Supplementary appendix This appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: McInnes IB, Behrens F, Mease PJ, et al. Secukinumab versus adalimumab for treatment of active psoriatic arthritis (EXCEED): a double-blind, parallel-group, randomised, active-controlled, phase 3b trial. Lancet 2020; 395: 1496–505. APPENDIX Secukinumab versus Adalimumab Comparison for the Treatment of Active Psoriatic Arthritis (EXCEED): A Randomised, Double-blind, Active-controlled Phase 3b Trial Iain B McInnes1*, Frank Behrens2, Philip J Mease3, Arthur Kavanaugh4, Christopher Ritchlin5, Peter Nash6, Jordi Gratacós Masmitja7, Philippe Goupille8, Tatiana Korotaeva9, Alice B Gottlieb10, Ruvie Martin11, Kevin Ding12, Pascale Pellet13, Shephard Mpofu14, and Luminita Pricop15 on behalf of EXCEED Study 1University of Glasgow, Glasgow, United Kingdom 2Rheumatology University Hospital and Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology TMP and Fraunhofer Cluster of Excellence for Immune- Mediated Diseases CIMD, Goethe University, Frankfurt, Germany 3Swedish Medical Centre/Providence St. Joseph Health and University of Washington, Seattle, United States 4Rheumatology, Allergy, Immunology Division, University of California, San Diego, School of Medicine, La Jolla, United States, La Jolla, United States 5Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, United States 6Department of Medicine, Griffith University, Brisbane, Australia 7Rheumatology Department, University Hospital Parc Taulí, Sabadell, UAB, Spain 8Department of Rheumatology and INSERM-CIC1415, University hospital of Tours, EA 7501 GICC, University of Tours, Tours, France 9Research Institute of Rheumatology n.a. V.A. Nasonova, Moscow, Russia 10Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, United States 11Novartis Pharmaceuticals Corporation, East Hanover, United States 12Novartis Pharmaceuticals Corporation, East Hanover, United States 13Novartis Pharma AG, Basel, Switzerland 14Novartis Pharma AG, Basel, Switzerland 15Novartis Pharmaceuticals Corporation, East Hanover, United States Corresponding author: Dr. (Prof.) Iain B McInnes Director Institute of Infection, Immunity and Inflammation College of Medical, Veterinary and Life Sciences University of Glasgow Scotland, United Kingdom Tel: + +44 141 330 8412 E-mail: [email protected] 1 1. List of Investigators Investigator and Position / Role Facility Name Country No. of other important Address Patients participants Country Enrolled Dr. Jane Zochling Principal Southern Clinical Research Pty Ltd Australia 12 Investigator Hobart, TAS, Australia, 7000 Dr. Peter Nash Principal Rheumatology Research Unit Sunshine Australia 8 Investigator Coast Maroochydore, QLD, Australia, 4558 Dr. Paul Bird Principal Optimus Clinical Research Australia 3 Investigator Kogarah, NSW, Australia, 2217 Prof Andrew Ostor Principal Emeritus Research Australia 10 Investigator Camberwell, VIC, Australia, 3145 Dr. Elke Boettcher Principal Ordination Dr Omid Zamani Austria 0 Investigator Austria Assoc. Prof Principal UMHAT Dr George Stranski Bulgaria 5 Nikolay Georgiev Investigator Pleven, Nikolov Bulgaria, 5800 Dr. Boycho Principal Military Medical Academy Sofia Bulgaria 4 Oparanov Investigator Sofia, Bulgaria, Bulgaria, 1606 Prof. Rumen Principal UMHAT Sveti Ivan Rilski EAD Bulgaria 3 Stoilov Investigator Sofia, Bulgaria, 1612 Dr. Ivan Goranov Principal MHAT Plovdiv AD Bulgaria 8 Investigator Plovdiv, Bulgaria, 4002 Prof. Anastas Principal UMHAT Kaspela Bulgaria 7 Batalov Investigator Plovdiv, Bulgaria, 4002 Prof. Rasho Principal UMHAT Sveti Ivan Rilski EAD Bulgaria 1 Rashkov Investigator Sofia, Bulgaria, 1612 Dr. Timothy Principal Manitoba Clinic Canada 4 McCarthy Investigator Winnipeg, MB, Canada, R3A 1M1 Dr Frederic Morin Principal Centre de Recherche Musculo- Canada 8 Investigator Squelettique Trois-Rivieres, QC, Canada, G8Z 1Y2 Dr Milton Baker Principal PerCuro Clinical Research Ltd Canada 3 Investigator Victoria, BC, Canada, V8V 3M9 Dr. Eva Principal Medical Plus s.r. o. Czech Republic 26 Dokoupilova Investigator Uherske Hradiste, Czech Republic, 686 01 Dr. Dagmar Principal Revmatologie Bruntal s.r. o. Czech Republic 11 Galatikova Investigator Bruntal, Czech Republic, 792 01 2 Dr. Rudolf Horvath Principal FN Motol Czech Republic 15 Investigator Praha 5, Czech Republic, 150 06 MD Herman F Principal Revmatologicky ustav Czech Republic 22 Mann Investigator Praha 2, Czech Republic, 128 50 Dr Petr Vitek Principal PV MEDICAL s r o Czech Republic 6 Investigator Zlin, Czech Republic, 760 01 Dr. Lars Erik Principal HS Frederiksberg Hospital, Parker Denmark 17 Kristensen Investigator institute Frederiksberg, Denmark, DK-2000 Dr. Triin Savi Principal