G Model BJP 327 1–18 ARTICLE IN PRESS Revista Brasileira de Farmacognosia xxx (2016) xxx–xxx ww w.elsevier.com/locate/bjp Review 1 Trichilia catigua: therapeutic and cosmetic values a b a a a 2 Q1 Renata Longhini , Audrey A.S.G. Lonni , Ana Luiza Sereia , Letícia M. Krzyzaniak , Gisely C. Lopes , a,∗ 3 João Carlos P. de Mello a 4 Programa de Pós-graduac¸ ão em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá, PR, Brazil b 5 Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Londrina, PR, Brazil 6 a b s t r a c t 7 a r t i c l e i n f o 8 9 Article history: Medicinal plants play an important role in human health care. It is estimated that about 25–30% of all 10 Received 18 July 2016 drugs are evaluated as therapeutic agents derived from natural products. Research in the pharmaceu- 11 Accepted 25 October 2016 tical industry has demonstrated that for complex diseases, natural products still represent a valuable 12 Available online xxx source for the production of new chemical compounds, since they possess privileged structures. Among 13 Brazilian biodiversity, “catuaba” is popularly used as a tonic to treat fatigue, stress, impotence, memory 14 Keywords: deficits, and digestive disorders. Studies show antibacterial, trypanocidal, antioxidant, antiarrhythmic, 15 Biological, chemical, analytical, and antidepressant, improvement of memory, anti-inflammatory and antinociceptive activities, as well as 16 technological activities phytocosmetic activity in cellulite treatment and in anti-ageing. The Brazilian plants known and used 17 Catuaba as catuaba are represented by more than twenty different species; however, the plant most commonly 18 Trichilia catigua found in Brazil as “catuaba” is the species Trichilia catigua A. Juss., Meliaceae. Thus, the aim of this paper is to present a review of T. catigua, with emphasis on biological activities, chemical and analytical devel- opment and formulations in order to provide a broader and deeper insight, seeking a herbal medicine and/or phytocosmetic as well as future prospects for commercial exploitation and directions for future studies. © 2016 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). 19 Contents 20 Introduction . .00 21 Some species used as catuaba in Brazil . 00 22 Anemopaegma arvense (Vell.) Stellfeld ex J.F. Souza . 00 23 Erythroxylum vacciniifolium Mart.. .00 24 Erythroxylum catuaba da Silva ex Hamet . 00 25 Meliaceae family . 00 26 Genus Trichilia . 00 27 Trichilia catigua A. Juss. 00 28 Chemical constituents and biological activities of Trichilia catigua . 00 29 Antimicrobial . 00 30 Trypanocidal . 00 31 Antioxidant . 00 32 Anti-cellulite . 00 33 Photoprotector . 00 34 Aphrodisiac . 00 35 Antiarrhythmic . 00 36 Antidepressant-like effects . 00 37 Anti-inflammatory and analgesic effect . 00 38 Other activities . 00 ∗ Corresponding author. E-mail: [email protected] (J.C. Mello). http://dx.doi.org/10.1016/j.bjp.2016.10.005 0102-695X/© 2016 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/). Please cite this article in press as: Longhini, R., et al. Trichilia catigua: therapeutic and cosmetic values. Revista Brasileira de Farmacognosia (2016), http://dx.doi.org/10.1016/j.bjp.2016.10.005 G Model BJP 327 1–18 ARTICLE IN PRESS 2 R. Longhini et al. / Revista Brasileira de Farmacognosia xxx (2016) xxx–xxx Toxicology. .00 Analytical methods and pharmaceutical forms . 00 Challenges. .00 General conclusion. .00 Authors’ contributions . ..