Interdisciplinary Seminar sponsored by the Departments of Chemistry & Biochemistry and Chemical Engineering, Materials Research Laboratory, and Institute of Terahertz Science & Technology Prof. Alexander Pines Glenn T. Seaborg Professor of Chemistry, University of California, Berkeley “Toward Miniaturization of NMR and MRI” When: Seminar at 4pm on February 13 (Monday), 2012 (RECEPTION FOLLOWS AT 5PM) Where: UCSB Bren School Auditorium, Room 1414 Abstract: Contemporary NMR and MRI instruments are big, immobile and expensive. I shall describe recent advances in our laboratory aimed at translating some of the capabilities of NMR and MRI on to a mobile microfluidic chip platform. Components of the converging methodologies include optical pumping and detection, functionalized biosensors, superconducting quantum interference detection, laser atomic magnetometry and remote microfluidic sensing at low magnetic field. Such developments will contribute to the possibility of targeted molecular and lab-on-a-chip NMR and MRI in physics, chemistry and biomedicine. Biography: Alexander Pines is the Glenn T. Seaborg Professor of Chemistry at the University of California, Berkeley, Senior Scientist in the Materials Sciences Division, Lawrence Berkeley National Laboratory (LBNL), and a Faculty Affiliate at the California Institute of Quantitative Biomedical Research. Pines obtained his Ph.D. in chemical physics at M.I.T. in 1972 and joined the Berkeley faculty later that year. Selected awards and honors include the Michael Faraday Medal, The Royal Society; Dickson Prize, Carnegie Mellon University; ACS Irving Langmuir Award; F. A. Cotton Medal for Excellence in Chemical Research; Russell Varian Prize; Wolf Prize in Chemistry; Member, U.S. National Academy of Sciences; Fellow, American Academy of Arts and Sciences; Foreign Member, The Royal Society; Foreign Honorable Member, NMR Society of Japan; Foreign Fellow, National Academy of Sciences, India; Lord Todd Professor, University of Cambridge; Harvard University; past President, International Society of Magnetic Resonance and several Honorary Doctorates. Alexander Pines is a pioneer in the development and applications of NMR spectroscopy. In his early work, he demonstrated time-reversal of dipole-dipole couplings in many-body spin systems, and introduced cross- polarization high resolution NMR of dilute spins, helping to launch the era of modern solid-state NMR in chemistry. He developed the areas of multiple-quantum spectroscopy, double rotation, and dynamic-angle spinning for quadrupolar nuclei. His combination of optical pumping and cross-polarization made it possible to observe enhanced NMR of surfaces and the selective "lighting up" of solution NMR and MRI. .