East Tallinn Central Hospital Estonia 6 Investigator Magdalena Policlinic Tallinn, Estonia, 11312 Dr. Mart Kull Principal Meditrials OU Estonia 21 Investigator Tartu, Estonia, 50406 Dr. Ene Ojassalu Principal North Estonia Medical Centre Estonia 13 Investigator Foundation Tallinn, Estonia, 13419 Dr. Pentti Jarvinen Principal Kiljavan laaketutkimus Finland 0 Investigator Hyvinkaa, Finland, 05800 MD. Aulikki Principal Pihlajalinna Ite Kuopio Finland 0 Kononoff Investigator Kuopio, Finland, 70100 Pr Philippe Principal CHRU - Hospital Trousseau France 0 Goupille Investigator Chambray les Tours, France, 37170 Dr. Gregoire Principal Centre Hospitalier Dubois France 0 Lambert De Cursay Investigator Brive-la-Gaillarde, France, 19100 Dr. Emmanuelle Principal Centre Hospitalier du Mans France 0 Dernis Investigator Le Mans, France, 72037 Dr. Slim Lassoued Principal Centre Hospitalier Jean Rougie France 0 Investigator Cahors, France, 46000 Dr. Martin Principal CHU Gabriel Montpied France 0 Soubrier Investigator Clermont Ferrand, France, 63000 Dr. Elisabeth Solau Principal CHU Hospital Jean Bernard France 0 Gervais Investigator Poitiers, France, 86000 Dr Eric Principal CHR ORLEANS France 0 Lespessailles Investigator Orleans, France, 45067 Dr. Pascal Richette Principal Centre hospitalier Lariboisiere France 0 Investigator Paris, France, 75010 3 Prof. Dr. med. Principal Rheumazentrum Ruhrgebiet St Josefs Germany 1 Juergen Braun Investigator Krankenhaus Herne, Germany, 44649 Dr. med. Jan Principal Rheumatologische Schwerpunktpraxis Germany 10 Brandt Juergens Investigator Dr Jan Brandt-Juergens Berlin, Germany, 12161 Prof. Dr. med. Principal Universitaetsmedizin Charite Germany 2 Gerd Ruediger Investigator Berlin, Burmester Germany, 10117 Dr. med. Georg P. Principal Praxis fur Klinische Studien Dr. med. Germany 9 Dahmen Investigator Georg Dahmen Hamburg, Germany, 22415 Mr. Andrei Principal Klinische Forschung Berlin Mitte Germany 2 Khariouzov Investigator GmbH Berlin, Germany, 10117 Prof. Dr. med. Principal Institut fuer Praeventive Medizin & Germany 3 Ruediger Moericke Investigator Klinische Forschung GbR Magdeburg, Germany, 39110 Prof. Dr. med. Principal Rheumazentrum Bad Doberan Germany 3 Gunther Neeck Investigator Bad Doberan, Germany, 18209 Prof. Dr. med. Principal Universitaetsmedizin Charite, Campus Germany 1 Denis Poddubnyy Investigator Mitte, Med. Klinik I Berlin, Germany, 12200 Dr. med. Florian Principal Rheumatologische Schwerpunktpraxis Germany 9 Schuch Investigator Erlangen Erlangen, Germany, 91056 Ms. Charlotte von Principal Klinische Forschung Schwerin gGmbH Germany 6 Engelhardt Investigator Schwerin, Germany, 19055 Prof. Dr. med. Principal St. Josef Hospital,Hauttumorzentrum, Germany 7 Thilo Gambichler Investigator Ruhr- Universität Bochum Bochum, Germany, 44791 Dr. med. Georg Principal Rheumapraxis an der Hase Germany 1 Gauler Investigator Osnabruck, Germany, 49074 Dr. med. Rieke Principal Schlosspark Klinik, Innere Medizin II, Germany 2 Alten Investigator Rheumatologie Berlin, Germany, 14059 Prof. Dr. med. Ulf Principal Universitaetsklinikum Leipzig AoR, Germany 9 Wagner Investigator Klinik für Gastroenterologie Leipzig, Germany, 04103 Prof. Dimitrios Principal University General Hospital ATTIKON Greece 0 Boumpas Investigator Chaidari Athens, Greece, Greece, 12462 4 Prof Dr Dimitrios Principal General Hospital of Athens Ippokrateio Greece 0 Vassilopoulos Investigator Athens, Greece, Greece, 11527 Prof. Petros Principal General Hospital of Athens Laiko Greece 0 Sfikakis Investigator Athens, Greece, Greece, 115 27 Prof. Athanasios G Principal General Hospital of Athens Laiko Greece 0 Tzioufas Investigator Athens, Greece, Greece, 115 27 Dr. Alexandros Principal General Hospital of Thessaloniki Greece 0 Garyfallos Investigator IPPOKRATEIO Thessaloniki, Greece, Greece, 54642 Dr. Regina Cseuz Principal Revita Reumatologiai Rendelő Hungary 1 Investigator Budapest, Hungary, 1027 Dr. Edit Drescher Principal Vital Medical Center Hungary 3 Investigator Veszprem, Hungary, 8200 Dr. Marta Kiraly Principal Petz Aladár Megyei Oktató Kórház Hungary 3 Investigator Reumatológiai Osztály Győr, Hungary, Hungary, 9025 Dr. Sandor Szanto Principal Debreceni Egyetem Klinikai Központ Hungary 5 Investigator Belgyógyászati Klinika, Re Debrecen, Hungary, 4032 Dr Edit Toth Principal Pest Megyei Flór Ferenc Kórház, Hungary 4 Investigator Reumatológiai és Fizioterá Kistarcsa, Hungary, 2143 Dr. Ilona Ujfalussy Principal Magyar Honvédség Egészségügyi Hungary 4 Investigator Központ, Reumatológiai Oszt Budapest, -, Hungary, 1062 Dr. Peter Balint Principal Orszagos Reumatologiai es Hungary 2 Investigator Fizioterapias Intezet Budapest, Hungary, 1023