Reagents for Veterinary/Animal Model Research 1+1 FREE! July/August 2013 Special: APRILkkkk recombinant protein Bovine , Human , Mouse , Rat & Swine Valid until 30 August 2013 • With the purchase of a 5 µg vial of APRIL protein, you will receive a se cond 5 µg vial of the same APRIL protein at no cost. • Not valid with other specials or offers. • Limit one no cost vial per order, 5 no cost vials per customer during the period o f the special. • Note "July/August 2013 Special" on your order. Tumor necrosis factor ligand superfamily member 13 (TNFSF13) also known as a proliferation -inducing ligand (APRIL) is a member of the tumor necrosis factor ligand (TNF) ligand family. Nineteen cytokines have been identified as part of the TNF family on the basis of sequence, functional, and structural similarities. Family members include TNF beta (TNFSF1), TNF alpha (TNFSF2), Lymphotoxin beta (TNFSF3), OX40 Ligand (TNFSF4), CD4 0 Ligand (TNFSF5), Fas Ligand (TNFSF6), CD27 Ligand (TNFSF7), CD30 Ligand (TNFSF8), 4 -1BB Ligand (TNFSF9), TRAIL (TNFSF10), TRANCE/RANKL (TNFSF11), TWEAK (TNFSF12), APRIL(TNFSF13), BAFF (TNFSF13B), LIGHT (TNFSF14), TL1A/VEGI (TNFSF15), and GITR Ligand (TNF SF18). APRIL/TNFSF13 is expressed by macrophages and dendritic cells. APRIL/TNFSF13 has been shown to play a role in protecting cells from undergoing apoptosis and promoting B cell development APRIL Homology Across Species Via XXI Ottobre 1944, 11/240055 CASTENASO (BO - Italy Tel +39.051.62.40.700 – Fax +39.051.62.40.706 W. www.temaricerca.com – E. [email protected] Reagents for Veterinary/Animal Model Research Advantages of Kingfisher recombinant proteins • Produced in yeast and therefore do not have endotoxin • Naturally folded • Post-translationally modified • Highly pure • Biological activity has been confirmed by an independent laboratory Ordering informations Code Description Size Host Molecular Applications Purity Weight RP0376B-005 Recombinant Bovine 5UG YEAST 16.5 KDa ELISA Standard, and as a >95% APRIL (TNFSF13) Western Blot Control. RP0292H-005 Recombinant Human 5UG YEAST 16.4 KDa ELISA Standard, and as a >95% APRIL (TNFSF13) Western Blot Control. RP0360M-005 Recombinant Mouse 5UG YEAST 16.4 KDa ELISA Standard, and as a >95% APRIL (TNFSF13) Western Blot Control. RP0383R-005 Recombinant Rat APRIL 5UG YEAST 16.4 KDa ELISA Standard, and as a >95% (TNFSF13) Western Blot Control. RP0415S-005 Recombinant Swine APRIL 5UG YEAST 16.5 KDa ELISA Standard, and as a >95% (TNFSF13) Western Blot Control. Via XXI Ottobre 1944, 11/240055 CASTENASO (BO - Italy Tel +39.051.62.40.700 – Fax +39.051.62.40.706 W. www.temaricerca.com – E. [email protected] .