Anti-CAMK2B monoclonal antibody (DCABH- 10166) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview Mouse monoclonal to CaMKII beta Antigen Description CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. Immunogen Recombinant fragment: FEPEALGNLV EGMDFHRFYF ENLLAKNSKP IHTTILNPHV HVIGEDAACI AYIRLTQYID GQGRPRTSQS EETRVWHRRD GKWQNVHFHC SGAPVAPL, corresponding to amino acids 405-502 of human CaMKII beta (NP_742078) with a proprietary tag. Isotype IgG1 Source/Host Mouse Species Reactivity Rat, Human Purity Protein A purified Conjugate Unconjugated Applications WB, ELISA, ICC/IF, Flow Cyt Positive Control WB: The immunogen; HeLa and PC12 cell lysates ICC/If: HeLa cell Format Liquid Size 100 μg Buffer Preservative: None; Constituents: 1X PBS, pH 7.2 Preservative None Storage store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Ship Shipped at 4°C. 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved GENE INFORMATION Gene Name CAMK2B calcium/calmodulin-dependent protein kinase II beta [ Homo sapiens ] Official Symbol CAMK2B Synonyms CAMK2B; calcium/calmodulin-dependent protein kinase II beta; calcium/calmodulin dependent protein kinase (CaM kinase) II beta , CAMKB; calcium/calmodulin-dependent protein kinase type II subunit beta; calcium/calmodulin dependent protein kinase type II be Entrez Gene ID 816 Protein Refseq NP_001211 UniProt ID A4D2J9 Chromosome Location 7p14.3-p14.1 Pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; CREB phosphorylation through the activation of CaMKII, organism- specific biosystem; CREB phosphorylation through the activation of Ras, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Function ATP binding; actin binding; calmodulin binding; calmodulin-dependent protein kinase activity; nucleotide binding; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.