobulin heavy chain variable region (58%)23. EGGTQKTSTLPAVLYSCGICK Immunoglobulin heavy chain variable region (28%)24. EMTDATNEEETEIKEDTK Ryanodine receptor 2 (cardiac), isoform CRA_c (77%)25. GDGTSQGCAVPVESDPRHPR Pro-epidermal growth factor isoform 3 preproprotein (65%)Titin (90%)26. GDRVTITWR Immunoglobulin kappa chain variable region (100%)Immunoglobulin light chain variable region (77%)27. GELSPGHFLSGFSAAGASV Ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin), isoform CRA_b (31%)28. GLCASAPFSCCLEQDVSRK T cell receptor beta variable 19 (36%)Immunoglobulin mu heavy chain (63%)29. GLEWVSAVSGSGTTTYYADSVK Immunoglobulin heavy chain variable region (100%)Immunoglobulin E heavy chain variable region 3 (100%)Immunoglobulin alpha heavy chain variable region (100%)Anti-GM2 glanglioside IgM heavy chain variable region (100%)30. GQPTYQICPRIIPTTESSCR NWD1 protein (30%)31. GSSGSSGKCETK N.A.32. GTEGLCPLLCHADGTPLGAGAR Sialic acid-binding Ig-like lectin 6 isoform 6 precursor (63%)CD33L1 [Homo sapiens] >gb|AAK83655.1| sialic acid binding immunoglobulin-like lectin 6 (63%)CD33L2 (63%)Latent TGF-beta binding protein-4 (31%) 33. HESHRAVEFYQVVCVVFVFYYAK Receptor-type tyrosine-protein phosphatase beta isoform a (34%)Protein tyrosine phosphatase, receptor type, B (34%)34. HIISHSGNNPYGCEECGK CLL-associated antigen KW-4 splice variant 2 (94%)35. IGTMVEDHR Titin (100%)Complement component C8 beta chain preproprotein (55%)36. KGGHSSPASSDK Mast cell-expressed membrane protein (75%)37. KGYIPSYLDK Thyroid hormone receptor beta isoform (100%)Immunoglobulin kappa 1 light chain (70%)38. KHPSTVQVK T-cell leukemia translocation altered gene, isoform CRA_b (88%)4 B-cell receptor CD22 isoform 3 precursor (77%)V-set and immunoglobulin domain-containing protein 10-like (88%)39. KTDQMVFHLETNSNSESHDK Protein tyrosine phosphatase, non-receptor type 20A (55%)Breast cancer-associated antigen SGA-72M (60%)40. LEPGNCKADETASK Protein-coupled receptor 112 (100%)Cancer antigen 1 (71%)41. LGLRCVTCNYCSQLCK Deformed epidermal autoregulatory factor 1 variant (93%)42. LNTPTDSTLWVSLCCPR Titin isoform novex-2 (64%)CDC42 binding protein kinase alpha (DMPK-like) (52%)43. LSPLESRPPCPAGLVR Immunoglobulin kappa light chain variable region (100%)Carbohydrate (keratan sulfate Gal-6) sulfotransferase 1, isoform CRA (68%)Discoidin domain receptor family, member 1 (56%)Receptor tyrosine kinase (56%)44. LSTGVFGGGTK Immunoglobulin lambda light chain VLJ region (100%)Immunoglobulin light chain variable region (100%)Immunoglobulin V lambda/J lambda light chain (90%)45. MAYLDQTLAGPSGTR Immunoglobulin kappa chain variable region (53%)46. MCSCPISSPGHIKGLGQEETPVR Interleukin 23 receptor (30%)5 Kainate receptor subunit KA2a (65%)Glutamate receptor subunit (47%)47. MIDSVMSCQQLTGLK Dynein heavy chain 2, axonemal (93%)Dynein heavy chain domain 3, isoform CRA_c (86%)48. MMGSTHIYDMSTVMSR Progestin and adipoQ receptor family member III, isoform CRA_b (50%)49. MPIMLRSSNCVLTGK Vascular endothelial growth factor D preproprotein (73%)T cell receptor alpha-chain V-region (V-J-C) precursor (73%)50. MSLEWLVAWSWSLDGLR CD19 antigen, isoform CRA_c (52%)Immunoglobulin heavy chain variable region (76%)51. MSLLHKHQESGCSGCPR Relaxin receptor 2 isoform 1 (35%)52. MSPSLFLPAMKEGCNAYK Nebulin isoform 2 (94%)53. MSSNCTSTTAVAVAPLSASK Ig heavy chain (40%)Immunoglobulin heavy chain variable region (50%)Mucin-19-like (100%)54. MSSPGPSQPPAEDPPWPAR Myopodin protein (84%)55. MSTMRLLTLALLFSCSVAR Fibroblast growth factor receptor 4, isoform CRA_a (47%)56. MSTRYHQAASDSYLELLK Dynein, axonemal, heavy chain 11 (100%)57. MVKSYFCYAEQELMK Insulin-like growth factor 2 mRNA binding protein 1, 6 isoform CRA_b (46%)58. MVMHARSGGNLEVMGLMLGK Receptor-type protein tyrosine phosphatase beta, RPTP beta, PTP zeta [human, brainstem, Peptide, 2307 aa] (45%）Receptor-type tyrosine-protein phosphatase U isoform 2 precursor (65%)Interleukin-20 receptor subunit beta precursor (70%)59. NTDEPMGITLKMLNHCIVAR 55 kDa erythrocyte membrane protein isoform 4 (70%)60. PATAPSCPSGSR Epidermal growth factor receptor isoform a variant (66%)Mucin 5 (83%)61. SAEPRGGVQVTTQQPR Cingulin (56%)62. SEMVLYIQSEPVSQDAKPTGHNR Cell adhesion kinase beta (30%)63. SESEEALPLDLDKNIHTPVSRPNR Major histocompatibility complex, class I, E (83%)64. SGRPEELVSCADCGRSGGSGR Retinoid X receptor, alpha, isoform CRA_a (71%)65. SISRPSSLRMSR Breast cancer nuclear receptor-binding auxiliary protein (66%)66. SIVHPSYNSNTLNNDIMLIK Cathepsin 6 preprotein (75%) 67. SLSCESLWPIEAR Latrophilin-3 precursor (92%) 68. SMPTNCVWLDGLSSNVSDQYLTR Vascular endothelial growth factor receptor 1 isoform 4 precursor (73%)Dynein heavy chain domain 1 isoform 1 (39%)Cadherin-7 (56%)Neuronal cell adhesion molecule isoform E precursor 7 (47%)Immunoglobulin heavy chain (56%)69. SPAQYQVVLSERLQALVNSLCAGQSP Tumor necrosis factor receptor superfamily member EDAR precursor (46%)Trabeculin-alpha (100%)70. SSGTSYPDVLK Immunoglobulin heavy chain variable region (100%)Immunoglobulin gamma 1 heavy chain variable region (72%)71. STNLPRNPSMADYEAR Protocadherin-8 isoform 2 precursor (50%)72. TAAEADMDAAAGPPVSTRQSK Nuclear receptor co-repressor (100%)73. TAKGSTGMEILLSTLENTK Immunoglobulin A heavy chain variable region (94%)Immunoglobulin heavy chain variable region VH (78%)Immunoglobulin gamma 3 heavy chain variable region (94%）74. TAKPASQEHARCSAIGTGESPK Profilaggrin (86%) 75. TATIIIHANASMSHTILLK Cadherin-related family member 4 precursor (36%)76. TGDPSPCPTPSHFDGVCDISCCEVK Mucin-2 precursor (96%) 77. TRTSFTAEQLYR Coronin, actin binding protein, 1B, isoform CRA_c (58%)78. TSGATQTTVGDALFTR MHC class I antigen (56%)Interleukin-9 (50%)79. TSTGAVRMQPK Immunoglobulin gamma 2 heavy chain variable region (81%)80. TVAMAGVAAMTAVTR HLA-B associated transcript 3 (100%)8 81. TVCVLSERR Protocadherin Fat 4 precursor (66%)82. TVGVIVSREAMTGR Cadherin-like 23 (71%)Interleukin-1 receptor associated kinase-2 (57%)83. TYFCQQSYTTPLTFGGGTK Immunoglobulin kappa light chain variable region (100%)Immunoglobulin light chain variable region (100%)IgM monoclonal antibody light chain variable region (100%)84. VCHSNLIESR B-cell lymphoma 6 protein isoform 2 (50%)Olfactory receptor, family 52, subfamily E, member 8 (100%)85. VHTGEKPYGCSECEKNLGK Zinc finger protein 614 (100%)86. VSSHSSQATKDSGVGLK Immunoglobulin epsilon heavy chain variable region (41%)87. YLAAAFPSACGK Activin A receptor, type IB, isoform CRA_c (50%)88. APAHHPAAISTAK MHC class I antigen (38%)89. APWWSSCRWR Leukocyte immunoglobulin-like receptor subfamily B member 5 (50%)Carcinoembryonic antigen-related cell adhesion molecule 8 precursor (100%)90. AEDTAVYYCAKJLTIR Immunoglobulin heavy chain variable region (100%)91. AELGGLLSPR Immunoglobulin heavy chain subgroup VIII V-D-J region (70%)9 92. AETLVFSTHAVISMR Immunoglobulin heavy chain variable region (66%)93. DGSISILGSDDATTCHIVVLR Colony stimulating factor 1 