Supplemental Table 1: Results of primary druggable genome v2 (DG2) Achilles heel siRNA screen in KMS11 multiple myeloma cells. Results are provided per siRNA as a B-score centered on the median and normalized to the standard deviation. All statistically validated vulnerable genes are listed in Table 1 in the paper; siRNA against other genes are unverified for sensitivity/specificity (individual siRNA results may be inaccurate and should be examined within a robust statistical framework). Entrez siRNA Gene SYMBOL Description B_Score Target Sequence Vendor target annotation Top refseq hit 1 A1BG alpha-1-B glycoprotein 0.02 CAGAAGATGCGTATCAGTATT NM_130786: NM_130786: 1 A1BG alpha-1-B glycoprotein -1.38 CTGCGTCTACGTGGACCTGAA NM_130786: NM_130786: 2 A2M alpha-2-macroglobulin -4.22 ACGGATGAGCATGGCCTTGTA NM_000014: NM_000014: 2 A2M alpha-2-macroglobulin 0.20 CACCAACTCAAAGATTCGTAA NM_000014: NM_000014: 53947 A4GALT alpha 1,4-galactosyltransferase (globotriaosylceramide synthase) 0.85 AGGAGAATAATCAATAGAATA NM_017436: NM_017436: 53947 A4GALT alpha 1,4-galactosyltransferase (globotriaosylceramide synthase) 1.32 CACGTGCTGGTCCTGATGAAA NM_017436: NM_017436: 13 AADAC arylacetamide deacetylase (esterase) 0.67 TTGGCTGATGACAACAAATTA NM_001086: NM_001086: 13 AADAC arylacetamide deacetylase (esterase) 1.06 CAGCCTCTTGATGTAGATTTA NM_001086: NM_001086: 22848 AAK1 AP2 associated kinase 1 -1.50 AACGTGAGTAGCGGTGATGTA NM_014911: NM_014911: 22848 AAK1 AP2 associated kinase 1 0.53 CCAGGTGGTAAACCTGATGAA NM_014911: NM_014911: 10157 AASS aminoadipate-semialdehyde synthase 0.51 AACGATTGATCTTGTGGCTTA NM_005763: NM_005763: 10157 AASS aminoadipate-semialdehyde synthase 0.50 AACGGTACATTACCTGATAAA NM_005763: NM_005763: 26574 AATF apoptosis antagonizing transcription factor 0.07 TCGAGAACTCATAGAACGGAA NM_012138: NM_012138: 26574 AATF apoptosis antagonizing transcription factor -0.58 TTGGAAGGAAGGATCAAACTA NM_012138: NM_012138: AB095936 1.11 TCCGGGTGATTCACTATAGAA AB095936 No hits found till 3 mismatches 18 ABAT 4-aminobutyrate aminotransferase 0.59 TCCCGATGATTCCATACGGAA NM_000663: NM_020686:NM_000663: 18 ABAT 4-aminobutyrate aminotransferase -1.10 CACGCACTCTAAAGCCATTCA NM_000663: NM_020686:NM_000663: 19 ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -2.65 CCGGAACATGCTACAATACCA NM_005502: NM_005502: 19 ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.29 CACCGACAATAAGCTGAATAA NM_005502: NM_005502: 10349 ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 0.63 AAAGAGATAAGCGTGCGTCAA NM_080282: NM_080282: 10349 ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 0.61 CAGCCTGTTAATCGTTAATAA NM_080282: NM_080282: 26154 ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 -2.28 CAGGTGACTCCGATAATATAA NM_015657: NM_015657: 26154 ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 -0.97 AAGCCTAATGATCCGACTTTA NM_015657: NM_015657:NM_173076: 20 ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 -3.23 CTGGAAGAACGTGACGCTCAA NM_001606: NM_001606: 20 ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 1.06 CTGGGTCAGTCCCGTATTTAT NM_001606: NM_001606:NM_212533: 21 ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 0.09 CCGCTTGAAGATTCAGTCGGA NM_001089: NM_001089: 21 ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 2.25 CCAAGTTTATCTCATCCTTTA NM_001089: NM_001089: 24 ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 -1.42 AAGGAGCCCATTGTTGATGAA NM_000350: NM_000350: 24 ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 -0.71 CCGTCTGAACATCACCTTCTA NM_000350: NM_000350: 23461 ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 1.71 GTACGTAATGTTCCAATCTAA NM_018672: NM_018672:NM_172232: 23461 ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.61 TGGCGAGCAATTCGAACTGCA NM_018672: NM_018672:NM_172232: 23460 ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 1.68 ACGCGAGGCTCGCCATCGCAA NM_080284: NM_080284:NM_172346: 23460 ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 1.80 AAGGATTACATTCTAGAGCTA NM_080284: NM_080284:NM_172346: 10347 ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 -0.59 CCCGGCCACGTGCGCATCAAA NM_019112: NM_019112:NM_033308: 10347 ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.80 GACGAGGATGTAGCCCGTGAA NM_019112: NM_019112:NM_033308: 10351 ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 -0.03 TTCGTTAGCATGCAATGCCAA NM_007168: NM_007168: 10351 ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 0.91 CTATCTGGCATTGGCGATTTA NM_007168: NM_007168: 10350 ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 -0.06 TCGATAGTTGCTACTGATCTA NM_080283: NM_080283:NM_172386: 10350 ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 -2.64 GAGGGCGATCATAGGGCATAA NM_080283: NM_080283:NM_172386: 5243 ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -0.60 ATCGAGTCACTGCCTAATAAA NM_000927: NM_000927: 5243 ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.00 CACGGAAGGCCTAATGCCGAA NM_000927: NM_000927: 23456 ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 -3.24 TAGACCCTAAGAAGTAATTAA NM_012089: NM_012089: 23456 ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 -3.19 CTAGGTATTATTAAGAATGAA NM_012089: NM_012089: 8647 ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.84 CGGGATGATAGTCAATTCCTT NM_003742: NM_003742: 8647 ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.02 TCAGATCGGGATGATAGTCAA NM_003742: NM_003742: 5244 ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 0.59 CCGACTGTCTACGGTCCGAAA NM_000443: NM_000443:NM_018849:NM_018850: 5244 ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 -0.93 TCGGCATTTAGTGACAAAGAA NM_000443: NM_000443:NM_018849:NM_018850: 340273 ABCB5 ATPATP-binding-binding cassette,cassette, subsub-family-family B (MDR/TAP),(MDR/TAP), member 5 1.951.95 TTGGAGAATATACGTACTATA NM_ 178559: NM_ 178559: 340273 ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 -0.58 TACGTACTATAGTGTCATTAA NM_178559: NM_178559: 10058 ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 0.06 CAGGCTCTCAACTGTGGTCAA NM_005689: NM_005689: 10058 ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 -2.04 CACCTACATTATCCAGCTGTA NM_005689: NM_005689: 22 ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -2.24 AACCCTCATAGTATCTATTCA NM_004299: NM_004299: 22 ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -0.48 AGCATTTATCTTGCTGGTCAA NM_004299: NM_004299: 11194 ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 -3.83 AAGCTGGAAGCTTCCGATGAA NM_007188: NM_007188: 11194 ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 0.90 AGGAATTTAAGTCATCCTTCA NM_007188: NM_007188: 23457 ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 2.53 CCCGGTCAATAAAGTGTACTA NM_019624: NM_019624:NM_203445:NM_203444:NM_019625: 23457 ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 4.45 CTGCGTGACCACGGCCATCTA NM_019624: NM_019624:NM_203445:NM_203444:NM_019625: NM_004996:NM_019902:NM_019901:NM_019900: 4363 ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -1.62 CCGAGTGGAATTCCGGAACTA NM_004996: NM_019899:NM_019862:NM_019898: NM_004996:NM_019902:NM_019901:NM_019900: 4363 ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -0.96 TCGGATGTCATCTGAAATGGA NM_004996: NM_019899:NM_019862:NM_019898: 89845 ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 0.01 AGCCCAGATTGTGGTAGATTA NM_033450: NM_033450: 89845 ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 0.29 CTGCTGGTACCCGTCAACAAA NM_033450: NM_033450: 85320 ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 0.35 AGGCTACTTGATGGCTCTCAA NM_032583: NM_145186:NM_033151:NM_032583: 85320 ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 -1.84 CTCCTCCAGTTGGATCATCAA NM_032583: NM_145186:NM_033151:NM_032583: NM_145188:NM_145190:NM_145189:NM_145187: 94160 ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 -0.45 CGGTAGGAAATTACCCTGAAA NM_033226: NM_033226: NM_145188:NM_145190:NM_145189:NM_145187: 94160 ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 0.39 CCGGAAAGTCATCGTTAGGAA NM_033226: NM_033226: 150000 ABCC13 ATP-binding cassette, sub-family C (CFTR/MRP), member 13 1.08 CTCGCTTGAATGTATGCGATA NM_138726: NM_138726: 150000 ABCC13 ATP-binding cassette, sub-family C (CFTR/MRP), member 13 -0.30 TAGGGTTATCTACAATATAAA NM_138726: NM_138726: 1244 ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -2.38 CCGTATCAGGTTTGCCAGTTA NM_000392: NM_000392: 1244 ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -1.35 CTGGAGTACCTACAAGCAATA NM_000392: NM_000392: 8714 ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.43 AAGGGTGAAATCCGCATTGAT NM_003786: NM_020037:NM_020038:NM_003786: 8714 ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.01 CCGGAATTATTCTGTGCGCTA NM_003786: NM_020037:NM_020038:NM_003786: 10257 ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.07 GAGGTTAAAGACAGTCATATA NM_005845: NM_005845: 10257 ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -3.17 CTCCTAGTACTTAGAAATACA NM_005845: NM_005845: 10057 ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 -1.52 ATAGCCTATATTTACAGTGAA NM_005688: NM_005688: 10057 ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 1.00 ATCCTTCACGATCAAACCTAA NM_005688: NM_005688: 368 ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 -1.28 CACGTGTGCTGTGCTGAGCAA NM_001171: NM_001171: 368 ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP),