The 5th Kyoto University— Inamori Foundation Joint Kyoto Prize Symposium Balancing between Construction and Destruction in Life July, 22 [Sun] 2018, 13:00 — Yurakucho Asahi Hall, Tokyo CONTENTS Balancing between Construction and Destruction in Life Welcome Addresses Juichi Yamagiwa, President, Kyoto University 4 Kazutoshi Mori Kazuo Inamori, President, Inamori Foundation 5 Concept 6 Shin-Ichi Fukuoka Program 7 Invited Speakers & Abstracts of Lectures 1. “What is Life? It is Dynamic Equilibrium.” Shin-Ichi Fukuoka 8 2. “Unfolded Protein Response: Cellular Response that Controls Quality of Proteins” 2 Kazutoshi Mori 10 3 2012 Kyoto Prize Laureate 3. “Cell Death and Fate of Dead Cells” Shigekazu Nagata in Basic Sciences Shigekazu Nagata 12 Yoshinori Ohsumi 4. “Autophagy Revealed from Studies on Tiny Cell, Yeast” Yoshinori Ohsumi 14 KUIP Organizing Committee 16 Archives 18 e 5th Kyoto University—Inamori Foundation Memo 21 Joint Kyoto Prize Symposium http://kuip.hq.kyoto-u.ac.jp/en/ Kyoto University—Inamori Foundation Joint Kyoto Prize Symposium WELCOME ADDRESS Juichi Yamagiwa Kazuo Inamori President, Kyoto University President, Inamori Foundation The Kyoto University-Inamori Foundation Joint Kyoto Prize Symposium (KUIP) is an annual international symposium It gives me great pleasure to co-host the 5th Kyoto University-Inamori Foundation Joint Kyoto Prize Symposium. hosted by Kyoto University in cooperation with the Inamori Foundation. On behalf of Kyoto University, I would like I would like to take this opportunity to sincerely thank you all for joining us here, today. I am especially grateful to take this opportunity to express our gratitude to President Kazuo Inamori and the Inamori Foundation for their to our wonderful guest speakers who have made time in their busy schedules to deliver lectures for us, and to ongoing support of Kyoto University and our activities. President Juichi Yamagiwa and everyone from Kyoto University for their dedicated efforts toward making this annual symposium a reality. The 34th award ceremony for the Kyoto Prize, one of Japan’s most prominent internationally recognized accolades, will be held in 2018. The award was conceived by Dr. Kazuo Inamori, president of the Inamori Foundation and an The Inamori Foundation was established in 1984 as an international foundation, and launched programs of public honorary fellow of Kyoto University, as a means to contribute to the advancement and development of humanity. In recognition and the support of creative activities to foster science, culture, and the enrichment of the human spirit, 2014, on the occasion of the award’s 30th anniversary, Kyoto University launched the Joint Kyoto Prize Symposium as well as through social contributions. That year also saw the inauguration of the international award known as the as an annual event with the aim of raising international awareness of the award. Kyoto Prize, which was all about my conviction that “people have no higher calling than to strive for the greater good 4 of humankind and society.” I had long wished to give something back to the society that had so warmly nurtured me 5 From 2014 to 2017, the symposium focused on the three categories and twelve fields of the Kyoto Prize, throughout my life, and I hoped that creation of an award to encourage researchers, who dedicate themselves day and each year it adopted as its themes the three fields in which the prize would be awarded two years later. and night to their research, would expedite progress of their research activities, thereby contributing to the progress The most accomplished and currently relevant researchers and specialists in those fields were invited to speak at and development of humanity. The Kyoto Prize embodies those ideas. Over the years, we have honored many the symposium. individuals who have made outstanding contributions to the scientific, cultural, and spiritual betterment of humankind The symposium’s lectures provided a platform for fresh encounters between scholars in diverse academic fields, in the three categories of Advanced Technology, Basic Sciences, and Arts and Philosophy. which would in turn lead to the development of new knowledge and contribute to the cultivation of the next Ever since the Inamori Foundation’s establishment, Kyoto University has demonstrated its deep appreciation for the generation of researchers. The symposium sought to contribute to the development of cutting edge technology and work of our Foundation and has offered its most generous cooperation. And, since 2014, it has helped us to increase new academic advances, the benefits of which were to be shared widely throughout society. recognition of the Kyoto Prize through this Symposium, which is held by the university and co-hosted by the Inamori From 2018, the KUIP Symposium will be held in Tokyo. The symposium is to focus on the outstanding field of Foundation. The Symposium began as an event to showcase latest trends in and attractive aspects of cutting-edge the main presenter, who is the laureate of the Kyoto Prize. The symposium consists of four notable scholars scholarship and the arts by