Datasheet Inhibitors / Agonists / Screening Libraries A DRUG SCREENING EXPERT

Product Name : Sultopride hydrochloride Catalog Number : T7180 CAS Number : 23694-17-9 Molecular Formula : C17H27ClN2O4S Molecular Weight : 390.93

Description: Sultopride Hydrochloride is a selective D2 and D3 antagonist.

Storage: 2 years -80°C in solvent; 3 years -20°C powder;

DMSO 50 mg/mL (127.90 mM) Solubility ( < 1 mg/ml refers to the product slightly soluble or insoluble )

Receptor (IC50) Dopamine

In vivo Activity Sultopride and are both chemically similar derivatives and selective antagonists of dopamine D2 receptors. However, these drugs differ in clinical properties. We compared the effects of sultopride and sulpiride on dopamine turnover in rats following the administration of these drugs alone or in combination with . The administration of sultopride or sulpiride markedly accelerated dopamine turnover in the rat brain. The increase in the level of dopamine metabolites in the striatum was more marked in the sultopride-treated rats. Sulpiride affected the limbic dopamine receptors preferentially, whereas sultopride affected the striatal and the limbic dopamine receptors equally. A low dose of apomorphine induced a reduction in the concentration of dopamine metabolites in the striatum and the nucleus accumbens by approximately 55%, but not in the medial prefrontal cortex. Sultopride was more effective in preventing an apomorphine-induced reduction in dopamine metabolite levels.

Reference 1. Differences in effects of sultopride and sulpiride on dopamine turnover in rat brain.

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