Arthritis By The Numbers - 1 - TABLE OF CONTENTS Introduction ......................................................................................................... 5 Section 1: General Arthritis Facts .......................................................................... 7 o Human and Economic Burdens ......................................................................................9 - Economic Burdens......................................................................................................9 - Employment Impact and Medical Cost Burden .......................................................10 •Osteoporosis ............................................................................................. 12 o Prevalence ......................................................................................................................12 o Human and Economic Burdens ......................................................................................13 - Health Burdens ...........................................................................................................14 - Economic Burdens......................................................................................................14 Section 2: Osteoarthritis (OA) ............................................................................... 16 •# OA Patient Story – Kathy Geller.......................................................................... 17 •Osteoarthritis (OA) o Prevalence ......................................................................................................................................19 - US General Population ............................................................................................................19 - Global Prevalence ....................................................................................................................19 o Human and Economic Burdens ....................................................................................................20 - Health Burdens .........................................................................................................................20 - Knee, Hip and Shoulder OA Burden ......................................................................................21 - Economic Burdens ....................................................................................................................22 - Global Burden ..........................................................................................................................23 o Military OA ....................................................................................................................................26 - Prevalence in the Military .........................................................................................................26 - Human and Economic Burdeny ................................................................................................26 - Global Burden for Military and Other Tactical Athletesy .......................................................26 Section 3: Autoimmune and Inflammatory Arthritis .............................................. 28 •# RA Patient Story – Eileen Schneider .................................................................... 30 •Rheumatoid Arthritis (RA) ..................................................................................... 31 o Prevalence .....................................................................................................................................31 o Human and Economic Burdens ....................................................................................................31 - Health Burdens .........................................................................................................................31 - Work/Employment Impact ......................................................................................................32 - Medical/Cost Burdens ............................................................................................................32 •# SLE Patient Story – Liz Morass .................................................................................................................33 •Systemic Lupus Erythematosus (SLE or Lupus) ........................................................ 34 o Prevalence .....................................................................................................................................34 o Human and Economic Burdens ....................................................................................................35 - Comorbidities and Health Burdens .........................................................................................35 - Pregnancy Impact .....................................................................................................................37 - Work/Employment Impact ......................................................................................................37 - Medical/Cost Burdens ............................................................................................................38 Arthritis Foundation •Sjögren’s Syndrome .............................................................................................. 40 o Prevalence (Primary Sjögren’s Syndrome) ..................................................................................40 o Comorbidities (Secondary Sjögren’s Syndrome) ........................................................................40 o Human and Economic Burdens ....................................................................................................41 - Health Burdens .........................................................................................................................41 - Work/Employment Impact ......................................................................................................45 - Medical/Cost Burdens ............................................................................................................45 •Adult-onset Scleroderma ....................................................................................... 46 o Prevalence ......................................................................................................................................46 o Human and Economic Burdens ....................................................................................................46 - Health Burdens .........................................................................................................................46 - Economic Burdens ....................................................................................................................47 •Spondyloarthritis (SpA) ......................................................................................... 48 o General Prevalence ......................................................................................................................48 •Ankylosing Spondyloarthritis (AS) ........................................................................ 48 o Prevalence .....................................................................................................................................48 o Human and Economic Burdens ....................................................................................................48 - Health Burdens ..............................................................................................................................48 - Economic Burdens ....................................................................................................................49 •# PsA Patient Story – Karen Lomas ........................................................................ 50 •Psoriatic Arthritis (PsA) .......................................................................................... 51 o Prevalence ......................................................................................................................................51 o Human and Economic Burdens ....................................................................................................51 - Health Burdens .........................................................................................................................51 - Economic Burdens ....................................................................................................................52 Section 4: Juvenile Idiopathic Arthritis (JIA) and Other Childhood Rheumatic Diseases ............................................. 54 •Common Forms of Juvenile Arthritis (JA) ................................................................ 55 •# JIA/Juvenile-onset Fibromyalgia Patient Story – Soler Family ............................ 56 •Juvenile Idiopathic Arthritis (JIA) ........................................................................... 58 o Prevalence .....................................................................................................................................58 o Human and Economic Burdens ....................................................................................................59 - Health Burdens .........................................................................................................................59 - Mental Health Impact ..............................................................................................................60 - School and Social Impact ........................................................................................................60