0.6 0.4 0.2 0.0 0.2 0.4 Glycocholate Taurocholate 0.6 Taurodeoxycholic acid Taurochenodeoxycholate Glycochenodeoxycholate AMP Putrescine 0.8 Biliverdin Hexose phosphate Sedoheptulose 1-phosphate Pentose phosphates O-tetradecanoyl-L-carnitine O-dodecanoyl-carnitine Tetradecenoyl Carnitine Serotonin Lactate L-Palmitoylcarnitine (15Z)-Tetracosenoic acid octenoyl-l-carnitine O-dodecenoyl-carnitine O-Decanoyl-L-carnitine O-Decenoyl-L-carnitine Citrate hexanoyl-L-carnitine L-octanoylcarnitine Succinate N-Acetylneuraminate Itaconate Fumarate Malate 6-Phospho-D-gluconate Glutathione S-Glutathionyl-L-cysteine Uracil Nicotinamide Adenosine Glutathione disulfide Cadaverine UDP-glucose Spermidine Acetylcholine Taurine Hypoxanthine Xanthine D-Ribose acyl-C5-OH Dimethylglycine acyl-C5 Pantothenol acyl-C4-OH Phosphate Hexadecenoyl-carnitine Guanosine Inosine Spermine Ethanolamine phosphate Decanoic acid (caprate) Dodecanoic acid D-Arabitol Creatine ( )12(13)-DiHOME ( )9(10)-DiHOME Ursodeoxycholic acid Taurolithocholic acid 3alpha-12alpha-Dihydroxy-5beta-cholanate Chenodeoxycholic acid propionyl-carnitine acetyl-carnitine butanoyl-l-carnitine Choline Creatinine Adenine D-Glyceraldehyde 3-phosphate/Glycerone phosphate Phosphocreatine Glycerol 3-phosphate Pyruvate 2-Oxoglutarate L-Adrenaline acyl-C4-DC Dodecanedioic acid Indole-3-acetate TMAO (trimethylamine N-oxide) Urate Cystathionine Leucine Isoleucine Ascorbate 2-Hydroxyglutarate/Citramalate Dehydroascorbate L-Citrulline L-Carnitine D-Glucose UDP-N-acetyl-D-glucosamine Bilirubin Betaine 2/3-Phospho-D-glycerate Phosphoenolpyruvate Hexadecanoic acid Octadecanoic acid (stearic acid) Allantoate gamma-Glutamyl-Se-methylselenocysteine 12(S)-HETE 15(S)-HETE 5(S)-HETE 8-HETE Octadecenoic acid (oleic acid) Hexadecenoic acid Octadecatrienoic acid (linolenic acid) Linoleate Stearidonic acid (7Z-10Z-13Z-16Z-19Z)-Docosa-7-10-13-16-19-pentaenoic acid Eicosatetraenoic acid (8Z-11Z-14Z)-Icosatrienoic acid Adrenic acid Docosahexaenoic acid Eicosapentaenoic acid (5Z-8Z-11Z-14Z-17Z)-Icosapentaenoic acid Tauroursodeoxycholic acid 5-6-Dihydrothymine 3-Methyleneoxindole Mannitol/sorbitol Indole Indole-3-acetaldehyde Asparagine 5-Oxoproline Cystine 3alpha-7alpha-12alpha-Trihydroxy-5beta-cholanate Glutamate Aspartate 5-Hydroxyisourate Ornithine gamma-L-Glutamylputrescine Threonine gamma-L-Glutamyl-D-alanine Guanine Methionine Tryptophan Arginine Tyrosine Glutamine Lysine Alanine Histidine Serine Carnosine Phenylalanine L-Methionine S-oxide gamma-Glutamyl-gamma-aminobutyrate Dopamine Valine Sphingosine Proline kynurenine Proteobacteria|Alphaproteobacteria|Rhizobiales Firmicutes|Bacilli|Bacillales|Bacillaceae_1|Bacillus Actinobacteria|Actinobacteria|Actinomycetales|Micrococcaceae Actinobacteria|Actinobacteria|Solirubrobacterales|Conexibacter Firmicutes|Bacilli|Lactobacillales|Lactobacillaceae|Lactobacillus Firmicutes|Bacilli|Bacillales|Staphylococcaceae|Staphylococcus Bacteroidetes|Cytophagia|Cytophagales|Cytophagaceae|Fibrella Firmicutes|Bacilli|Lactobacillales|Enterococcaceae|Enterococcus Firmicutes|Bacilli|Lactobacillales|Streptococcaceae|Streptococcus Bacteroidetes|Bacteroidia|Bacteroidales|Prevotellaceae|Prevotella Firmicutes|Bacilli|Lactobacillales|Carnobacteriaceae|Granulicatella Candidatus_Saccharibacteria|Saccharibacteria_generancertae_sedis Proteobacteria|Betaproteobacteria|Burkholderiales|Oxalobacteraceae Planctomycetes|Planctomycetia|Planctomycetales|Planctomycetaceae Proteobacteria|Alphaproteobacteria|Caulobacterales|Caulobacteraceae Actinobacteria|Actinobacteria|Actinomycetales|Micrococcaceae|Kocuria Proteobacteria|Betaproteobacteria|Neisseriales|Neisseriaceae|Eikenella Proteobacteria|Alphaproteobacteria|Rhodobacterales|Rhodobacteraceae Firmicutes|Clostridia|Clostridiales|Clostridiaceae_1|Clostridiumensu_stricto Firmicutes|Bacilli|Bacillales|Bacillales_Incertae_Sedis_XII|Exiguobacterium Proteobacteria|Gammaproteobacteria|Enterobacterales|Enterobacteriaceae Actinobacteria|Actinobacteria|Actinomycetales|Micrococcaceae|Arthrobacter Actinobacteria|Actinobacteria|Actinomycetales|Micrococcaceae|Micrococcus Proteobacteria|Betaproteobacteria|Burkholderiales|Comamonadaceae|Delftia Actinobacteria|Actinobacteria|Actinomycetales|Nocardioidaceae|Nocardioides Fusobacteria|Fusobacteriia|Fusobacteriales|Fusobacteriaceae|Fusobacterium Proteobacteria|Betaproteobacteria|Burkholderiales|Oxalobacteraceae|Massilia Actinobacteria|Actinobacteria|Actinomycetales|Actinomycetaceae|Actinomyces Actinobacteria|Actinobacteria|Micrococcales|Microbacteriaceae|Microbacterium Bacteroidetes|Bacteroidia|Bacteroidales|Porphyromonadaceae|Porphyromonas Deinococcus-Thermus|Deinococci|Deinococcales|Deinococcaceae|Deinococcus Bacteroidetes|Flavobacteriia|Flavobacteriales|Flavobacteriaceae|Flavobacterium Actinobacteria|Actinobacteria|Actinomycetales|Brevibacteriaceae|Brevibacterium Proteobacteria|Betaproteobacteria|Burkholderiales|Comamonadaceae|Leptothrix Proteobacteria|Betaproteobacteria|Burkholderiales|Burkholderiaceae|Cupriavidus Actinobacteria|Actinobacteria|Actinomycetales|Microbacteriaceae|Microbacterium Proteobacteria|Betaproteobacteria|Burkholderiales|Alcaligenaceae|Achromobacter Proteobacteria|Gammaproteobacteria|Pseudomonadales|Moraxellaceae|Moraxella Actinobacteria|Actinobacteria|Corynebacteriales|Mycobacteriaceae|Mycobacterium Actinobacteria|Actinobacteria|Actinomycetales|Geodermatophilaceae|Blastococcus Proteobacteria|Gammaproteobacteria|Pasteurellales|Pasteurellaceae|Haemophilus Bacteroidetes|Flavobacteriia|Flavobacteriales|Flavobacteriaceae|Chryseobacterium Proteobacteria|Alphaproteobacteria|Rhodospirillales|Rhodospirillaceae|Skermanella Proteobacteria|Betaproteobacteria|Burkholderiales|Comamonadaceae|Polaromonas Proteobacteria|Alphaproteobacteria|Rhodospirillales|Acetobacteraceae|Roseomonas Bacteroidetes|Sphingobacteriia|Sphingobacteriales|Chitinophagaceae|Flavisolibacter Proteobacteria|Alphaproteobacteria|Rhodobacterales|Rhodobacteraceae|Paracoccus Actinobacteria|Actinobacteria|Propionibacteriales|Propionibacteriaceae|Cutibacterium Proteobacteria|Gammaproteobacteria|Enterobacterales|Enterobacteriaceae|Klebsiella Actinobacteria|Actinobacteria|Propionibacteriales|Propionibacteriaceae|Friedmanniella Proteobacteria|Alphaproteobacteria|Rhodobacterales|Rhodobacteraceae|Rhodobacter Actinobacteria|Actinobacteria|Corynebacteriales|Corynebacteriaceae|Corynebacterium Proteobacteria|Gammaproteobacteria|Pseudomonadales|Moraxellaceae|Acinetobacter Proteobacteria|Alphaproteobacteria|Rhizobiales|Methylobacteriaceae|Methylobacterium Proteobacteria|Gammaproteobacteria|Pseudomonadales|Moraxellaceae|Enhydrobacter Proteobacteria|Alphaproteobacteria|Caulobacterales|Caulobacteraceae|Brevundimonas Proteobacteria|Betaproteobacteria|Burkholderiales|Oxalobacteraceae|Noviherbaspirillum Proteobacteria|Gammaproteobacteria|Enterobacterales|Enterobacteriaceae|Enterobacter Actinobacteria|Actinobacteria|Propionibacteriales|Propionibacteriaceae|Propionibacterium Proteobacteria|Alphaproteobacteria|Caulobacterales|Caulobacteraceae|Phenylobacterium Proteobacteria|Alphaproteobacteria|Rhodobacterales|Rhodobacteraceae|Rubellimicrobium Proteobacteria|Alphaproteobacteria|Sphingomonadales|Sphingomonadaceae|Sphingomonas Proteobacteria|Gammaproteobacteria|Pseudomonadales|Pseudomonadaceae|Pseudomonas Proteobacteria|Alphaproteobacteria|Sphingomonadales|Sphingomonadaceae|Sphingorhabdus Proteobacteria|Gammaproteobacteria|Enterobacterales|Enterobacteriaceae|Escherichia/Shigella Proteobacteria|Betaproteobacteria|Burkholderiales|Burkholderialesncertae_sedis|Aquabacterium Proteobacteria|Gammaproteobacteria|Xanthomonadales|Xanthomonadaceae|Stenotrophomonas.