Tech Help: Email: [email protected] | Toll Free: 800.891.9699 (US Only) | Enzyme Inhibitors Enzymes are biological catalysts that drive various reactions within a cell. They are required for nearly every function of a living cell/organism from digestion of food to the synthesis of DNA. Enzymes are usually very specific as to which reactions they catalyze and the substrates that are involved. Enzyme activity can be modulated by different classes of molecules. Enzyme Inhibitors are molecules that bind to the enzyme and decrease or completely stop their function. Since blocking the activity of an enzyme can have profound effects on the downstream cellular events sometimes with pathological or disease consequences, enzyme inhibition is a crucial component of new drug design. The discovery of new and potent enzyme inhibitors and developing better classes of inhibitors constitutes a dynamic branch of biochemical and pharmacological research in the area of Diabetes, Cancer, HIV and many more. BioVision offers a comprehensive collection of more than 800 enzyme inhibitors covering all the core biological/pharmacological research areas. ACAT (Acyl-CoA cholesteryl Acyl Transferase) Inhibitors Product Name Cat. No. Size CAS. No. Product Name Cat. No. Size CAS. No. Arecoline hydrobromide B1824 100 mg, 500 mg 300-08-3 Endostatin, human recombinant 4759 20 μg, 100 μg, 1 mg N/A Avasimibe 9506 5 mg, 25 mg 166518-60-1 Endostatin, human recombinant 4799 100 μg, 1 mg N/A Naringenin 1772 250 mg, 1 g 480-41-1 Fumagillin 2368 1 mg, 5 mg 23110-15-8 Pellitorine 2053 1 mg, 5 mg 18836-52-7 Isoxanthohumol 2529 5 mg, 25 mg 70872-29-6 Penicillide B1245 250 µg, 1 mg 55303-92-9 2-Methoxyestradiol 2166 5 mg, 25 mg 362-07-2 Pyripyropene A B1910 500 µg, 1 mg 147444-03-9 SKLB610 2610 5 mg, 25 mg 1125780-41-7 Terpendole C 2214 250 µg, 1 mg 156967-65-6 Thiabendazole 2161 1 g 148-79-8 TMP-153 B1181 10 mg, 50 mg 128831-46-9 Tranilast 1876 10 mg, 50 mg 53902-12-8 ACC (Acetyl-CoA Carboxylase) Inhibitors Angiotensin Receptor Antagonists Product Name Cat. No. Size CAS. No. Product Name Cat. No. Size CAS. No. ACC2 Inhibitor 1717 1 mg, 5 mg N/A BIBS39 B1071 5 mg, 25 mg 133085-33-3 CP-640186 9422 5 mg, 25 mg 591778-68-6 EXP-3174 9672 5 mg, 25 mg 124750-92-1 CP-640186 hydrochloride B1254 5 mg, 25 mg 591778-70-0 Losartan potassium 2750 50 mg, 250 mg 124750-99-8 Valsartan 2004 25 mg, 100 mg, 500 mg 137862-53-4 ACE (Angiotensin-Converting Enzyme) Inhibitors Product Name Cat. No. Size CAS. No. Arginase Inhibitors ACE2 Inhibitor, DX600 9687 100 µg, 500 µg, 1 mg N/A Product Name Cat. No. Size CAS. No. Captopril B1187 1 g, 5 g 62571-86-2 BEC 2359 1 mg, 5 mg 63107-40-4 Adenylase Cyclase Inhibitors Aromatase Inhibitors Product Name Cat. No. Size CAS. No. Product Name Cat. No. Size CAS. No. 2',5'-Dideoxyadenosine 2770 5 mg, 25 mg 6698-26-6 Exemestane 9473 5 mg, 25 mg 107868-30-4 KH7 2350 5 mg, 25 mg 330676-02-3 ATPase Inhibitors PACAP (human, chicken, mouse, ovine, B1562 100 μg, 500 μg 143748-18-9 porcine, rat) (6-38) Product Name Cat. No. Size CAS. No. SQ 22536 2019 5 mg, 25 mg 17318-31-9 Bafilomycin A1 1829 50 µg, 250 µg 88899-55-2 (-)-Blebbistatin 2406 1 mg, 5 mg 856925-71-8 AKR (Aldo-Keto Reductase) Inhibitors (+)-Blebbistatin 2407 1 mg, 5 mg 1177356-70-5 Product Name Cat. No. Size CAS. No. (±)-Blebbistatin 2405 5 mg, 25 mg 674289-55-5 AKR1C3 Inhibitor I 2403 5 mg, 25 mg N/A Bufalin 2509 10 mg, 50 mg 465-21-4 AKR1C3 Inhibitor II 2404 5 mg, 25 mg N/A Autophagy Inhibitors AKR1C3 Inhibitor III 2424 5 mg, 25 mg N/A Product Name Cat. No. Size CAS. No. Androgen Receptor Antagonists ATM Kinase Inhibitor, KU-55933 1685 5 mg 587871-26-9 Product Name Cat. No. Size CAS. No. Bafilomycin A1 1829 50 µg, 250 µg 88899-55-2 ARN-509 9535 5 mg, 25 mg 956104-40-8 Chloroquine Diphosphate 1825 100 mg, 500 mg 50-63-5 MDV-3100 9479 10 mg, 50 mg 915087-33-1 EZSolution™ Gö 6976 1785 500 µg 136194-77-9 ODM-201 9668 5 mg, 25 mg 1297538-32-9 Gö 6976 1711 500 µg 136194-77-9 Angiogenesis Inhibitors 3-Methyladenine 2249 25 mg, 100 mg 5142-23-4 Spautin-1 2037 5 mg, 25 mg 1262888-28-7 Product Name Cat. No. Size CAS. No. Angiostatin Human 4919 100 μg, 500 μg N/A Bcl-2 (B-cell lymphoma 2) Inhibitors Angiostatin K1-3, human recombinant 4920 20 μg, 100 μg, 1 mg N/A Product Name Cat. No. Size CAS. No. BIBF1120 2167 5 mg, 25 mg 928326-83-4 A-1155463 B1821 5 mg, 25 mg 1235034-55-5 Borrelidin 2367 250 µg, 1 mg 7184-60-3 A-1210477 B1826 5 mg, 25 mg 1668553-26-1 Castanospermine 2293 10 mg, 50 mg 79831-76-8 A-1331852 B1948 5 mg, 25 mg 1430844-80-6 Ordering: Email: [email protected] | Tel:408.493.1800 | Web: www.biovision.com 2 Product Name Cat. No. Size CAS. No. Product Name Cat. No. Size CAS. No. ABT-263 2467 5 mg, 25 mg 923564-51-6 110044-82-1 DiscoveryPak™ Calpain Inhibitors Set 136632-32-1 ABT-737 2463 5 mg, 25 mg 852808-04-9 (Containing Cat. No. 1834, 1835, 1506, S228 1 Set 133410-84-1 AT-101 2380 5 mg, 25 mg 90141-22-3 2195, 1906) 88191-84-8 BCl-2 Inhibitor GX15-070 2040 5 mg 803712-67-6 179528-45-1 MDL 28170 2195 10 mg, 50 mg 88191-84-8 BCl-2 Inhibitor, ABT-199 2253 1 mg, 5 mg 1257044-40-8 1257044-40-8 PD 150,606 1906 5 mg, 25 mg 179528-45-1 DiscoveryPak™ Bcl2 Inhibitors Set 923564-51-6 (Containing Cat. No. 2253, 2467, 2463, S229 1 Set 852808-04-9 Caspase & Granzyme B Inhibitors 2380, 2040) 90141-22-3 Product Name Cat. No. Size CAS. No. 803712-67-6 Ac-DEVD-CHO B1951 1 mg, 5 mg 169332-60-9 BDA366 B1827 5 mg, 25 mg 1909226-00-1 Apoptosis inhibitor 2783 5 mg, 25 mg 54135-60-3 BH3I-1 B1277 5 mg, 25 mg 300817-68-9 AZ10417808 2786 1 mg, 5 mg 331645-84-2 CC-122 B1650 5 mg, 25 mg 1015474-32-4 Biotin-DEVD-FMK 1124 20 µl (10 mM) N/A CID-5721353 B1275 5 mg, 25 mg 301356-95-6 Biotin-IETD-FMK 1121 20 µl (10 mM) N/A HA14-1 B1832 5 mg, 25 mg 65673-63-4 Biotin-VAD-FMK 1123 20 µl (10 mM) 1135688-15-1 Pyridoclax B1817 1 mg, 5 mg 1651890-44-6 Biotin-VDVAD-FMK 1032 20 µl (10 mM) N/A S63845 B1819 250 μg, 1 mg 1799633-27-4 Boc-D-FMK 1160 1 mg, 5 mg 187389-53-3 TW-37 2789 5 mg, 25 mg 877877-35-5 Caspase Family Inhibitor Set K107 5 x 25 µl N/A WEHI-539 B1818 5 mg, 25 mg 1431866-33-9 Caspase Family Inhibitor Set II K108 7 x 25 µl N/A BMP (Bone Morphogenetic Protein) Inhibitors Caspase Family Inhibitor Set III K210 8 x 25 µl N/A Product Name Cat. No. Size CAS. No. Caspase Family Inhibitor Set IV K220 12 x 25 µl N/A DMH-1 9542 5 mg, 25 mg 1206711-16-1 Caspase