0HGLFLQDO0XVKURRP $&OLQLFLDQ¶V2YHUYLHZ 'U&KULVWRSKHU+REEV3K'/$F$+* /LFHQVHG$FXSXQFWXULVW SULPDU\KHDOWKFDUH SURYLGHULQ&DOLIRUQLD &OLQLFDOKHUEDOLVW 5HVHDUFK6FLHQWLVW8&%HUNHOH\ $XWKRURIMedicinal Mushrooms, RWKHUERRNVRQ KHUEDOPHGLFLQH KWWSZZZUDLQERZOLJKWFRPGRZQORDGV0HGLFLQDOB0XVKURRPVB&B+REEVSGI 0XVKURRPVDV)XQFWLRQDO)RRGV 3RSXODULW\KLJKLQ$VLDMXVWEHJLQQLQJLQ(XURSH 1RUWK$PHULFD²PXVKURRPH[WUDFWVVROGZLWKRXW QHHGRIDSSURYDORUUHJLVWUDWLRQ 0RVWSRSXODUVKLLWDNHPDLWDNHUHLVKLFRUG\FHSV WXUNH\WDLOVOLRQ¶VPDQHFKDJDAgaricus blazei 3URGXFWVDYDLODEOHPXVKURRPP\FHOLXPSRZGHU JURZQRQJUDLQVR\EHDQV SRZGHUHGH[WUDFWVLQ FDSVXOHVRUWDEOHWVHWKDQROLFH[WUDFWV ZLWKRU ZLWKRXWJO\FHULQ +HDOWK%HQHILWVRI0XVKURRPV 9HU\OLWWOHIDWQRFKROHVWHURO 9DOXDEOHPLQHUDOFRQWHQWKLJKWUDFHPLQHUDOV +LJKLQYLWDPLQVHVSHFLDOO\%YLWDPLQV 3OHXURWXV SURYLGHVDEHWWHUVXSSO\RI% YLWDPLQVWKDQDQ\FRPPRQIRRGH[FHSWPHDW *UHDWVOLPPLQJIRRG &KROHVWHUROUHJXODWLRQ6KLLWDNH3OHXURWXV 9HU\KLJKLQILEHU²FHOOXORVHOLJQDQFKLWLQ 0XVKURRPDV)RRG*UHHQ %HQHILWV +LJKO\QXWULWLRXV²R\VWHU PXVKURRPLVKLJK TXDOLW\SURWHLQYLWDPLQV PLQHUDOV 7XUNH\7DLOVTrametes versicolor, SURGXFHV PDQ\HQ]\PHVXVHGIRU GHWR[LQJ WR[LFVLWHV ELREOHDFKLQJ RISDSHU HWF 0LQHUDO&RQWHQWRI)XQJL 0XVKURRPVDVPHGLFLQH 0HGLFLQH² DSSURYHGGUXJVLQ -DSDQ&KLQDIRU FDQFHUWUHDWPHQW DGMXYDQWV ZLWK FKHPR +HDOWK VXSSOHPHQWVWR VXSSRUWLPPXQLW\ %LRORJLFDO$FWLYLW\RI)XQJL $OOIXQJLDQG\HDVWVKDYHWULSOHKHOL[ SRO\VDFFKDULGHV EHWDJOXFDQV LQFHOOZDOOV +HDWEUHDNVGRZQFKLWLQH[SRVHVDFWLYH PROHFXOHV %LQGLQJRIODUJHPROHFXODUZHLJKWIXQJDO FRPSRXQGVWRJXWUHFHSWRUV RIWRWDO ± FRPSOH[LPPXQHDFWLYDWLRQ ± 'HFWLQWROOOLNHUHFHSWRUVRWKHUUHFHSWRUV ([DPSOH0XVKURRPEHWDJOXFDQV ȕJOXFDQVGRFNWRLPPXQH UHFHSWRUVLQFOXGLQJ'HFWLQ FRPSOHPHQWUHFHSWRU &5 DQG 7/5 ± 7ULJJHUDJURXSRILPPXQHFHOOV LQFOXGLQJPDFURSKDJHVQHXWURSKLOV PRQRF\WHVQDWXUDONLOOHUFHOOVDQG GHQGULWLFFHOOV ± )XQJDOEHWDJOXFDQVDUHWDNHQXSE\ PDFURSKDJHV ± 7KHQGLJHVWHGWRIUDJPHQWV ± 7DNHQXSDQGGLVWULEXWHGLQVLGHWKH