Emergency Telephone Numbers MIT Massachusetts Institute of Technology Department of Chemistry Department of Chemistry Call 100 for emergency assistance in the event of fires, serious injuries, or chemical spills of particularly hazardous substances. Call 2-EHSS during daytime hours for access to Chemical Hygiene Plan the Environmental Health and Safety Office. and Safety Manual Campus Police 617-253-1212 2021 Medical Department Emergencies 617-253-1311 Chemical Hygiene Plan and Safety Manual Medical Department General Information 617-253-4481 http://web.mit.edu/medical/ Operations Center (FIXIT) 617-253-4948 Safety 617-452-3477 http://web.mit.edu/environment/ehs/general_safety.html Industrial Hygiene 617-452-3477 http://web.mit.edu/environment/ehs/chemical_safety.html Biosafety 617-452-3477 http://web.mit.edu/environment/ehs/biosafety.html Radiation Protection 617-452-3477 http://web.mit.edu/environment/ehs/radiation.html Environmental Management 617-452-3477 http://web.mit.edu/environment/ehs/waste.html 2021 Photos courtesy of Andy Ryan Photography and Liz McGrath massachusetts institute of technology department of chemistry Chemical Hygiene Plan and Safety Manual 2021 Professor Troy Van Voorhis Head, Department of Chemistry Chemistry Department Chemical Hygiene and Safety Committee 2021 Professor Rick L. Danheiser, Chair Scott Ide (EHS Coordinator and Chemical Hygiene Officer) Nile Abularrage (Student Member) Professor Stephen Buchwald Hayden Monroe Carder (Student Member) Professor Christopher Cummins Kyan D'Angelo (Student Member) Dr. John Dolhun (Director, Undergraduate Laboratories) Luis Galindo (Laser Biomedical Research Center) Hanna Moon (Student Member) Professor Mohammad Movassaghi Julius Oppenheim (Student Member) Professor Alexander T. Radosevich Professor Ronald T. Raines Jacob Joshua Lee Rodriguez (Student Member) Professor Gabriela Schlau-Cohen Professor Matthew Shoulders Tara Sverko (Student Member) Dr. Richard Wilk (Administrative Officer) Chemical Hygiene Plan Thirty-first Edition, 2021 Original edition prepared by Professor Rick L. Danheiser with the assistance of Professor Frederick D. Greene, Professor John Essigmann, Marc B. Jones, B. Scott Jaynes, Jill M. Netka, Jennifer L. Robinson and other members of the Chemistry Department Chemical Hygiene Committee Working with Biological Hazards Prepared by Professor John M. Essigmann with the assistance of Lisa Bailey, Timothy Connors, Daniel Treiber, Elizabeth Trimmer, and Jill A. Mello Working with Electrical Hazards Prepared by Professor Hans-Conrad zur Loye Working with Lasers Prepared by Professors Hans-Conrad zur Loye, Moungi Bawendi, and Robert W. Field Working with Radiation and Radioactive Materials Prepared by B. Scott Jaynes Table of Contents Section One: Chemical Hygiene Plan 5 I. Introduction 5 A. Policy ................................................................................................................................. 5 B. Purpose ............................................................................................................................. 5 C. Personnel Covered by this Plan ...................................................................................... 5 Acknowledgment ............................................................................................................. 5 II. Responsibility, Authority, and Resources 6 A. Department Head ............................................................................................................. 6 B. EHS Committee, EHS Coordinator, and Chemical Hygiene Officer ............................ 6 C. Laboratory Supervisors ....................................................................................................7 D. Group EHS Representatives and Fire Wardens ............................................................. 8 E. Employees, Staff, and Research Personnel ................................................................... 8 F. Environmental Health and Safety Office ........................................................................ 9 III. Information and Training 10 A. Initial Training and Refresher Training ..........................................................................10 B. Information on Hazardous Substances ........................................................................ 11 C. Chemical Container Labels ..............................................................................................13 IV. Protective Equipment 14 A. Eye Protection .................................................................................................................14 B. Protective Apparel ..........................................................................................................15 C. Respirators ......................................................................................................................15 D. Laboratory Hoods ...........................................................................................................16 E. Fire Extinguishers, Safety Showers, and Eyewash Facilities.......................................19 F. Photochemical Reactions Using UV Light and Light Emitting Diodes (LEDs) with Blue Light ................................................................................................................20 V. Standard Operating Procedures for Working with Hazardous Substances 21 A. Classes of Hazardous Substances ................................................................................21 B. Risk Assessment for Hazardous Substances .............................................................. 26 C. General Procedures for Working with Toxic Substances ........................................... 27 D. General Procedures for Working with Flammable, Pyrophoric and Explosive Substances ....................................................................................................40 VI. Procedures for Working with Particularly Hazardous Substances 49 A. Identification and Classification of Particularly Hazardous Substances .................. 49 B. Designated Areas ...........................................................................................................52 C. General Procedures for Working with Substances of Moderate to High Chronic Toxicity or High Acute Toxicity .......................................................................53 D. Additional Procedures for Working with Substances of Known High Chronic Toxicity .....................................................................................................55 E. Special Handling Procedures for Some Common Particularly Hazardous Substances ................................................................................................. 57 VII. Prior Approval Requirements 69 A. Prior Approval Requirements for Certain PHSs .......................................................... 69 B. Prior Approval Requirements to Meet DHS Reporting Regulations .......................... 70 C. Restrictions on the Purchase of Certain Chemicals ................................................... 70 D. Prior Approval Requirements for Certain Explosive Compounds ............................. 70 VIII. Toxic Substances Control Act (TSCA) 71 IX. Shipping Hazardous Materials 71 X. Medical Surveillance 72 XI. Researchers with Medical Conditions 72 XII. Accidents and Emergencies 73 A. Organization, Responsibility, and Training .................................................................. 73 B. Emergency Procedures ................................................................................................. 73 C. Laboratory Emergency Information Cards .................................................................. 74 D. Accident Reports ............................................................................................................ 74 XIII. Appendix 76 OSHA LAB STANDARD 29 CFR 1910.1450 .................................................................. 76 Chemical Hygiene Quiz Questions ................................................................................ 83 Section Two: Working with Biological Hazards 85 A. Introduction .................................................................................................................... 85 B. Registration of Personnel Working with Biohazardous Materials ............................. 85 C. Biohazard Classification ................................................................................................ 86 D. Procedures for Personnel Working with Potentially Pathogenic Agents .................. 86 E. Containment of Biohazardous Material ....................................................................... 87 F. Storage, Decontamination, and Disposal of Biohazardous Material ......................... 88 G. Medical Surveillance ...................................................................................................... 89 H. Accidents ........................................................................................................................ 89 Section Three: Working with Electrical Hazards 90 A. Introduction ....................................................................................................................90 Section Four: Working with Lasers 92 A. Introduction .................................................................................................................... 92 B. Laser Classification .......................................................................................................