Anti-NME2 (aa 1-100) polyclonal antibody (DPABH- 15730) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Antigen Description Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. Specificity The peptide sequence for this antibody is 100% homologous with human NME1-NME2 (accession # Q32Q12). However, it has not been tested experimentally for reactivity to NME1. Immunogen Synthetic peptide conjugated to KLH, from within N terminal amino acids 1-100 of Human NME2. Please note that the immunogen used is 100% conserved in NME1 and it is likely that this antibody will alos recognise NME1 (not tested). Isotype IgG Source/Host Rabbit Species Reactivity Mouse, Human Purification Protein G purified Conjugate Unconjugated Applications ELISA, WB, IHC-P Format Liquid Size 100 μg Buffer Constituents: PBS Preservative 0.09% Sodium Azide Storage Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles. GENE INFORMATION Gene Name NME2 non-metastatic cells 2, protein (NM23B) expressed in [ Homo sapiens ] 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Official Symbol NME2 Synonyms NME2; non-metastatic cells 2, protein (NM23B) expressed in; nucleoside diphosphate kinase B; NM23 H2; NDP kinase B; c-myc transcription factor; histidine protein kinase NDKB; nucleotide diphosphate kinase B; c-myc purine-binding transcription factor PUF; non-metastatic cells 2, protein (NM23) expressed in; PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2; MGC2212; MGC111212; Entrez Gene ID 4831 Protein Refseq NP_001018147 UniProt ID P22392 Chromosome Location 17q21.33 Pathway Metabolic pathways; Metabolism; Metabolism of nucleotides; Nucleotide Metabolism; Purine metabolism; Pyrimidine metabolism; Function ATP binding; DNA binding; kinase activity; metal ion binding; nucleoside diphosphate kinase activity; nucleotide binding; protein binding 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.