Young vs Aged MSI Correlations Symbol Description Young CA Aged CA Young DG Aged DG CA v DG in CA in DG in CA in DG AARSL alanyl-tRNA synthetase like 672 +/- 50 780 +/- 24 666 +/- 26 777 +/- 38 -0.959643 0.0904189 0.04684 0.0097575 0.0922137 AASDH 2-aminoadipic 6-semialdehyde dehydrogenase 587 +/- 19 771 +/- 21 501 +/- 29 664 +/- 26 -6.83E-05 8.644E-05 0.002318 0.0046175 0.0347906 ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 437 +/- 47 523 +/- 31 335 +/- 10 398 +/- 11 -0.001844 0.1582204 0.002045 0.1826101 0.0544598 ABHD14A abhydrolase domain containing 14A 1760 +/- 56 1515 +/- 91 1973 +/- 103 1818 +/- 29 0.010547 -0.048824 -0.200935 0.0371071 0.3262792 ABP1 Amiloride binding protein 1 (amine oxidase (copper-containing)) 105 +/- 10 165 +/- 23 154 +/- 17 181 +/- 18 0.021482 0.0527017 0.302632 5.18E-05 0.0770133 ABTB2 Ankyrin repeat and BTB (POZ) domain containing 2 654 +/- 122 485 +/- 39 505 +/- 32 342 +/- 18 -0.030184 -0.236531 -0.002265 0.5021444 0.0832426 ACAA2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) 589 +/- 56 854 +/- 62 529 +/- 31 645 +/- 33 -0.03897 0.0097889 0.030153 0.000594 0.1078687 ACACB acetyl-Coenzyme A carboxylase beta 124 +/- 17 175 +/- 13 138 +/- 12 164 +/- 12 0.943167 0.0376355 0.152219 0.0293754 0.3358733 ACADL acyl-Coenzyme A dehydrogenase, long chain 234 +/- 12 184 +/- 12 226 +/- 9 179 +/- 19 -0.359297 -0.013599 -0.065477 0.0959391 0.0845069 ACAT1 acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) 4099 +/- 188 3515 +/- 106 3250 +/- 137 3238 +/- 137 -0.007467 -0.027046 -0.954273 0.1128106 0.9705821 ACCN1 amiloride-sensitive cation channel 1, neuronal (degenerin) 1925 +/- 136 1421 +/- 164 1179 +/- 59 900 +/- 42 -0.000254 -0.040656 -0.004392 0.0273253 0.0121481 ACIN1 apoptotic chromatin condensation inducer 1 1859 +/- 171 1790 +/- 102 2092 +/- 94 1822 +/- 45 0.172929 -0.735092 -0.03529 0.8562892 0.0993413 ACO1 aconitase 1, soluble 964 +/- 82 811 +/- 43 950 +/- 45 803 +/- 46 -0.754764 -0.139533 -0.048938 0.1183283 0.0289747 ACOT9 acyl-CoA thioesterase 9 370 +/- 33 344 +/- 40 284 +/- 9 218 +/- 20 -0.001741 -0.63831 -0.024981 0.6715461 0.2839666 ACP1 acid phosphatase 1, soluble 2644 +/- 165 2074 +/- 157 2357 +/- 91 2031 +/- 147 -0.085298 -0.031306 -0.10182 0.009087 0.0106821 ACP6 acid phosphatase 6, lysophosphatidic 881 +/- 49 984 +/- 51 742 +/- 28 837 +/- 8 -0.002935 0.171551 0.018151 0.0355159 0.0710112 ACSS1 acyl-CoA synthetase short-chain family member 1 229 +/- 21 311 +/- 28 196 +/- 16 228 +/- 23 -0.013777 0.0442198 0.295382 0.092173 0.4151929 ACTC actin, alpha, cardiac muscle 84 +/- 15 206 +/- 35 98 +/- 11 212 +/- 35 0.021907 0.0155645 0.029736 0.0980108 0.1657953 ACTR10 actin-related protein 10 homolog (S. cerevisiae) 6172 +/- 108 6822 +/- 248 6301 +/- 210 7510 +/- 229 0.046595 0.0483003 0.003988 0.5901922 0.0845271 ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) 3191 +/- 134 2571 +/- 136 2763 +/- 211 2529 +/- 81 -0.241727 -0.008683 -0.339256 0.0015617 0.5937013 ACVR1B activin A receptor, type IB 1767 +/- 140 1532 +/- 52 1675 +/- 66 1338 +/- 98 -0.117997 -0.163381 -0.023761 0.2017275 0.249096 ACY1 aminoacylase 1 493 +/- 28 523 +/- 20 