INDEX AId Aid AId AId thosefollowed'i~Y Aid Note: Page numbers followed by "I" indicate figures; Aid generic name. Ale Ale Ale Ale A percent ionization, 14-16, 15f-16f a-Adrenergic antagonists, 641 Alf AAS. See Androgen(s) reactions, 12, 131 Adrenergic-blocking agents, 519 AU Abacavir, 345 strength of, 12, 14, 141 Adrenergic drugs, 558 AU Abarelix acetate, 6991, 700--70I, 700f AcipHex. See Rabeprazole sodium centrally active, 641--642 Alf Abbokinase. See Urokinase Acitretin, half-life of, 6 Adrenergic neurotransmitters, 519-524, 5201 Ali, Abciximab, 149,629 Aclovate. See Alclometasone dipropionate biosynthesis of, 519, 521j, 522 Ali Abilify. See Aripiprazole Acquired immunity, 1591, 161-165 drugs affecting, 528-531 Ali Abitrexate. See Methotrexate innate vs., 159, 1591 metabolism of, 523-524, 5231, 524f All< Abmoclorin. See Chlorambucil Acrivastine, 7411, 756-757 storage and release of, 522 All< Absolute ethanol, 182 ACT-D. See Dactinomycin-D structure and physicochemical propenies of, Absolute specificity, 885 ACTH. See Adrenoconicotropic honnone; 519,520f Al1< Absorption, distribution, metabolism, and elimination Conicotropin uptake of, 522-523 All (ADME) models, for computer-aided drug Acthar. See Conicotropin injection Adrenergic receptors, 524-528 All design, 25 Acthar Gel. See Repository conicotropin injection a, 525-526, 5251-5261, 527f Acarbose, 662--663, 687--688, 687f--688f Acthrel. See Conicorelin antagonists, 545-555 All Accuretic. See Quinapril hydrochloride Actidil. See Triprolidine hydrochloride {3, 5251, 526-527, 5261, 528f-529f ACE. See Angiotensin-convening enzyme Actinomycin, 2601, 384, 384j, 388 subtypes of, 524-525, 5251-5261 Acebutolol, 552-553, 553f-554f Actinomycin-D. See Dactinomycin-D Adrenergic stimulants, 519 Acetaldehyde, in alcohol metabolism, 182 Actinospectocin. See Spectinomycin hydrochloride Adrenergic system inhibitors, 639 Acetaminophen Action potentials, neuronal membrane penneability Adrenoconicotropic honnone (ACTH), 810, 855, as antipyretic, 803-806, 804f-806f during, 719-720 891,8921 conjugation of, 89-90, 92, 97, 99 Actiq. See Fentanyl Adrenoconicotropic honnone injection, metabolism of, 8, 73-74 Activase. See Alteplase; Alteplase, recombinant 891,8921 toxicity in, 805-806, 806f Activella, 8461 Adria. See Doxorubicin hydrochloride Acetanilide, 803-804 Active-site-directed irreversible inhibition, 25 Adriamycin. See Doxorubicin hydrochloride Acetohexamide, 660, 671j, 6731, 676, 677j, 680 Actonel. See Risedronate sodium Adrucil. See 5-Fluorouracil metabolism of, 59, 61, 80, 82 Actoplus Met. See Metfonnin; Pioglitazone Adsorbed diphtheria and tetanus toxoid, 173 AU Acetophenone, metabolism of, 80--82 Actos. See Pioglitazone Adsorbed tetanus and diphtheria toxoid for (+)-Irans-(IS,2S)-acetoxycyclopropyltrimethylammo­ Actron. See Ketoprofen adults, 174 nium, 565, 5661 Acute gouty mhritis, 810--811, 810f Adsorbed tetanus toxoid, 173 AU Acetoxyethyl onium salts, 5671 Acute pain, 776-777 Adsorption, of virus, 333 All 2-Acetylaminofluorene, metabolism of, 73-74 Acute phase factors; 160, 1601 Advil. See Ibuprofen All Acetylation, 97-102 Acyclovir, 341 AeroBid. See Flunisolide Acetylation polymorphism, 101 metabolism