Cancer Prevention and Research Institute of Texas Oversight Committee Nominations Subcommittee Meeting May 13, 2014 Basic Cancer Research Panel 1 Tom Curran, Ph.D./FRS, Chair Peer Review Panel Members for Approval 1. Allan Balmain, Ph.D. 2. Steve Fiering, Ph.D. 3. Jacquelyn Hank, Ph.D. 4. Frank Rauscher, Ph.D. 5. Heide Schatten, Ph.D. 6. Joshua Schiffman, M.D. 7. Bart Williams, Ph.D. 8. Yu-Ching Yang, Ph.D. BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE Balmain, Allan Professor in Residence eRA COMMONS USER NAME (credential, e.g., agency login) abalmain EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION (if applicable) MM/YY FIELD OF STUDY University of Glasgow BSc 1966 Hons. Chemistry University of Glasgow PhD 1969 Organic Chemistry German Cancer Research Centre, Heidelberg, Postdoctoral 1971-72 West Germany University of Strasbourg, France Postdoctoral 1969-71 A. Personal Statement The goal of our research is to identify the genetic events that underlie multistage epithelial tumor development, using mouse models of cancer. We have focused on models that recapitulate the genetic heterogeneity in human populations, with a view to development of approaches to personalized diagnosis and treatment. The models used have primarily been focused on skin, but also include comparative analyses of lung carcinomas and lymphoma. The focus of the most recent projects is the development of “Systems Genetics” approaches to analysis of multistage carcinogenesis. These seek to integrate multidimensional data sets to provide a network view of normal genetic architecture in mouse and human tissues, and the perturbations that take place during development of benign tumors and their progression to metastasis. Studies to date have revealed important roles for genes and pathways linked to stem cell fate decisions, cell cycle control, and inflammation. These gene expression network approaches represent a novel and highly promising route to the identification of the critical interacting components of important cancer signaling pathways. B. Professional Experience 1972-1976 Tenured member of staff, German Cancer Research Centre, Heidelberg, Germany 1976-1982 Staff Scientist, Beatson Institute for Cancer Research, Glasgow 1982-1994 Group Leader, Beatson Institute for Cancer Research, Glasgow 1984-1994 CRC Special Appointment 1994-1996 Director of Laboratory Research, Professor of Molecular Oncology, University of Glasgow, Jerry Turner Fellow of the Cancer Research Campaign 1996-1999 Vice President, Research, Onyx Pharmaceuticals, Richmond CA 1999-2001 Professor of Cancer Genetics, Cancer Research Institute and Department of Biochemistry and Biophysics, University of California-San Francisco 2001-present: Barbara Bass Bakar Distinguished Professor of Cancer Genetics, UCSF Helen Diller Family Comprehensive Cancer Center Co-Leader, UCSF Cancer Genetics Program. Director, Genome Analysis Core Honors 1970 Royal Society European Programme Fellowship 1971 Alexander Von Humboldt-Stiftung Fellowship 1991 Keynote Lecture, UK MBCN, Warwick 1992 Distinguished Lecturer Series, Yale University 1993 Keynote Lecture, ECCO 7 London 1995 Fellow of the Royal Society of Edinburgh 1999 UICC Roll of Honor 2000 Tom Connors Prize and Lecture, British Association for Cancer Research Program Director/Principal Investigator: (Last, first, middle) Balmain, Allan 2003 Distinguished Lecturer Series, Harvard University School of Public Health 2004 Distinguished Visitor, Biomedical Research Council, Singapore 2004 The DiMaggio Lecture, Dana Farber Cancer Center 2006 Opening lecture, AACR conference on Cancer Susceptibility and Cancer Susceptibility Syndromes, Hawaii 2007 The Cori Award Lecture, Roswell Park, Buffalo, NY 2007 Keynote Address, CCRI, University of Texas, San Antonio, TX 2007 John B. Little Award, Harvard School of Public Health 2008 Keynote lecture, McArdle Cancer Center Symposium 2008 Keynote Lecture, European Symposium on Hormones and Cell Regulation Mont Ste Odile, France 2009 Keynote Lecture and J.Walter Juckett Distinguished Lecture, Vermont Cancer Center 2010 Keynote Lecture, 56th Annual Radiation Research Society Symposium, Hawaii 2010 Keynote Lecture, University of Maastricht Genetics Meeting, Maastricht 2011 American Skin Association Achievement Award 2013 Herman Beerman Award, Society for Investigative Dermatology 2013 Elected Fellow of the American Academy of Arts and Sciences. C. Selected Peer-reviewed Publications (from last 10 years). 