Gold Sodium Thiosulfate

Total Page：16

File Type：pdf, Size：1020Kb

Gold Sodium Thiosulfate You have shown a positive allergic reaction to Gold Sodium Thiosulfate. You should avoid contact with this substance. Information about this substance is below. What is it? Gold Sodium Thiosulfate is a metal used primarily in jewelry, dental work, and in gold plating. How can I avoid it? Individuals who are allergic to gold should be able to avoid this metal. This may require not wearing gold jewelry, removing gold dental prostheses, or not receiving gold-based medicines. Many patients who have positive patch test results to gold, find no relevance of their gold reaction to their dermatitis. Uses: • Ceramics and glassware • Photography • Cosmetics • Porcelain and gilding glass • Currency (coins) • Intracoronary Stents • Dental fillings / implants • Pool supplies • Electronic circuits • Previous rheumatoid Arthritis treatment • Enamels • Iodine remover • Eye and dental prostheses • Leather tanning • Gold-plating process • Ammonia remover • Jewelry • Gold-plated intracoronary stents • Medicines and pharmaceuticals Other names for Gold Sodium Thiosulfate: • Auranofin • Gold stannate • Auricidine • Gold trichloride - gold chloride • Aurocidin • Hyposulfite sodium • Aurolin • Myochrysine • Auropex • Novacrysin • Auropin • Potassium bromoaurate • Aurosan • Potassium dicyanoaurate • Aurothion • Ridaura • Aurothiodulfate natrium • Sanochrysine • Aurothiosulfate sodium • Sel de Fordos et Gelis • Bis (monothiosulfato-(2<)-0,S) aurate (3<0) trisodium • Sodium aurothiomalate • Bis (monothiosulfato)aurate(3<) trisodium • Sodium aurothiosulfate • Crisalbine • Sodium chloraurate • Crytion • Sodium thiosulfoaurate • Double thiosulfate of gold and sodium • Sulfocrisol • Gold sodium thiomalate - injectable therapeutic gold • Thiochrysine ©2018 Mayo Foundation for Medical Education and Research MCS7562-188revWIP.

Copy Link

Recommended publications

Wo 2009/082437 A9
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) CORRECTED VERSION (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 2 July 2009 (02.07.2009) WO 2009/082437 A9 (51) International Patent Classification: KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, C07D 207/08 (2006.01) A61K 31/402 (2006.01) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, C07D 207/09 (2006.01) A61P 5/26 (2006.01) NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, C07D 498/04 (2006.01) SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (21) International Application Number: PCT/US2008/013657 (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (22) International Filing Date: G M M N S D S L s z τ z U G Z M 12 December 2008 (12.12.2008) z w Eurasian (A M B γ KG> M D RU> τ (25) Filing Language: English TM), European (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (26) Publication Language: English M C M T N L N O P L P T R O S E S I s T R OAPI (30) Priority Data: B F ' B J ' C F ' C G ' C I' C M ' G A ' G N ' 0 G W ' M L ' M R ' 61/008,731 2 1 December 2007 (21 .12.2007) US N E ' S N ' T D ' T G ) - (71) Applicant (for all designated States except US): LIG- Declarations under Rule 4.17: AND PHARMACEUTICALS INCORPORATED [US/ — as to applicant's entitlement to apply for and be granted US]; 11085 N.
[Show full text]
Classification of Medicinal Drugs and Driving: Co-Ordination and Synthesis Report
Project No. TREN-05-FP6TR-S07.61320-518404-DRUID DRUID Driving under the Influence of Drugs, Alcohol and Medicines Integrated Project 1.6. Sustainable Development, Global Change and Ecosystem 1.6.2: Sustainable Surface Transport 6th Framework Programme Deliverable 4.4.1 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Due date of deliverable: 21.07.2011 Actual submission date: 21.07.2011 Revision date: 21.07.2011 Start date of project: 15.10.2006 Duration: 48 months Organisation name of lead contractor for this deliverable: UVA Revision 0.0 Project co-funded by the European Commission within the Sixth Framework Programme (2002-2006) Dissemination Level PU Public PP Restricted to other programme participants (including the Commission x Services) RE Restricted to a group specified by the consortium (including the Commission Services) CO Confidential, only for members of the consortium (including the Commission Services) DRUID 6th Framework Programme Deliverable D.4.4.1 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Page 1 of 243 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Authors Trinidad Gómez-Talegón, Inmaculada Fierro, M. Carmen Del Río, F. Javier Álvarez (UVa, University of Valladolid, Spain) Partners - Silvia Ravera, Susana Monteiro, Han de Gier (RUGPha, University of Groningen, the Netherlands) - Gertrude Van der Linden, Sara-Ann Legrand, Kristof Pil, Alain Verstraete (UGent, Ghent University, Belgium) - Michel Mallaret, Charles Mercier-Guyon, Isabelle Mercier-Guyon (UGren, University of Grenoble, Centre Regional de Pharmacovigilance, France) - Katerina Touliou (CERT-HIT, Centre for Research and Technology Hellas, Greece) - Michael Hei βing (BASt, Bundesanstalt für Straßenwesen, Germany).
[Show full text]
(Sodium Aurothiomalate Injection, Mfr. Std.) 10, 25 and 50 Mg/Ml Anti
PRESCRIBING INFORMATION PrMYOCHRYSINE® (sodium aurothiomalate injection, Mfr. Std.) 10, 25 and 50 mg/mL Anti-Rheumatic Agent (disease modifying) sanofi-aventis Canada Inc. Date of Revision: 2150 St. Elzear Blvd. West November 29, 2007 Laval, Quebec H7L 4A8 Submission Control No.: 114637 s-a Version 2.0 dated NAME OF DRUG PrMYOCHRYSINE® Sodium aurothiomalate injection, Mfr. Std. 10, 25 and 50 mg/mL THERAPEUTIC CLASSIFICATION Anti-rheumatic agent (disease modifying) ACTIONS AND CLINICAL PHARMACOLOGY Sodium aurothiomalate exhibits anti-inflammatory, antiarthritic and immunomodulating effects. The predominant clinical effect of MYOCHRYSINE (sodium aurothiomalate) appears to be suppression of the synovitis in the active stage of the rheumatoid disease. The precise mechanism of action is unknown but it has been suggested that the drug may act by inhibiting cell-mediated and humoral immune mechanisms. Additional modes of action include alteration or inhibition of various enzyme systems, suppression of phagocytic activity of macrophage and polymorphonuclear leukocytes, and alteration of collagen biosynthesis. The metabolic fate of sodium aurothiomalate in humans is unknown but it is believed not to be broken down to elemental gold. It is very highly bound to plasma proteins. Sixty to 90% is excreted very slowly by the renal route while 10 to 40% is eliminated in the feces mostly via biliary secretion. The biologic half-life of gold following a single 50 mg dose of parenteral gold has been reported to range from 6 to 25 days. It increases following successive weekly doses. The appearance of clinical effect is slow. It may take at least 8 weeks to become significant and the maximum benefits may not be achieved for at least 6 months.
[Show full text]
Should I Take Methotrexate
I have never taken medication for rheumatoid arthritis before. Should I take methotrexate (Rheumatrex®) alone or with other disease- modifying anti-rheumatic drugs for rheumatoid arthritis? A Cochrane decision aid to discuss options with your doctor This decision aid is for you if: □ You are16 or older. □ Your doctor has told you that you have active rheumatoid arthritis (RA). □ You have never taken methotrexate or any disease-modifying anti-rheumatic drug before such as azathioprine (Imuran®), cyclosporine (Neoral®), gold therapy or sodium aurothiomalate (Myochrysine®), hydroxychloroquine (Plaquenil®), leflunomide (Arava®), penicillamine (Cuprimine®) sulfasalazine (Salazopyrin®, generics), tacrolimus (Prograf®) or others. What is Rheumatoid Arthritis (RA)? When you have rheumatoid arthritis, your immune system, which normally fights infection, attacks the lining of your joints making them inflamed. This inflammation causes your joints to be hot, swollen, stiff, and painful. The small joints of your hands and feet are usually affected first. If the inflammation goes on without treatment, it can lead to damaged joints. Once the joint is damaged it cannot be repaired, so treating rheumatoid arthritis early is important. What is Methotrexate? Methotrexate is a disease-modifying antirheumatic drug (DMARD). It is the most commonly used DMARD in rheumatoid arthritis. It works to control inflammation in your joints. Methotrexate is taken once per week and it comes in pill form or as an injection. Methotrexate only works while you are taking it. It will take 6 to 8 weeks for the methotrexate to work. It is important for you to keep taking the medicine. Your doctor may start you on a low dose and gradually increase your dose.