of, 7-8 Aerosporin. See Polymyxin B sulfate Acetylcholine (ACh), 24, 558 Acylases, penicillin resistance and, 266 AF-DX 116,567, 568f confonnational flexibility of, 29-30, 29f AD 32. See Valrubicin Aflatoxin B.. metabolism of, 54, 56 confonnation of, 564-565, 565f Adalat. See Nifedipine African sleeping sickness, 221 ganglionic stimulation by, 596-597, 597f Adamantanamines, 336 Afrin. See Oxymetazoline hydrolysis of, 570--571, 572f Adapin. See Doxepin hydrochloride Afrinol. See L-( +)-Pseudoephedrine neuromuscular junction transmission and, 599--600 Adaptogen, 970 Aftate. See Tolnaftate as neurotransmitter, 558-559, 563-564, 563f-564j, Addison disease, 857, 859-860 Age, drug metabolism and, 104 596-597, 597f Adefovir dipivoxil, 340--341 Agenerase. See Amprenavir nicotinic effect of, 597-598 Adenine arabinoside, 40, 40j, 340, 378 Agglutination, immunological, 164 pharmaceutical, 568 Adenosine monophosphate (AMP), 561-563 Aggregation, of recombinant proteins, 134 release of, 563-564, 563f in platelet aggregation, 657, 657f Aggrenox. See Dipyridamole storage of, 563, 563f in smooth muscle relaxation, 618--619, 619f Aging, of cholinesterases, 578, 578f structure-activity relationships of, 566-567, Adenosine monophosphate-activated protein kinase a-Agonists, 534-535, 540 566f-567j, 5671 (AMPK), metforrnin activation by, 686 al-Agonists, 525, 5251-5261 structure of, 558 Adenylate cyclase, 562-563, 562f a,-Agonists, 525, 5251-5261 synthesis of, 563-564, 563f-564f gastric acid secretion and, 760, 761f {3-Agonists, 540--543 Acetylcholine chloride, 568 ADH. See Vasopressin {3,-Agonists, 525, 5251-5261 Acetylcholine receptors, 559-563 Adjuvants, vaccines and, 176-177 {3,-Agonists, 543 activation of, 562-563, 562f ADM. See Doxorubicin hydrochloride Akineton. See Biperiden muscarinic, 560--563, 56If-562j, 566-567, 566f ADME models. See Absorption, distribution, Akineton hydrochloride. See Biperiden nicotinic, 559-560, 559f-56Oj, 5591 metabolism, and elimination hydrochloride Acetylcholinesterase (AChE), 558, 563-564, 563f ADR. See Doxorubicin hydrochloride Alamast. See Pemirolast potassium ophthalmic A action of, 570--572, 572f Adrenal conex honnones, 853-864, 854f-857j, 8581, solution A inhibition of, 570--572, 5711-5721, 572f 86Of,864f Albamycin. See Novobiocin sodium A phosphorylation of, 577-578, 577f-578f biological activities of, 855-856 Albendazole, 226 A reactivation of, 577-578, 577f biosynthesis of, 854-855, 854f Albiglutide, 690j, 691 Acetylcholinesterase inhibitors, 570--572, 5711-5721, endogenous, 853-854 Albuminoids, 8831 572f metabolism of, 855, 855f Albumins, 8831 A irreversible, 5721, 577-581, 577f-578j, 580f mineraloconicoid receptor antagonists, Albuterol. See Salbutamol A reversible, 572-576, 5721, 573f 615,864 Alclometasone, 861 A Acetyl-CoA, 563-564, 563f-564f structural classes of, 856-859, 856f-857j, 8581 Alclometasone dipropionate, 857f A Acetylmethadol (LAAM), 788j, 789 therapeutic uses of, 859-860 Alcofenac, metabolism of, 53 A Acetylsalicylic acid. See Aspirin Adrenalin. See Epinephrine Alcohol(s) A ACh. See Acetylcholine Adrenergic agents, 519-555, 5201 as anti-infective agents, 181-182 AChE. See Acetylcholinesterase adrenergic receptor antagonists, 545-555 metabolism of, 181-182 p Acidosis, antiarrhythmic activity and, 632 neurotransmitters, 519-524 as sedative-hypnotics, 455-456 p Acids, 12-17 drugs affecting, 528-531 Alcohol intolerance, cephalosporins and, 285 p conjugate, 12, 131 receptors, 524-528 Aldactone. See Spironolactone p definition of, 12 sympathomimetic agents, 531-545 Aldehyde oxidase, 78 p 984 Index 985 Aldehydes Amenorrhea, progestins for, 839 danazo!. 