435 +/- 30 520 +/- 22 -0.072713 0.3972113 0.048724 0.6064414 0.155183 ACY1L2 aminoacylase 1-like 2 224 +/- 39 230 +/- 24 450 +/- 41 321 +/- 40 0.001236 0.8951819 -0.050237 0.5937618 0.3209364 ADA adenosine deaminase 265 +/- 19 352 +/- 29 341 +/- 51 373 +/- 25 0.130605 0.0331452 0.593305 0.0330362 0.5864965 ADAM10 ADAM metallopeptidase domain 10 1557 +/- 99 1808 +/- 84 1420 +/- 70 1612 +/- 46 -0.053577 0.0837127 0.049117 0.0627916 0.3649355 ADAM15 ADAM metallopeptidase domain 15 (metargidin) 1022 +/- 24 1299 +/- 94 1046 +/- 106 1001 +/- 50 -0.089311 0.0308546 -0.711056 0.1417549 0.7624836 ADCK4 aarF domain containing kinase 4 430 +/- 24 546 +/- 40 383 +/- 31 503 +/- 38 -0.139029 0.0374119 0.039519 0.2730918 0.306371 ADD1 adducin 1 (alpha) 4262 +/- 135 3716 +/- 140 3921 +/- 116 3527 +/- 163 -0.000231 -0.018613 -0.086088 0.0313122 0.2337141 ADD3 adducin 3 (gamma) 2311 +/- 330 3058 +/- 364 3069 +/- 265 3733 +/- 91 0.020001 0.1598374 0.054267 0.1569602 0.2721863 ADI1 acireductone dioxygenase 1 841 +/- 61 1306 +/- 144 924 +/- 99 1052 +/- 80 -0.633769 0.0213659 0.342331 0.0411467 0.8502112 ADPRH ADP-ribosylarginine hydrolase 189 +/- 23 309 +/- 20 168 +/- 16 281 +/- 20 -0.015382 0.0030101 0.00234 0.0028139 0.0090525 AFF3 AF4/FMR2 family, member 3 128 +/- 17 237 +/- 14 224 +/- 20 358 +/- 44 0.000454 0.0007359 0.034613 0.0013776 0.0003071 AFTIPHILINaftiphilin protein 689 +/- 9 552 +/- 54 739 +/- 50 699 +/- 28 0.034714 -0.050685 -0.502967 0.1353892 0.6185892 AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 124 +/- 10 226 +/- 20 169 +/- 8 232 +/- 26 0.32873 0.0024393 0.066576 0.0077687 0.0848176 AGXT2L1 alanine-glyoxylate aminotransferase 2-like 1 3918 +/- 414 5586 +/- 247 3574 +/- 289 4607 +/- 398 -0.017396 0.0082839 0.070131 0.0534143 0.1478785 AHCYL1 S-adenosylhomocysteine hydrolase-like 1 5935 +/- 600 7815 +/- 704 6059 +/- 511 8209 +/- 330 0.89046 0.0702645 0.007299 0.178801 0.1949046 AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 3672 +/- 96 3351 +/- 98 3165 +/- 122 3121 +/- 103 -0.010338 -0.04181 -0.788981 0.0745863 0.7081707 AIM1 absent in melanoma 1 368 +/- 97 238 +/- 44 114 +/- 15 175 +/- 22 -0.04556 -0.265509 0.050898 0.4169037 0.3555645 AKAP2 A kinase (PRKA) anchor protein 2 119 +/- 16 187 +/- 25 136 +/- 11 180 +/- 30 0.449089 0.048877 0.230583 0.1043416 0.7033942 AKAP8L A kinase (PRKA) anchor protein 8-like 115 +/- 15 71 +/- 9 120 +/- 16 99 +/- 3 0.145062 -0.038473 -0.237324 0.0940107 0.464845 AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 1175 +/- 77 1379 +/- 69 853 +/- 46 1153 +/- 50 -0.000463 0.0781494 0.001841 0.3070654 0.0892846 AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 722 +/- 43 917 +/- 15 718 +/- 9 959 +/- 30 0.634132 0.0049548 0.000763 0.0088467 0.0075985 AKT3 V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) 4120 +/- 100 3342 +/- 250 3311 +/- 184 3045 +/- 90 -0.019216 -0.025143 -0.234272 0.0121962 0.4146659 ALDH3A1 aldehyde dehydrogenase 3 family, memberA1 99 +/- 11 267 +/- 57 115 +/- 22 357 +/- 54 0.192629 0.0317146 0.008136 0.1405832 0.1298736 S1- alphabetical list of aging-related genes.xls Page 1 Young vs Aged MSI Correlations Symbol