Appendix M: List of Citations Accepted and Rejected by ECOTOX Criteria. The citations in this appendix were considered for inclusion in ECOTOX. Citations include the ECOTOX Reference number, as well as rejection codes (if relevant). Reference in section H.1 include ETU (major degradate of mancozeb and maneb) related article accepted by ECOTOX and OPP and cited within this risk assessment and a brief description of the study. References in section H.2 were for articles relevant to mancozeb, maneb, and ETU, accepted by ECOTOX and OPP but were not cited within the risk assessment. References in section H.3 were articles relevant to mancozeb, maneb, and ETU related articles which were accepted by ECOTOX, but not by OPP. In order to be included in the ECOTOX database, papers must meet the following minimum criteria: (1) the toxic effects are related to single chemical exposure; (2) the toxic effects are on an aquatic or terrestrial plant or animal species; (3) there is a biological effect on live, whole organisms; (4) a concurrent environmental chemical concentration/dose or application rate is reported; and (5) there is an explicit duration of exposure. Section H.4 includes the list of exclusion terms and descriptions for citations not accepted by ECOTOX. For mancozeb, maneb, and ETU, there were hundreds of references that were not accepted by ECOTOX for one or more of the reasons included in section H.4. A full list of the citations reviewed and rejected by the criteria for ECOTOX is listed in section H.5. the toxic effects are related to single chemical exposure; the toxic effects are on an aquatic or terrestrial plant or animal species; there is a biological effect on live, whole organisms; a concurrent environmental chemical concentration/dose or application rate is reported; and there is an explicit duration of exposure. H.1. ECOTOX accepted study on ETU which was used qualitatively in the risk assessment. The bolded number preceding the citation represents the ECOTOX reference number. ECOTOX Record Number and Citation: 90116 George P.Datson, John M. Rogers, Donald J. Versteeg, Thomas D.Sabourin, Donald Baines, and Sarah S. Marsh- 1991. Interspecies Comparisons of A/D Ratios Are Not Constant across Species. Society of Toxicology. Purpose of Review (DP Barcode or Litigation): Litigation 1 Date of Review: August 15, 2007 Summary of Study Findings: Xenapus laevis adult female and developmental stages were exposed to ETU via water column under static water conditions with daily renewal for 4 days. The developmental stages were from the blastulation (shortly after fertilization) to the free swimming tadpole stage. The adult toxic endpoint observed for was mortality. Concentrations were 0, 500, and 1000 mg/liter with 5 adults per concentration. Developmental stages were assessed for morphological developmental, growth (length), and death during development. Developmental concentrations were 0, 100, 250, 500, 750, and 100 mg/liter with 40 embryos per concentration. No adverse affects were observed at the highest concentration tested. The reason this study can only be used in a qualitative basis is because there was no indication if the gel was removed from the organisms during the blastulation