Tablet S1. Transcription factors induced at least two fold by OHT with p<0.01 Probe.Set.ID Gene Symbol Gene Title 207826_s_at ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 218839_at HEY1 hairy/enhancer-of-split related with YRPW motif 1 203574_at NFIL3 nuclear factor, interleukin 3 regulated 209291_at ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 44783_s_at HEY1 hairy/enhancer-of-split related with YRPW motif 1 220225_at IRX4 iroquois homeobox protein 4 220493_at DMRT1 doublesex and mab-3 related transcription factor 1 204194_at BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 204622_x_at NR4A2 nuclear receptor subfamily 4, group A, member 2 206140_at LHX2 LIM homeobox 2 212696_s_at RNF4 ring finger protein 4 207144_s_at CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 41037_at TEAD4 TEA domain family member 4 36711_at MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) 216248_s_at NR4A2 nuclear receptor subfamily 4, group A, member 2 204131_s_at FOXO3A forkhead box O3A 204132_s_at FOXO3A forkhead box O3A 50221_at TFEB transcription factor EB 204281_at TEAD4 TEA domain family member 4 31845_at ELF4 E74-like factor 4 (ets domain transcription factor) 221558_s_at LEF1 lymphoid enhancer-binding factor 1 208502_s_at PITX1 paired-like homeodomain transcription factor 1 204249_s_at LMO2 LIM domain only 2 (rhombotin-like 1) 204798_at MYB v-myb myeloblastosis viral oncogene homolog (avian) 210319_x_at MSX2 msh homeobox homolog 2 (Drosophila) 221950_at EMX2 empty spiracles homolog 2 (Drosophila) 203408_s_at SATB1 special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's) 206915_at NKX2-2 NK2 transcription factor related, locus 2 (Drosophila) 216417_x_at HOXB9 homeobox B9 202692_s_at UBTF upstream binding transcription factor, RNA polymerase I 207978_s_at NR4A3 nuclear receptor subfamily 4, group A, member 3 213150_at HOXA10 homeobox A10 209587_at PITX1 paired-like homeodomain transcription factor 1 210655_s_at FOXO3A forkhead box O3A 208157_at SIM2 single-minded homolog 2 (Drosophila) 204082_at PBX3 pre-B-cell leukemia transcription factor 3 214651_s_at HOXA9 homeobox A9 210649_s_at ARID1A AT rich interactive domain 1A (SWI- like) 213147_at HOXA10 homeobox A10 210016_at MYT1L myelin transcription factor 1-like 203973_s_at CEBPD CCAAT/enhancer binding protein (C/EBP), delta 220392_at EBF2 early B-cell factor 2 206289_at HOXA4 homeobox A4 210162_s_at NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 209905_at HOXA9 homeobox A9 205935_at FOXF1 forkhead box F1 203358_s_at EZH2 enhancer of zeste homolog 2 (Drosophila) 218284_at SMAD3 SMAD, mothers against DPP homolog 3 (Drosophila) 209292_at ID4 Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 204621_s_at NR4A2 nuclear receptor subfamily 4, group A, member 2 204039_at CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 219884_at LHX6 LIM homeobox 6 218128_at NFYB nuclear transcription factor Y, beta 215152_at MYB v-myb myeloblastosis viral oncogene homolog (avian) 209454_s_at TEAD3 TEA domain family member 3 202724_s_at FOXO1A forkhead box O1A (rhabdomyosarcoma) 205193_at MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) 209205_s_at LMO4 LIM domain only 4 205906_at FOXJ1 forkhead box J1 213906_at MYBL1 v-myb myeloblastosis viral oncogene homolog (avian)-like 1 206283_s_at TAL1 T-cell acute lymphocytic leukemia 1 206510_at SIX2 sine oculis homeobox homolog 2 (Drosophila) 219990_at E2F8 E2F transcription factor 8 202449_s_at RXRA retinoid X receptor, alpha 200878_at EPAS1 endothelial PAS domain protein 1 206657_s_at MYOD1 myogenic differentiation 1 206363_at MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) 212689_s_at JMJD1A jumonji domain containing 1A 205932_s_at MSX1 msh homeobox homolog 1 (Drosophila) 208510_s_at PPARG peroxisome proliferative activated receptor, gamma 213920_at CUTL2 cut-like 2 (Drosophila) 202672_s_at ATF3 activating transcription factor 3 210239_at IRX5 iroquois homeobox protein 5 211219_s_at LHX2 LIM homeobox 2 205555_s_at MSX2 msh homeobox homolog 2 (Drosophila) 210170_at PDLIM3 PDZ and LIM domain 3 209959_at NR4A3 nuclear receptor subfamily 4, group A, member 3 209293_x_at ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 218917_s_at ARID1A AT rich interactive domain 1A (SWI- like) 207069_s_at SMAD6 SMAD, mothers against DPP homolog 6 (Drosophila) 206558_at SIM2 single-minded homolog 2 (Drosophila) 207060_at EN2 engrailed homolog 2 210555_s_at NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 206377_at FOXF2 forkhead box F2 212612_at RCOR1 REST corepressor 1 209239_at NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) 210948_s_at LEF1 lymphoid enhancer-binding factor 1 204668_at RNF24 ring finger protein 24 202340_x_at NR4A1 nuclear receptor subfamily 4, group A, member 1 218127_at NFYB nuclear transcription factor Y, beta 206511_s_at SIX2 sine oculis homeobox homolog 2 (Drosophila) 211467_s_at NFIB nuclear factor I/B 209347_s_at MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) 215264_at EMX1 empty spiracles homolog 1 (Drosophila) 206589_at GFI1 growth factor independent 1 221016_s_at TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) /// transcription factor 7-like 1 (T-cell specific, HMG-box) 205817_at SIX1 sine oculis homeobox homolog 1 (Drosophila) 205604_at HOXD9 homeobox D9 214881_s_at UBTF upstream binding transcription factor, RNA polymerase I 204529_s_at TOX thymus high mobility group box protein TOX 213844_at HOXA5 homeobox A5 208216_at DLX4 distal-less homeobox 4 204188_s_at RARG retinoic acid receptor, gamma 206645_s_at NR0B1 nuclear receptor subfamily 0, group B, member 1 209262_s_at NR2F6 nuclear receptor subfamily 2, group F, member 6 218129_s_at NFYB nuclear transcription factor Y, beta 202531_at IRF1 interferon regulatory factor 1 40284_at FOXA2 forkhead box A2 202723_s_at FOXO1A forkhead box O1A (rhabdomyosarcoma) 211771_s_at POU2F2 POU domain, class 2, transcription factor 2 /// POU domain, class 2, transcription factor 2 210818_s_at BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 203490_at ELF4 E74-like factor 4 (ets domain transcription factor) 216925_s_at TAL1 T-cell acute lymphocytic leukemia 1 205259_at NR3C2 nuclear receptor subfamily 3, group C, member 2 209664_x_at NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 207725_at POU4F2 POU domain, class 4, transcription factor 2 208978_at CRIP2 cysteine-rich protein 2 218344_s_at RCOR3 REST corepressor 3 206387_at CDX2 caudal type homeobox transcription factor 2 206847_s_at HOXA7 homeobox A7 218850_s_at LIMD1 LIM domains containing 1 210271_at NEUROD2 neurogenic differentiation 2 209261_s_at NR2F6 nuclear receptor subfamily 2, group F, member 6 218881_s_at FOSL2 FOS-like antigen 2 218724_s_at TGIF2 TGFB-induced factor 2 (TALE family homeobox) 208492_at RFXAP regulatory factor X-associated protein 214614_at HLXB9 homeobox HB9 214457_at HOXA2 homeobox A2 214401_at PAX1 paired box gene 1 215006_at EZH2 Enhancer of zeste homolog 2 (Drosophila) 204189_at RARG retinoic acid receptor, gamma 206228_at PAX2 paired box gene 2 205225_at ESR1 estrogen receptor 1 210103_s_at FOXA2 forkhead box A2 209710_at GATA2 GATA binding protein 2 209189_at FOS v-fos FBJ murine osteosarcoma viral oncogene homolog 221866_at TFEB transcription factor EB 205286_at TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 207260_at FEV FEV (ETS oncogene family) 216161_at SBNO1 Sno, strawberry notch homolog 1 (Drosophila) 208487_at LMX1B LIM homeobox transcription factor 1, beta 217399_s_at FOXO3A forkhead box O3A 210745_at ONECUT1 one cut domain, family member 1 220804_s_at TP73 tumor protein p73 219568_x_at SOX18 SRY (sex determining region Y)-box 18 214326_x_at JUND jun D proto-oncogene 216928_at TAL1 T-cell acute lymphocytic leukemia 1 220480_at HAND2 heart and neural crest derivatives expressed 2 211466_at NFIB nuclear factor I/B 203393_at HES1 hairy and enhancer of split 1, (Drosophila) 204530_s_at TOX thymus high mobility group box protein TOX 210556_at NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 fold by OHT TTEST OHT 113 unique TFs 9.0 3.02267E-12 ARID1A 100.7 3.30322E-11 ATF3 2.7 3.41166E-11 BACH1 27.4 3.42266E-11 CDX2 66.9 1.96087E-10 CEBPA 12.1 2.33272E-10 CEBPD 11.2 4.1045E-10 CITED1 3.7 9.00757E-10 CRIP2 18.1 1.93485E-09 CUTL2 8.1 2.01815E-09 DLX4 2.8 2.20603E-09 DMRT1 23.3 3.27527E-09 E2F8 5.0 3.27765E-09 EBF2 2.3 3.41224E-09 ELF4 27.0 4.6143E-09 EMX1 4.0 5.09799E-09 EMX2 3.2 5.55042E-09 EN2 4.2 7.83035E-09 EPAS1 3.6 1.01405E-08 ESR1 3.3 1.16226E-08 EZH2 5.7 1.20024E-08 FEV 5.1 1.29333E-08 FOS 6.2 1.63506E-08 FOSL2 23.9 1.73649E-08 FOXA2 4.3 2.02575E-08 FOXF1 4.7 2.09327E-08 FOXF2 2.3 2.3856E-08 FOXJ1 2.9 2.47067E-08 FOXO1A 2.7 2.47876E-08 FOXO3A 2.8 2.51846E-08 GATA2 11.4 2.87736E-08 GFI1 4.5 2.95973E-08 HAND2 5.9 3.04831E-08 HES1 2.7 3.05259E-08 HEY1 14.4 3.47266E-08 HLXB9 2.6 3.70825E-08 HOXA10 6.2 4.21138E-08 HOXA2 2.8 4.43601E-08 HOXA4 5.8 4.81339E-08 HOXA5 3.7 4.94957E-08 HOXA7 5.5 5.08813E-08 HOXA9 15.2 5.86654E-08 HOXB9 7.1 5.94509E-08 HOXD9 11.3 7.26726E-08 ID3 6.5 7.80711E-08 ID4 9.4 1.0584E-07 IRF1 3.6 1.12827E-07 IRX4 2.9 1.1679E-07 IRX5 16.3 1.193E-07 JMJD1A 21.0 1.22548E-07 JUND 21.1 1.39176E-07