Common Name: PHENYLHYDRAZINE HYDROCHLORIDE CAS Number: 59-88-1 RTK Substance number: 2659 DOT Number: UN 2572 Date: September 1999 ----------------------------------------------------------------------- ----------------------------------------------------------------------- HAZARD SUMMARY * Phenylhydrazine Hydrochloride can affect you when * Exposure to hazardous substances should be routinely breathed in and by passing through your skin. evaluated. This may include collecting personal and area * Contact can irritate and burn the skin and eyes. air samples. You can obtain copies of sampling results * Breathing Phenylhydrazine Hydrochloride can irritate from your employer. You have a legal right to this the nose, throat and lungs causing coughing, wheezing information under OSHA 1910.1020. and/or shortness of breath. * If you think you are experiencing any work-related health * High levels can interfere with the ability of the blood to problems, see a doctor trained to recognize occupational carry Oxygen causing headache, fatigue, dizziness, and a diseases. Take this Fact Sheet with you. blue color to the skin and lips (methemoglobinemia). Higher levels can cause trouble breathing, collapse and WORKPLACE EXPOSURE LIMITS even death. The following exposure limits are for Phenylhydrazine: * Exposure to Phenylhydrazine Hydrochloride can cause headache, nausea, vomiting, lightheadedness, nervousness, OSHA: The legal airborne permissible exposure limit shaking, seizures, and coma. (PEL) is 5 ppm averaged over an 8-hour * Repeated exposure can damage the red blood cells causing workshift. anemia. * Phenylhydrazine Hydrochloride may cause a skin NIOSH: The recommended airborne exposure limit is allergy. If allergy develops, very low future exposure can 0.14 ppm, which should not be exceeded at any cause itching and a skin rash. time. * Phenylhydrazine Hydrochloride may damage the liver and kidneys. ACGIH: The recommended airborne exposure limit is 0.1 ppm averaged over an 8-hour workshift. IDENTIFICATION Phenylhydrazine Hydrochloride is a white to tan solid with * The above exposure limits are for air levels only. When a weak odor. It is used in the manufacture of dyes and skin contact also occurs, you may be overexposed, even pharmaceuticals. though air levels are less than the limits listed above. REASON FOR CITATION WAYS OF REDUCING EXPOSURE * Phenylhydrazine Hydrochloride is on the Hazardous * Where possible, enclose operations and use local exhaust Substance List because it is cited by EPA. ventilation at the site of chemical release. If local exhaust * Definitions are provided on page 5. ventilation or enclosure is not used, respirators should be worn. HOW TO DETERMINE IF YOU ARE BEING * Wear protective work clothing. EXPOSED * Wash thoroughly immediately after exposure to The New Jersey Right to Know Act requires most employers Phenylhydrazine Hydrochloride and at the end of the to label chemicals in the workplace and requires public workshift. employers to provide their employees with information and * Post hazard and warning information in the work area. In training concerning chemical hazards and controls. The addition, as part of an ongoing education and training federal OSHA Hazard Communication Standard, 1910.1200, effort, communicate all information on the health and requires private employers to provide similar training and safety hazards of Phenylhydrazine Hydrochloride to information to their employees. potentially exposed workers. PHENYLHYDRAZINE HYDROCHLORIDE page 2 of 6 This Fact Sheet is a summary source of information of all MEDICAL potential and most severe health hazards that may result from exposure. Duration of exposure, concentration of the Medical Testing substance and other factors will affect your susceptibility to For those with frequent or potentially high exposure (half the any of the potential effects described below. TLV or greater, or significant skin contact), the following are --------------------------------------------------------------------------- recommended before beginning work and at regular times after that: HEALTH HAZARD INFORMATION * Liver and kidney function tests. Acute Health Effects * Complete blood count. The following acute (short-term) health effects may occur immediately or shortly after exposure to Phenylhydrazine If symptoms develop or overexposure is suspected, the Hydrochloride: following are recommended: * Contact can irritate and burn the skin and eyes. * Blood methemoglobin level. * Breathing Phenylhydrazine Hydrochloride can irritate * Evaluation by a qualified allergist, including careful the nose, throat and lungs causing coughing, wheezing exposure history and special testing, may help diagnose and/or shortness of breath. skin allergy. * High levels can