Supplementary Table 2 Differentially expressed genes in PC3 prostate adenocarcinoma cells 48 h after transfection with siRXFP1 versus siNC control siRNA. Genes with P<0.05 are shown Average fold change PROBE_ID TargetID Title (siRXFP1/siNC) ILMN_1757406 HIST1H1C histone cluster 1, H1c 2.358875 ILMN_1691846 G0S2 G0/G1switch 2 2.148632 ILMN_1706505 COL5A1 collagen, type V, alpha 1 2.030442 ILMN_1715684 LAMB3 laminin, beta 3 1.891462 ILMN_1809402 MAN2A1 mannosidase, alpha, class 2A, member 1 1.843399 ILMN_1666503 DENND2A DENN/MADD domain containing 2A 1.794946 ILMN_1746465 FJX1 four jointed box 1 (Drosophila) 1.777726 ILMN_1688670 CDCP1 CUB domain containing protein 1 1.743697 ILMN_1708341 PDZK1 PDZ domain containing 1 1.740739 ILMN_1658702 HIST1H2BJ histone cluster 1, H2bj 1.621722 ILMN_1756777 HBEGF heparin-binding EGF-like growth factor 1.594607 ILMN_1727315 DENND1A DENN/MADD domain containing 1A 1.581216 CKLF-like MARVEL transmembrane domain ILMN_1705442 CMTM3 containing 3 1.529026 estrogen receptor binding site associated, ILMN_1729144 EBAG9 antigen, 9 1.507585 ILMN_1666507 PLAUR plasminogen activator, urokinase receptor 1.480579 plakophilin 1 (ectodermal dysplasia/skin ILMN_1663454 PKP1 fragility syndrome) 1.475808 ILMN_1706643 COL6A3 collagen, type VI, alpha 3 1.47301 ILMN_1795055 LRRC3 leucine rich repeat containing 3 1.471709 ILMN_1722845 RAB3B RAB3B, member RAS oncogene family 1.432296 ILMN_1691508 PLAUR plasminogen activator, urokinase receptor 1.423904 ILMN_1703531 EDG3 sphingosine-1-phosphate receptor 3 1.421666 ILMN_1803728 SLC35E4 solute carrier family 35, member E4 1.361908 adenosine deaminase, tRNA-specific 2, ILMN_1676554 DEADC1 TAD2 homolog (S. cerevisiae) 0.752997 ILMN_1752889 PLSCR1 phospholipid scramblase 1 0.73679 ILMN_1783621 LOC129607 0.723609 ILMN_1685275 MCAM melanoma cell adhesion molecule 0.71626 eukaryotic translation initiation factor 1A ILMN_1717834 MGC11102 domain containing 0.712811 cytochrome P450, family 2, subfamily S, ILMN_1705403 CYP2S1 polypeptide 1 0.710565 ILMN_1786601 PLAGL2 pleiomorphic adenoma gene-like 2 0.699806 ILMN_1738989 GOLSYN Golgi-localized protein 0.693171 echinoderm microtubule associated ILMN_1791990 EML2 protein like 2 0.692269 ILMN_1742547 NRP1 neuropilin 1 0.685449 NHP2 non-histone chromosome protein 2- ILMN_1763460 NHP2L1 like 1 (S. cerevisiae) 0.683673 grancalcin, EF-hand calcium binding ILMN_1800602 GCA protein 0.680923 ILMN_1665909 LASP1 LIM and SH3 protein 1 0.678523 proteasome (prosome, macropain) 26S ILMN_1732767 PSMD9 subunit, non-ATPase, 9 0.67817 solute carrier family 16, member 14 ILMN_1736546 SLC16A14 (monocarboxylic acid transporter 14) 0.677312 ILMN_1712985 C17ORF58 chromosome 17 open reading frame 58 0.676035 ILMN_1669497 OSBPL10 oxysterol binding protein-like 10 0.67551 ILMN_1749821 MED28 mediator complex subunit 28 0.673531 RAB3 GTPase activating protein subunit 1 ILMN_1739876 RAB3GAP1 (catalytic) 0.673259 ILMN_1756992 MUC1 mucin 1, cell surface associated 0.67274 guanine nucleotide binding protein (G protein), alpha inhibiting activity ILMN_1775762 GNAI2 polypeptide 2 0.671533 ILMN_1654392 KIAA0323 KIAA0323 0.664346 ILMN_1725842 CSNK1G2 casein kinase 1, gamma 2 0.660565 ILMN_1689336 HOXA10 homeobox A10 0.653391 ILMN_1653404 NKIRAS2 NFKB inhibitor interacting Ras-like 2 0.644015 ILMN_1769390 LOC116236 hypothetical protein LOC116236 0.640575 ILMN_1759003 SNX12 sorting nexin 12 0.638957 ILMN_1754174 LOXL4 lysyl oxidase-like 4 0.637852 ILMN_1677877 UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.637458 solute carrier family 35 (UDP-galactose ILMN_1792135 SLC35A2 transporter), member A2 0.631048 myosin phosphatase-Rho