[Show full text]
NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (Nsaids)
NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) A. Description Interfere with prostaglandin synthesis Alleviate inflammation and subsequent discomfort of rheumatoid conditions (GA) Available in oral and parenteral (IM) preparations CYCLOOXYGENASE INHIBITORS : are preferred because it does not decrease the cytoprotective lining of the stomach. Celebrex (Celecoxib) Vioxx (Rofecoxib)(No longer on market as of September 2004) Bextra (Valdecoxib)(No longer on market as of April 2005) There are also other COX-2 Inhibitors being developed, including: Prexige Lumiracoxib) Arcoxia (Etoricoxib) B. Examples Diclofenac (Voltaren) Etodolac (Lodine) Ibuprofen (Motrin) Naproxen (Naprosyn) Salicylates (ASA) COX-2 SELECTIVE INHIBITORS are the newest of the NSAIDs KETOROLAC is the only NSAID that can be administered by injection (intramuscularly or intravenously) and is indicated for the short-term use of severe to moderate pain. C. Major Side Effects GI irritation (local effect) Skin rash (hypersensitivity) Blood dyscrasias (decreased RBCs, WBCs, platelet synthesis) CNS and GU disturbances D. Nursing Care Administer with meals to reduce GI irritation Monitor blood work Assess vital signs Instruct client to report the occurrence of any side effects to the physician Encourage diet rich in nutrient-dense foods such as fruits, vegetables, whole grains, and legumes to improve and maintain nutritional status and prevent possible drug-induced nutrient deficiencies ANTIGOUT AGENTS (Uricosuric agent) A. Description Act by decreasing uric acid
[Show full text]
Report of the Expert Committee for the Selection and Inclusion Of
Report of the Expert Committee / A Report of the Expert Committee for the Selection and Inclusion of Medicines in the Pan American Health Organization Strategic Fund – July 2013 Report of the Expert Committee for the Selection and Inclusion of Medicines in the Pan American Health Organization Strategic Fund – July 2013 PAHO HQ Library Cataloguing-in-Publication Data ***************************************************************************************** Pan American Health Organization. Report of the Expert Committee for the Selection and Inclusion of Medicines in the Pan American Health Organization Strategic Fund – July 2013. Washington, DC : PAHO, 2013. 1. Pharmaceutical Preparations. 2. Chronic Disease. 3. Cardiovascular Diseases. 4. Neoplasms. 5. Immunosuppressive Agents. 6. Complementary Therapies. 7. Americas. I. Title. II. PAHO Strategic Fund. ISBN 978-92-75-11814-6 (NLM Classification: QV55) The Pan American Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full. Applications and inquiries should be addressed to the Department of Knowledge Management and Communications (KMC), Pan American Health plansOrganization, for new Washington,editions, and D.C.,reprints U.S.A. and ([email protected]). translations already available. The Department of Health Systems and Services (HSS) will be glad to provide the latest information on any changes made to the text, © Pan American Health Organization, 2013. All rights reserved. Publications of the Pan American Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention. All rights are reserved. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the Pan American Health Organization concerning the status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.
[Show full text]
Gold Levels Produced by Treatment with Auranofin and Sodium Aurothiomalate
Ann Rheum Dis: first published as 10.1136/ard.42.5.566 on 1 October 1983. Downloaded from Annals ofthe Rheumatic Diseases, 1983, 42, 566-570 Gold levels produced by treatment with auranofin and sodium aurothiomalate D. LEWIS,' H. A. CAPELL,1 C. J. McNEIL,2 M. S. IQBAL,2 D. H. BROWN, 2 AND W. E. SMITH2 From the 1CentreforRheumatic Diseases, University DepartmentofMedicine, Baird Street, Glasgow G4 OEH, and the 2Department ofPure and Applied Chemistry, University ofStrathclyde, Glasgow GJ IXL SUMMARY Sixty-three patients with rheumatoid arthritis were randomly divided into 3 groups, and treated with either sodium aurothiomalate (Myocrisin), auranofin, or placebo. Gold levels in whole blood, plasma, and haemolysate were measured serially along with clinical and laboratory para- meters of efficacy. Auranofin produced a higher ratio of haemolysate to plasma gold than Myocrisin, and it appears that the affinity of the red cell for gold is reduced during therapy with auranofin. Gold levels did not correlate with changes in the pain score, erythrocyte sedimentation rate, and C-reactive protein, nor with the development of toxicity. In the Myocrisin group the haemolysate gold level achieved was dependent on the number of cigarettes smoked. In the auranofin group there was no such correlation, but the haemolysate gold level was higher for smokers than non-smokers. The likely action of gold is discussed. copyright. Gold compounds have been used in the treatment of The purpose of the present study was to measure rheumatoid arthritis for over 50 years, and theirplace the distribution ofgold in the blood of patients receiv- in clinical practice is firmly established.' 2 However, ing Myocrisin or auranofin, both in order to deter- there remains a need to monitor the use of these mine whether or not parameters such as haemolysate compounds very carefully to establish efficacy and to gold or the ratio of haemolysate to plasma gold are anticipate the onset of any toxic reaction which may correlated with efficacy or toxicity and to improve http://ard.bmj.com/ occur.
