US009913798B2 (12 ) United States Patent ( 10 ) Patent No. : US 9 , 913 ,798 B2 Florence et al . (45 ) Date of Patent: Mar. 13, 2018 ( 54 ) TOPICAL SKIN CARE FORMULATIONS USPC .. .. .. .. .. .. .. .. .. .. 424 / 59 COMPRISING PLANT EXTRACTS See application file for complete search history . ( 71 ) Applicant: Mary Kay Inc. , Addison , TX (US ) ( 56 ) References Cited ( 72 ) Inventors : Tiffany Florence , Dallas, TX (US ); U . S . PATENT DOCUMENTS David Gan , Southlake , TX (US ) ; 5 , 705 , 170 A 1 / 1998 Kong et al. Michelle Hines , Hickory Creek , TX 7 , 759, 393 B2 7 / 2010 Joerger et al. (US ) 2008 /0044502 A1 2 /2008 Wirth et al. 2008 / 0227842 Al 9 /2008 Krautler et al. ( 73 ) Assignee : Mary Kay Inc. , Addison , TX (US ) 2009 /0149420 A1 6 /2009 Raederstorff et al . @ 2012/ 0003332 A1* 1 / 2012 Zheng . .. .. A61K 8 / 466 ( * ) Notice : Subject to any disclaimer , the term of this 424 / 725 patent is extended or adjusted under 35 U . S . C . 154 (b ) by 0 days . FOREIGN PATENT DOCUMENTS 101686728 A 3 / 2010 ( 21) Appl. No .: 15 /214 , 182 2001 - 187725 A 7 / 2001 ( 22 ) Filed : Jul. 19 , 2016 352 2003 - 113064 * 4 / 2003 (65 ) Prior Publication Data OTHER PUBLICATIONS International Search Report and Written Opinion issued in PCT US 2017 /0105925 A1 Apr. 20 , 2017 Application No. PCT/ US2012 /034673 , dated Nov. 26 , 2012 Office Action issued in Chinese Application No. 201280022458 .6 , Related U . S . Application Data dated Dec. 5 , 2014 . (63 ) Continuation of application No. 14 / 104 ,193 , filed on * cited by examiner Dec . 12 , 2013 , now Pat . No . 9 ,408 , 801 , which is a continuation of application No. 13 /888 , 068 , filed on Primary Examiner — David J Blanchard May 6 , 2013 , now Pat. No . 8 ,636 , 989 , which is a Assistant Examiner — Sarah Alawadi continuation of application No. 13 /453 ,690 , filed on (74 ) Attorney, Agent, or Firm — Norton Rose Fulbright Apr. 23 , 2012 , now Pat. No . 8 ,444 , 959 . US LLP ( 60 ) Provisional application No . 61/ 477, 812 , filed on Apr. (57 ) ABSTRACT 21, 2011 . Disclosed is a topical skin composition and corresponding methods for its use that includes an extract from Phaseolus ( 51) Int . Cl. vulgaris , Citris sinensis , Wedelia trilobata , Burretiodendron A61K 8 /97 ( 2017 .01 ) hsienmu , Bauhinia brachycarpa var. cavaleriei, Cystacan A610 19 /02 ( 2006 .01 ) thus paniculatus, Caesalpinia minax , Pueraria wallichii , A610 19 / 08 ( 2006 .01 ) Tetracentron sinense, Bridelia insulana , Hedyotis verticil A610 17 / 04 ( 2006 . 01 ) lata , Syzygium fruticosum , Cercidiphyllum japonicum , A610 19 / 00 ( 2006 .01 ) Bauhinia glauca , Rhododendron siderophyllum , Cudrania A61K 8 / 02 ( 2006 . 01 ) pubescens, Cajanus cajan , Wendlandia uvariifolia , Sieges A6IK 36 / 14 ( 2006 .01 ) beckia glabrescens , Azolla imbricate , Juncus bufonius, A61K 36 / 185 ( 2006 .01 ) Poikilospermum suaveolens, Clerodendrum trichotomum A61K 36 / 48 ( 2006 .01 ) var. fargesii , Porandra ramosa , Annona glabra , Sterculia A61K 36 / 74 ( 2006 .01 ) pexa , Phoebe puwenensis , Myriopteron extensum , Croton ( 52 ) U . S . CI. lachnocarpa , Dillenia turbinata , Alpinia blepharocalyx , CPC . .. .. .. A61K 8 / 97 ( 2013 .01 ) ; A61K 8 / 0212 Crotalaria spectabilis , Ficus lacor , Ravenala madagascar (2013 .01 ) ; A61K 36 / 14 (2013 .01 ) ; ACIK iensis , Cocculus orbiculatus, Drynaria fortunei , Acrachne 36 / 185 ( 2013 .01 ) ; A61K 36 / 48 ( 2013 .01 ) ; racemosa , Pseuderanthemum polyanthum , Eriobotrys ser A61K 36 / 74 (2013 .01 ) ; A61Q 17 /04 ( 2013. 01 ) ; rata , Vernonia arborea , Adianthum caudatum , Phaseolus A610 19 / 00 ( 2013 .01 ) ; A610 19 /008 lunatus, Ipomoea cairica , Alopecurus aequalis , Arenga pin ( 2013 .01 ) ; A610 19 / 02 ( 2013 . 01 ) ; A610 nata , Rhynchosia yunnanensis, Syzygium cumini, Clausena 19 /08 (2013 .01 ) ; A61K 2800 /782 (2013 .01 ) dunniana , Cyclosurus parasiticus, or Solanum carolinense . (58 ) Field of Classification Search ??? . .. .. A61K 8 / 97 15 Claims, 1 Drawing Sheet U . S . Patent Mar . 13 , 2018 US 9 ,913 ,798 B2 Plantmaterial (Powdered ) 800 - 1000g 400 g 1 . Soaked with 95 % EtOH , 1 . Soaked with armonia standing overnight at r . t . 2 . Extracted under reflux for 2 . Extracted under reflux with 3 times ( 2 hr, 1 hr , 1 hr. ) CHCl3 for 4 times , each 1 hr . 3 . Concentrated under 3 . Concentrated under reduced pressure reduced pressure Extract (1 ) Extract with enriched alkaloids (I ' ) 59 59 Mixed with 100 mlH2O Extracted wtih petroleum ether for 3 times, each 100 ml H20 Part Petroleum ether extract (II ) Extracted with CHCl3 for 3 times , each 100 ml H20 Part CHCI , Extract (III ) Extracted with n - BuoH for 3 times, each 100 ml H20 part and emulsion n -BuOH Extract ( IV ) Filtered and lyophilized H2O part ( V ) US 9 , 913 , 798 B2 TOPICAL SKIN CARE FORMULATIONS cream , a lotion , a solution , an anhydrous stick , a serum , etc . COMPRISING PLANT EXTRACTS The composition can include from about 0 .001 % to about 5 % by weight of said extract from Burretiodendron hsienmu, CROSS REFERENCE TO RELATED from about 0 . 