Anti-PPAP2A (Internal) polyclonal antibody (CABT- B799) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Target PPAP2A Immunogen Synthetic peptide Isotype IgG Source/Host Rabbit Species Reactivity Human, Mouse, Zebrafish Purification Protein A Purified Total IgG Conjugate Unconjugated Applications IHC, WB Format Liquid Concentration 1 mg/ml (Please refer to the vial label for the specific concentration) Size 100 μg Buffer Phosphate buffered saline (PBS) Preservative None Storage Store at 4°C for short-term use. For longer periods of storage, aliquot and store at -20°C. Avoid repeat freeze-thaw cycles. BACKGROUND Introduction PPAP2A is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of PPAP2A is found to be regulated by androgen in a prostatic adenocarcinoma cell line.The protein encoded by this 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of this gene is found to be regulated by androgen in a prostatic adenocarcinoma cell line. At least two alternatively spliced transcript variants encoding distinct isoforms have been described. Keywords PPAP2A;phosphatidic acid phosphatase type 2A;lipid phosphate phosphohydrolase 1;LPP1;PAP 2a;PAP2a;PAP2-alpha;phosphatidic acid phosphatase 2a;lipid phosphate phosphohydrolase 1a;phosphatidate phosphohydrolase type 2a GENE INFORMATION Synonyms PAP2a2; LLP1a; PAP-2a; LPP1; PAP2alpha2; PAP2; PAP2a; PAPalpha1; PPAP2A; PAP 2a 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.