[Show full text]
The Antiproliferative Effect of Sodium Aurothiomalate
Annals of the Rheumatic Diseases, 1986; 45, 389-395 Cultured human cells can acquire resistance to the antiproliferative effect of sodium aurothiomalate A GLENNAS' 2 AND H E RUGSTAD' From the 'Division of Clinical Pharmacology, Institute for Surgical Research, Rikshospitalet, the National Hospital, and the 2Oslo Sanitetsforening Rheumatism Hospital, Oslo, Norway SUMMARY Cultured human epithelial cells (HE), grown as monolayers, acquired resistance to otherwise lethal concentrations (300 [tmol/l, culture medium) of sodium aurothiomalate during five months' exposure to stepwise increased concentrations of the drug. The resistance acquired was shown by exposure to drug concentrations ranging from 25 to 300 [mol/, resulting in 100% of the resistant cells (HeMy(,) surviving compared with controls. Only 13% of the sensitive parent cells survived when exposed to 300 [tmol/l for four days. The IHEMV, cells were also resistant to the antiproliferative effects of equimolar concentrations of thiomalic acid without gold. The cytosolic gold concentration and the association of '99Au with cytosolic proteins after gel filtration were similar in both cell lines after sodium aurothiomalate exposure to the exponentially growing cells. No synthesis of gold binding proteins of metallothionein character was observed in the HEMyo cells. The concentration of free thiomalate in the sonicates and cytosols of the HeMV, cells was decreased to 25-30% of the concentration found in the HE cells. Comparison with previous data for the cytosolic concentration of total thiomalate in the HE cells suggests that most of the cytosolic thiomalate present was free thiomalate. We conclude that the cells can develop resistance to the antiproliferative effect of sodium aurothiomalate, and that the resistance may be due to their capacity to maintain low concentrations of free thiomalate in the sonicates and cytosols.
[Show full text]
3258 N:O 1179
3258 N:o 1179 LIITE 1 BILAGA 1 LÄÄKELUETTELON AINEET ÄMNENA I LÄKEMEDELSFÖRTECKNINGEN Latinankielinen nimi Suomenkielinen nimi Ruotsinkielinen nimi Englanninkielinen nimi Latinskt namn Finskt namn Svenskt namn Engelskt namn Abacavirum Abakaviiri Abakavir Abacavir Abciximabum Absiksimabi Absiximab Abciximab Acamprosatum Akamprosaatti Acamprosat Acamprosate Acarbosum Akarboosi Akarbos Acarbose Acebutololum Asebutololi Acebutolol Acebutolol Aceclofenacum Aseklofenaakki Aceklofenak Aceclofenac Acediasulfonum natricum Asediasulfoninatrium Acediasulfonnatrium Acediasulfone sodium Acepromazinum Asepromatsiini Acepromazin Acepromazine Acetarsolum Asetarsoli Acetarsol Acetarsol Acetazolamidum Asetatsoliamidi Acetazolamid Acetazolamide Acetohexamidum Asetoheksamidi Acetohexamid Acetohexamide Acetophenazinum Asetofenatsiini Acetofenazin Acetophenazine Acetphenolisatinum Asetofenoli-isatiini Acetfenolisatin Acetphenolisatin Acetylcholini chloridum Asetyylikoliinikloridi Acetylkolinklorid Acetylcholine chloride Acetylcholinum Asetyylikoliini Acetylkolin Acetylcholini Acetylcysteinum Asetyylikysteiini Acetylcystein Acetylcysteine Acetyldigitoxinum Asetyylidigitoksiini Acetyldigitoxin Acetyldigitoxin Acetyldigoxinum Asetyylidigoksiini Acetyldigoxin Acetyldigoxin Acetylisovaleryltylosini Asetyyli-isovaleryyli- Acetylisovaleryl- Acetylisovaleryltylosine tartras tylosiinitartraatti tylosintartrat tartrate Aciclovirum Asikloviiri Aciklovir Aciclovir Acidum acetylsalicylicum Asetyylisalisyylihappo Acetylsalicylsyra Acetylsalicylic acid Acidum alendronicum
[Show full text]
Biochemical Indices Ofresponse to Hydroxychloroquine and Sodium Aurothiomalate in Rheumatoid Arthritis 481
Ann Rheum Dis: first published as 10.1136/ard.40.5.480 on 1 October 1981. Downloaded from Annals of the Rheumatic Diseases, 1981, 40, 480-488 Biochemical indices of response to hydroxychloroquine and sodium aurothiomalate in rheumatoid arthritis J. S. DIXON, M. E. PICKUP, H. A. BIRD, M. R. LEE, V. WRIGHT, AND W. W. DOWNIE From the Clinical Pharmacology Unit, Royal Bath Hospital, Harrogate, and the University Department of Medicine, General Infirmary, Leeds SUMMARY Biochemical and clinical changes have been monitored in 30 patients with rheumatoid arthritis treated with either hydroxychloroquine or sodium aurothiomalate over a period of 6 months. Acute-phase reactants improved in both treatment groups, while serum sulphydryl and serum histidine improved only in the gold-treated