Authors: Peter D. Karp Suzanne Paley Julio Collado-Vides Ingrid Keseler Markus Krummenacker Cesar Bonavides-Martinez An online version of this diagram is available through EcoCyc.org and may be used for analysis of omics datasets. Lines in the diagram correspond to reactions; nodes correspond to metabolites. Carol Fulcher Ian Paulsen Socorro Gama-Castro Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways in the right, and signaling pathways in the bottom-left. Pathways are colored according to their cellular function, such as biosynthesis of cofactors. Reactions not assigned to any pathway are in the far right of the cytoplasm. EcoCyc: Escherichia coli K-12 MG1655 Cellular Overview In the inner and outer membranes are transporters (with arrows) and other membrane proteins. In the periplasm are periplasmic enzymes and other periplasmic proteins. Connections between pathways are omitted for legibility.