interfere with the ability of the blood to carry Oxygen causing headache, fatigue, dizziness, and a Any evaluation should include a careful history of past and blue color to the skin and lips (methemoglobinemia). present symptoms with an exam. Medical tests that look for Higher levels can cause trouble breathing, collapse and damage already done are not a substitute for controlling even death. exposure. * Exposure to Phenylhydrazine Hydrochloride can cause headache, nausea, vomiting, lightheadedness, nervousness, Request copies of your medical testing. You have a legal shaking, seizures, and coma. right to this information under OSHA 1910.1020. Chronic Health Effects Mixed Exposures The following chronic (long-term) health effects can occur at * Because more than light alcohol consumption can cause some time after exposure to Phenylhydrazine Hydrochloride liver damage, drinking alcohol may increase the liver and can last for months or years: damage caused by Phenylhydrazine Hydrochloride. Cancer Hazard WORKPLACE CONTROLS AND PRACTICES * There is limited evidence that Phenylhydrazine Hydrochloride causes cancer in animals. It may cause Unless a less toxic chemical can be substituted for a hazardous leukemia. substance, ENGINEERING CONTROLS are the most * Many scientists believe there is no safe level of exposure effective way of reducing exposure. The best protection is to to a carcinogen. Such substances may also have the enclose operations and/or provide local exhaust ventilation at potential for causing reproductive damage in humans. the site of chemical release. Isolating operations can also reduce exposure. Using respirators or protective equipment is Reproductive Hazard less effective than the controls mentioned above, but is * According to the information presently available to the sometimes necessary. New Jersey Department of Health and Senior Services, Phenylhydrazine Hydrochloride has not been tested for In evaluating the controls present in your workplace, consider: its ability to affect reproduction. (1) how hazardous the substance is, (2) how much of the substance is released into the workplace and (3) whether Other Long-Term Effects harmful skin or eye contact could occur. Special controls * Repeated exposure can damage the red blood cells causing should be in place for highly toxic chemicals or when anemia. significant skin, eye, or breathing exposures are possible. * Phenylhydrazine Hydrochloride may cause a skin allergy. If allergy develops, very low future exposure can In addition, the following control is recommended: cause itching and a skin rash. * Phenylhydrazine Hydrochloride may damage the liver * Where possible, automatically transfer Phenylhydrazine and kidneys. Hydrochloride from drums or other storage containers to process containers. PHENYLHYDRAZINE HYDROCHLORIDE page 3 of 6 Good WORK PRACTICES can help to reduce hazardous * Wear a face shield along with goggles when working with exposures. The following work practices are recommended: corrosive, highly irritating or toxic substances. * Workers whose clothing has been contaminated by Respiratory Protection Phenylhydrazine Hydrochloride should change into IMPROPER USE OF RESPIRATORS IS DANGEROUS. clean clothing promptly. Such equipment should only be used if the employer has a * Do not take contaminated work clothes home. Family written program that takes into account workplace conditions, members could be exposed. requirements for worker training, respirator fit testing and * Contaminated work clothes should be laundered by medical exams, as described in OSHA 1910.134. individuals who have been informed of the hazards of exposure to Phenylhydrazine Hydrochloride. * Where the potential exists for exposure over 0.14 ppm (as * Eye wash fountains should be provided in the immediate Phenylhydrazine), use a MSHA/NIOSH approved work area for emergency use. supplied-air respirator with a full facepiece operated in a * If there is the possibility of skin exposure, emergency pressure-demand or other positive-pressure mode. For shower facilities should be provided. increased protection use in combination with an auxiliary * On skin contact with Phenylhydrazine Hydrochloride, self-contained breathing apparatus operated in a pressure- immediately wash or shower to remove the chemical. At demand or other positive-pressure mode. the end of the workshift, wash any areas of the body that may have contacted Phenylhydrazine Hydrochloride, HANDLING AND STORAGE whether or not known skin contact has occurred. * Do not eat, smoke, or drink where Phenylhydrazine * Prior to working with Phenylhydrazine Hydrochloride Hydrochloride is handled, processed, or stored, since the you should be trained on its proper handling and storage. chemical can be swallowed.