receptor (61%)Interleukin 1 recepter-like 2 (47%)Immunoglobulin heavy chain variable region (33%)94. GDRVTITWR Immunoglobulin kappa chain variable region (100%)95. GGNSGGSSSICYVLLGFIGTSK T cell receptor beta variable 7 (68%)Immunoglobulin heavy chain variable region (40%)96. GLECIGYMYSSGSSFYNPSLKSR Immunoglobulin mu heavy chain variable region (100%)97. GLEWVSAVSGSGTTTYYADSUK Immunoglobulin mu heavy chain variable region (100%)98. GLSDSVRSCR Thymocyte antigen CD1d (60%)Immunoglobulin heavy chain variable region (70%)99. KAPQVYTIPPKE Anti-colorectal carcinoma heavy chain (100%)Immunoglobulin heavy chain (66%)100. KAPQVYTIPPKEQMAKD Anti-colorectal carcinoma heavy chain (100%)Immunoglobulin heavy chain (88%)101. KCELNCQAMGYR Immunoglobulin A heavy chain variable region (58%)102. KNTQPIMDTDGSYFVYSKL Immunoglobulin heavy chain (100%)103. KSSGTSYPDVLKC T cell receptor delta chain variable (61%)104. KVTCVVVDISKD Hepatitis B virus receptor binding protein (75%)10 Immunoglobulin heavy chain (75%)Anti-colorectal carcinoma heavy chain (100%)105. RLGEDNINVVEGNEQFISASKS T cell receptor variable alpha chain (50%)106. LSSVTAADTNVYYCAR Immunoglobulin mu heavy chain variable region (100%)107. RSVSELPIMHQDWLNGKE Hepatitis B virus receptor binding protein (100%)Immunoglobulin heavy chain (100%)108. RTLYLQMNSLR Immunoglobulin epsilon heavy chain variable region (90%)Immunoglobulin heavy chain variable region (100%)109. SLPGSPKDSSHLLSPLR Immunoglobulin heavy chain (VH4) variable region (41%)110. SLVVAAVAPDNRNPAFTTMGWLFLK Immunoglobulin heavy chain variable region (52%)B-cell receptor CD22 isoform 3 precursor (40%)111. TAKGSTGMEILLSTLENTK Immunoglobulin A heavy chain variable region (94%)112. TVFSDSQLSGLEK MHC class II transactivator (92%)T-cell receptor alpha chain V region-human (fragment) (46%)113. APTVVLMMTK Protein tyrosine kinase, receptor type, D (80%)MHC class II antigen (80%)Immunoglobulin heavy chain variable region (70%)114. ATSRGCITIIGGGDTATCCAK Ephrin type-A receptor 5 (47%)Immunoglobulin heavy chain variable region (57%)11 Mucin-17 protein (33%)115. GPLCGCCPGRSSQK Interleukin-4 receptor alpha chain (64%)Immunoglobulin variable region (57%)116. KAPSILSVLK Interleukin-12 receptor, beta 1, isoform CRA_b (90%)117. KDVLTITLTPKV Truncated soluble vascular endothelial growth factor receptorAnti-colorectal carcinoma heavy chain (100%)Immunoglobulin lambda-light chain variable region (75%)118.KGHQDSCPFELTACPNEGCTSQVPR TNF receptor-associated factor 6 (68%)Immunoglobulin heavy chain variable region (32%)119. KVCNYVSWIKQ CDC20-like protein, isoform CRA_g (81%)Immunoglobulin heavy chain variable region (90%)120. LSGSCRSTDSLHPCPPTALPR Microtubule-actin crosslinking factor 1, isoform CRA_i (80%)Immunoglobulin light chain variable region (38%)Mucin-3B, partial (80%)121. MAYLQQTLAGPSGTR TNF receptor-associated factor 1 isoform b (40%)Immunoglobulin kappa chain variable region (53%)122. MSSNCTSTTAVAVAPLSASK TNF receptor superfamily , member 11a precursor variant (95%)Mucin-19-like (100%)Immunoglobulin heavy chain variable region (50%)12 123. RVNSAAFPAPIEKT Mutant anaplastic lymphoma receptor tyrosine kinase (71%)Anti-colorectal carcinoma heavy chain (100%)Immunoglobulin heavy chain (64%)124. TLSGSAALWAESEK Ephrin type-A receptor 10 isoform 3 (90%)Immunoglobulin rearranged L-chain V-region (57%)13

Melanoma Associated Antigen (Mutated) 1 (36%)

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