Table I: Incubation of primary human endothelial cells with IFN-γ results in a significant increase in the transcription of 215 genes Locus Fold ID Accession # Name Symbol Changeb p value 6373 AF002985 chemokine (C-X-C motif) ligand 11 CXCL11 298.28 5.66E-06 6373 AF030514 chemokine (C-X-C motif) ligand 11 CXCL11 229.77 2.59E-08 3627 NM_001565 chemokine (C-X-C motif) ligand 10 CXCL10 178.82 1.86E-08 3620 M34455 indoleamine-pyrrole 2,3 dioxygenase INDO 117.81 3.77E-06 4283 NM_002416 chemokine (C-X-C motif) ligand 9 CXCL9 78.17 8.36E-07 2633 AW014593 guanylate binding protein 1, interferon-inducible, 67kDa GBP1 52.15 1.07E-03 2633 NM_002053 guanylate binding protein 1, interferon-inducible, 67kDa GBP1 43.83 6.36E-04 2633 BC002666 guanylate binding protein 1, interferon-inducible, 67kDa GBP1 27.75 6.19E-04 115362 BG545653 Guanylate binding protein 5 GBP5 27.12 1.50E-05 NAc AI075407 NAc NAc 25.87 2.24E-03 94240 AA633203 epithelial stromal interaction 1 (breast) EPSTI1 23.43 2.87E-05 NAc AW392551 NAc NAc 22.64 3.81E-06 5920 NM_004585 retinoic acid receptor responder (tazarotene induced) 3 RARRES3 19.87 9.68E-07 2634 BF509371 guanylate binding protein 2, interferon-inducible GBP2 19.58 2.15E-03 10673 AF134715 tumor necrosis factor (ligand) superfamily, member 13b TNFSF13B 19.38 1.18E-06 6890 NM_000593 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) TAP1 18.23 9.80E-07 6355 AI984980 chemokine (C-C motif) ligand 8 CCL8 17.67 5.16E-07 10537 NM_006398 gamma-aminobutyric acid (GABA) B receptor, 1 GABBR1 16.74 1.44E-05 51365 NM_015900 phospholipase A1 member A PLA1A 15.62 1.24E-04 115362 BG271923 Guanylate binding protein 5 GBP5 15.60 1.22E-04 10964 NM_006820 interferon-induced protein 44-like IFI44L 15.36 1.73E-03 3437 NM_001549 interferon-induced protein with tetratricopeptide repeats 3 IFIT3 14.98 2.03E-04 54625 AA056548 poly (ADP-ribose) polymerase family, member 14 PARP14 14.29 1.66E-04 151636 AA577672 deltex 3-like (Drosophila) DTX3L 13.56 5.42E-03 NAc AW151360 NAc NAc 13.18 4.11E-04 51056 NM_015907 leucine aminopeptidase 3 LAP3 11.64 2.40E-03 6376 U84487 chemokine (C-X3-C motif) ligand 1 CX3CL1 11.22 4.14E-03 proteasome (prosome, macropain) subunit, beta type, 9 (large 5698 NM_002800 multifunctional peptidase 2) PSMB9 11.12 9.12E-04 6398 BF939675 secreted and transmembrane 1 SECTM1 10.64 2.88E-02 2643 NM_000161 GTP cyclohydrolase 1 (dopa-responsive dystonia) GCH1 10.56 1.02E-03 219285 BE966604 sterile alpha motif domain containing 9-like SAMD9L 10.20 6.84E-04 1462 BF218922 chondroitin sulfate proteoglycan 2 (versican) CSPG2 10.19 1.51E-05 8743 NM_003810 tumor necrosis factor (ligand) superfamily, member 10 TNFSF10 10.06 5.33E-03 2634 NM_004120 guanylate binding protein 2, interferon-inducible GBP2 10.05 1.39E-04 80833 NM_014349 apolipoprotein L, 3 APOL3 9.50 1.19E-03 116071 AW083820 basic leucine zipper transcription factor, ATF-like 2 BATF2 9.45 4.60E-04 Transcribed locus, strongly similar to XP_498081.1 PREDICTED: NAc AI694413 similar to Olfactory receptor 2I2 [Homo sapiens] NAc 9.25 1.10E-03 219285 BE669858 sterile alpha motif domain containing 9-like SAMD9L 9.17 7.46E-04 NAc W58601 Transcribed locus NAc 9.00 1.71E-05 3600 NM_000585 