Supplemental Table 1. Genes that were increased or decreased more than two-fold in anti- FGFR2IIIc monoclonal antibody-treated cells Fold change Gene Symbol Description HCT-15 LoVo NKD1 Protein naked cuticle homolog 1 (Naked-1) (hNkd1) 24.74 2.18 (hNkd) [Source: UniProtKB/Swiss-Prot; Acc: Q969G9] [ENST00000268459] SAA1 Homo sapiens serum amyloid A1 (SAA1), transcript 21.09 3.84 variant 1, mRNA [NM_000331] LRRC18 Homo sapiens leucine-rich repeat containing 18 13.70 4.60 (LRRC18), mRNA [NM_001006939] ABCB5 Homo sapiens ATP-binding cassette, sub-family B 11.78 2.54 (MDR/TAP), member 5 (ABCB5), transcript variant 2, mRNA [NM_178559] CXCL1 Homo sapiens chemokine (C-X-C motif) ligand 1 10.61 7.05 (melanoma growth-stimulating activity, alpha) (CXCL1), mRNA [NM_001511] SERPINA9 Homo sapiens serpin peptidase inhibitor, clade A 9.63 4.14 (alpha-1 antiproteinase, antitrypsin), member 9 (SERPINA9), transcript variant A, mRNA [NM_175739] LCN2 Homo sapiens lipocalin 2 (LCN2), mRNA 9.00 4.78 [NM_005564] HS6ST3 Homo sapiens heparan sulfate 6-O-sulfotransferase 3 8.53 2.70 (HS6ST3), mRNA [NM_153456] CXCL3 Homo sapiens chemokine (C-X-C motif) ligand 3 7.89 4.55 (CXCL3), mRNA [NM_002090] IL8 Homo sapiens interleukin 8 (IL8), mRNA 7.34 9.61 [NM_000584] CXorf18 PREDICTED: Homo sapiens chromosome X open 6.55 2.06 reading frame 18 (CXorf18), miscRNA [XR_040313] BEST1 Homo sapiens bestrophin 1 (BEST1), transcript variant 6.54 2.43 1, mRNA [NM_004183] CXCL2 Homo sapiens chemokine (C-X-C motif) ligand 2 6.39 5.52 (CXCL2), mRNA [NM_002089] USH2A Homo sapiens Usher syndrome 2A (autosomal 5.88 8.33 recessive, mild) (USH2A), transcript variant 2, mRNA [NM_206933] FLJ34503 Homo sapiens hypothetical FLJ34503 (FLJ34503), non- 5.18 3.85 coding RNA [NR_027060] CCL2 Homo sapiens chemokine (C-C motif) ligand 2 (CCL2), 4.44 4.71 mRNA [NM_002982] LTB Homo sapiens lymphotoxin beta (TNF superfamily, 4.09 31.54 member 3) (LTB), transcript variant 1, mRNA [NM_002341] CPA4 Homo sapiens carboxypeptidase A4 (CPA4), transcript 3.84 4.11 variant 1, mRNA [NM_016352] CXCL2 Homo sapiens chemokine (C-X-C motif) ligand 2 3.61 5.22 (CXCL2), mRNA [NM_002089] CCL20 Homo sapiens chemokine (C-C motif) ligand 20 3.58 58.35 (CCL20), transcript variant 1, mRNA [NM_004591] TCF23 Homo sapiens transcription factor 23 (TCF23), mRNA 3.53 5.72 [NM_175769] S100A3 Homo sapiens S100 calcium-binding protein A3 3.24 5.53 (S100A3), mRNA [NM_002960] KLKB1 Homo sapiens kallikrein B, plasma (Fletcher factor) 1 3.15 2.01 (KLKB1), mRNA [NM_000892] FAM19A3 Homo sapiens family with sequence similarity 19 3.13 2.35 (chemokine (C-C motif)-like), member A3 (FAM19A3), transcript variant 2, mRNA [NM_001004440] LAMA3 Homo sapiens laminin, alpha 3 (LAMA3), transcript 3.09 2.16 variant 1, mRNA [NM_198129] CPA3 Homo sapiens carboxypeptidase A3 (mast cell) (CPA3), 2.96 3.16 mRNA [NM_001870] LOC150197 Homo sapiens hypothetical LOC150197 (LOC150197), 2.95 2.58 non-coding RNA [NR_026919] UCA1 Homo sapiens