INTERNATIONAL BEHAVIOURAL AND NEURAL GENETICS SOCIETY 8th Annual Meeting May 19-22, 2006 University of British Columbia Vancouver, Canada Conference Program and Abstracts Sponsored by National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, USA National Institute of Mental Health, National Institutes of Health, USA National Institute on Aging, National Institutes of Health, USA National Institute of Child Health and Human Development, National Inst of Health, USA Exhibitor: ViewPoint Life Sciences Inc, Montreal, Canada Special thanks to – Program Committee: Daniel Goldowitz (chair), Tamara Phillips, Nina Popova, Inga Poletaeva, and Catharine Rankin Local Organizer: Catharine Rankin, with great assistance by Mark Rutledge-Gorman UBC Conferences and Accommodations: Mariela McIlwraith and Karen Stefanson IBANGS 8th Annual Meeting – 2006 Page 1 CONFERENCE PROGRAM International Behavioural and Neural Genetics Society (IBANGS) Friday, May19 15:00-18:00 On-site registration available in Gage Tower, Ruth Blair A 18:00-20:00 Opening Gala Reception at Kenny Bldg, Dept of Psychology (Registration Available on site.) Saturday, May 20 07:30-08:30 Continental Breakfast at Buchanan Lower Lobby POSTERS!!! (Posters may be put up on Saturday morning and stay up all day) 07:30-16:00 Registration available (Buchanan Lower Lobby) 08:30-08:45 Opening Remarks Buchanan 100 (location of all talks) SPEAKERS: note to all speakers: Please go to the lecture hall one half hour before your talk to load your talk on the computer and ensure that everything is working 08:45-10:00 Presidential Plenary Address by Dr. Susumu Tonegawa, Howard Hughes Medical Institute, Massachusetts Institute of Technology, USA, “Molecular, cellular, and circuit mechanisms for hippocampal memory” 10:00-10:30 Coffee Break 10:30-12:30 Symposium I: From mouse genetics to genomics to behavior: 35 years of progress. A symposium to honor the winner of the 2005 IBANGS Distinguished Scientist Award, Dr. Lorraine Flaherty; Chair: Douglas Wahlsten Gene Rinchik -Taconic Farms, Inc., Hudson, New York, USA - Common themes from my 30 years with Lori Flaherty Valerie Bolivar - Wadsworth Center, New York State Department of Health, Troy, New York, USA - Dissecting behavior: The power of mouse genetics Melloni Cook – University of Memphis, Tennessee, USA – Of mice and Lori: Simple lessons in genetics, friendship and courage Gretchen Kusek - University at Albany, State University of New York, New York USA - X Chromosome control of corpus callosum formation 12:30-12:45 Symposium I discussion 12:45-14:00 Lunch 14:00-16:00 Paper Session (speaker is underlined and speaker’s institution is listed) Chair Inga Poletaeva Oliver Ambrée, N Görtz, A Herring, N Sachser, W Paulus, K Keyvani – University of Münster, Germany - Environmental enrichment reduces Aβ deposition in a transgenic mouse model of Alzheimer’s disease: Involvement of multiple processes Eunji Cheong, S Lee, J Choi, M Sun, C Lee, H-S Shin – Korea Institute of Science & Technology, Seoul, Korea - The molecular switch of thalamic sensory gating P Stafford, F Casidy, J Badger, C Zhao, S Roche, P McKeon, Seth Dobrin - Center for Medical Genetics, Marshfield Clinic, Marshfield, Wisconsin IBANGS 8th Annual Meeting – 2006 Page 2 USA – Genetics and genomics of Bipolar Disorder: Combining multiple data types and generating meaning from the mania Mary-Anne Enoch, K White, J Waheed, X-Z Hu, C Harris, D Goldman - National Institute on Alcohol Abuse and Alcoholism, NIH, USA – Differences in genetic origins and attentional responses between pure and comorbid anxiety disorders in humans Christopher Kliethermes, J Crabbe - University of California-San Francisco, USA – Behavioral, pharmacological, and gene expression differences between lines of mice bred for differences in exploratory behavior David Segal, K Walder, M Malakellis, A Sanigorski, G Collier - Deakin University, Waurn Ponds, Australia – Large scale gene expression analysis in the hypothalamus of an animal model of depression Douglas Swanson, E Brauer, G Ramirez, M Butler, E Polosetsky, Y Benjamini, I Golani, D Goldowitz - University of Tennessee, Memphis, USA – A neuroethological approach to dissecting the roles of cerebellar purkinjie cells in open field behavior Michael Butterfield, C Rankin – University of British Columbia, Canada - The effects of stimulation and ethanol exposure on long-term memory training in C. elegans 16:00-18:00 Poster Session in Buchanan Lower Lobby Sunday, May 21 07:30-08:30 Continental Breakfast (Buchanan Lobby) 07:30-17:00 Registration available (Buchanan Lobby) SPEAKERS: note to all speakers: Please go to the lecture hall one half hour before your talk to load your talk on the computer