Supplementary Online Content Global Burden of Disease Cancer Collaboration. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016 A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncology. Published online June 2, 2018. doi:10.1001/jamaoncol.2018.2706 eAppendix. eTables 1 through 16. eFigures 1 through 72. This supplementary material has been provided by the authors to give readers additional information about their work. © 2018 Fitzmaurice C et al. JAMA Oncology. Downloaded From: https://jamanetwork.com/ on 09/27/2021 1 Supplementary Online Content Global Burden of Disease Cancer Collaboration. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability‐adjusted life years for 29 cancer groups, 1990 to 2016: a systematic analysis for the Global Burden of Disease Study 2016. eAppendix Definition of indicator ............................................................................................................................... 5 Data sources .............................................................................................................................................. 5 Cancer incidence data sources.............................................................................................................. 5 Mortality/incidence ratio data sources ................................................................................................ 5 Cancer mortality data sources .............................................................................................................. 5 Bias of categories of input data ............................................................................................................ 5 Data analysis ............................................................................................................................................. 6 Cancer registry data formatting ............................................................................................................ 6 Cause of death database formatting ........................................................................................................ 9 CODEm models ......................................................................................................................................... 9 Liver cancer etiology split models ............................................................................................................. 9 CodCorrect .............................................................................................................................................. 10 Incidence estimation ............................................................................................................................... 10 Prevalence and YLD estimation .............................................................................................................. 10 Probability of cancer ............................................................................................................................... 13 References .............................................................................................................................................. 14 © 2018 Fitzmaurice C et al. JAMA Oncology. Downloaded From: https://jamanetwork.com/ on 09/27/2021 2 eTable 1: GATHER Guidelines checklist ...................................................................................................... 17 eTable 2: Sources for cancer incidence and mortality‐to‐incidence ratio data by country, year, and registry ........................................................................................................................................................ 19 eTable 3: Number of site‐years for cancer mortality data by type ............................................................. 46 eTable 4: List of International Classification of Diseases (ICD) codes mapped to the Global Burden of Disease cause list for cancer incidence data ............................................................................................... 48 eTable 5: List of International Classification of Diseases (ICD) codes mapped to the Global Burden of Disease cause list for cancer mortality data ............................................................................................... 50 eTable 6: Undefined cancer code categories (ICD‐10) and respective target codes for cancer registry incidence data ............................................................................................................................................. 53 eTable 7: Sociodemographic Index groupings by geography, based on 2016 values ................................ 53 eTable 8: Covariates selected for CODEm for each GBD cancer group and expected direction of covariate .................................................................................................................................................................... 59 eTable 9: Comparison of GBD 2015 and GBD 2016 covariates used and level of covariates ..................... 83 eTable 10: Results for CODEm model testing ........................................................................................... 108 eTable 11: Percent change before and after CodCorrect by cancer for all ages, both sexes combined, 2016 .......................................................................................................................................................... 118 eTable 12: Duration of four prevalence phases by cancer ....................................................................... 120 eTable 13: Disability weights .................................................................................................................... 123 eTable 14: Decomposition of trends in incidence globally, and by SDI quintile, both sexes, 2006 to 2016 .................................................................................................................................................................. 124 eTable 15: Contribution of YLDs and YLLs to DALYs by cancer, global, both sexes, 2016 ........................ 150 eTable 16: Probability of developing cancer within selected age intervals, global, and by SDI quintile, by sex, 2006‐2016 in % (odds) ....................................................................................................................... 151 eFigure 1: Flowchart GBD cancer mortality, YLL estimation .................................................................... 178 eFigure 2: Flowchart GBD cancer incidence, prevalence, YLD estimation ............................................... 179 eFigure 3: Sociodemographic Index quintiles, 2016 ................................................................................. 180 eFigure 4: Contribution of YLDs and YLLs to DALYs by cancer, global, both sexes, 2016 ......................... 181 eFigure 5: Average annual percent change in age‐standardized death and incidence rates between 2006 and 2016 for both sexes, by SDI quintile, all neoplasms .......................................................................... 182 eFigure 6: Average annual percent change in age‐standardized death and incidence rates between 2006 and 2016 for both sexes, by SDI quintile, tracheal, bronchus, and lung cancer ....................................... 183 eFigure 7: Average annual percent change in age‐standardized death and incidence rates between 2006 and 2016 for both sexes, by SDI quintile, colon and rectum cancer ........................................................ 184 eFigure 8: Average annual percent change in age‐standardized death and incidence rates between 2006 and 2016 for both sexes, by SDI quintile, breast cancer .......................................................................... 185 eFigure 9: Average annual percent change in age‐standardized death and incidence rates between 2006 and 2016, by SDI quintile, prostate cancer ............................................................................................... 186 eFigure 10: Average annual percent change in age‐standardized death and incidence rates between 2006 and 2016 for both sexes, by SDI quintile, stomach cancer .............................................................. 187 eFigure 11: Average annual percent change in age‐standardized death and incidence rates between 2006 and 2016 for both sexes, by SDI quintile, liver cancer ..................................................................... 188 © 2018 Fitzmaurice C et al. JAMA Oncology. Downloaded From: https://jamanetwork.com/ on 09/27/2021 3 eFigure 12: Average annual percent change in age‐standardized death and incidence rates between 2006 and 2016, by SDI quintile, cervical cancer ....................................................................................... 189 eFigure 13: Average annual percent change in age‐standardized death and incidence rates between 2006 and 2016 for both sexes, by SDI quintile, leukemia ......................................................................... 190 eFigure 14: Average annual percent change in age‐standardized death and incidence rates between 2006 and 2016 for both sexes, by SDI quintile, non‐Hodgkin lymphoma ................................................ 191 eFigure 15: Cancer ranking by total incidence based on global level for developing and developed