Table 4: Protective Action Criteria (PAC) Rev 23 based on applicable AEGLs, ERPGs, or TEELs (chemicals listed in alphabetical order) PAC Rev 23 – August 2007 Table 4 presents an alphabetical listing of the chemicals in the PAC data set and provides Chemical Abstracts Service Registry Numbers (CAS RNs),1 PAC data, and technical information on the source of the PACs. Table 4 provides PACs for TEEL-0 (i.e., PAC-0), PAC-1, PAC-2, and PAC-3 in units of mass per unit volume (mg/m3) with the ppm to mg/m3 conversion (carried out at 25ºC and 760 mmHg) performed before rounding. The columns presented in Table 4 provide the following information: Heading Definition No. The ordered numbering of the chemicals as they appear in this alphabetical listing. Chemical The common name of the chemical compound. Compound CAS RN The Chemical Abstracts Service Registry Number for this chemical. TEEL-0 This is the threshold concentration below which most people will experience no appreciable risk of health effects. This PAC is always based on TEEL-0 because AEGL-0 or ERPG-0 values do not exist. PAC-1 Based on the applicable AEGL-1, ERPG-1, or TEEL-1 value. PAC-2 Based on the applicable AEGL-2, ERPG-2, or TEEL-3 value. PAC-3 Based on the applicable AEGL-3, ERPG-3, or TEEL-3 value. Source of PACs Technical comments by the developers of the PAC data set that indicate the source of the data used to derive PAC values. The term “SAR,” often in red font, stands for “Structure Activity Relationships.” Other abbreviations are defined below or in the introductory material found at: http://www.hss.energy.gov/HealthSafety/WSHP/chem_safety/teel.html/. This column will be enhanced in the near future to improve the clarity and completeness of its information. • Chemicals for which AEGLs are available have their chemical name and CAS RN displayed in a bolded and larger font. • Chemicals for which ERPGs are available, but no AEGLs, have their chemical name and CAS RN displayed in a bolded font. • Chemicals for which TEELs are available, but no AEGLs or ERPGs, have their chemical name and CAS RN displayed using a regular font. The following information is pertinent to the derivation of hierarchy-based TEEL values: • Values are restricted by the hierarchy-based TEEL for the next higher category, so that: TEEL-0 ≤ TEEL-1 ≤ TEEL-2 ≤ TEEL-3. 1 Visit http://info.cas.org/ for information on the Chemical Abstracts Service and CAS RNs. Introduction to PAC Table 4 – PAC Rev 23 – 08/30/2007 Page 1 of 2 • The most recent available references (at the time of PAC/TEEL derivation) for Permissible Exposure Limits (PELs), Threshold Limit Values (TLVs), Recommended Exposure Limits (RELs), Workplace Environmental Exposure Levels (WEELs) and German limits (MAKs) are used. The most convenient source for these values is Guide to Occupational Exposure Values - 2007, compiled by the American Conference of Governmental Industrial Hygienists (see http://www.acgih.org/Store/ProductDetail.cfm?id=1911). • For particulate materials, limits used (in mg/m3) are for total dust, even though limits are sometimes also given for the respirable fraction. • “PNOS” = Particulates Not Otherwise Specified. This TLV-TWA value is for total dust, and the respirable fraction is assumed to be 30% of total concentration. • For substances that are in particulate form, all TEEL values have been reduced to a maximum value of 500 mg/m3. This concentration constitutes an upper bound for a stable cloud of respirable dust. The reason for this is that the coagulation rate of particles is a function of the square of the concentration number. Higher concentrations are unstable. • For a few chemicals whose ERPG-1 value was odor-based, rather than toxicity-based, the PAC-1 value was adjusted to the PEL-STEL, TLV-STEL, or 3 x TLV-TWA value. This is noted in the Comments Column of Table 2 when this substitution is made. • In the absence of other concentration limits or appropriate toxicity data for a chemical, a few values are based on British, Finnish, Russian, or other guidelines. • The usual order of use of toxicity data for TEEL-2 and/or TEEL-3 is subordinate to human toxicity data for a particular chemical. A few values depart from the usual guidelines, and are estimates based on existing concentration limits (at other TEEL values) and/or a comparison with similar chemicals and/or a review of available toxicity data. For example, the TEEL-3 value for 1-Bromo-3-chloro-5,5-dimethylhydantoin is estimated from the toxicity-based