Atlas of Genetics and Cytogenetics in Oncology and Haematology Home Genes Leukemias Tumors Cancer prone Deep Insight Case Reports Portal Journals Teaching X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA Atlas Journal Atlas Journal versus Atlas Database: the accumulation of the issues of the Journal constitutes the body of the Database/Text-Book. TABLE OF CONTENTS Volume 11, Number 4, Oct-Dec 2007 Previous Issue / Next Issue Genes WWOX (16q23.1). Teresa Druck, Hoda Hagrass, Kay Huebner. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 499-506. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/WWOXID508ch16q23.html VRK1 (14q32.2). Pedro A. Lazo, Francisco M. Vega, Ana Sevilla, Alberto Valbuena, Marta Sanz-Garcia, Inmaculada Lopez-Sanchez, Sandra Blanco. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 507-514. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/VRK1ID43556ch14q32.html SPINK7 (5q33.1). Xiying Yu, Shih-Hsin Lu. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 515-519. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/SPINK7ID40396ch5q33.html PPM1D (17q23). Dmitry Bulavin, Oleg Demidov. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 520-525. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/PPM1DID41803ch17q23.html P53; TP53 (17p13) - updated. Magali Olivier. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 526-535. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/P53ID88.html LOXL4 (10q24.2). Kornelia Molnarne Szauter, Tibor Gorogh, Katalin Csiszar. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 536-541. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/LOXL4ID41193ch10q24.html Atlas Genet Cytogenet Oncol Haematol 2007; 4 I ITK (5q33.3). Berthold Streubel. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 542-546. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/ITKID43329ch5q33.html.html IKZF2 (2q34). Rupa Sridharan, Stephen Smale. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 547-551. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/IKZF2ID42885ch2q34.html EBAG9 (8q23.2). Ahmad Faried, Leri S. Faried. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 552-556. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/EBAG9ID40393ch8q23.html DKK1 (10q11.2). Oscar Aguilera, Alberto Munoz. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 557-562. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/DKK1ID44007ch10q11.html AKAP9 (7q21.2). Raffaele Ciampi, Yuri E Nikiforov. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 563-566. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/AKAP9ID42999ch7q21.html S100B (21q22.3). M Rosario Fernandez-Fernandez, Alan R Fersht. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 567-573. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/S100BID42195ch21q22.html PTGS2 (1q31.1). Panagiotis A Konstantinopoulos, Michalis V Karamouzis, Athanasios G Papavassiliou. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 574-580. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/PTGS2ID509ch1q31.html PLCB2 (15q15). Valeria Bertagnolo, Federica Brugnoli, Mascia Benedusi, Silvano Capitani. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 581-587. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/PLCB2ID41743ch15q15.html MME (3q25.2). Emina E Torlakovic. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 588-597. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/MMEID41386ch3q25.html GRB2 (17q25.1). Gagani Athauda, Donald P Bottaro. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 598-608. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/GRB2ID386ch17q25.html CENTG1 (12q14.1). Chan Chi Bun, Ye Keqiang. Atlas Genet Cytogenet Oncol Haematol 2007; 4 II Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 609-614. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/CENTG1ID44037ch12q14.html CARD8 (19q13.32). Frank A Kruyt. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 615-620. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/CARD8ID913ch19q13.html ARHGEF2 (1q22). Valery Poroyko, Anna Birukova. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 621-625. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/ARHGEF2ID43150ch1q22.html Leukaemias t(7;9)(q11;p13). Marina Bousquet, Nicole Dastugue, Pierre Brousset. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 626-628. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Anomalies/t0709q11p13ID1195.html t(6;8)(q27;p12). José Luis Vizmanos. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 629-634. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Anomalies/t68ID1090.html t(5;9)(q33;q22). Berthold Streubel. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 635-638. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Anomalies/t0509q33q22ID1458.html T-lineage acute lymphoblastic leukemia (T-ALL). Susana C Raimondi. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 639-660. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Anomalies/TALLID1374.html t(9;11)(p22;p15). Cristina Morerio, Claudio Panarello. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 661-663. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Anomalies/t0911p22p15ID1232.html Solid Tumours Thyroid: Papillary Carcinoma with inv(7)(q21q34). Raffaele Ciampi, Yuri E. Nikiforov. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 664-667. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Tumors/PapilThyrCarcinv7ID5459.html Soft Tissue Tumors: t(X;20)(p11.23;q13.33) in Biphasic Synovial Sarcoma. Clelia Tiziana Storlazzi, Fredrik Mertens. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 668-669. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Tumors/SynovialSarcomtX20ID5464.html Soft Tissue Tumors: Aggressive angiomyxoma. Francesca Micci, Petter Brandal. Atlas Genet Cytogenet Oncol Haematol 2007; 4 III Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 670-676. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Tumors/AggresAngiomyxomaID5203.html Posterior uveal melanoma - updated. Marco Castori, Paola Grammatico. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 677-684. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Tumors/UvealmelanomID5047.html Neurofibroma. Lan Kluwe, Christian Hagel, Victor Mautner. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 685-690. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Tumors/NeurofibromaID5098.html Head and Neck: Pleomorphic salivary gland adenoma with inv(8)(q12q12) (CHCHD7/PLAG1). Julia Asp, Goran Stenman. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 691-693. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Tumors/SalivAdenCHCHD7PLAG1ID5431.html Head and Neck: Pleomorphic salivary gland adenoma with ins(8)(q12;q11q11) (TCEA1- PLAG1). Julia Asp, Goran Stenman. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 694-696. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Tumors/SalivAdenTCEA1PLAG1ID5430.html Cancer Prone Diseases Hemihyperplasia isolated. Shubha R Phadke. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 697-699. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Kprones/HemihyperplasiaID10046.html Deep Insights Case Reports inv(8)(p11.2q13) found in a patient with chronic myelomonocytic leukemia that progressed to acute myeloid leukemia. Jennifer JS Laffin, Sara J Morrison-Delap, Wayne A Bottner, Eric B Johnson, Patricia Howard- Peebles, Kate J Thompson, Gordana Raca, Karen D Montgomery, Daniel F Kurtycz. Atlas Genet Cytogenet Oncol Haematol 2007; Vol 11: 700-703. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Reports/08LaffinID100027.html Educational Items © Atlas of Genetics and Cytogenetics in Oncology and Haematology X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA Home Genes Leukemias Tumors Cancer prone Deep Insight Case Reports Portal Journals Teaching For comments and suggestions or contributions, please contact us [email protected]. Atlas Genet Cytogenet Oncol Haematol 2007; 4 IV Atlas of Genetics and Cytogenetics in Oncology and Haematology WWOX (WW domain containing oxidoreductase) Identity Other names FOR murine name WOX1 Hugo WWOX Location 16q23.1 DNA/RNA Description WWOX is comprised of 9 coding exons in a region of approximately one million base pairs that includes the common fragile site FRA16D. Transcription RT-PCR amplification of Wwox in normal and tumor cDNA samples has shown products apparently originating from alternative transcripts or transcript variants, respectively. Expressed truncated proteins have not been detected. Pseudogene None reported. Protein Atlas Genet Cytogenet Oncol Haematol 2007; 4 499 Alignment of human (hWwox), mouse (Mwwox), fly (fWwox), mosquito (moWwox) and worm (ceWwox) Wwox proteins. The locations of the WW1 and WW2 domains are shown, as well as the predicted sites for nuclear localization, NADP binding, mitochondrial targeting, substrate binding and a proton acceptor. Description WWOX is a 414 amino acid protein that contains two WW domains and a short-chain dehydrogenase/reductase (SDR) domain. Expression WWOX is highly expressed in secretory epithelial cells of reproductive, endocrine and exocrine organs and is expressed in all or most other tissues at a lower level. The protein is not expressed or is expressed at low level in many tumor types, including breast, pancreatic,