stage; therefore, there is uncertainty regarding the amount of test substance the organism was actually exposed to. Description of Use in Document (QUAL, QUAN, INV): Qualitative H.2. Articles relevant to mancozeb, maneb, and ETU, accepted by ECOTOX and OPP but were not cited within the risk assessment because endpoints were less sensitive than existing data. (H.2.) Mancozeb 1. Abbott, J. D., Bruton, B. D., and Patterson, C. L. (1991). Fungicidal Inhibition of Pollen Germination and Germ-Tube Elongation in Muskmelon. Hortscience 26: 529-530. EcoReference No.: 63745 Chemical of Concern: CuOH,MZB,CTN,BMY; Habitat: T; Effect Codes: REP; Rejection Code: OK(CuOH,BMY),NO CROP(MZB,CTN). 2. Agrawal, S. C. (1987). Fungicidal Control of Stem Blight of Pigeonpea Caused by Phytophthora- drechsleri-f-sp-Cajani. Indian J.Plant Prot. 15: 35-38. Chemical of Concern: MZB; Habitat: T; Rejection Code: NO CROP (MZB). 3. Ahad, S. F., Ali, N., and Shah, M. (1992). Effect of Nitrogen, Phosphorus, Potassium and Fungicidal Sprays on Fruit Quality and Yield of Apple. Sarhad J.Agric. 8: 167-174. Chemical of Concern: MZB; Habitat: T; Rejection Code: NO CROP (MZB). 4. Ahmed, I., Bashir, M., Khan, B., Hatim, M., and Sultani, M. I. (1987). Effect of Seed Dressing Fungicides on Yield and Yield Components of Wheat. Pak.J.Agric.Res. 8: 361-365. Chemical of Concern: MZB; Habitat: T; Rejection Code: NO CROP (MZB). 5. Al Najjar, N. R. and Soliman, A. S. (1980). Cytological Effects of Fungicides I. Mitotic Effects of Vitavax-200 and Dithane S-60 on Wheat and Two Related Species. Cytologia (Tokyo) 45: 163-168. EcoReference No.: 46874 2 Chemical of Concern: MZB; Habitat: T; Rejection Code: NO CROP(MZB). 6. Alabi, O. and Emechebe, A. M. (1990). Field Evaluation of Seed Treatment and Foliar Spray Fungicides for the Control of Cowpea Brown Blotch Induced by Colletotrichum capsici. Samaru J.Agric.Res. 7: 151-158. Chemical of Concern: MZB; Habitat: T; Rejection Code: NO CROP (MZB). 7. Alagarsamy, G., Krishnamohan, G., and Jeyarajan, R. (1989). Field Evaluation of Fungicides Against Leaf Spot of Cotton Caused by Alternaria macrospora Zimm. Indian J.Plant Prot. 17: 105- 106. EcoReference No.: 90326 Chemical of Concern: MZB,CAP,Captan,IPD,TPM; Habitat: T; Effect Codes: POP; Rejection Code: OK(IPD,TPM),OK TARGET,NO CROP(CAP,MZB,Captan) . 8. Ali, S. A., Pathak, R. K., and Saraf, R. K. (1998). Fungicidal Seed Treatment in Coriander. Adv.Plant Sci. 11: 303-304. EcoReference No.: 90455 Chemical of Concern: CBD,Captan,THM,MZB; Habitat: T; Effect Codes: POP; Rejection Code: OK(CBD,THM),OK TARGET(Captan,MZB). 9. Allen, T. W., Enebak, S. A., and Carey, W. A. (2004). Evaluation of Fungicides for Control of Species of Fusarium on Longleaf Pine Seed. Crop Prot. 23: 979-982. EcoReference No.: 90919 Chemical of Concern: BMY,DFC,MZB,TBA; Habitat: T; Effect Codes: REP,POP; Rejection Code: LITE EVAL CODED(MZB). 10. Amer, M. A., Hoorne, D., and Poppe, J. (1993). In-Vivo Evaluation of Adjuvants for More Effective Control of Celery Leaf-Spot Septoria-apiicola and Powdery Mildew Erysiphe-graminis of Wheat with Fungicides. In: 3rd Int.Symp.on Adjuvants for Agrochemicals, Aug.3-7, 1992, Cambridge, England, UK, Pestic.Sci. 37: 113-120. Chemical of Concern: MZB; Habitat: T; Rejection Code: NO CROP (MZB). 