CURRICULUM VITAE Hendrik Peter Nicolas Scholl October 1, 2013 DEMOGRAPHIC INFORMATION Current Title and Appointments Dr. Frieda Derdeyn Bambas Professor of Ophthalmology The Wilmer Eye Institute, Johns Hopkins University Medical School Director, Retinal Degeneration Clinic (Retina Division, Wilmer Eye Institute) Director, Visual Neurophysiology Service (Johns Hopkins Hospital) Co-director of the Johns Hopkins Center for STem Cells and Ophthalmic Regenerative Medicine (STORM) Personal Data Wilmer Eye Institute Johns Hopkins University 748 Maumenee Building 1800 Orleans Street Baltimore, MD 21287-9277 phone: (443) 287 5495 e-mail: [email protected] Education and Training (in chronological order) Doctoral/graduate 1989 – 1997 Medical Doctor (Dr. med.), Medical Faculty, University of Tübingen, Germany Thesis: Motion thresholds of colored stimuli of different luminance contrasts are increased in ocular hypertension and early primary-open-angle-glaucoma 1989 – 1997 Magister Artium (Master of Arts), University of Tübingen (Faculty of Philosophy) Thesis: Remembrance and authenticity. Husserl‘s, Bergson‘s and Heidegger‘s philosophy of time with comments on Proust 1/1/1994 – 5/31/1994 Medical School, Brown University, Providence, Rhode Island, USA Clinical Clerkship: Medicine; Electives: (1) Ophthalmology, (2) Emergency Medicine Postdoctoral 1997 – 2001 Resident in Ophthalmology and Post-Doc Researcher, University Eye Hospital Tübingen Training in anterior and posterior segment clinical ophthalmology Specialized Clinic “Inherited Retinal Dystrophies” Head of the Lab for Cone-type specific Electroretinography 10/1/2001 – 9/30/2003 Clinical Research Fellowship in Medical Retinal Disease, Moorfields Eye Hospital, London, UK; Research group Prof. Alan C. Bird Research Fellowship of the German Research Foundation (DFG) 1/1/2004 – 12/31/2006 Heisenberg-Fellowship of the German Research Foundation (DFG) “Phenotyping, genotyping and genotype-phenotype correlation in age-related maculopathy (ARM) and macular degeneration (AMD)” Professional Experience 10/1/2004 – 2/14/2010 Privatdozent (Associate Professor), Medical Faculty, University of Bonn, Germany Consultant Ophthalmologist (Oberarzt), Vitreoretinal Surgeon and Research Coordinator Dept. of Ophthalmology, University of Bonn Head of the Clinical Electrophysiology Unit (ISCEV standard for Electroretinography, Electro-Oculography, Visual Evoked Potentials) Head of the Low-Vision-Center 7/31/2006 - 2/14/2010 Coordinator and Supervising Ophthalmologist of the Specialized Clinic Inherited Retinal and Macular Diseases, Dept. of Ophthalmology, University of Bonn 9/28/2007 – 8/16/2008 Health Management: Advanced training, mibeg-Institute Medicine, Cologne (www.mibeg.de); Certificate „Health Manager“ (1) Health Care Policy and Economy-related Framework of the Health System; (2) Commercially-oriented Management; (3) Controlling; (4) Strategic and Organizational Processes in Hospitals; (5) Quality Management; (6) Positioning of Health Care Institutions in the Public; (7) Management Strategies for Physicians-in-Chief 3/1/2008 – 2/14/2010 Head of the Clinical Trial Center of the Dept. of Ophthalmology, Univ. of Bonn „European Vision Institute – Clinical Trials – Sites of Excellence“ (EVI.CT.SE) 3/1/2010 – present Professor of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University Medical School Director of the Visual Neurophysiology Service (Johns Hopkins Hospital) Director of the Retinal Degeneration Clinic (Retina Division, Wilmer Eye Institute) 12/1/2011 – present The Dr. Frieda Derdeyn Bambas Professor of Ophthalmology (inaugural recipient), Wilmer Eye Institute, Johns Hopkins University Medical School RESEARCH ACTIVITIES Peer Reviewed Original Science Publications 1. The AMD Gene Consortium, Fritsche LG et al. (2013) Seven new loci associated with age-related macular degeneration. Nat Genet. 45: 433-9, 439e1-2. 2. Moshiri A, Scholl HPN, Canto-Soler MV & Goldberg MF (2013) A morphogenetic model for radial streaking in the fundus of the carrier state of X-linked albinism. JAMA Ophthalmol. 131: 691-3. 3. Charbel Issa P, Gillies MC, Chew EY, Bird AC, Heeren TF, Peto T, Holz FG, Scholl HPN (2012) Macular telangiectasia type 2. Prog Retin Eye Res. 34: 49-77. 4. Chen CJ, Scholl HPN, Birch DG, Iwata K, Miller NR, Goldberg MF (2012) Characterizing the phenotype and genotype of a family with occult macular dystrophy. Arch Ophthalmol 130: 1554-9. 5. Fritsche LG, Fleckenstein M, Fiebig BS, Schmitz-Valckenberg S , Almut Bindewald-Wittich A, Keilhauer CN , Renner AB, Mackensen F, Moessner A, Pauleikhoff D, Adrion C, Mansmann U, Scholl HPN, Holz FG (2012) A subgroup of age-related macular degeneration is associated with mono-allelic mutations in the ABCA4 gene. Invest Ophthalmol Vis Sci. 53: 2112-2118. 6. Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HPN, Charbel Issa P, Cano M, Brandstätter H, Tsimikas S, Skerka C, Superti-Furga G, Handa JT, Zipfel PF, Witztum JL, Binder CJ (2011) Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature 478: 76-81. 7. Lauer N, Mihlan M, Hartmann A, Schlötzer-Schrehardt U, Keilhauer C, Scholl HPN, Charbel Issa P, Holz F, Weber BH, Skerka C, Zipfel PF (2011) Complement regulation at necrotic cell lesions is impaired by the age- related macular degeneration-associated factor-h his402 risk variant. J Immunol. 187: 4374-83. 2 8. Finger RP, Fenwick E, Marella M, Charbel Issa P, Scholl HPN, Holz FG, Lamoureux EL (2011) The relative impact of vision impairment and cardiovascular disease on quality of life: The example of Pseudoxanthoma elasticum. Health Qual Life Outcomes. 9(1): 113. 9. Finger RP, Charbel Issa P, Hendig D, Scholl HPN, Holz FG (2011) Monthly ranibizumab for choroidal neovascularizations secondary to angioid streaks in pseudoxanthoma elasticum: A one-year prospective study. Am J Ophthalmol. 152: 695-703. 10. Finger RP, Fimmers R, Holz FG, Scholl HPN (2011) Incidence of blindness and severe visual impairment in Germany - projections for 2030. Invest Ophthalmol Vis Sci. 52: 4381-9. 11. Finger RP, Fimmers R, Holz FG, Scholl HPN (2011) Prevalence and causes of registered blindness in the largest federal state of Germany. Brit J Ophthalmol. 95: 1061-7. 12. Finger RP, Charbel Issa P, Schmitz-Valckenberg S, Holz FG, Scholl HPN (2011) Long-term effectiveness of intravitreal bevacizumab for choroidal neovascularization secondary to angioid streaks in pseudoxanthoma elasticum. Retina 31: in press. 13. Charbel Issa P, Finger RP, Kruse K, Baumüller S, Scholl HPN, Holz FG (2011) Monthly ranibizumab for non-proliferative macular telangiectasia type 2: A 12-months prospective study: Am J Ophthalmol. 151: 876- 886. 14. Troeger E, Sliesoraityte I, Charbel Issa P, Scholl HPN, Zrenner E, Wilke R (2010) An integrated software solution for multi-modal mapping of morphological and functional ocular data. Conf Proc IEEE Eng Med Biol Soc. 2010: 6280-6283. 15. Charbel Issa P, Troeger E, Finger R, Holz FG, Wilke R, Scholl HPN (2010) Structure-function correlation of the human central retina. PLoS One. 22;5(9): e12864. 16. Joshua A Szental JA, Baird PN, Richardson AJ, Islam FMA, Scholl HPN, Charbel Issa P, Holz FG, Gillies M, Guymer RH (2010) Analysis of Glutathione S-Transferase Pi isoform (GSTP1) single nucleotide polymorphisms and macular telangiectasia type 2. Int Ophthalmol. 30: 645-50. 17. Haller JA, Bandello F, Belfort R Jr, Blumenkranz MS, Gillies M, Heier J, Loewenstein A, Yoon YH, Jacques ML, Jiao J, Li XY, Whitcup SM; OZURDEX GENEVA Study Group (2010) Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion. Ophthalmology. 117: 1134-1146.e3. 18. Charbel Issa P, Finger RP, Götting C, Hendig D, Holz FG, Scholl HPN (2010) Centrifugal fundus abnormalities in pseudoxanthoma elasticum. Ophthalmology. 117:1406-14. 19. Finger RP, Charbel Issa P, Kellner U, Schmitz-Valckenberg S, Fleckenstein M, Scholl HPN, Holz FG. (2010) Spectral domain optical coherence tomography in adult-onset vitelliform macular dystrophy with cuticular drusen. Retina 30: 1455-64. 20. Porz G, Scholl HPN, Holz FG, Finger RP (2010) Methoden zur Ermittlung persönlicher Krankheitskosten am Beispiel retinaler Erkrankungen [Methods for estimating personal costs of disease using retinal diseases as an example.] Ophthalmologe 107: 216-20. 21. Baumüller S, Charbel Issa P, Scholl HPN, Schmitz-Valckenberg S, Holz FG (2010) Outer retinal hyperreflective spots on spectral-domain optical coherence tomography in macular telangiectasia type 2. Ophthalmology 117: 2162-8. 22. Hecker LA, Edwards AO, Ryu E, Tosakulwong N, Baratz KH, Brown WL, Charbel Issa P, Scholl HPN, Pollok-Kopp B, Schmid-Kubista KE, Bailey KR, Oppermann M (2010) Genetic control of the alternative pathway of complement in humans and age-related macular degeneration. Hum Mol Genet. 19:209-15. 23. Finger RP, Porz G, Fleckenstein M, Charbel Issa P, Lechtenfeld W, Brohlburg D, Scholl HPN, Holz FG (2010) The Retina Hotline – 18 months results from a telephone hotline for patients with retinal diseases. Retina 30:635–639. 24. Scholl HPN, Fleckenstein M, Fritsche LG, Schmitz-Valckenberg S, Göbel A, Adrion C, Herold C, Keilhauer CN, Mackensen F, Mößner A, Pauleikhoff A, Weinberger AWA, Mansmann U, Holz FG, Becker T, Weber BHF (2009) CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD. PLoS ONE 4:e7418. 3 25. Finger RP, Charbel Issa P, Ladewig M, Götting C, Holz FG, Scholl