inviting to Kyoto world-leading scientists and artists active in fields for which the Kyoto including the laureate. This will ensure that the symposium reflects the interdisciplinary spirit of the Kyoto Prize in Prize would be awarded two years later. encouraging interaction among diverse fields of study and kaleidoscope of viewpoints. Having completed the first four-year round, we have decided to hold this annual Symposium in Tokyo, as of 2018, The scholars of Kyoto University not only organize the symposium but also participate in the lectures as speakers. and to invite and focus on the achievements of a previous Kyoto Prize laureate with the help of scientists and We believe that the symposium will provide you great opportunity to experience the cutting-edge of academic researchers who are playing leading roles in the same field. This year, we are honored to welcome Dr. Yoshinori research. Ohsumi, recipient of the 2012 Kyoto Prize in Basic Sciences and the 2016 Nobel Prize in Physiology or Medicine, together with three notable researchers who are working at the forefront of the field. This year’s theme is “Balancing I hope that you will continue to support and enjoy future editions of the Joint Kyoto Prize Symposium, and I hope between Construction and Destruction in Life.” We hope that this event will give you an opportunity to empathize with that through our endeavors we can promote the Kyoto Prize and contribute to the further development of Kyoto as the philosophy shared by Kyoto University and the Inamori Foundation, which is to realize “contributions to harmony a city of culture and scholarship. within the human and ecological communities on this planet,” “advancement and integration of scientific and spiritual wisdom in diverse fields,” and “transmission of unsurpassed knowledge.” It is my sincere hope that the Kyoto University-Inamori Foundation Joint Kyoto Prize Symposium will become widely recognized among researchers around the world as an attractive event and will continue to enjoy public favor for many years to come. Kyoto University—Inamori Foundation Joint Kyoto Prize Symposium CONCEPT PROGRAM The Kyoto University-Inamori Foundation Joint Kyoto Prize Symposium (KUIP) is held annually by Kyoto University and July 22 (Sun.) 2018 co-hosted by the Inamori Foundation. The symposium features notable scholars, researchers, and artists working in the designated fields of the Kyoto Prize, one of the most prestigious international awards in Japan. By providing a meeting place for researchers and artists in diverse fields and a venue for the presentation of new academic 13:00 — 13:15 Opening Ceremony and artistic developments, the symposium seeks to showcase cutting-edge scholarship and art across disciplinary boundaries and contribute to fostering the next generation of scholars. The symposium’s lectures and events aim to appeal not only to academics and artists, but also to the general public. Shin-Ichi Fukuoka 13:15 — 13:55 Biologist / Professor, School of Cultural and What is life? It is Dynamic Equilibrium. Creative Studies, Aoyama Gakuin University / Background and Objectives Visiting Professor, Rockefeller University The Kyoto University-Inamori Foundation Joint Kyoto Prize Symposium (KUIP) was established in 2014 to mark the Kazutoshi Mori Unfolded Protein Response: 30th anniversary of the Inamori Foundation and the Kyoto Prize. 13:55 — 14:35 Professor, Graduate School of Science Cellular Response that Controls Quality Kyoto University The Kyoto Prize is based on a unique philosophy and selection process, and is widely regarded as one of the most of Proteins prestigious international awards for lifetime achievement in the sciences, engineering, arts, and philosophy. It is our hope that, through raising international awareness of the Kyoto Prize and spotlighting its laureates, we will contribute 14:35 — 14:55 Break to the advancement of scholarship and the recognition of its achievements. Through holding the KUIP Symposium we aim to advance Kyoto University’s mission to contribute to harmonious coexistence within the Earth’s human and ecological community. Shigekazu Nagata 14:55 — 15:35 Distinguished Professor, Immunology Frontier Cell Death and Fate of Dead Cells Research Center (IFReC), Osaka University To achieve this goal, Kyoto University has hosted an international symposium annually from 2014 to 2017 at the university’s Clock Tower Centennial Hall, focusing on the three categories and twelve fields in which the Kyoto Prize 6 7 is awarded. A great number of participants, including researchers, students, and people from all walks of life have 2012 Kyoto Prize Laureate in Basic Sciences attended the symposium each year. Autophagy Revealed from Studies on 15:35 — 16:15 Yoshinori Ohsumi Starting from 2018, the KUIP symposium will be held in Tokyo under the following concepts. With its new location Honorary Professor, Institute of Innovative Research Tiny Cell, Yeast and format, we hope that the KUIP Symposium will continue to celebrate the Kyoto Prize, and encourage aspiring Tokyo Institute of Technology artists and researchers of the world.