1 Curriculum Vitae Takahiro Shiota, MD, PhD, FACC, FESC, FASE, FAHA Office Address: Cedars-Sinai Medical Center Heart Institute 127 S. San Vicente Blvd., A3411 Los Angeles, CA 90048 (310) 423-6889 Office Email: [email protected] EDUCATION: 1991 Ph.D. in Cardiology. Faculty of Medicine, University of Tokyo, Tokyo, Japan 1977-1983 M.D. Faculty of Medicine, University of Tokyo, Tokyo, Japan 1972-1976 B.S. in Physics. Faculty of Science, University of Tokyo, Tokyo, Japan LICENSURE AND CERTIFICATION National Board of Echocardiography (#2000-252) California Medical License (#000015) Ohio Medical License (#35. 080318) ECFMG (#0-576-045-9) Japanese Medical License (#274951) PROFESSIONAL EXPERIENCE 1/2009-present Associate Director Division of Noninvasive Cardiology Cedars-Sinai Heart Institute Los Angeles, CA 12/2001-12/2008 Clinical Staff Department of Cardiovascular Medicine Cleveland Clinic, Cleveland, OH 7/1999-11/2001 Advanced Cardiac Department of Cardiovascular Medicine Imaging Fellow Cleveland Clinic, Cleveland, OH 9/1997- 6/1999 Project Staff Department of Cardiovascular Medicine 2 Cleveland Clinic, Cleveland, OH 8/1992- 8/1997 Research Director Cardiac Imaging Laboratory, Clinical Care Center for Congenital Heart Disease, Oregon Health Sciences University, Portland, OR PROFESSIONAL ACTIVITIES: Academic Appointment 7/2009-present Professor of Medicine, Department of Medicine, Cedars-Sinai, Los Angeles, CA 8/2008-present Clinical Professor of Medicine, David Geffen School of Medicine at UCLA 7/2007-12/2008 Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 7/2004-6/2007 Associate Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 6/2000-6/2004 Associate Professor of Medicine, Cleveland Clinic Health Sciences Center, Ohio State University School of Medicine, Columbus, OH 7/1997-8/1997 Associate Professor of Medicine, Clinical Care Center for Congenital Heart Disease, Department of Pediatric Cardiology, Oregon Health Sciences University, Portland, OR 7/1993-6/1997 Assistant Professor of Medicine, Clinical Care Center for Congenital Heart Disease, Department of Pediatric Cardiology, Oregon Health Sciences University, Portland, OR 8/1992-6/1993 Instructor, Clinical Care Center for Congenital Heart Disease, Department of Pediatric Cardiology, Oregon Health Sciences University, Portland, OR Society Memberships 1996-Present Fellow of the American College of Cardiology (F.A.C.C.) 2007-Present Fellow of the American Heart Association (F.A.H.A.) 2008-Present Fellow of the European Society of Cardiology (F.E.S.C.) 1996-Present Fellow of the American Society of Echocardiology (F.A.S.E.) 3 Other Professional Activities 1/1/14-Present Board Member of IRB at Cedars Sinai Medical Center 2013-Present Vice President, Asian-Pacific Association of Echocardiography 1/1/13-Present Vice President, Asian-Pacific Association of Echocardiography 1/1/12-12/31/13 President, Los Angeles Society of Echocardiogrphy 1/1/11-Present International Advisory Board Member, Journal of Japanese College of Cardiology 1/1/10-Present International Task Force Representative to Japan, American Society of Echocardiography 1/1/09-12/31/10 Scientific Advisory Board Member, International Academy of Cardiology 1/1/08-12/31/2013 Editor-in-Chief, “Cardiac Ultrasound Today” 9/1/05-8/31/09 Quality Assurance Officer in Cardiology at Cleveland Clinic 1993-Present Abstract grader and peer reviewer for Circulation, Journal of the American College of Cardiology, American Heart Journal, American Journal of Cardiology and Journal of the American Society of Echocardiography. HONORS 2007 “America’s Top Cardiologists” 2014 Highly Commended for 3D Echocardiography 2nd edition at the British Medical Association Medical Book Awards GRANT SUPPORT: 1. R01HL122492 (PI – Chugh, Co-Investigator-Takahiro Shiota) NIH NHLBI Total Costs: $ 2,357,464 Sudden Cardiac Death in Middle Age This study is a population-based translational approach to identify novel mechanisms of ventricular arrhythmogenesis in middle-aged residents of a large community. 11/14/14 – 11/13/18 2. Grant-in-Aid, American Heart Association, Ohio Valley Affiliate. 3-Dimensional echocardiographic evaluation of the heart: Quantitative application for valvular heart disease. Role on Project: Principal Investigator 7/1/99-6/30/01 4 3. National Aeronautics and Space administration. Digital echocardiography in manned space flight: remote diagnosis and quantitative analysis. Role on Project: Co- Investigator. P.I. James D. Thomas, MD. 7/1/97-6/30/99 4. Grant-in-Aid, American Heart Association, Oregon Affiliate. 