Inhibitor Boc-D-FMK 1120 20 µl (10 mM) 187389-53-3 EZSolution™ LDN193189 2092 5 mg 1062368-24-4 Caspase-1 Inhibitor Z-YVAD-FMK 1012 20 µl (10 mM), 100 µl (2 mM) N/A LDN193189 1995 5 mg, 25 mg 1062368-24-4 Caspase-10 Inhibitor AEVD-FMK 1112 20 µl (10 mM), 100 µl (2 mM) 1135688-47-9 Caspase-12 Inhibitor Z-ATAD-FMK 1079 20 µl (10 mM), 100 µl (2 mM) N/A Bone Resorption Inhibitors Caspase-13 Inhibitor LEED-FMK 1115 20 µl (10 mM), 100 µl (2 mM) N/A Product Name Cat. No. Size CAS. No. Caspase-2 Inhibitor Z-VDVAD-FMK 1073 20 µl (10 mM), 100 µl (2 mM) N/A Alendronate sodium 2168 50 mg, 250 mg 121268-17-5 Caspase-3 Inhibitor Q-DEVD-Oph 1175 1 mg, 3 mg, 5 mg N/A Pamidronate disodium 1884 50 mg, 250 mg 57248-88-1 Caspase-3 Inhibitor Z-DEVD-FMK 1009 20 µl (10 mM), 100 µl (2 mM) 210344-95-9 Zoledronic acid hydrate 2653 10 mg, 50 mg 165800-06-6 Caspase-3 inhibitor, Z-DQMD-FMK 2782 1 mg, 5 mg N/A Bromodomain Inhibitors Caspase-3/7 Inhibitor 2780 1 mg, 5 mg 220509-74-0 Caspase-4 Inhibitor Z-LEVD-FMK 1108 20 µl (10 mM), 100 µl (2 mM) N/A Product Name Cat. No. Size CAS. No. Caspase-5 Inhibitor Z-WEHD-FMK 1100 20 µl (10 mM), 100 µl (2 mM) N/A BAZ2-ICR B1865 5 mg, 25 mg 1665195-94-7 Caspase-6 Inhibitor Z-VEID-FMK 1011 20 µl (10 mM), 100 µl (2 mM) N/A BI-7273 B1879 5 mg, 25 mg 1883429-21-7 Caspase-8 Inhibitor Z-IETD-FMK 1064 20 µl (10 mM), 100 µl (2 mM) N/A BI-9564 B1880 5 mg, 25 mg 1883429-22-8 Caspase-8 Inhibitor, Q-IETD-Oph 1176 1 mg, 3 mg, 5 mg N/A Bromodomain Inhibitor, (+)-JQ1 2070 1 mg, 5 mg 1268524-70-4 Caspase-9 Inhibitor Z-LEHD-FMK 1074 20 µl (10 mM), 100 µl (2 mM) N/A Bromosporine 2652 1 mg, 5 mg 1619994-69-2 Caspase-9 Inhibitor, Q-LEHD-Oph 1177 1 mg, 3 mg, 5 mg N/A CPI-0610 B1201 5 mg, 25 mg 1380087-89-7 Caspase-Family Inhibitor Z-VAD-FMK 1010 20 µl (10 mM), 100 µl (2 mM) 187389-52-2 CPI-203 9404 1 mg, 5 mg 1446144-04-2 EMAP-II Inhibitor Z-ASTD-FMK 1127 20 µl (10 mM) N/A GSK-2801 9553 5 mg, 25 mg 1619994-68-1 FITC-DEVD-FMK 9499 100 Assays N/A I-BET151 2220 1 mg, 5 mg 1300031-49-5 FITC-IETD-FMK 9533 100 Assays N/A I-BET726 B1569 5 mg, 25 mg 1300031-52-0 FITC-LEHD-FMK 9534 100 Assays N/A I-BET762 2628 1 mg, 5 mg 1260907-17-2 FITC-VAD-FMK 9497 100 Assays N/A I-CBP112 9405 1 mg, 5 mg N/A FITC-VDVAD-FMK 9498 100 Assays N/A EZSolution™ (+)-JQ1 2091 1 mg 1268524-70-4 FMK Negative Control 1122 20 µl (10 mM), 100 µl (2 mM) 197855-65-5 (-)-JQ1 2384 1 mg 1268524-71-5 Granzyme B Inhibitor Ac-IEPD-CHO 1119 1 mg N/A Mivebresib B1564 5 mg, 25 mg 1445993-26-9 Granzyme B Inhibitor Z-AAD-CH2Cl 1128 20 µl (10 mM) N/A MS436 2680 5 mg, 25 mg 1395084-25-9 Ivachtin 2788 1 mg, 5 mg 745046-84-8 OF-1 9592 5 mg, 25 mg 919973-83-4 Pan-caspase inhibitor, Q-VD(OMe)-Oph 2787 1 mg, 5 mg N/A OTX015 2651 1 mg, 5 mg 202590-98-5 EZSolution™ Q-DEVD-Oph 1178 1 mg N/A PFI-1 2203 1 mg, 5 mg 1403764-72-6 EZSolution™ Q-VD-Oph 1173 1 mg 1135695-98-5 PFI-3 2895 5 mg, 25 mg 1819363-80-8 Q-VD-OPh 1170 1 mg, 3 mg, 5 mg 1135695-98-5 RVX-208 9408 1 mg, 5 mg 1044870-39-4 EZSolution™ Q-VD-OPh, Negative Control 1174 1 mg N/A SGC-CBP30 9554 5 mg, 25 mg 1613695-14-9 QVD-OPh Negative Control 1171 1 mg, 3 mg, 5 mg N/A Calpain Inhibitors VX-765 2781 5 mg, 25 mg 273404-37-8 Product Name Cat.