urothelial cancer-associated 1 (non- 2.93 3.72 protein coding) (UCA1), non-coding RNA [NR_015379] TNF Homo sapiens tumor necrosis factor (TNF superfamily, 2.66 9.19 member 2) (TNF), mRNA [NM_000594] OR13C4 Homo sapiens olfactory receptor, family 13, subfamily 2.48 2.24 C, member 4 (OR13C4), mRNA [NM_001001919] PDZK1IP1 Homo sapiens PDZK1-interacting protein 1 2.48 11.12 (PDZK1IP1), mRNA [NM_005764] PIWIL2 Piwi-like protein 2 (Cancer/testis antigen 80) (CT80) 2.11 15.18 [Source: UniProtKB/Swiss-Prot; Acc: Q8TC59] [ENST00000356766] MYL7 Homo sapiens myosin, light chain 7, regulatory 2.11 2.22 (MYL7), mRNA [NM_021223] TMEM30B Homo sapiens transmembrane protein 30B 2.05 2.45 (TMEM30B), mRNA [NM_001017970] C6orf223 Homo sapiens chromosome 6 open reading frame 223 -2.23 -3.96 (C6orf223), mRNA [NM_153246] PLA2G1B Homo sapiens phospholipase A2, group IB (pancreas) -2.32 -2.75 (PLA2G1B), mRNA [NM_000928] DUSP19 Homo sapiens dual specificity phosphatase 19 -2.32 -8.61 (DUSP19), transcript variant 1, mRNA [NM_080876] EDNRB Homo sapiens endothelin receptor type B (EDNRB), -2.51 -7.80 transcript variant 2, mRNA [NM_003991] LOC100133862 Rheumatoid factor RF-IP9 Fragment [Source: -2.68 -6.35 UniProtKB/TrEMBL; Acc: A2J1M2] [ENST00000390633] TMEM119 Homo sapiens transmembrane protein 119 (TMEM119), -2.79 -5.69 mRNA [NM_181724] PAPPA Homo sapiens pregnancy-associated plasma protein A, -2.91 -8.85 pappalysin 1 (PAPPA), mRNA [NM_002581] TUBB2B Homo sapiens tubulin, beta 2B (TUBB2B), mRNA -2.94 -2.12 [NM_178012] SLFNL1 Homo sapiens cDNA FLJ23878 fis, clone LNG13675. -3.07 -4.94 [AK074458] HIST1H2BA Homo sapiens histone cluster 1, H2ba (HIST1H2BA), -3.23 -2.66 mRNA [NM_170610] HAP1 Homo sapiens huntingtin-associated protein 1 (HAP1), -3.39 -7.62 transcript variant 2, mRNA [NM_177977] PIWIL2 Homo sapiens piwi-like 2 (Drosophila) (PIWIL2), -3.77 -7.47 transcript variant 2, mRNA [NM_018068] C21orf125 Homo sapiens chromosome 21 open reading frame 125 -3.97 -2.36 (C21orf125), non-coding RNA [NR_026960] SEZ6 Homo sapiens seizure-related 6 homolog (mouse) -4.66 -2.57 (SEZ6), transcript variant 1, mRNA [NM_178860] FAM189A2 Homo sapiens family with sequence similarity 189, -5.92 -2.19 member A2 (FAM189A2), transcript variant 1, mRNA [NM_004816] RUNDC2B Homo sapiens cDNA FLJ13765 fis, clone -5.92 -2.84 PLACE4000128, weakly similar to Mus musculus putative transcription factor mRNA. [AK023827] PTN Homo sapiens pleiotrophin (PTN), mRNA -6.26 -2.89 [NM_002825] MAB21L1 Homo sapiens mab-21-like 1 (C. elegans) (MAB21L1), -6.83 -17.19 mRNA [NM_005584] ZNF169 Homo sapiens zinc finger protein 169, mRNA (cDNA -9.52 -3.54 clone IMAGE: 5259146), complete cds. [BC035060] PACSIN1 Homo sapiens protein kinase C and casein kinase -16.47 -2.03 substrate in neurons 1 (PACSIN1), mRNA [NM_020804] ZNF385B Homo sapiens zinc finger protein 385B (ZNF385B), -17.48 -7.00 transcript variant 1, mRNA [NM_152520] NXPH3 Homo sapiens neurexophilin 3 (NXPH3), mRNA -21.34 -4.70 [NM_007225] .