ERG\ ± 7KHVHELQGWR&5UHFHSWRUV ± ,QGXFLQJJUDQXORF\WHVWRSURGXFH 6RXUFH&KDQet al. &URVVVHFWLRQRI IXQJDOFHOOZDOO ȕ 'JOXFDQ 6RXUFH&KDQet al. )LJXUH,PPXQHDFWLYDWLRQLQGXFHGE\ȕJOXFDQV )URP&KDQet al ȕJOXFDQVFDQDFWRQDYDULHW\RIPHPEUDQH UHFHSWRUVIRXQGRQWKHLPPXQHFHOOV PD\DFWVLQJO\RULQFRPELQHZLWKRWKHU OLJDQGV 9DULRXVVLJQDOLQJSDWKZD\DUHDFWLYDWHGDQG WKHLUSDWKZD\VDUHVKRZQ 5HDFWRUFHOOVLQFOXGHPRQRF\WHV PDFURSKDJHVGHQGULWLFFHOOVQDWXUDONLOOHU FHOOVDQGQHXWURSKLOV &RUUHVSRQGLQJVXUIDFHUHFHSWRUVDUHOLVWHG ,PPXQRPRGXODWRU\IXQFWLRQVLQGXFHGE\ȕ JOXFDQVLQYROYHERWKLQQDWHDQGDGDSWLYH LPPXQHUHVSRQVH ȕJOXFDQVDOVRHQKDQFHRSVRQLFDQGQRQ RSVRQLFSKDJRF\WRVLVDQGWULJJHUDFDVFDGH RIF\WRNLQHVUHOHDVH WXPRUQHFURVLVIDFWRU 71) ĮDQG YDULRXVW\SHVRILQWHUOHXNLQV ,/V 7ULSOH+HOL[RI EHWD ! JOXFDQ 'JOXFDQJHRPHWU\ 7ULSOHKHOL[FRQIRUPDWLRQPLJKWJLYHIOH[LELOLW\WRFHOOZDOO ,QWDFWWHUWLDU\VWUXFWXUHFDQFRQIHULQFUHDVHGLPPXQRPRGXODWLRQ $OFRKROH[FHVVLYHKHDWLQJFRXOGGLVUXSWWHUWLDU\VWUXFWXUHV %HWDJOXFDQVĺ'HFWLQ5HFHSWRU 0DFURSKDJHVSURFHVVȕJOXFDQV 6RPH3RVVLEOH,QGLFDWLRQV 6KLLWDNHIRULPPXQHZHDNQHVVLQIHFWLRQV 6KLLWDNH7XUNH\7DLOVIRU&DQFHU 9LUDO6\QGURPHV+HSDWLWLV&KHUSHV+,9 &RUG\FHSVIRUIDWLJXHSHUIRUPDQFH ³DGDSWRJHQ´DQWLDJLQJVXSSOHPHQW 5HLVKLIRULQVRPQLDDQ[LHW\QHUYRXV V\VWHPGLVRUGHUVUHODWHGWRVWUHVV 5HLVKLIRUUHVSLUDWRU\SUREOHPV 5HVHDUFK6XPPDU\ 0RUHWKDQUHFRJQL]HGVSHFLHVRI PXVKURRPVDUHNQRZQWRKDYHVSHFLILF LPPXQRWKHUDSHXWLFSURSHUWLHV )LIW\QRQWR[LFPXVKURRPVVSHFLHV\LHOGHG SRWHQWLDOLPPXQRFHXWLFDOVin vitro 6L[VSHFLHVKDYHEHHQVWXGLHVLQKXPDQ FDQFHUV J Society Integr Oncol6XPPHU ± 7KHUDSHXWLF8VH²4XHVWLRQV 0XVKURRPSURGXFWVZLGHO\XVHGPDQ\FRXQWULHV ,PSRUWDQWTXHVWLRQV ± :KROHPXVKURRPVRULVRODWHGFRQVWLWXHQWV" ± 6PDOOHUSLHFHVRIKHWHURJOXFDQVDFWLYH"$OFRKROKHDW +FODOOUHGXFHVL]HRILQLWLDOFRPSRXQGV ± )UXLWERG\RUP\FHOLXPPRUHHIIHFWLYH" ± )UHVKYVGU\ ± 'RVHWRRKLJKDGRVHFDQOHDGWRLPPXQHVXSSUHVVLRQ QRWKLJKHQRXJKLPPXQHDFWLYDWLRQPD\EHLQFRPSOHWH 0RUH4XHVWLRQV &OLQLFDO3HUVRQDO8VH &RPPRQ4XHVWLRQV ± 6XEVWUDWHKRVWVSHFLHVYDULHVIRUPRVWSRO\SRUHV ± 6SHFLILFVFRSHRILQGLFDWLRQV"([SHFWDWLRQVRIUHVXOWV ± 'XUDWLRQRIWUHDWPHQW":LOOLPPXQHDFWLYDWLRQ GHFUHDVHZLWKWLPH"'RVHDQGGRVDJH" ± )RUFDQFHUPRUHHIIHFWLYHZLWKUDGLDWLRQRU FKHPRWKHUDS\"2UDORQH" ± ,QWHJUDWLRQLQWRPRGHUQKHDOWKFDUH²FRQWUROOHGVWXGLHV DUHQHHGHG &RQFOXVLRQ 0RUHFRQWUROOHGKXPDQFOLQLFDOWULDOVQHHGHG 0XVKURRPH[WUDFWVDUHHIIHFWLYHIRUFRXQWHUDFWLQJVRPH KDUPIXOHIIHFWVRIFKHPRDQGUDGLDWLRQ &RXQWHUDFWLPPXQHVXSSUHVVLRQ 0XVKURRPH[WUDFWVFDQOHDGWRLQFUHDVHGVXUYLYDOWLPHVDQG LPSURYHGTXDOLW\RIOLIH 3UHOLPLQDU\SXEOLVKHGUHVHDUFKDVZHOODVFOLQLFDOUHSRUWV VKRZHIIHFWLYHQHVVIRUKHSDWLWLV&DQGRWKHUYLUDOV\QGURPHV 0RUHKLJKTXDOLW\VWXGLHVDUHQHHGHGWRFRQILUPVSHFLHV GRVHDQGGRVDJHVFRSHRIDFWLYLW\DQGVDIHW\ 3URGXFWV²FKRRVHFDUHIXOO\ %DVLFSULQFLSDOV ± :DQWKLJKHVWȕJOXFDQOHYHOSRVVLEOH $EVROXWHO\WKHPRVWUHVHDUFKHGDFWLYHIRU LPPXQRPRGXODWLRQ 6WDQGDUGL]DWLRQLVSUHIHUUHG JXDUDQWHHG )RUDOOLPPXQRDFWLYHSRO\SRUHVHVSHFLDOO\ZKHQXVHG IRUFDQFHUSUHYHQWLRQDGMXQFWWUHDWPHQW W\SLFDOO\ JURZLQJRQZRRG²UHLVKLWXUNH\WDLOVHVSHFLDOO\ /RRNDW0F&OHDU\ 'UDJD SDSHUWKDWWHVWV FRPPHUFLDOSURGXFWV²PRVWP\FHOLXPSURGXFWVKDG ORZȕJOXFDQFRQWHQWDQGPRGHUDWHKLJK VWDUFKJO\FRJHQFRQWHQW 3URGXFWV )UXLWLQJERG\YVP\FHOLXPSURGXFWV ± 0\FHOLXPDQGIUXLWLQJERG\both KDYHWKHSRWHQWLDOWR SURYLGHKLJKTXDOLW\DFWLYLW\ ± 7KH\DUHERWKDFWLYHEXWWKH\DUHQRWHTXLYDOHQW²GLIIHUHQW JHQHH[SUHVVLRQ ± )UXLWLQJERG\LVRIWHQGHVLUDEOHRUDPL[RIIUXLWLQJERG\DQG P\FHOLXP ± ,IWKHSURGXFWFRQWDLQVRQO\P\FHOLXPLWVKRXOGEHWHVWHGIRU DFWLYHV VXFKDVȕJOXFDQWHUSHQHVFRUG\FHSLQHULQDFLQHV HWF ± ,QVRPHFDVHVP\FHOLXPKDVSURYHQDFWLYHVWKDWWKHIUXLWLQJ ERG\GRHVQ¶WKDYH²LHHericium HULQDFLQH ZLWKQHUYH JURZWKDFWLYLW\QHUYHSURWHFWLYHHIIHFWV /HHet al., 3URGXFWV0DNH\RXURZQ 0RVWFRVWHIIHFWLYH ± &ROOHFWIURPZLOGDUHDV OHDUQOHWKDOWR[LFRQHVILUVWLHAmanita GyromitraGalerina ± 0DNLQJGULHGWHDDWKRPHLVHDV\ ,QVWUXFWLRQV ± 6RDNIUXLWLQJERGLHVLQòWRôSRWRIZDWHUIRUVHYHUDOKRXUV ± 6LPPHUIRUVHYHUDOKRXUV ± %OHQGZDWHUDQGFRRNHGIUXLWLQJERGLHVWRDVOXUU\ ± $GGWVSYLW&SRZGHUIRUSLQWRIWHDFRQFHQWUDWHDQGRUNHHSLQ UHIULJHUDWRU²XSWRPRQWKVKHOIOLIH WDNHòWRWVS[GDLO\ ± OR FRQFHQWUDWHEOHQGWRVPRRWKLHFRQVLVWHQF\SRXULQWRIUXLWOHDWKHU WUD\VLQIRRGGHK\GUDWRUDQGGU\DWDERXWGHJ) ± 7DNHRXWZDIHUVDQGSRZGHULQEOHQGHURUFRIIHHJULQGHUWRDSRZGHU ± .HHSVIRU\HDUVLQJODVVDZD\IURPKHDWDQGOLJKW ± 6SULQNOHRQIRRGXVHLQVRXSVPDNHLQVWDQWWHDRUHQFDSVXODWH ± 'RVHJUDPVWZLFHGDLO\XSWR[WKDWDPRXQWDVQHHGHG 7UDGLWLRQDO&KLQHVH0HGLFLQH +LVWRULFDOPHGLFDOXVHLQ$VLDLVRIWHQEDVHGRQWKH SUHFHSWVRIWUDGLWLRQDO&KLQHVHPHGLFLQH 7&0 0XVKURRPVSHFLHVDUHRIWHQDGGHGWRVRXSVWUDGLWLRQDO IRRGVDQGHDWHQUHJXODUO\IRULPPXQHVXSSRUWRWKHU KHDOLQJTXDOLWLHV RYHU\HDUV 2IWHQDGGHGWRSUHVFULSWLRQVWRWUHDW³GHILFLHQF\´RU[X FRQGLWLRQVRI.LGQH\+HDUW/XQJ6SOHHQV\VWHPV 7UDGLWLRQDO&KLQHVH0HGLFLQH,, 0RVWFRPPRQVSHFLHVDGGHGWRSUHVFULSWLRQV LQFOXGH ± +RHOHQIXOLQJ Wolfiporia cocos 7RQLI\6SOHHQV\VWHP GLJHVWLRQ UHPRYHH[FHVVZDWHU FRXQWHUDFWIDWLJXHLPSURYHLPPXQHVWDWXV ± =KXOLQJ Grifola umbellatus 'LXUHWLFKHUEUHPRYHH[FHVVZDWHU HGHPD FDQFHU ± /LQJ]KL Ganoderma lucidum &DOP³VSLULW´IRUGLVWXUEHG³VKHQ´UHVSLUDWRU\DLOPHQWV SDQDFHD ± 'RQJ&KRQJ;LD&DR Cordyceps sinensis ([KDXVWLRQVH[XDOGHELOLW\WREXLOG³HVVHQFH´ 0RVW&OLQLFDOO\5HOHYDQW 0HGLFLQDO0XVKURRPV Lentinus edodes 6KLLWDNH Trametes versicolor 7XUNH\WDLOV Ganoderma lucidum 5HLVKL Grifola frondosa 0DLWDNH Wolfiporia cocos +RHOHQ)XOLQJ Pleurotus VSS 2\VWHUPXVKURRP Cordyceps sinensis GRQJFKRQJ[LDFDR 2WKHULQWHUHVWLQJVSHFLHV Agaricus blazeiTremella fuciformisInonotus obliquus, Heiricium Trametes versicolor 7XUNH\7DLOV 8ELTXLWRXVSRO\SRUH RQQHDUO\HYHU\ FRQWLQHQW 'HOLJQLILHVPDQ\ KDUGZRRGVHVSHFLDOO\ RDNVIUXLWWUHHV 3UHVFULSWLRQGUXJVLQ -DSDQIRUWUHDWPHQWRI FDQFHUZLWKSXULILHG SURWHLQSRO\VDFFKDULGH FRPSOH[HV 36336. Trametes versicolor 7XUNH\7DLOV Stereum VSS )DOVH7XUNH\7DLOV =RQHGKDLU\FDS 7XUNH\WDLOV URXJKZKLWHSRUH VXUIDFH StereumVPRRWK RUDQJHSRUH VXUIDFH *URZLQVLPLODU KDELWDWVRQ KDUGRRGV Trametes versicolor 7XUNH\7DLOV²OHIWRUULJKW" 6XPPDU\RITrametes versicolor FDQFHU &OLQLFDO7ULDOV&RQGXFWHGLQ$VLD 7\SHRI&DQFHU 1RRI5&7 6WRPDFK 5&7VN &RORUHFWDO 5&7VN (VRSKDJHDO 5&76N %UHDVW 5&7VN -6RF,QWHJU2QFRO6XPPHU ± 36.363 36.363FUXGHH[WUDFWVIURPT. versicolor SUHSDUHGIURPVWUDLQ&0RITv E\ZDWHU H[WUDFWLRQ SRO\VDFFKDULGHDQGSURWHLQ SURWHRJO\FDQPROHFXOHVELRDYDLODEOHRUDOO\ %LRDFWLYHPROHFXOHVIRXQGLQERQHPDUURZ VDOLYDU\JODQGEUDLQOLYHUVSOHHQSDQFUHDV DQGWXPRUWLVVXHZLWKLQKRXUV in vivo Trametes versicolor PRVWVWXGLHG 2QHPHGLFLQDOPXVKURRPTvKDVEHHQVWXGLHGLQ SKDVH,,,DQG,,,UDQGRPL]HGFOLQLFDOWULDOV 6WRPDFKFRORUHFWDOHVRSKDJHDODQGEUHDVWFDQFHU SDWLHQWV -DSDQHVHDQG.RUHDQFOLQLFDOGDWDSURYLGHVXSSRUW IRUWKHK\SRWKHVLVWKDWLPPXQRPRGXODWLRQFDQ LQIOXHQFHWKHFOLQLFDOFRXUVHLQYDULRXVFDQFHUV 0HWDDQDO\VLVLQFRORUHFWDOFDQFHUSDWLHQWV DOOVKRZLQJDSRVLWLYHLPSDFWRQFOLQLFDORXWFRPHV 6DNDPRWRet al 0XVKURRP5HVHDUFKLQ86 %DVW\U8QLYHUVLW\DQG8QLYHUVLW\RI0LQQHVRWD PLOOLRQDZDUGHGIRUH[SORUHWKHIHDVLELOLW\IRUXVHRIPXVKURRP H[WUDFWVDVLPPXQRPRGXODWLQJDJHQWV Trametes Versicolor LQ:RPHQZLWK%UHDVW&DQFHU 3KDVH,,UDQGRPL]HGSODFHERFRQWUROOHGWULDORIDPXVKURRPH[WUDFW 7UDPHWHVYHUVLFRORURU7Y :RPHQZLWKHDUO\VWDJHEUHDVWFDQFHUZKRKDYHFRPSOHWHGDGMXYDQW UDGLDWLRQWKHUDS\ ,PPXQHUHFRYHU\²HQKDQFHGQDWXUDONLOOHUFHOODFWLYLW\HWF 6HOIUHSRUWHGTXDOLW\RIOLIHIDWLJXHVFRUHV 2QJRLQJUHVHDUFKIRU%UHDVW3URVWDWH&DQFHUUHIXQGHG /LQNWRJUHDWDUWLFOHRQ7UDPHWHV KWWSZZZQFELQOPQLKJRYSPFDUWLFOHV30& Trametes versicolor PXVKURRP LPPXQHWKHUDS\LQEUHDVWFDQFHU ³'DWDIURPPXOWLSOHHSLGHPLRORJLFDQGFOLQLFDO VWXGLHV«VXJJHVWWKDWLPPXQHIXQFWLRQKDVD UROHLQEUHDVWFDQFHUSUHYHQWLRQ´ ³,PPXQHWKHUDS\XWLOL]LQJWKHSRO\VDFFKDULGH FRQVWLWXHQWVRITrametes versicolor 7Y DV FRQFXUUHQWDGMXYDQWFDQFHUWKHUDS\PD\EH ZDUUDQWHGDVSDUWRIDFRPSUHKHQVLYHFDQFHU WUHDWPHQWDQGVHFRQGDU\SUHYHQWLRQVWUDWHJ\´ -6RF,QWHJU2QFRO 6XPPHU ³$SRVLWLYHLPSDFWRQFOLQLFDORXWFRPHV´ ³7KHUHKDYHEHHQPDQ\SHHUUHYLHZHG