Description Young CA Aged CA Young DG Aged DG CA v DG in CA in DG in CA in DG ALDH3B1 aldehyde dehydrogenase 3 family, member B1 147 +/- 9 263 +/- 37 91 +/- 15 124 +/- 5 -0.002691 0.024391 0.084644 0.0284083 0.1508073 ALG5 asparagine-linked glycosylation 5 homolog (S. cerevisiae, dolichyl-phosphate beta-glucosylt 601 +/- 24 662 +/- 22 529 +/- 14 623 +/- 25 -0.004397 0.089144 0.015616 0.0442575 0.0523303 ALKBH8 alkB, alkylation repair homolog 8 (E. coli) 473 +/- 41 658 +/- 40 571 +/- 39 657 +/- 38 0.100357 0.009148 0.144295 0.026047 0.1802512 ALS2CR7 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 7 167 +/- 14 134 +/- 8 171 +/- 14 126 +/- 13 -0.89375 -0.070817 -0.048406 0.0693331 0.0090109 AMY1A amylase, alpha 1A; salivary 217 +/- 46 706 +/- 123 210 +/- 34 692 +/- 108 -0.311506 0.0086487 0.008796 0.20853 0.1553613 ANAPC1 anaphase promoting complex subunit 1 942 +/- 48 810 +/- 32 776 +/- 30 736 +/- 25 -0.002459 -0.048252 -0.328608 0.0962622 0.410849 ANAPC10 anaphase promoting complex subunit 10 140 +/- 9 189 +/- 9 212 +/- 8 217 +/- 21 0.001658 0.003833 0.804792 0.0042811 0.1671211 ANAPC11 APC11 anaphase promoting complex subunit 11 homolog (yeast) 1418 +/- 65 1478 +/- 46 1036 +/- 22 1185 +/- 40 -2.42E-05 0.4651226 0.015793 0.9601436 0.2593954 ANAPC13 anaphase promoting complex subunit 13 1133 +/- 61 1351 +/- 62 1288 +/- 122 1286 +/- 100 0.659716 0.0312862 -0.989156 0.0454783 0.4677743 ANGPT1 angiopoietin 1 1046 +/- 93 1388 +/- 95 1366 +/- 231 1407 +/- 71 0.128906 0.0281217 0.870727 0.0085604 0.9933055 ANKH ankylosis, progressive homolog (mouse) 2365 +/- 119 2794 +/- 121 2527 +/- 92 2834 +/- 84 0.309715 0.0303359 0.035778 0.1664892 0.3065043 ANKHD1 ankyrin repeat and KH domain containing 1 870 +/- 60 1083 +/- 30 945 +/- 57 1001 +/- 44 -0.975161 0.0145608 0.45834 0.0060792 0.436999 ANKIB1 ankyrin repeat and IBR domain containing 1 1928 +/- 106 2973 +/- 269 1694 +/- 82 1917 +/- 65 -0.007949 0.009743 0.063334 9E-05 0.0839082 ANKMY1 ankyrin repeat and MYND domain containing 1 80 +/- 6 123 +/- 12 89 +/- 10 110 +/- 19 -0.871513 0.0124915 0.377353 0.0331304 0.1804862 ANKRD10 ankyrin repeat domain 10 912 +/- 51 1028 +/- 46 829 +/- 38 1027 +/- 65 -0.235634 0.116825 0.035519 0.1665156 0.2166634 ANKRD11 ankyrin repeat domain 11 147 +/- 24 240 +/- 28 262 +/- 22 250 +/- 72 0.044845 0.0307121 -0.879094 0.0139103 0.3395989 ANKRD16 ankyrin repeat domain 16 117 +/- 11 155 +/- 15 124 +/- 12 175 +/- 8 0.207757 0.078603 0.005667 0.4099566 0.0824376 ANKRD20Aankyrin repeat domain 20 family, member A1 143 +/- 19 247 +/- 40 57 +/- 20 106 +/- 21 -0.004106 0.0508737 0.130608 0.0214372 0.1929429 ANKRD34 ankyrin repeat domain 34 1681 +/- 72 1443 +/- 63 1781 +/- 88 1714 +/- 34 0.039068 -0.031915 -0.501221 0.0025436 0.8755633 ANKRD37 ankyrin repeat domain 37 571 +/- 66 630 +/- 24 455 +/- 38 593 +/- 37 -0.099949 0.4327419 0.027995 0.4128942 0.0187851 ANKRD43 ankyrin repeat domain 43 1626 +/- 115 1329 +/- 135 1930 +/- 112 1590 +/- 92 0.041881 -0.125069 -0.044003 0.1207345 0.1464073 ANKRD52 ankyrin repeat domain 52 1020 +/- 66 863 +/- 45 1073 +/- 53 917 +/- 18 0.324193 -0.080713 -0.030652 0.1436219 0.1729886 ANKS1B ankyrin