TEEL-3 for 3-Bromo-1-chloro-5,5-dimethylhydantoin. • The PACs presented in these tables are toxicity-based and do not take flammability data into consideration in their development. In order to alert users as to the potential for explosion and flammability hazards, Table 2 uses special formatting to indicate the relationship of these values to the lower explosive limit (LEL) of a chemical substance. Additional information on the chemicals presented in Table 4 is provided in PAC Tables 1, 2, and 3. Definitions of AEGL, ERPG, and TEELs values (-0,-1,-2, and -3) are provided at the beginning of PAC Tables 2 and 3. Table 4, other PAC Tables, introductory/explanatory material (including a glossary of acronyms and abbreviations), definitions of PAC values, and alternative methods of displaying PAC information are available electronically at: http://www.hss.energy.gov/HealthSafety/WSHP/chem_safety/teel.html. Additional technical information on PACs and TEELs, contact information, and links to other sources of information is accessible on the Subcommittee for Consequence Assessment and Protective Action (SCAPA) webpages at: http://orise.orau.gov/emi/scapa/teels.htm. Chemicals without an identified CAS RN number are issued an identification number, preceded by the letter “z,” for purposes of the PAC data set. The same “z” number that was used in “TEELs Rev 21” has been retained, where applicable. Introduction to PAC Table 4 – PAC Rev 23 – 08/30/2007 Page 2 of 2 08/30/2007 Table 4: Protective Action Criteria (PAC) Rev 23 (mg/m3) based on PACs Rev 23 applicable AEGLs, ERPGs, or TEELs (chemicals listed in alphabetical order) PACs based on AEGLs, ERPGs, or TEELs 3 No. Chemical Name CAS RN (mg/m ) Source of PACs TEEL-0 PAC-1 PAC-2 PAC-3 1 Acacia; (Gum Arabic) 9000-01-5 200 500 500 500 Rat oral LD50, rat oral TDlo 2 Acenaphthene 83-32-9 0.4 1.25 7.5 250 Rat ip LD50, rat TClo 3 Acenaphthylene 208-96-8 0.06 0.2 1.25 500 Rat ip LD50, rat TClo AEGL-1, AEGL-1, AEGL-2, 4 Acetaldehyde 75-07-0 40 81 486 1,510 AEGL-3 5 Acetamide 60-35-5 25 75 500 500 Rat oral LD50, rabbit oral TDlo 6 Acetanilide 103-84-4 0.4 1 7.5 50 Human oral TD lo, human oral LDlo 7 Acetic acid 64-19-7 12 12 86 610 ERPG-1, ERPG-1, ERPG-2, ERPG-3 Acetic acid ethenyl ester, polymer with 1,1- 8 27360-07-2 10 30 50 250 Used PNOS default. bis(ethenyloxy) butane and ethenol 9 Acetic acid, 2-propenyl ester 591-87-7 2 6 40 200 Rat LC50 10 Acetic acid, lithium salt 546-89-4 12.5 35 250 500 Mouse oral LDlo. 11 Acetic acid, manganese(2+) salt, tetrahydrate 6156-78-1 0.892 2.68 22.3 500 Mn concentration limits. AEGLs = bold 12pt font / ERPGs (but not AEGLs) = bold 10pt font The “Source of PACs” column will be enhanced in the near future to improve the clarity and completeness of its information. 1 08/30/2007 Table 4: Protective Action Criteria (PAC) Rev 23 (mg/m3) based on PACs Rev 23 applicable AEGLs, ERPGs, or TEELs (chemicals listed in alphabetical order) PACs based on AEGLs, ERPGs, or TEELs 3 No. Chemical Name CAS RN (mg/m ) Source of PACs TEEL-0 PAC-1 PAC-2 PAC-3 12 Acetic acid, manganese(II) salt (2:1) 638-38-0 0.63 9.45 15.7 500 Mn compound concentration limits. 13 Acetic Anhydride 108-24-7 20 20 20 750 PEL-TWA, REL-C, IDLH. AEGL-1, AEGL-1, AEGL-2, 14 Acetone 67-64-1 475 475 7,600 13,500 AEGL-3 15 Acetone thiosemicarbazide 1752-30-3 20 60 100 100 LOC, LC50 16 Acetone-d6 666-52-4 524 524 8,390 14,900 Acetone (67-64-1) limits used. AEGL-1, AEGL-1, AEGL-2, 17 Acetonitrile 75-05-8 21.8 21.8 537 1,120 AEGL-3 18 Acetonitrile-d3 2206-26-0 75 100 100 750 Used Acetonitrile TEELs. 19 Acetophenone 98-86-2 10 30 50 350 Concentration limits, rat oral LD50 20 Acetoxytriphenylstannane 900-95-8 0.345 0.689 20 50 Concentration limits, rat oral LD50 21 Acetyl bromide 506-96-7 1 3 20 100 Mouse ip LD50 Acetyl carbinol; (Acetol (1); 1-Hydroxy-2- 22 116-09-6 7.5 25 200 500 Rat oral LD50. propanone) AEGLs = bold 12pt font / ERPGs (but not AEGLs) = bold 10pt font The “Source of PACs” column will be enhanced in the near future to improve the clarity and completeness of its information. 2 08/30/2007 Table 4: Protective Action Criteria (PAC) Rev 23 (mg/m3) based on PACs Rev 23 applicable AEGLs, ERPGs, or TEELs (chemicals listed in alphabetical order) PACs based on AEGLs, ERPGs, or TEELs 3 No. Chemical Name CAS RN (mg/m ) Source of PACs TEEL-0 PAC-1 PAC-2 PAC-3 23 Acetyl chloride 75-36-5 0.0075 0.02 0.15 400 Human TClo, rat oral LD50 24 Acetyl triethyl citrate 77-89-4 6 20 125 500 Mouse ip TD lo, rat oral LD50.