patients. Correlation matrices were constructed from mean clinical and biochemical data at successive clinic visits. Correlations obtained with gold were more frequent and of a higher level of significance than those obtained with hydroxychloro- quine at the doses we studied. This lends support to the use of correlation matrices as a screening test for potential long-term antirheumatoid activity of drugs in man. copyright. In an attempt to define biochemical and clinical 39 to 66 years; 2 male, aged 31 and 49 years) were changes that occur when patients with rheumatoid allocated to HCQ therapy, and a further 15 patients arthritis are exposed for the first time to 'specific (11 female, mean age 52 7, range 36 to 67 years; antirheumatoid' therapy, and to see if these changes 4 male, mean age 54*5, range 45 to 64 years) were differ between drugs we have performed serial allocated to gold therapy.
[Show full text]
Hydroxychloroquine and Sulphasalazine Alone and in Combination in Rheumatoid Arthritis: a Randomised Double Blind Trial
Annals of the Rheumatic Diseases 1993; 52: 711-715 71 Hydroxychloroquine and sulphasalazine alone and in combination in rheumatoid arthritis: a randomised double blind trial Karen Lisbeth Faarvang, Charlotte Egsmose, Peter Kryger, Jan P0denphant, Margrethe Ingeman-Nielsen, Troels M0rk Hansen Abstract and hydroxychloroquine was superior to Objectives-To compare the effects of treatment with a single drug. The two drugs hydroxychloroquine and sulphasalazine were chosen because of their low incidence of alone and in combination in rheumatoid serious side effects. In addition, we aimed to arthritis. determine whether previous treatment with Methods-A six month randomised, gold salts or penicillamine affected the multicentre, double blind trial with three outcome. Finally, the selection of patients for parallel groups was performed. Ninety one the study from the total population of patients outpatients with active rheumatoid with RA at the three participating rheumato- arthritis were included. Monthly assess- logical clinics was recorded. ments of erythrocyte sedimentation rate, morning stiffness, number of swollen joints, a pain score, and global assess- Patients and methods ments were carried out. Radiographs of PATIENTS hands and wrists were taken before and During the inclusion period 776 patients with after the trial. RA were registered in the three participating Results-Sixty two patients completed the departments. Ninety one of these met the study. The 29 withdrawals caused no criteria for inclusion in the trial. They all had evident bias, and there was no difference RA defined according to the American in side effects among the three groups. All Rheumatism Association 1958 criteria.' The Department of variables improved significantly with mean age was 61 years (range 18-82) and the Rheumatology, Kong time.
[Show full text]
Sodium Aurothiomalate
Wirral University Teaching Hospital NHS Foundation Trust Shared Care Guideline Sodium aurothiomalate (i.m gold) for rheumatoid arthritis and other rheumatological diseases (Adults) It is vital for safe and appropriate patient care that there is a clear understanding of where clinical and prescribing responsibility rests between Consultants and General Practitioners (GPs). This guideline reinforces the basic premise that: When clinical and / or prescribing responsibility for a patient is transferred from hospital to GP, the GP should have full confidence to prescribe the necessary medicines. Therefore, it is essential that a transfer of care involving medicines that a GP would not normally be familiar with, should not take place without the “sharing of information with the individual GP and their mutual agreement to the transfer of care.” These are not rigid guidelines. On occasions, Consultants and GPs may agree to work outside of this guidance. As always, the doctor who prescribes the medication has the clinical responsibility for the drug and the consequences of its use. Indications: Dosage and administration: Sodium aurothiomalate (gold) is Given by deep intramuscular injection. used in the management of active Test dose 10 mg must be given in clinic followed by 30 mins progressive rheumatoid arthritis observation to look for signs of allergic reaction, followed by 50 mg once weekly until there is definite evidence of remission, then reduced to 50 mg every 4 weeks continued for up to 5 years after complete remission, dose to be reduced
[Show full text]