interacting ILMN_1678692 M-RIP protein 0.626517 protein phosphatase 2, regulatory subunit ILMN_1780940 PPP2R5D B', delta isoform 0.625489 branched chain aminotransferase 2, ILMN_1695110 BCAT2 mitochondrial 0.62442 ILMN_1791478 MTPN myotrophin 0.622552 ILMN_1754199 BCL7B B-cell CLL/lymphoma 7B 0.620721 ILMN_1788878 C10ORF83 chromosome 10 open reading frame 83 0.620467 ILMN_1667839 C14ORF130 chromosome 14 open reading frame 130 0.620264 ILMN_1789505 ITPR1 inositol 1,4,5-triphosphate receptor, type 1 0.618577 ILMN_1697872 C21ORF121 chromosome 21 open reading frame 121 0.617437 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small ILMN_1728163 CTDSP1 phosphatase 1 0.615529 interferon (alpha, beta and omega) ILMN_1752923 IFNAR1 receptor 1 0.614082 translocase of inner mitochondrial ILMN_1765332 TIMM10 membrane 10 homolog (yeast) 0.613879 ILMN_1804815 ACP2 acid phosphatase 2, lysosomal 0.611762 ILMN_1723912 IFI44L interferon-induced protein 44-like 0.611461 ILMN_1723768 NLRX1 NLR family member X1 0.610799 myxovirus (influenza virus) resistance 1, ILMN_1662358 MX1 interferon-inducible protein p78 (mouse) 0.607699 ILMN_1689318 NUAK1 NUAK family, SNF1-like kinase, 1 0.607489 ILMN_1813746 CORO2A coronin, actin binding protein, 2A 0.601455 isocitrate dehydrogenase 1 (NADP+), ILMN_1696432 IDH1 soluble 0.600654 ILMN_1656361 LOC201175 hypothetical protein LOC201175 0.592056 ILMN_1729767 TARBP2 TAR (HIV-1) RNA binding protein 2 0.591086 chaperonin containing TCP1, subunit 4 ILMN_1776073 CCT4 (delta) 0.58872 phosphatidylinositol 4-kinase, catalytic, ILMN_1666597 PI4KB beta 0.585031 ILMN_1793267 ETHE1 ethylmalonic encephalopathy 1 0.583694 solute carrier family 7 (cationic amino acid ILMN_1720373 SLC7A5 transporter, y+ system), member 5 0.583536 ILMN_1694432 CRIP2 cysteine-rich protein 2 0.578778 ILMN_1720319 SLC35A4 solute carrier family 35, member A4 0.559968 ubiquitin related modifier 1 homolog (S. ILMN_1774196 URM1 cerevisiae) 0.549359 UDP-Gal:betaGlcNAc beta 1,4- ILMN_1692267 B4GALT3 galactosyltransferase, polypeptide 3 0.544992 ILMN_1742450 TAPBP TAP binding protein (tapasin) 0.535814 ILMN_1683263 TSPAN8 tetraspanin 8 0.529905 solute carrier family 35 (UDP-galactose ILMN_1742731 SLC35A2 transporter), member A2 0.528521 ILMN_1755405 FRAG1 FGF receptor activating protein 1 0.52765 sarcospan (Kras oncogene-associated ILMN_1775486 SSPN gene) 0.521142 ILMN_1654465 GPI glucose phosphate isomerase 0.520037 ILMN_1775501 IL1B interleukin 1, beta 0.515477 ILMN_1788163 SNX15 sorting nexin 15 0.512142 aldo-keto reductase family 7, member A2 ILMN_1677043 AKR7A2 (aflatoxin aldehyde reductase) 0.51088 ILMN_1707727 ANGPTL4 angiopoietin-like 4 0.491705 ILMN_1753345 SCAMP5 secretory carrier membrane protein 5 0.479704 ILMN_1722905 MRPS11 mitochondrial ribosomal protein S11 0.47849 ILMN_1658577 C8ORF30A chromosome 8 open reading frame 30A 0.476033 ubiquitination factor E4B (UFD2 homolog, ILMN_1675674 UBE4B yeast) 0.462687 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of ILMN_1786105 PCBD1 hepatocyte nuclear factor 1 alpha 0.455866 lysosomal-associated protein ILMN_1745110 LAPTM4A transmembrane 4 alpha 0.447195 translocase of inner mitochondrial ILMN_1813260 TIMM17B membrane 17 homolog B (yeast) 0.439358 aldehyde dehydrogenase 3 family, ILMN_1702503 ALDH3A1 memberA1 0.439124 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of ILMN_1795906 PCBD1 hepatocyte nuclear factor 1 alpha 0.403219 ILMN_1725852 S100A2 S100 calcium binding protein A2 0.403094 ILMN_1726108 LASS2 LAG1 homolog, ceramide synthase 2 0.3713 hypoxanthine phosphoribosyltransferase 1 ILMN_1736940 HPRT1 (Lesch-Nyhan syndrome) 0.371294 .