3-Dimensional modeling of cardiac flow events as imaged by color Doppler echocardiography. Role on Project: Principal Investigator 7/1/97-6/30/99 5. PHS NIH NHLBI (R01 HL43287). Multicenter study of miniaturized multiplane TEE probes. Role on Project: Co-Investigator. P.I. David J. Sahn, MD. 2/1/95- 1/31/98 6. PHS NIH NHLBI (R01 HL36472). Phase array for multiplane esophageal echos in infants. Role on Project: Co-Investigator. P.I. David J. Sahn, MD. 8/1/87-1/31/96 7. PHS NIH NHLBI (R01 HL43287). Improved understanding of cardiac flows. Role on Project: Co-Investigator. P.I. David J. Sahn, MD. 9/1/90-8/31/95 CURRENT RESEARCH PROJECTS 4/1/14-Present Geometry of Postinfarction Ventricular Septal Defect in Comparison with Congenital Ventricular Septal Defect: A Real-Time Three- Dimensional Transesophageal Echocardiography Study. 6/1/14-Present Volume Reduction of Mitral Regurgitation is Main Contributor to Increase of Cardiac Forward Flow in Patients with Preprocedural Mitral Regurgitation after Transcatheter Aortic Valve Replacement: Hemodynamic analysis using echocardiography. 8/1/14-Present Absence of Chordae Tendineae near Valve Coaptation Leads to Mitral Regurgitation in Lone Atrial Fibrillation. INVITED SPEAKER, MODERATOR AND CHAIRPERSON 1. Cardiology Grand Rounds: University of Illinois, Chicago, April 1993. "Quantitation of Mitral Regurgitation Using Doppler Echocardiography" 2. 8th Annual Advances in Echocardiography, Chicago, September 1993. 3. Topics of Faculty Science: Oregon Health Sciences University, Congenital Heart Research Center, February 1994 “Contrast Echocardiography” 5 4. Topics of Faculty Science: Oregon Health Sciences University, March 1994. "Color Doppler flow convergence region of mitral regurgitation" 5. 9th Annual Advances in Echocardiography, Chicago, September 1994. 6. Topics of Faculty Science: Oregon Health Sciences Universitiy, March 1995. “Three-Dimensional Color Doppler Echocardiography” 7. 43rd Annual Scientific Meeting of Japanese College of Cardiology; Yokohama, Japan, September 1995. "Doppler Flow Convergence Quantitation in Aortic and Mitral Regurgitation" 8. 10th Annual Advances in Echocardiography, Chicago, September 1995. 9. Topics of Faculty Science: Oregon Health Sciences University, November 1995. "Digital Phonocardiography of Mitral Regurgitation" 10. Anesthesiology Conference: Oregon Health Sciences University, December 1995. "Three-Dimensional Echocardiography Using Multi-plane Transesophageal Echocardiography" 11. 11th Annual Advances in Echocardiography, Chicago, September 1996. 12. 8th Annual Scientific Sessions of American Society of Echocardiography: Florida, June 1997. Meet the Expert “Automated Cardiac Flow Measurement” 13. Contrast Echocardiography Conference of Japanese Society of Echocardiography: Osaka, Japan, August 1997. “New Development of Contrast Echocardiography” 14. 14th Annual Advances in Echocardiography, Chicago, September 1997. 15. 9th Annual Scientific Sessions of American Society of Echocardiography: San Francisco, June 1998. Meet the Expert “Model Study” 16. 70th Scientific Sessions of American Heart Association, Moderator, How to Session :Dallas, Novemver 1998. “3D Echocardiography, the Past, the Present and the Future” 17. 10th Annual Scientific Sessions of American Society of Echocardiography: Washington DC, June 1999. Symposium “3D Echocardiography” 18. Echo Kobe 2000 Conference of Japanese Society of Echocardiography: Kobe, Japan, July 2000. “Case Studies with Experts” “Echocardiographic Qunatification of Cardiac Function in the Year of 2000” 6 19. Contrast Echocardiography Conference of Japanese Society of Echocardiography: Osaka, Japan, August 2000. “Clinical Applications of Contrast Echocardiography” 20. Cardiothoracic Surgical Grand Rounds, Saitama College of Medicine, Japan, August 2000. “Cardiac Surgery with Echocardiography” 21. Cardiology Grand Rounds: Kawasaki College of Medicine, Kurashiki, Japan, August 2000. “Three Dimensional Echocardiography” 22. 15th Annual Advances in Echocardiography, Chicago, September 2000. “3D Stress Contrast Echocardiography” 23. Cardiology Grand Rounds: Faculty of Medicine, University of Kagoshima, Kagoshima, Japan, August 2001. “3D Echocardiography”, “Medical Education in the United States” 24. American Society of Echocardiography, Faculty and Moderator, Seattle, June 2001. “New Technology” 25. Echo Kobe 2001, Conference of Japanese Society of Echocardiography, Kobe, Japan. July 2001. “3D Echocardiography”, “Case Studies at Cleveland Clinic” 26. Cardiology Grand Rounds: Kawasaki College of Medicine, Kawasaki, Japan, August 2001. “Case studies at Cleveland Clinic” 27. Cardiology Grand Rounds, Faculty of Medicine, University of Kagoshima, Kagoshima, Japan, August 2001 “3D Echocardiography”, “Medical Education in the United States” 28. The Mitral Valve Meeting, Cleveland Clinic, Cleveland,