interleukin 15 IL15 8.83 2.97E-03 1193 AI768628 chloride intracellular channel 2 CLIC2 8.68 3.43E-03 115361 BG260886 guanylate binding protein 4 GBP4 8.66 7.64E-04 3659 NM_002198 interferon regulatory factor 1 IRF1 8.61 1.96E-04 Locus Fold ID Accession # Name Symbol Changeb p value NAc AI608902 NAc NAc 8.07 1.11E-04 2635 AL136680 guanylate binding protein 3 GBP3 8.02 6.20E-03 3431 NM_004509 SP110 nuclear body protein SP110 8.01 2.52E-04 57674 AA233374 chromosome 17 open reading frame 27 C17orf27 7.75 1.19E-04 441168 AV734646 hypothetical protein LOC441168 RP1-93H18.5 7.66 3.68E-05 168537 AA858297 GTPase, IMAP family member 7 GIMAP7 7.59 1.64E-02 129607 AI742057 hypothetical protein LOC129607 LOC129607 7.51 8.40E-04 54739 AA142842 XIAP associated factor-1 BIRC4BP 7.46 2.97E-03 10068 AI521549 interleukin 18 binding protein IL18BP 7.39 3.52E-03 8743 AW474434 tumor necrosis factor (ligand) superfamily, member 10 TNFSF10 7.26 4.70E-02 64135 NM_022168 interferon induced with helicase C domain 1 IFIH1 7.06 6.11E-03 6891 AA573502 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) TAP2 6.92 5.58E-03 1462 NM_004385 chondroitin sulfate proteoglycan 2 (versican) CSPG2 6.75 4.71E-04 6648 R34841 Superoxide dismutase 2, mitochondrial SOD2 6.74 2.75E-02 140711 BF437747 Chromosome 20 open reading frame 118 C20orf118 6.47 2.37E-04 5359 AI825926 phospholipid scramblase 1 PLSCR1 6.47 7.01E-03 10346 AA083478 tripartite motif-containing 22 TRIM22 6.38 2.78E-02 3431 AF280094 SP110 nuclear body protein SP110 6.37 1.26E-03 140711 AA603344 Chromosome 20 open reading frame 118 C20orf118 6.32 5.77E-04 80830 NM_030641 apolipoprotein L, 6 APOL6 6.25 4.45E-05 3433 AA131041 interferon-induced protein with tetratricopeptide repeats 2 IFIT2 6.19 9.80E-03 23586 NM_014314 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 DDX58 6.18 3.26E-04 7412 NM_001078 vascular cell adhesion molecule 1 VCAM1 6.16 3.06E-03 28984 NM_014059 response gene to complement 32 RGC32 6.05 4.17E-04 2920 M57731 chemokine (C-X-C motif) ligand 2 CXCL2 6.01 3.42E-03 6773 H98105 signal transducer and activator of transcription 2, 113kDa STAT2 6.00 2.08E-04 9111 NM_004688 N-myc (and STAT) interactor NMI 5.98 4.20E-03 54625 AW297731 Poly (ADP-ribose) polymerase family, member 14 PARP14 5.98 4.68E-02 6772 BC002704 signal transducer and activator of transcription 1, 91kDa STAT1 5.89 3.99E-03 84166 AA005023 nucleotide-binding oligomerization domains 27 NOD27 5.71 8.38E-05 6376 NM_002996 chemokine (C-X3-C motif) ligand 1 CX3CL1 5.57 3.66E-03 83666 AF307338 poly (ADP-ribose) polymerase family, member 9 PARP9 5.56 7.29E-03 8519 AA749101 interferon induced transmembrane protein 1 (9-27) IFITM1 5.56 4.64E-03 8542 AF323540 apolipoprotein L, 1 APOL1 5.49 1.57E-05 219285 AI064690 Sterile alpha motif domain containing 9-like SAMD9L 5.44 1.58E-04 23780 BC004395 apolipoprotein L, 2 APOL2 5.40 3.00E-04 716 M18767 complement component 1, s subcomponent C1S 5.37 1.53E-02 145741 BE218239 Nuclear localized factor 1 NLF1 5.36 3.54E-03 7453 M61715 tryptophanyl-tRNA synthetase WARS 5.36 5.40E-03 NAc AI655467 Full length insert cDNA clone YX74D05 NAc 5.21 1.68E-03 55601 NM_017631 hypothetical protein FLJ20035 FLJ20035 5.19 