IN THE UNITED STATES DISTRICT COURT FOR THE SOUTHERN DISTRICT OF NEW YORK MONTANA BOARD OF INVESTMENTS; Civil Action No. --- TEACHER RETIREMENT SYSTEM OF TEXAS; CALIFORNIA PUBLIC COMPLAINT EMPLOYEES' RETIREMENT SYSTEM; CALIFORNIA STATE TEACHERS' JURY TRIAL DEMANDED RETIREMENT SYSTEM; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; ARIZONA STATE RETIREMENT SYSTEM; CAISSE DE D:EPOT ET PLACEMENT DU QUEBEC; THRIVENT LARGE CAP GROWTH PORTFOLIO (f/k/a Lutheran Brotherhood Employees' Equities Fund); THRIVENT LARGE CAP GROWTH PORTFOLIO (f/k/a/ Growth Portfolio); THRIVENT LARGE CAP GROWTH PORTFOLIO (f/k/a Investors Growth Portfolio); THRIVENT FINANCIAL FOR LUTHERANS FOUNDATION (f/k/a Lutheran Brotherhood Foundation); THRIVENT FINANCIAL FOR LUTHERANS (f/k/a Lutheran Brotherhood); THRIVENT LARGE CAP STOCK FUND (f/k/a Lutheran Brotherhood Fund); THRIVENTLARGECAPGROWTHFUND (:f/k/a Lutheran Brotherhood Growth Fund); THRIVENTLARGECAPVALUEFUND (f/k/a Lutheran Brotherhood Value Fund); THRIVENT LARGE CAP VALUE PORTFOLIO (f/k/a Value Portfolio); THRIVENT LARGE CAP VALUE PORTFOLIO (f/k/a Equity Income Portfolio); THRIVENT LARGE CAP GROWTH FUND (f/k/a The AAL Aggressive Growth Fund); THRIVENT LARGE CAP GROWTH FUND (f/k/a The AAL Technology Stock Fund); THRIVENT LARGE CAP GROWTH PORTFOLIO (:f/k/a AAL Aggressive Growth Portfolio); THRIVENT BALANCED FUND (f/k/a The AAL Balanced Fund); THRIVENT LARGE CAP STOCK FUND (f/k/a The AAL Ca ital Growth Fund); THRIVENT LARGE CAP VALUE FUND (f/k/a The AAL Equity Income Fund); THRIVENT LARGE CAP STOCK PORTFOLIO (f/k/a Capital Growth Portfolio); THRIVENT PARTNER TECHNOLOGY PORTFOLIO (f/k/a Technology Stock Portfolio); THRIVENT LARGE CAP INDEX FUND-I (f/k/a The AAL Large Company Index Fund); THRIVENT LARGE CAP INDEX FUND (f/k/a The AAL Large Company Index Fund II); THRIVENT BALANCED PORTFOLIO (f/k/a Balanced Portfolio); AND THRIVENT LARGE CAP INDEX PORTFOLIO (f/k/a Large Company Index Portfolio); AMERICAN CENTURY MUTUAL FUNDS, INC. - GROWTH FUND; AMERICAN CENTURY MUTUAL FUNDS, INC. - SELECT FUND; AMERICAN CENTURY MUTUAL FUNDS, INC. - ULTRA FUND; AMERICAN CENTURY MUTUAL FUNDS, INC. - BALANCED FUND; AMERICAN CENTURY MUTUAL FUNDS, INC. - CAPITAL VALUE FUND; AMERICAN CENTURY MUTUAL FUNDS, INC. - FUNDAMENTAL EQUITY FUND; AMERICAN CENTURY MUTUAL FUNDS, INC. - CAPITAL GROWTH FUND; AMERICAN CENTURY VARIABLE PORTFOLIOS, INC. - VP BALANCED FUND; AMERICAN CENTURY VARIABLE PORTFOLIOS, INC. - VP VALUE FUND; AMERICAN CENTURY VARIABLE PORTFOLIOS, INC. - VP INCOME & GROWTH FUND; AMERICAN CENTURY VARIABLE PORTFOLIOS, INC. - VP ULTRA FUND; AMERICAN CENTURY VARIABLE PORTFOLIOS, INC. - VP LARGE COMPANY VALUE FUND; AMERICAN CENTURY WORLD MUTUAL FUNDS, INC. - GLOBAL GROWTH FUND; AMERICAN CENTURY WORLD MUTUAL FUNDS, INC. - LIFE SCIENCES FUND; AMERICAN CENTURY CAPITAL PORTFOLIOS, INC. - EQUITY INCOME FUND; AMERICAN CENTURY CAPITAL PORTFOLIOS, INC. - VALUE FUND; AMERICAN CENTURY CAPITAL PORTFOLIOS, INC. - EQUITY INDEX FUND; AMERICAN CENTURY CAPITAL PORTFOLIOS, INC. - LARGE COMPANY VALUE FUND; AMERICAN CENTURY STRATEGIC ASSET ALLOCATIONS, INC. - STRATEGIC ALLOCATION: CONSERVATIVE FUND; AMERICAN CENTURY STRATEGIC ASSET ALLOCATIONS, INC. - STRATEGIC ALLOCATION: MODERATE FUND; AMERICAN CENTURY STRATEGIC ASSET ALLOCATIONS, INC. - STRATEGIC ALLOCATION: AGGRESSIVE FUND; AMERICAN CENTURY QUANTITATIVE EQUITY FUNDS, INC. - INCOME AND GROWTH FUND; AMERICAN CENTURY QUANTITATIVE EQUITY FUNDS, INC. - EQUITY GROWTH FUND; AMERICAN CENTURY TOTAL RETURN EQUITY; AMERICAN CENTURY INVESTMENT MANAGEMENT, INC. – PIGSLG; PITT COUNTY MEMORIAL HOSPITAL; MARY REYNOLDS BABCOCK FOUNDATION; DOMINICAN CONVENT OF OUR LADY OF THE ROSARY; FRANCISCAN SISTERS OF THE ATONEMENT INC.; CONGREGATION OF THE SISTERS OF ST. JOSEPH OF SPRINGFIELD INC.; SISTERS OF SAINT URSULA OF THE BLESSED VIRGIN; ELI BROWN & SONS, INC.; BOYD DE BROSSARD; THE DOLPHIN TRUST; SHARON B. DRAGER, MD P.C. PROFIT SHARING PLAN; LW & JW, LLC; PRESENTATION CAPITAL ASSET PROGRAM II; ELEANOR MILLER ALGER TTEE FBO JANE MILLER ROSS; JANE MILLER ROSS; MR. ROBERT GRAFF; JUDY LEY ALLEN; ST. THOMAS CHURCH GENERAL FUND A/C #2; KAISER PERMANENTE RETIREMENT PLAN; SISTERS OF THE HOLY CROSS INC.; FRANCISCAN SISTERS OF THE POOR FDN INC.; ANDREW JAY - HOON KIM LLC; LOS ANGELES DEPT. WATER & POWER EMPLOYEE RETIREMENT; TEAMSTERS LOCAL 500 SEVERANCE TRUST FUND; JOSEPH G. TIMPONE IRA ROLLOVER; THE JOINT INVESTMENT COMMITTEE OF THE CITY OF WICHITA RETIREMENT SYSTEMS; NORAMCO QUALITY FUNDS USA – ALGER; ALGER SPECTRA FUND, INC.; THE ALGER INSTITUTIONAL FUNDS - ALGER LARGE CAP GROWTH INSTITUTIONAL FUND; THE ALGER INSTITUTIONAL FUNDS - ALGER CAPITAL APPRECIATION INSTITUTIONAL FUND; THE ALGER FUNDS - ALGER GREEN FUND; THE ALGER INSTITUTIONAL FUNDS - ALGER BALANCED INSTITUTIONAL FUND; THE ALGER FUNDS - ALGER CAPITAL APPRECIATION FUND; THE ALGER FUNDS - ALGER GROWTH & INCOME FUND; THE ALGER FUNDS - ALGER HEALTH SCIENCES FUND; THE ALGER FUNDS - ALGER LARGE CAP GROWTH FUND; THE ALGER PORTFOLIOS - ALGER GROWTH & INCOME PORTFOLIO; THE ALGER PORTFOLIOS - ALGER LARGE CAP GROWTH PORTFOLIO; THE ALGER PORTFOLIOS - ALGER BALANCED PORTFOLIO; THE ALGER PORTFOLIOS - ALGER CAPITAL APPRECIATION PORTFOLIO; ALGER SICAV - THE ALGER AMERICAN ASSET GROWTH FUND; ALGER SICAV - ALGER U.S. LARGECAP FUND; JANUS FUND; JANUS TWENTY FUND; JANUS GROWTH AND INCOME FUND; JANUS WORLDWIDE FUND; JANUS BALANCED FUND; JAD INTECH RISK- MANAGED GROWTH FUND; JAD INTECH RISK-MANAGED CORE FUND; INTECH U.S. CORE FUND; JANUS RESEARCH FUND; JAD LARGE CAP GROWTH FUND; JAD GROWTH & INCOME FUND; JANUS FORTY FUND; JAD BALANCED FUND; JAD RESEARCH CORE FUND; JAD WORLDWIDE FUND; JANUS RESEARCH CORE FUND; JAS LARGE CAP GROWTH PORTFOLIO; JANUS ASPEN WORLDWIDE PORTFOLIO; JANUS ASPEN BALANCED PORTFOLIO; JANUS GLOBAL LIFE SCIENCES FUND; JANUS ORION FUND; JCF US ALL CAP GROWTH FUND; JCF US BALANCED FUND; JCF US TWENTY FUND; JCF GLOBAL LIFE SCIENCES FUND; JCF US RESEARCH FUND; JCF INTECH US RISK MANAGED CORE FUND; JCMLLC - INTECH RISK- MANAGED GLOBAL CORE; INTECH U.S. LARGE CAP VALUE FUND SEED ACCOUNT; JANUS INSTITUTIONAL SELECT GROWTH PORTFOLIO; INTECH US ENHANCED PLUS FUND LLC; INTECH US BROAD LARGE CAP GROWTH FUND LLC; JANUS INSTITUTIONAL LARGE CAP GROWTH PORTFOLIO; COLLEGE RETIREMENT EQUITIES FUND - STOCK ACCOUNT; TIAA-CREF MUTUAL FUNDS - EQUITY INDEX FUND (f/k/a TIAA-CREF Institutional Mutual Funds); TIAA-CREF MUTUAL FUNDS - GROWTH & INCOME FUND (f/k/a TIAA-CREF Institutional Mutual Funds); TIAA-CREF MUTUAL FUNDS - GROWTH EQUITY FUND (f/k/a TIAA-CREF Institutional Mutual Funds); TIAA-CREF MUTUAL FUNDS - SOCIAL CHOICE EQUITY FUND (f/k/a TIAA- CREF Institutional Mutual Funds); TIAA- CREF ASSET MANAGEMENT COMMINGLED FUNDS TRUST I - ANALYSTS PORTFOLIO FUND; TIAA- CREF ASSET MANAGEMENT COMMINGLED FUNDS TRUST I – LARGE-CAP VALUE FUND; TIAA-CREF ASSET MANAGEMENT COMMINGLED FUNDS TRUST I - LARGE-CAP GROWTH FUND; TIAA SEPARATE ACCOUNT VA- 1 - STOCK INDEX ACCOUNT; TIAA- CREF FUNDS - TIAA-CREF EQUITY INDEX FUND; TIAA-CREF FUNDS - TIAA-CREF GROWTH & INCOME FUND; TIAA-CREF FUNDS - TIAA-CREF GROWTH EQUITY FUND; TIAA-CREF FUNDS - TIAA-CREF LARGE-CAP VALUE FUND; TIAA-CREF FUNDS - TIAA-CREF LARGE-CAP VALUE INDEX FUND; TIAA-CREF FUNDS - TIAA-CREF S&P 500 INDEX FUND; TIAA-CREF FUNDS - TIAA-CREF SOCIAL CHOICE EQUITY FUND; TIAA-CREF LIFE FUNDS - GROWTH & INCOME FUND; AND TIAA-CREF LIFE FUNDS - GROWTH EQUITY FUND, PLAINTIFFS, v. PFIZER INC.; HENRY A. McKINNELL; JOHN L. LaMATTINA; KAREN L. KATEN; JOSEPH M. FECZKO; AND GAIL CAWKWELL, DEFENDANTS. TABLE OF CONTENTS I. INTRODUCTION .............................................................................................................. 1 II. NATURE AND SUMMARY OF THE ACTION .............................................................. 2 III. JURISDICTION AND VENUE ....................................................................................... 18 IV. THE PARTIES.................................................................................................................. 18 A. Plaintiffs ................................................................................................................ 18 B. Defendants ............................................................................................................ 26 V. PFIZER DEVELOPS CELEBREX AND BEXTRA AS A SAFE ALTERNATIVE TO TRADITIONAL NSAIDS ............................................................. 31 A. The Safety Risks Associated With Traditional, Non-Selective NSAIDs ................................................................................................................. 31 B. Discovery Of The COX-2 Enzyme Raises Hopes For A Selective NSAID That Is Safer Than Traditional Pain Killers ............................................. 32 C. Pfizer Enters The Race For The First COX-2 Inhibitor ........................................ 33 D. Pfizer Successfully Launches Celebrex In 1999 ................................................... 38 E. Pfizer Successfully Launches Bextra In 2001 ...................................................... 39 F. Pfizer Significantly Increases Its Financial Stake In The COX-2 Market ................................................................................................................... 40 G. Celebrex And Bextra Become Critical To Pfizer’s Overall Financial Results ................................................................................................... 41 VI. DEFENDANTS CONSISTENTLY EMPHASIZE THE CARDIOVASCULAR SAFETY AND COMMERCIAL IMPORTANCE OF CELEBREX AND BEXTRA .........................................................