1. To MD, Perez-Losada J , Mao J-H , Hsu J , Jacks T, Balmain A. A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice. Nature Genetics. 2006 Aug;38(8):926- 30. 2. Wakabayashi Y, Mao, JH, Brown K, Girardi M and Balmain A. Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature. 2007 Feb 15;445(7129):761-5. 3. Mao JH, Wu D; Perez-Losada J, Jiang T, Li Q; Neve RM, Gray JW, Cai WW, Balmain A. Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell. 2007 Feb;11(2):161-73. 4. To MD, Wong CE, Karnezis AN,Del Rosario R, Di Lauro R, and Balmain A. Kras regulatory elements and exon 4A determine mutation specificity in lung cancer, Nature Genetics. 2008 Oct;40(10):1240-4. 5. Mao JH, Kim IJ, Wu D, Climent J, Kang HC, DelRosario R, Balmain A. FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science. 2008 Sep 12;321(5895):1499- 502. 6. Quigley DA, To MD, Pérez-Losada J, Pelorosso FG, Mao JH, Nagase H, Ginzinger DG, and Balmain A. Genetic architecture of mouse skin inflammation and tumor susceptibility. Nature. 2009 Mar 26;458(7237):505-8. 7. Quigley DA, To MD, Kim IJ, Lin, K, Albertson DG, Sjolund J, Pérez-Losada J and Balmain A. Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility. Genome Biology 2011, 12:R 8. Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica- Worms H, Balmain A, Kaushansky K, Wahl GM. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 2011 Jul 1;25(13):1426-38 9. Mao JH, Wu D, Kim IJ, Kang HC, Wei G, Climent J, Kumar A, Pelorosso FG, Delrosario R, Huang EJ, Balmain A. Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma. Oncogene. 2011 Jul 25. doi: 10.1038/onc.2011.306. 10. To MD, Quigley DA, Mao JH, Del Rosario R, Hsu J, Hodgson G, Jacks T, Balmain A. Progressive Genomic Instability in the FVB/KrasLA2 Mouse Model of Lung Cancer. Mol Cancer Res. 2011 Sep 20. 11. To MD, Rosario, RD, Westcott, PM, Banta KL, Balmain A. Interactions between wild type and mutant Ras genes in lung and skin carcinogenesis. Oncogene. 2012 Sep 3. doi: 10.1038/onc.2012.404 12. Kang, HC, Quigley DA, Kim IJ, Wakabayashi Y, Ferguson-Smith MA, D’Alessandro, M, Lane EB, Akhurst RJ, Goudie DR and Balmain A. Multiple Self-Healing Squamous Epithelioma (MSSE): rare PHS 398/2590 (Rev. 06/09) Page ___ Other Support Format Page BIOGRAPHICAL SKETCH NAME POSITION TITLE Steven N. Fiering, Ph.D. Associate Professor eRA COMMONS USER NAME SNFIERING EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION (if YEAR(s) FIELD OF STUDY applicable) University of Michigan, Ann Arbor B.S. 1969-1975 Geology Eastern Michigan University M.S. 1983-1984 Microbiology Stanford University Ph.D. 1985-1990 Genetics Fred Hutchinson Cancer Research Ctr., Seattle Postdoc 1991-1997 Genetics A. Personal statement I established the Dartmouth Transgenic and Genetic Construct Shared Resource upon my recruitment to Dartmouth in 1997 and have directed it since. In 2002 the Core C of the Immunology INBRE was funded as part of that grant and we have developed and provided genetically modified and experimentally manipulated mice under that grant ever since. The Immunology INBRE is in its third round of funding and we are focused on providing published immunologically relevant mouse models that are not currently available at Dartmouth. In that context we have established the ability to generate mice with humanized lymphocyte compartments and plan to continue to expand on that to include mice with myeloid as well as lymphoid humanization through hydrodynamic injection of human cytokine plasmids. We are enthused to collaborate with Dr. Berwin on developing these new models and providing them to him for experimental use. B. Positions and Honors Employment / Experience 1975-1982 The Soy Plant, Ann Arbor, MI, Partner in a food processing business. 9/82-12/84 Eastern Michigan University, Teaching Assistant, Microbiology 9/85- 9/90 Graduate student in the laboratory of Dr. Len Herzenberg at Stanford 10/90-9/91 Research Group Leader, AFRC Centre for Genome Research, Edinburgh, Scotland 10/91-6/97 Postdoctoral Fellow in the lab of Dr. Mark Groudine, Fred Hutchinson Cancer Research Center 6/97-7/04 Assistant Professor, Dept. of Microbiology/Immunology, Dartmouth Medical School 7/01-7/04 Assistant Professor Genetics