7.30E-03 5359 NM_021105 phospholipid scramblase 1 PLSCR1 5.14 4.34E-02 7453 NM_004184 tryptophanyl-tRNA synthetase WARS 5.05 4.20E-05 9246 NM_004223 ubiquitin-conjugating enzyme E2L 6 UBE2L6 4.89 1.08E-04 3628 NM_002194 inositol polyphosphate-1-phosphatase INPP1 4.85 4.56E-03 myxovirus (influenza virus) resistance 1, interferon-inducible 4599 NM_002462 protein p78 (mouse) MX1 4.79 2.84E-03 Locus Fold ID Accession # Name Symbol Changeb p value AFFX- HUMISGF3A/ 6772 M97935_3 signal transducer and activator of transcription 1, 91kDa STAT1 4.79 1.86E-02 3428 BG256677 interferon, gamma-inducible protein 16 IFI16 4.78 4.76E-02 94240 BE645480 Epithelial stromal interaction 1 (breast) EPSTI1 4.73 3.07E-03 91543 AI337069 radical S-adenosyl methionine domain containing 2 RSAD2 4.67 1.58E-03 similar to Caspase-4 precursor (CASP-4) (ICH-2 protease) (TX 648470 AA041298 protease) (ICE(rel)-II) LOC648470 4.59 1.56E-02 NAc AA781795 NAc NAc 4.57 5.06E-04 v-maf musculoaponeurotic fibrosarcoma oncogene homolog 4094 AF055376 (avian) MAF 4.56 4.74E-04 11217 BG540494 A kinase (PRKA) anchor protein 2 AKAP2 4.33 1.57E-02 NAc AW964431 NAc NAc 4.32 4.06E-04 91543 AW189843 radical S-adenosyl methionine domain containing 2 RSAD2 4.19 1.15E-03 9021 AI244908 suppressor of cytokine signaling 3 SOCS3 4.17 1.90E-02 8767 AF064824 receptor-interacting serine-threonine kinase 2 RIPK2 4.17 1.51E-03 3660 NM_002199 interferon regulatory factor 2 IRF2 4.15 3.13E-02 CD74 molecule, major histocompatibility complex, class II 972 K01144 invariant chain CD74 4.13 8.22E-04 3430 BC001356 interferon-induced protein 35 IFI35 4.08 4.83E-03 4939 NM_016817 2'-5'-oligoadenylate synthetase 2, 69/71kDa OAS2 4.07 3.39E-02 25939 AF147427 SAM domain and HD domain 1 SAMHD1 4.06 8.93E-03 7444 NM_006296 vaccinia related kinase 2 VRK2 4.04 8.94E-03 55859 NM_018476 brain expressed, X-linked 1 BEX1 3.99 1.78E-04 843 NM_001230 caspase 10, apoptosis-related cysteine peptidase CASP10 3.96 2.36E-04 3601 NM_002189 interleukin 15 receptor, alpha IL15RA 3.89 1.09E-03 64108 NM_022147 receptor transporter protein 4 RTP4 3.88 2.53E-04 1052 NM_005195 CCAAT/enhancer binding protein (C/EBP), delta CEBPD 3.85 4.59E-03 8519 NM_003641 interferon induced transmembrane protein 1 (9-27) IFITM1 3.82 2.15E-02 6737 NM_003141 tripartite motif-containing 21 TRIM21 3.82 2.09E-03 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, 834 M87507 convertase) CASP1 3.78 1.87E-02 121506 AI051248 chromosome 12 open reading frame 46 C12orf46 3.77 1.23E-03 10384 NM_006994 butyrophilin, subfamily 3, member A3 BTN3A3 3.76 1.63E-02 6772 NM_007315 signal transducer and activator of transcription 1, 91kDa STAT1 3.73 4.25E-03 3431 AF280095 SP110 nuclear body protein SP110 3.68 1.46E-02 54739 NM_017523 XIAP associated factor-1 BIRC4BP 3.67 1.11E-03 4938 NM_016816 2',5'-oligoadenylate synthetase 1, 40/46kDa OAS1 3.65 2.08E-02 55905 NM_018683 zinc finger protein 313 ZNF313 3.65 4.76E-03 10561 NM_006417 interferon-induced protein 44 IFI44 3.59 3.35E-02 961 BG230614 CD47 molecule CD47 3.58 1.88E-02 55281 NM_018295 transmembrane protein 140 TMEM140 3.55 2.69E-03 2355 N36408 FOS-like antigen 2 FOSL2 3.51 2.06E-02 55905 AF090934 zinc finger protein