THE FOUNDATION OF HOPE FUNDED RESEARCH & MHI GRANTS LIST MASTER REPORT 1985-Present Since the first year a gift was made in 1985, The Foundation of Hope for Research and Treatment of Mental Illness has awarded almost 210 research grants and community service grants totaling more than $7.6 million. Types of research projects funded include but not limited to schizophrenia, eating disorders, depression, bipolar disorders, PMS, autism, thyroid dysfunction, postpartum depression, post-traumatic stress disorder and social phobias. Researcher/Applicant Title Date Amount Biobehavioral Markers of Suicide Risk in Female Adolescents on the Autism Dr. Brenna Maddox 4/21 $39,992 Spectrum Co-occurrence of Disorders of Gut-Brain Interaction and Feeding and Eating Dr. Camden Matherne Disorders in Adolescence: Prevalence, Complications, and Clinical 4/21 $40,396 Management A Pilot Study of Psilocybin-Assisted Therapy in Treatment-Resistant Dr. Rob McClure 4/21 $101,078 Depression: acute changes, duration of effect and predictors of response The Comorbidity of Depression and Cardiovascular Disease in Midlife Dr. Margo Nathan 4/21 $39,617 Women: Investigating novel biological Pathways of risk Monitoring Affective State Change with Wearable Technology: Assessing Dr. Julianna Prim Physiological and Behavioral Mechanisms in Premenstrual Dysphoric 4/21 $40,000 Disorder Striatum-Targeted Anhedonia Rapid Treatment (START): a novel transcranial Dr. Justin Riddle magnetic stimulation paradigm for treating symptoms of anhedonia in 4/21 $38,280 depression Developing and Evaluating a Computable Phenotype for Treatment-Resistant Dr. Xiaoming Zeng 4/21 $41,302 Schizophrenia Dr. Karen Poulos & Dr. Amy Ursano UNC Psychiatry Pediatric Behavior Clinic 12/20 $20,000 Dr. Jessica Baker Probing the Neural Substrates of Bulimia Nervosa 5/20 $39,065 A Stimulus PET/MR Study of Gender Differences in Neuroinflammation in Dr. Gabriel Dichter 5/20 $50,000 Autism Depression in the Menopause Transition: Stress and inflammation as Dr. Serena Fiacco 5/20 $31,107 Pathways of Risk The Foundation of Hope Funded Research & MHI Grants Master Report 1985-Present Researcher/Applicant Title Date Amount Identifying the role of parental traits in explaining phenotypic variability in Dr. Jessica Girault children with neurogenetic developmental disorders: towards early 5/20 $39,718 individualized intervention Dissection of Top-down Cortical Circuits Underlying Auditory Oddball Dr. Hiroyuki Kato 5/20 $40,000 Response, a Biomarker for Schizophrenia Microbiome and Methylation (M&M): A Source of Information for Precision Dr. Mary Kimmel 5/20 $42,000 Medicine Probing Gene-Environment Interactions in Schizophrenia and Stress: Dr. Zoe McElligott 5/20 $60,000 Integrating Human GWAS and Mouse Models Dr. A. Leslie Morrow Mechanisms of Brexanolone Therapeutics in Post-Partum Depression 5/20 $48,070 A web-based intervention to prove mental health outcomes among newly Dr. Eliza Park 5/20 $39,997 diagnosed parents with cancer A transitional approach to identify biomarkers of COVID-19 related social Dr. Anthony Zannas 5/20 $85,000 stress in healthcare workers Dr. Karen Poulos & Dr. Amy Ursano UNC Psychiatry Pediatric Behavior Clinic 11/19 $20,000 UNC Psychiatry Pediatric Behavior Clinic – EOH/Pilot Program Licensed Dr. Karen Poulos & Dr. Amy Ursano 11/19 $43,450 Psychology Associate Dr. Terry Morris, Executive Director Vets to Vets United 11/19 $43,450 A Mechanistic Examination of Continuous-Cycle Oral Contraceptive Dr. Jessica Baker 5/19 $46,942 Administration in Bulimia Nervosa Depression in the pubertal transition: circadian rhythms and sleep Dr. Elizabeth Andersen Dr. Paul Geiger 5/19 $38,400 impairment as mechanisms of risk Dr. Zoe McElligott Evaluating oxytocin in opioid withdrawal: a transitional study 5/19 $50,000 Genetic Risk Factors of Post-Traumatic Stress Disorder in Solid Organ Dr. Rebekah Nash 5/19 $39,886 Transplant Recipients Dr. Jose Rodriguez-Romaguera Dissecting the Neural Circuits of Hyperarousal States in Psychiatry 5/19 $200,000 2 The Foundation of Hope Funded Research & MHI Grants Master Report 1985-Present Researcher/Applicant Title Date Amount Quantifying the brain developmental trajectory of autism-associated brain Dr. Guorong Wu 5/19 $39,069 overgrowth using 3D cellular resolution imaging Epigenetic Mechanisms of Post-Traumatic Stress and Depression after Sexual Dr. Anthony Zannas 5/19 $75,000 Assault Dr. Karen Poulos & Dr. Amy Ursano UNC Psychiatry Pediatric Behavior Clinic 9/18 $20,000 UNC Center for Excellence in Community Mental Health – Wellness on Dr. Thava Mahadevan 9/18 $65,650 Wheels (WoW) Depression Susceptibility in Adolescent Females: Estrogen Variability, Stress Dr. Elizabeth Andersen 5/18 $38,710 Exposure, and Fronto-Limbic Brain