001 % to about 5 % by weight of said extract APPLICATIONS 5 from Bauhinia brachycarpa var . cavaleriei , and from about 0 .001 % to about 5 % by weight of said extract from Tetra This application is a continuation of U . S . patent applica centron sinense ( ranges inside and out side of the stated tion Ser. No . 14 / 104 , 193 filed Dec . 12 , 2013 , which is a range is also contemplated , e . g . , 0 .0001 % , 6 % , 7 % , 8 % , 9 % , continuation of U . S . patent application Ser . No. 13 / 888 , 068 10 % , 15 % , 20 % , and more ) . The composition can further filed May 6 , 2013 ( U . S . Pat. No. 8 ,636 , 989 ), which is a 10 include a moisturization agent, an antioxidant, a structuring continuation of U . S . patent application Ser . No. 13 /453 ,690 , or thickening agent, and /or an emulsifier ( examples of each filed Apr. 23 , 2012 ( U . S . Pat. No . 8 , 444 , 959 ) , which claims of these ingredients is provided below ) . The composition the benefit of U . S . Provisional Application No . 61 /477 , 812 , can further include a silicone containing compound and /or a filed Apr . 21, 2011. The contents of the referenced applica sunscreen agent (examples of these ingredients are also tions are incorporated into the present application by refer - 15 provided below ) . The extracts can be aqueous extracts , ence . alcoholic extracts , glycolic extracts , or oil extracts . In par ticular instances, the extracts are aqueous extracts . The BACKGROUND OF THE INVENTION extracts can each be obtained from the whole plant of Burretiodendron hsienmu, Bauhinia brachycarpa var . cav A . Field of the Invention 20 aleriei, and Tetracentron sinense , or from any part of the The present invention relates generally to compositions plant thereof ( e . g . , root , stem , leaf , flower , seed ) at the that include one or any combination of plant extracts to treat exclusion of other parts of the plant. In particular instances , a variety of skin conditions. The extracts can be included in the extracts are aqueous extracts from the whole plants , topical skin compositions , edible compositions, injectible respectively . The composition can be formulated as a compositions , oral compositions, hair care compositions, 25 cleanser product, a toner product, a moisturizer product , or etc . a mask product . Additionally , each of the MMP - 1 inhibitors B . Description of Related Art can also have further functionalities that can be beneficial to Ageing , chronic exposure to adverse environmental fac - skin . For instance , the first MMP - 1 inhibitor can also be an tors , malnutrition , fatigue, etc . , can change the visual antioxidant, a lipoxygenase inhibitor , and a tyrosinase appearance , physical properties , or physiological functions 30 inhibitor. The second MMP - 1 inhibitor can also be an of skin in ways that are considered visually undesirable . The antioxidant and a lipoxygenase inhibitor. The third MMP - 1 most notable and obvious changes include the development inhibitor can also be an antioxidant . Further, the combined of fine lines and wrinkles, loss of elasticity , increased extracts can be used to treat a variety of skin conditions by sagging , loss of firmness , loss of color evenness or tone, applying a composition having said extracts to skin in need coarse surface texture, and mottled pigmentation . Less obvi - 35 of such treatment. As indicated above , the composition can ous , but measurable changes which occur as skin ages or be effective in inhibiting MMP- 1 activity in skin , which can endures chronic environmental insult include a general aid in reducing the appearance of fine lines and wrinkles , reduction in cellular and tissue vitality, reduction in cell sagging skin , loose skin , and /or skin that has an overall aged replication rates , reduced cutaneous blood flow , reduced appearance . The composition can also inhibit lipoxygenase moisture content, accumulated errors in structure and func - 40 activity , which can further aid in the skin treatment process tion , alterations in the normal regulation of common bio - while having an added benefit of reducing sebum production chemical pathways, and a reduction in the skin ' s ability to in skin cells , thereby treating the appearance of oily skin . remodel and repair itself . Many of the alterations in appear - The composition can also inhibit tyrosinase activity , which ance and function of the skin are caused by changes in the is a key enzyme in the pathway for producing melanin . This