11. Andrieu, N., Jaworska, G., Genet, J.-L., and Bompeix, G. (2001). Biological Mode of Action of Famoxadone on Plasmopara viticola and Phytophthora infestans. Crop Prot. 20: 253-260. EcoReference No.: 90210 Chemical of Concern: FDN,AZX,FZM,DMH,CMX,MZB; Habitat: T; Effect Codes: POP,REP; Rejection Code: OK TARGET(MZB),OK(FDN,AZX,FZM,DMH,CMX). 12. Arauz, L. F. and Sutton, T. B. (1990). Protectant and After-Infection Activity of Fungicides Against Botryosphaeria obtusa on Apple. Plant Dis. 74: 1029-1034. EcoReference No.: 90001 Chemical of Concern: BMY,BTN,FUZ,MZB,TEZ; Habitat: T; Effect Codes: GRO; Rejection Code: OK TARGET(MZB). 13. Atamanalp, M. and Yanik, T. (2003). Alterations in Hematological Parameters of Rainbow Trout (Oncorhynchus mykiss) Exposed to Mancozeb. Turk.J.Vet.Anim.Sci. 27: 1213-1217. EcoReference No.: 72218 Chemical of Concern: MZB; Habitat: A; Effect Codes: CEL; Rejection Code: LITE EVAL 3 CODED(MZB). 14. Atwood, S. T., Sheets, T. J., Sutton, T. B., and Leidy, R. B. (1987). Stability of Selected Pesticide Formulations and Combinations in Aqueous Media. J.Agric.Food Chem. 35: 169-172. EcoReference No.: 90321 Chemical of Concern: AZ,MZB,Captan,PSM,CPY; Habitat: T; Effect Codes: ACC,REP,GRO; Rejection Code: OK(AZ,PSM,CPY),OK TARGET(MZB,Captan). 15. Babu, T. R. and Azam, K. M. (1987). Toxicity of Different Fungicides to Adult Cryptolaemus montrouzieri Mulsant (Coleoptera: Coccinellidae). Crop Prot. 6: 161-162. EcoReference No.: 77522 Chemical of Concern: CBD,TDF,MZB,CuS,CAP; Habitat: T; Effect Codes: MOR; Rejection Code: LITE EVAL CODED(TDF,CAP,MZB),OK(CBD),NO MIXTURE(CuS). 16. Bajet, N. B., Renfro, B. L., and Valdez Carrasco, J. M. (1994). Control of Tar Spot of Maize and Its Effect on Yield. Int.J.Pest Manag. 40: 121-125. EcoReference No.: 76494 Chemical of Concern: MZB,CBD,Captan,PCZ; Habitat: T; Effect Codes: POP,PHY; Rejection Code: LITE EVAL CODED(PCZ),OK(CBD,Captan),NO CROP(MZB,Captan). 17. Balamuralikrishnan, M. and Jeyarajan, R. (1998). Effects of Fenarimol Sprays on Powdery Mildew Incidence in Grapevine. J.Mycol.Plant Pathol. 28: 181-188. Chemical of Concern: MZB; Habitat: T; Rejection Code: NO CROP (MZB). 18. Ballal, C. R. and Kumar, P. (1991). Differential Response of Allorhogas pyralophagus (Hymenoptera: Braconidae) to Various Pesticides. Indian J.Agric.Sci. 61: 78-79. EcoReference No.: 90487 Chemical of Concern: DCF,PHSL,OXD,DMT,ES,CYP,MZB,Zineb,PPHD,FNT,DCM,FNV; Habitat: T; Effect Codes: MOR,BEH,REP,POP; Rejection Code: LITE EVAL CODED(MZB),OK(ALL CHEMS),OK TARGET(DMT). 19. Barwal, R. N. and Gupta, D. K. (1991). Seasonal Incidence and Control of Pod Borer (Euborellia annulipes) and Cercospora Leaf Spots in Groundnut. Indian J.Plant Prot. 19: 156-160. EcoReference No.: 89847 Chemical of Concern: HCCH,CBL,MP,HPT,AND,CBD,MZB,Zineb,Ziram,CTN; Habitat: T; Effect Codes: POP,REP; Rejection Code: LITE EVAL CODED(MZB,CTN),OK(ALL CHEMS). 20. Bashir, M. and Ilyas, M. B. (1986). Evaluation of Fungicides Against Ascochyta Gram Blight. Pak.J.Bot. 18: 147-152. EcoReference No.: 70579 Chemical of Concern: TDF,TBA,BMY,CBX,CTN,MZB,PNB,Dino; Habitat: T; Effect Codes: POP; Rejection Code: LITE EVAL CODED(MZB,CTN),OK(ALL CHEMS).