Dynamics Mechanism of Action of Transcranial Alternating Current Stimulation for the Dr. Flavio Frohlich 5/18 $100,000 Treatment of Major Depression Disorder Cellular and Molecular mechanisms governing cortical surface area Dr. Heather Hazlett overgrowth in iPSC-derived neural cells from longitudinally characterized 5/18 $49,720 autism individuals Dr. Donita Robinson Reversing the pharmacological effects of cocaine by allopregnanolone 5/18 $54,506 Dr. Kai Xia Predicting Early Brain Development via Deep Learning of DNA 5/18 $39,742 Dr. Takahiro Soda The Genetics of ECT 5/18 $39,990 Dr. Karen Poulus & Dr. Amy Ursano UNC Pediatric Behavior Clinic (formerly Wake Pediatric Behavior Clinc) 11/17 $20,000 Dr. Myra Brickell, Board President Filling the Gaps of Wake County, Inc. (FIGS) 9/17 $11,708 Mr. Edward Binanay, UNC Burn Center Chris White Fund 9/17 $11,708 Dr. Terry Morris, Executive Director Vets to Vets United 9/17 $11,708 Dr. Cynthia Bulik "Binge Eating Genetics INitiative (BEGIN)" 5/17 $40,000 3 The Foundation of Hope Funded Research & MHI Grants Master Report 1985-Present Researcher/Applicant Title Date Amount Dr. Fredrik Jarskog "Randomized controlled trial of pyridoxine for tardive dyskinesia" 5/17 $99,905 "Excitation-inhibition imbalance in autistic auditory cortex and its effects on Dr. Hiroyuki Kato 5/17 $100,000 spectro-temporal sound integration" Dr. Darin Knapp "Alcohol Intoxication mediated through medial septal circuitry" 5/17 $39,210 Dr. Cort Pedersen “Testing Oxytocin Treatment of Opioid Withdrawal” 5/17 $40,808 Dr. Joseph Piven "Prospective Identification of Individuals with a Brain Overgrowth Form of Dr. Mark Zylka 5/17 $40,000 Autism" Dr. Jason Stein "Characterizing the Hormone Sensitive Phenotype of Postpartum Depression: Dr. Crystal Edler Schiller 5/17 $39,357 An Experimental Investigation of Mood, Behavior, and Brain Function Dr. Hiroyuki Kato Deep Phenotyping of Behavioral Patterns Associated with Neuropsychiatric 11/16 $162,707 Dr. Garret D. Stuber Disease Achieving Synergy with Multimodal Brain Stimulation: Electricity meet Dr. Flavio Frohlich 11/16 $156,613 Magnetism Dr. Rebecca Knickmeyer Santelli Identifying Metabolites in the Microbiome-Gut-Brain Axis during infancy 5/16 $64,881 Dr. Karen Poulos & Dr. Amy Ursano Wake Pediatric Behavior Clinic - Foundation of Hope Signature Grant 5/16 $10,000 Dr. Terry Morris, Executive Director Vets to Vets United 5/16 $10,974 Ms. Dawn Carter, Chair Clark's Promise - Raleigh 5/16 $10,973 Mr. Barry Bryant, Executive Director Hopeline - NC 5/16 $8,974 Single cell transcriptional profiling to identify novel Neurocircuit targets for Dr. Garret D. Stuber 5/16 $45,000 reproductive mood disorders. Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Dr. Crystal Edler Schiller 5/16 $40,000 Neural Reward System in the Perimenopause 4 The Foundation of Hope Funded Research & MHI Grants Master Report 1985-Present Researcher/Applicant Title Date Amount Fecal Microbiota Transplantation for Severe and Enduring Anorexia Nervosa Dr. Cynthia Bulik 5/16 $33,250 (FMT for SE-AN) Predicting the Trajectory of Restrictive Eating in Childhood from Genetic Risk Dr. Stephanie Zerwas 5/16 $45,000 for Anorexia Nervosa Establishing Network Targets during Developmental for Non-Invasive Brain Dr. Yuhui Li 5/16 $37,549 Stimulation Dr. Samantha Meltzer-Brody gPACT - a rapid, large & inexpensive study of Postpartum Depression 12/15 $99,000 Dr. Karen Poulos & Dr. Amy Ursano Wake Pediatric Behavior Clinic - Foundation of Hope Signature Grant 11/15 $43,600 Dr. Garret Stuber Defining, Mining, and Reversing Neurocircuit Adaptions in Addiction 5/15 $100,000 Next Generation Non-invasive Brain Stimulation: A Novel Solution Enabled by Dr. Flavio Frohlich 5/15 $200,000 Mobile Technology and Big Data The Gut Microbiome and Perinatal Mood and Anxiety Disorders (PMAD) : A Dr. Mary Kimmel Pilot Study to Examine the Microbiome in Relation to Perinatal Changes in 5/15 $39,912 Stress & Immune Systems Dr. Stephanie Zerwas Autoimmune Illness, Infections, and Genetic Risk for Anorexia Nervosa 5/15 $39,981 Identifying Susceptibility Loci for Tourette’s Syndrome in a Densely Affected Dr. James Crowley 5/15 $40,000 Pedigree Investigating Brain and Behavior Development in Typical and High-Risk Dr. Sarah Short 5/15 $46,921 Children Dr. Karen Poulos & Dr. Amy Ursano Wake Pediatric Behavior Clinic - Foundation of Hope Signature Grant 12/14 $26,625 Dr. Karen Grewen Oxytocin effects on cocaine-induced Maternal neglect: A Translational Study 5/14 $39,956 Deconstructing Maternal Circuit Elements that Underlie Anxiety & Dr. Jenna McHenry 5/14 $40,000 Motivation Longitudinal Assessment of Mental Health Needs of Advanced Cancer Dr. Eliza Park 5/14 $38,898 Patients with Dependent Children 5 The Foundation of Hope