Supplementary Table I. List of the active principles divided according to the target apparatus and pharmacological mechanisms of action, with indication of the type of side effect using a number from 1 to 4 (1: ototoxic drugs; 2: drugs inducing tinnitus; 3: drugs inducing vertigo or dizziness; 4: drugs inducing generic hearing disorders). Sub-lists A1-A2-A3-A4 show the active principles sorted by type of audio-vestibular side effect (A1: ototoxic drugs; A2: drugs inducing tinnitus; A3: drugs inducing vertigo or dizziness; A4: drugs inducing vertigo or dizziness). Gastrointestinal System – Amiloride hydrochloride+furosemide . .1,2 – Furosemide . 1 Antispasmotic and other drugs used for intestinal motility – Furosemide with triamterene. 1,2 disorders (usually in renal impairment or in hypoproteinaemia) • Antimuscarinic – Torasemide. .1 – Butylscopolamine bromide . .3 • Potassium-sparing and other diuretics – Propantheline bromide . .3 – Amiloride and hydrochlorothiazide . 2,3 – Sulphate atropine . .3 – Spironolactone with furosemide. .2 Antisecretory and protective drugs on gastric mucosa Anti-arrhythmics • H2 blockers • Class IB – Cimetidine. .3 – Lidocaine hydrochloride. 2 – Famotidine. 3 • Class IC – Nizatidine . .3 – Flecainide acetate . .2,3 – Ranitidine . .3 – Propafenone hydrochloride . 3 • Chelates and complexes • Class III – Sucralfate . 3 – Amiodarone hydrochloride . 1,3 • Ventricular arrhythmias • Prostaglandins analogues – Mexiletine hydrochloride . 3 – Misoprostol. .3 • Others • Proton pump inhibitors Adenosine. 2 – Esomeprazole . 3 Beta blockers – Lansoprazole. 3 – Acebutolol.. 3 – Omeprazole . .3 – Atenolol. .. 3 – Pantoprazole . 3 – Atenolol + diuretics. .3 – Rabeprazole sodium . 3 – Atenolol + calcium channel blockers. 3 Anti-diarrheal drugs – Bisoprolol fumarate . 3 • Gastrointestinal motility inhibitors – Bisoprolol fumarate + diuretics. .3 – Loperamide hydrochloride . .3 – Carvedilol. 3 Chronic intestinal disorders – Celiprolol hydrochloride . 3 • Aminosalicylates – Esmolol hydrochloride . 3 – Sulfasalazine . 2,3 – Metoprolol tartrate . 2,3 • Cytokines inhibitors – Metoprolol + diuretics . 3 – Infliximab . 3 – Nadolol . .2,3 – Nebivolol . .3 Cardiovascular System – Oxprenolol + diuretics . 3 – Pindolol . 3 Positive inotropes – Propranolol hydrochloride . 3 • Cardiac glycoside – Sotalol hydrochloride . .3 – Digitoxin . .. 3 – Timolol maleate . 2,3 – Digoxin . .. 3 Hypertension and heart failure Diuretics • Anti-hypertensive vasodilators • Thiazide and related diuretics – Sildenafil . 3 – Chlorthalidone . .. .3 – Sodium nitroprusside. 3 – Hydrochlorotiazide . .3 (related with rapid reduction of blood pressure) – Indapamide . 3 • Centrally-acting anti-hypertensive drugs • Loop diuretics – Clonidine hydrochloride . .3 – Methyl dopa . .3 – Moxonidina . .2,3 Nifedipine + atenolol . .. 3 • Alpha blockers Nisoldipine . 3 – Doxazosin. .2,3 Verapamil hydrochloride . .3 – Terazosin . .3 • Piperazine derivates • Drugs used for regulate renin-angiotensin – Ranolazine. 2,3 system • Selective sinus node inhibitors – Ace inhibitors – Ivabradine. 3 Captopril . .3 • Peripheral vasodilators and related drugs Captopril + diuretics . 3 – Pentoxifylline . 3 Captopril + hydrochlorothiazide. 3 Sympathomimetics Cilazapril . .3 • Cardiopulmonary resuscitation Cilazapril + diuretics . .3 – Adrenaline . 3 Enalapril maleate . .2,3 Parenteral anticoagulants Enalapril + diuretics . .2,3 – Fondaparinux . .3 Fosinopril . 3 Anti-platelet agents Fosinopril + diuretics . .3 – Acetylsalicyic acid (with analgesic doses). 2 Imidapril Hydrocloride. .2 – Cilostazol. .2 Lisinopril . 3 – Clopidogrel bisulfate . 3 Lisinopril + diuretics . 3 – Dipyridamole . 3 Moexipril hydrochloride . 2,3 – Ticagrelor. 3 Moexipril + diuretics . .2,3 Peripheral vasodilators Perindopril . .3 Moxisylyte. 3 Perindopril + diuretics . .3 Antithrombotic drugs Quinapril . .3 • Direct thrombin inhibitors Quinapril+diuretics . 3 – Argatroban monohydrate. 1 Ramipril . .. 2, 3 Anti-fibrinolytic and hemostatic drugs Sacubitril with valsartan. .3 – Tranexamic acid (in rapid intravenous injection). 3 Ramipril+diuretics . .3 Blood derivatives Trandolapril . .3 – Human coagulation factor VIII . .3 Trandolapril + calcium channel blockers . 3 – Human coagulation factor IX . .3 – Angiotensin II receptor blockers Lipid – lowering medications Candesartan cilexetil . 3 • Fibrates Candesartan + diuretics . 3 – Bezafibrate . .3 Eprosartan . 3 – Ciprofibrate . 3 Irbesartan . 2 – Fenofibrate . .3 Irbesartan+diuretics . .2,3 – Gemfibrozil . .3 Losartan potassium . .2,3 • Statins Losartan potassium+diuretic. ..