and ensure that everything is working 08:45-10:00 Plenary Address by Distinguished Scientist Award recipient Dr. Douglas Wahlsten, University of Windsor, Ontario, Canada, “Genetic heritability: An old bottle for some 21st century wine” (Buchanan 100) 10:00-10:30 Coffee Break 10:30 -12:30 Symposium II: Emotion, play, and dominance; Chair: Gareth Lahvis Michel Cabanac - Laval University, Quebec, Canada - Threshold of consciousness in phylogeny Gordon Burghardt - University of Tennessee, Knoxville, USA - The origins of vertebrate play: A role for the heritability of experience Gareth Lahvis - University of Wisconsin, Madison, USA – Motivations for social approach behaviors among juvenile Mus musculus Jaak Panksepp - Washington State University, Pullman, USA - Ultrasonic vocalizations as indices of affective states in rats and associated genetic consequences 12:30-12:45 Symposium II Discussion 12:45-14:00 Lunch IBANGS 8th Annual Meeting – 2006 Page 3 14:00-16:00 Symposium III: Mouse sensory systems and behaviour; Chair: Richard Brown Aimee Wong - Dalhousie University, Halifax, Nova Scotia, Canada - The influence of visual ability on the behavior of mice in a battery of tests Richard Brown - Dalhousie University, Halifax, Nova Scotia, Canada - Olfaction and mouse behaviour Sandra McFadden - Western Illinois University, Macomb, Illinois, USA - Hearing and mouse behavior Alexander Bachmanov - Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA - Taste and behavior in mice Shad Smith - McGill University, Montreal, Quebec, Canada - Genetic variability and considerations for pain measurement in inbred and transgenic mice Richard Dyck - University of Calgary, Alberta, Canada - Vibrissa function and somatosensory cortex plasticity in mice 16:00-16:15 Symposium III Discussion 16:15-17:15 IBANGS Business Meeting Buchanan 100 Monday, May 22 07:30-8:30 Continental Breakfast Buchanan Lobby 08:00-17:00 Registration available SPEAKERS: note to all speakers: Please go to the lecture hall one half hour before your talk to load your talk on the computer and ensure that everything is working 08:30-10:30 Symposium IV: Recent perspectives on the role of monoamine systems in depression; Chairs: F. Scott Hall and Andrew Holmes F. Scott Hall - Molecular Neurobiology Branch, National Institute on Drug Abuse, NIH, USA - Antidepressant-like effects of DAT or NET, but not SERT, gene knockout on behavior in the forced swim test Tim Newman - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, USA - Rhesus macaque homologues of human polymorphic alleles of monoaminergic genes Steven A. Thomas - University of Pennsylvania, Philadelphia, Pennsylvania, USA - Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors Klaus Peter Lesch - University of Wuerzburg, Germany - Gene-environment interaction in emotion regulation 10:30-10:45 Symposium IV Discussion 10:45-11:15 Coffee Break 11:15-12:00 Plenary Address by Young Scientist Award recipient Dr. Andrew Holmes, National Institute on Alcohol Abuse and Alcoholism, NIH, USA, “The Ascent of Mouse: using mice to understand the causes and cures of neuropsychiatric disease” 12:00-13:30 Lunch 13:30-14:45 Invited Talks – Outstanding Young Investigators Chair: Catharine IBANGS 8th Annual Meeting – 2006 Page 4 Rankin Viviane Labrie – Mt. Sinai Hospital Hospital and University of Toronto, Ontario, Canada – Decreased glycine affinity at the NMDA receptor results in impaired switching behaviors in mice that are reversed by D- Serine Christine Ponder – Columbia University, New York, USA - Short-term selected lines for fear conditioning: QTL and gene expression analysis Yann Mineur – Yale University, New Haven, Connecticut USA - Localized expression of Beta2-containing nicotinic acetylcholine receptors in dopaminergic neurons in mice supports locomotor activating, but not rewarding effects of nicotine Heather Haughey – University of Colorado at Boulder, USA - The human GABAA Receptor α2 Gene (GABRA2): findings from an alcohol endophenotype study and post-mortem brain expression anaylses 14:45-15:00 Break 15:00-17:00 Symposium V: Ethological and genetic analysis of social behaviour; Chairs: Enrico Alleva and Robert Gerlai Enrico Alleva - Istituto Superiore di Sanità, Rome, Italy - Effects of early social enrichment on adult mouse social phenotype Hewlet McFarlane - National Institute of Mental Health, NIH, USA – Social play in C57BL/6J and BTBR T+ tf/J mice James Curley - University of Cambridge, United Kingdom - The role of the maternal environment on the development of alternative behavioural phenotypes in mice Robert Gerlai - University of Toronto, Ontario, Canada – Social behaviour of zebrafish: A target of mutagenesis? 17:15-17:30 Symposium V Discussion