849I, 851 as anti-infective agents, 182-183 Amerge, See Naratriptan endogenous, 847 as sedative-hypnotics, 456-457 Amfenac, 799I, 800 metabolism of, 847, 848f Aldesleukin, 141, 909t, 911 Amigesic. See Salsalate 5a-reductase inhibitors, 852, 852f-853f Aldomet. See Methyldopa Amikacin, 294, 299-300 SARMs, 853, 853f Aldomet ester hydrochloride. See Methyldopate inactivation of, 296 in sports, 849-850 hydrochloride Amikin. See Amikacin structural classes of, 847-848, 848t, 849f Aldosterone, 821I, 853-857, 854I, 856I, 858t 7-Arnino-5-nitroindazole, conjugation of, 90-91 therapeutic uses of, 848-849 Aldosterone antagonists, 615, 864 Amino acid solutions, 881 Androgen receptors (ARs), 825 Aleglitazar, 682, 683f Aminoalcohols, 592-594 Androlone decanoate, 849f Alemtuzumab, 148 Aminoalcohol esters, 588-591 Androstenedione, 821I, 823I, 847, 848f Alendronate sodium, 707t, 708 Aminoalcohol ethers, 591-592 Anectine. See Succinylcholine chloride Aleve. See Naproxen Aminoalkyl ethers, See Ethanolamine antihistamines Anesthesia, general, stages of, 711 Alfenta. See Alfentanil Amino amide local anesthetics, 726--729, 727f-728f Anesthesiophoric agents, 588 Alfentanil, 787I, 788 Aminoamides, 594-595 Anesthetics, 711-730 Alferon N. See Interferon alfa-n3 p-Aminobenzoic acid (PABA), 217 inhaled general anesthetics, 711-716, 712t, 714f-716f Alfuzosin, 548 acetylation of, 97, 100 injectable general anesthetics, 716--718, 717f-718f Alidase. See Hyaluronidase for injection in allergic reactions to local anesthetics, 724-726 local, 718-730, 718f-719I, 72lf-722I, 724f, Alimta. See Pemetrexed Aminoglutethimide, 835I, 836 727f-728f Aliskiren, 614-615 Aminoglycosides, 26Ot, 294-301 Anger camera, 417-418, 417f Alkalosis, antiarrhythmic activity and, 632 chemistry of, 294-295 Angina pectoris, 617 Alkane anesthetics, structure-activity relationships of, discovery of, 294 Angiotensin, 607-609, 608f-609f 712-713,712f mechanism of action of, 295 Angiotensin amide, 905 Alkanol anesthetics, 713 microbial resistance to, 295-296 Angiotensin antagonists, 612-614 Alkeran. See Melphalan spectrum of activity of, 295 Angiotensin-converting enzyme (ACE), 607-609, 609f Alkylamine antihistamines. See Propylamine structure-activity relationships of, 296--297 Angiotensin-converting enzyme inhibitors, antihistamines types of, 297-301 609-61O,6IOf Alkylating agents, 358-372 f3-AminokelOnes, 467-468 prodrugs, 610-612, 61 If, 612t busulfan, 362, 364I, 369-370 4-Aminoquinolines, 246t-247t, 248-250, 249f Angiotensin II, 607-609, 608f-609I, 614 dacarbazine, 366--367, 367f-368I, 371 8-Arninoquinolines, 246t-247t, 250-251, 250f Angiotensin II blockers, 612-614 individual agents, 368-372 Aminosalicylate sodium, 217 Angiotensinogen, 607, 608I, 614 mechanism